Analysis of the Broad’s Avana CRISPR (Broad Institute Cancer Dependency Map 2018, Meyers et al. 2017) and the Broad and Dana-Farber Cancer Institite’s Achilles shRNA (MacFarland et al. 2018, Data Science 2018).
The Avana screen produced results using CERES (Meyers et al. 2017) (GitHub), which generates gene dependency scores from sgRNA depletion scores from gene essentiality screens and eliminates bias arising from the effect of copy number variation on Cas9 DNA cleavage. The lower the CERES score, the higher the likelihood that the gene is essential in the associated cell line. Scores are scaled per cell line such that a score of 0 is the median effect of nonessential genes and -1 is the median effect of common core essential genes.
All annotation files (copy number, mutation status, and gene expression) (Consortium and Consortium 2015, Barretina et al. 2012) were downloaded from the DepMap Data Portal.
library(bsselectR)
library(data.table)
library(ggpubr)
library(ggsignif)
library(kableExtra)
library(reshape2)
library(tidyverse)
adj_signif <- function(df) {
# Takes df from compare_means and creates a signif code column for adjusted p-vals
df$p.signif <- ifelse(df$p.signif == "ns", NA, df$p.signif)
df$p.signif.adj <- ifelse(df$p.adj <= 0.0001, "****",
ifelse(df$p.adj <= 0.001, "***",
ifelse(df$p.adj <= 0.01, "**",
ifelse(df$p.adj <= 0.05, "*", NA))))
df$p.short <- formatC(df$p, format = "g", digits = 2)
df$p.adj.short <- formatC(df$p.adj, format = "g", digits = 2)
return(df)
}
WilcoxonByDrug <- function(drug, dataset, data_name) {
use_data <- filter(dataset, Drug == drug)
sig <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = "Hugo_Symbol", data = use_data, method = "wilcox.test", p.adjust.method = "BH")
sig <- adj_signif(sig)
sig <- sig[order(sig$p),]
sig$Drug <- drug
sig$Dataset <- toupper(data_name)
return(sig)
}
WilcoxonByDrugAllGenes <- function(melt_file, grid_file, data_name) {
druglist <- as.character(unique(melt_file$Drug))
sig_df <- NULL
for(i in 1:length(druglist)) {
print(paste0("Current drug in process: ", druglist[i], " (drug ", i, " of ", length(druglist), ")."))
flush.console()
melted <- filter(melt_file, Drug == druglist[i])
use_data <- merge(grid_file, melted, by = "accession_id", all.x = TRUE)
use_data <- merge(use_data, ccl_converter, by = "accession_id", all.x = TRUE)
use_data <- merge(use_data, maf_df, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
use_data$Mutation_Status_Nonsilent <- ifelse(is.na(use_data$Mutation_Status_Nonsilent), "Other", use_data$Mutation_Status_Nonsilent)
use_data$Hugo_Symbol <- factor(use_data$Hugo_Symbol)
use_data$AUC <- as.numeric(use_data$AUC)
use_data <- filter(use_data, !is.na(use_data$AUC))
use_data$Drug_Gene <- paste0(use_data$Drug, "_", use_data$Hugo_Symbol)
use_data_ptmuts <- filter(use_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
use_data_ptmuts$Keep_PtMut_Tests <- ifelse(use_data_ptmuts$Reference_Allele_Length == 1 | is.na(use_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(use_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
use_data_ptmuts <- filter(use_data_ptmuts, Keep_PtMut_Tests == TRUE)
sig <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = "Hugo_Symbol", data = use_data_ptmuts, method = "wilcox.test", p.adjust.method = "BH")
sig <- adj_signif(sig)
sig <- sig[order(sig$p),]
sig <- filter(sig, p <= 0.05)
sig$Drug <- druglist[i]
sig$Dataset <- toupper(data_name)
sig_df <- rbind(sig_df, sig)
}
return(sig_df)
}
makeDrugBoxplots <- function(drug, dataset) {
if(dataset == "CCLE" | dataset == "ccle") {
use_data <- filter(ccle_data_g2p_genesfilt, Drug == drug)
use_color <- as.character(use_data$Color_Nonsilent)
names(use_color) <- use_data$Mutation_Status_Nonsilent
sig <- ccle_signif_g2p_ByDrug[[drug]]
label_text <- data.frame(p.signif = sig$p.signif, p.signif.adj = sig$p.signif.adj, Hugo_Symbol = sig$Hugo_Symbol)
label_text$Hugo_Symbol <- factor(label_text$Hugo_Symbol, levels = g2p_genes)
}
else if(dataset == "CTRP" | dataset == "ctrp") {
use_data <- filter(ctrp_data_g2p_genesfilt, Drug == drug)
use_color <- as.character(use_data$Color_Nonsilent)
names(use_color) <- use_data$Mutation_Status_Nonsilent
sig <- ctrp_signif_g2p_ByDrug[[drug]]
label_text <- data.frame(p.signif = sig$p.signif, p.signif.adj = sig$p.signif.adj, Hugo_Symbol = sig$Hugo_Symbol)
label_text$Hugo_Symbol <- factor(label_text$Hugo_Symbol, levels = g2p_genes)
}
else if(dataset == "GDSC" | dataset == "gdsc") {
use_data <- filter(gdsc_data_g2p_genesfilt, Drug == drug)
use_color <- as.character(use_data$Color_Nonsilent)
names(use_color) <- use_data$Mutation_Status_Nonsilent
sig <- gdsc_signif_g2p_ByDrug[[drug]]
label_text <- data.frame(p.signif = sig$p.signif, p.signif.adj = sig$p.signif.adj, Hugo_Symbol = sig$Hugo_Symbol)
label_text$Hugo_Symbol <- factor(label_text$Hugo_Symbol, levels = g2p_genes)
}
else { return("Error: Invalid dataset.") }
plot <- ggplot(data = use_data, aes(x = Mutation_Status_Nonsilent, y = AUC)) +
facet_wrap(~ Hugo_Symbol, drop = FALSE, nrow = 1) +
geom_boxplot(mapping = aes(fill = Mutation_Status_Nonsilent), position = position_dodge(0.85), outlier.shape = 3, outlier.size = 0.5) +
scale_fill_manual(values = use_color) +
guides(color = FALSE) +
geom_text(data = label_text, mapping = aes(x = 1.5, y = max(use_data$AUC), label = p.signif), nudge_y = 0.2) +
theme(strip.text.x = element_text(size = 10, angle = 45), legend.position = "top", axis.ticks.x = element_blank(), axis.text.x = element_blank(), axis.title.x = element_blank()) +
labs(fill = "Mutation Status", y = "AUC", x = "Mutation Status", title = paste0(toupper(dataset), ": ", drug))
return(plot)
}
This comprehensive cancer cell line information curated by Daniel Charytonowicz.
ccl_converter <- read.delim("./data_munging/cell_line_database_v1_20180911.tsv", row.names = 1, sep = "\t", header = TRUE)
ccl_info <- read.delim("./data_munging/DepMap-2018q3-celllines.csv", sep = ",", header = TRUE, na.strings = c("", NA))
ccl_info$Primary.Disease <- gsub("\\\\", "", ccl_info$Primary.Disease)
ccl_info$Primary.Disease <- gsub("Ewings", "Ewing's", ccl_info$Primary.Disease)
# From figshare
crispr_meta <- read.delim("./data_munging/sample_info_18Q3_crispr.csv", sep = ",", header = TRUE, na.strings = c("", NA))
colnames(crispr_meta)[7] <- "CCLE_Name"
For mutation calling, get paired gene name and cell line fields in a data frame. For this analysis, we don’t care about how many mutations there are per gene or what type of mutations there are, so I didn’t save more information. I took unique gene-cell line combinations since we only cared about mutation presence/absence. Add a Mutation_Status column denoting all entries in MAF files as mutations present in the associated cell lines.
maf_raw <- read.delim("./data_munging/CCLE_DepMap_18q3_maf_20180718.txt.gz", header = TRUE, sep = "\t")
# Filter for cell lines in CRISPR screen
maf_raw <- filter(maf_raw, Broad_ID %in% unique(crispr_meta$Broad_ID))
colnames(maf_raw)[colnames(maf_raw) == "Tumor_Sample_Barcode"] <- "CCLE_Name"
# Select columns
maf_df <- subset(maf_raw, select = c("Hugo_Symbol", "CCLE_Name", "Broad_ID", "Variant_Classification", "Reference_Allele", "Tumor_Seq_Allele1"))
maf_df$Reference_Allele_Length <- ifelse(maf_df$Reference_Allele == "-", 0, nchar(as.character(maf_df$Reference_Allele)))
maf_df$Tumor_Seq_Allele1_Length <- nchar(as.character(maf_df$Tumor_Seq_Allele1))
# Add Mutation_Status column
maf_df$Mutation_Status_Nonsilent <- ifelse(maf_df$Variant_Classification == "Silent", "Other", "Mutant")
maf_df <- unique(subset(maf_df, select = c("Hugo_Symbol", "CCLE_Name", "Broad_ID", "Mutation_Status_Nonsilent", "Reference_Allele_Length", "Tumor_Seq_Allele1_Length")))
cn <- read.delim("./data_munging/public_18Q3_gene_cn_v2.csv.gz", sep = ",", check.names = FALSE, header = TRUE)
# Convert log2 ratios (log2(CN/2)) to CN
cn[2:ncol(cn)] <- lapply(cn[2:ncol(cn)], function(x) 2 * (2 ^ x))
# Remove Entrez gene IDs from colnames
colnames(cn) <- gsub(" .*", "", colnames(cn))
colnames(cn)[1] <- "Broad_ID"
# Melt
cn_melt <- melt(data = cn, id.vars = "Broad_ID", measure.vars = colnames(cn[2:ncol(cn)]), variable.name = "Hugo_Symbol", value.name = "Copy_Number")
saveRDS(cn_melt, "./data_munging/rds/cn_melt_18Q3.rds", compress = "xz")
cn_melt <- readRDS("./data_munging/rds/cn_melt_18Q3.rds")
Gene expression data (Reads Per Kilobase of transcript, per Million mapped reads, RPKM).
ge <- read.delim("./../crispr_lineages_giant_files/CCLE_DepMap_18q3_RNAseq_RPKM_20180718.gct.gz", skip = 2, header = TRUE, sep = "\t", check.names = FALSE)
# Edit columns
ge$Name <- NULL
colnames(ge)[1] <- "Hugo_Symbol"
# Melt
ge_melt <- melt(data = ge, id.vars = "Hugo_Symbol", measure.vars = colnames(ge[2:ncol(ge)]), value.name = "RPKM")
## Split variable column
ge_melt <- with(ge_melt, cbind(Hugo_Symbol, colsplit(variable, pattern = " ", names = c("CCLE_Name", "Broad_ID")), RPKM))
## Remove parentheses around Broad IDs
ge_melt$Broad_ID <- gsub("\\(|\\)", "", ge_melt$Broad_ID)
saveRDS(ge_melt, "./../crispr_lineages_giant_files/ge_melt_18Q3.rds", compress = "xz")
ge_melt <- readRDS("./../crispr_lineages_giant_files/ge_melt_18Q3.rds")
g2p <- read.delim("./data_munging/g2p_full_level_A_dataset_v2_10_10_2018.tsv", sep = "\t", header = TRUE)
g2p$Drug <- tolower(g2p$Drug)
g2p$Drug_Gene <- ifelse(is.na(g2p$Drug) | is.na(g2p$Gene), NA, paste0(g2p$Drug, "_", g2p$Gene))
g2p <- subset(g2p, grepl("^CID", g2p$DrugID))
g2p_drug_genes <- as.character(unique(g2p$Drug_Gene[!is.na(g2p$Drug_Gene)]))
g2p_genes <- unique(sapply(strsplit(g2p_drug_genes, "_", fixed = TRUE), function(x) x[2]))
g2p_drugs <- unique(sapply(strsplit(g2p_drug_genes, "_", fixed = TRUE), function(x) x[1]))
g2p_genes
## [1] "ALK" "EGFR" "PDGFRA" "JAK2" "KIT" "ABL1" "BRAF"
## [8] "BRCA1" "DPYD" "G6PD" "TSC2" "UGT1A1" "IDH2" "PDGFRB"
## [15] "MET" "ERBB3" "KRAS" "RET" "ROS1" "ESR1" "ERBB2"
## [22] "BRCA2" "PML" "TPMT" "TSC1" "MGMT" "PDGFB" "AKT1"
## [29] "MYD88" "PTCH1" "DNMT3A" "CYP19A1" "FLT3" "NPM1"
g2p_drugs
## [1] "ceritinib" "crizotinib"
## [3] "gefitinib" "afatinib"
## [5] "imatinib" "ruxolitinib"
## [7] "sunitinib" "regorafenib"
## [9] "dasatinib" "ponatinib"
## [11] "brigatinib" "vemurafenib"
## [13] "trametinib" "cobimetinib"
## [15] "olaparib" "2-fluoropyrimidine"
## [17] "erlotinib" "osimertinib"
## [19] "dabrafenib" "everolimus"
## [21] "nilotinib" "capecitabine"
## [23] "enasidenib" "icotinib"
## [25] "cabozantinib" "fluorouracil"
## [27] "fulvestrant" "lapatinib"
## [29] "azd" "alectinib"
## [31] "rucaparib" "niraparib"
## [33] "docetaxel" "tretinoin"
## [35] "purine" "guanine"
## [37] "temozolomide" "pralidoxime mesylate"
## [39] "nafomine malate" "neratinib"
## [41] "ap26113" "bosutinib monohydrate"
## [43] "tegafur" "arsenic"
## [45] "irinotecan" "vandetanib"
## [47] "letrozole" "ibrutinib"
## [49] "vismodegib" "daunorubicin"
## [51] "pazopanib" "belinostat"
## [53] "anastrozole" "midostaurin"
## [55] "cyclophosphamide" "selumetinib"
## [57] "palbociclib"
# Order and genes taken from pink heatmapo from Daniel's analyses
g2p_genes <- c("EGFR", "KRAS", "ERBB2", "ERBB3", "MET", "ALK", "ROS1", "PDGFRA", "ABL1", "KIT", "PDGFRB", "PDGFB", "BRAF", "G6PD", "RET", "BRCA1", "BRCA2", "UGT1A1", "TSC1", "TSC2", "AKT1", "IDH2", "DPYD", "ESR1", "CYP19A1", "TPMT", "FLT3", "NPM1", "DNMT3A", "PML", "PTCH1", "JAK2", "MYD88", "MGMT")
dep <- read.delim("./data_munging/gene_dependency_18Q3.csv.gz", sep = ",", header = TRUE, check.names = FALSE)
# Remove Entrez gene IDs from colnames
colnames(dep) <- gsub(" .*", "", colnames(dep))
The latest CRISPR CERES score data (18Q3, August 2018) was pulled from the DepMap Data Portal (Broad Institute Cancer Dependency Map 2018, Meyers et al. 2017).
crispr <- read.delim("./data_munging/gene_effect_18Q3.csv.gz", sep = ",", header = TRUE, check.names = FALSE)
# Remove Entrez gene IDs from colnames
colnames(crispr) <- gsub(" .*", "", colnames(crispr))
Merge annotation data:
# Melt CRISPR dataset for merging
crispr_melt <- melt(crispr, id.vars = "Broad_ID", measure.vars = colnames(crispr)[2:ncol(crispr)], variable.name = "Hugo_Symbol", value.name = "Score")
# Melt dependency probabilities dataset for merging
dep_melt <- melt(dep, id.vars = "Broad_ID", measure.vars = colnames(dep)[2:ncol(dep)], variable.name = "Hugo_Symbol", value.name = "Dep_Prob")
# Merge dependency probabilities
crispr_melt <- merge(crispr_melt, dep_melt, by = c("Broad_ID", "Hugo_Symbol"), all.x = TRUE)
# Merge cell line metadata
crispr_melt <- merge(crispr_melt, ccl_info, by = "Broad_ID", all.x = TRUE)
crispr_melt <- merge(crispr_melt, crispr_meta, by = c("CCLE_Name", "Broad_ID"), all.x = TRUE)
# Merge mutation annotations
crispr_muts <- merge(crispr_melt, maf_df, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
crispr_muts$Hugo_Symbol <- factor(crispr_muts$Hugo_Symbol)
crispr_muts <- crispr_muts %>% mutate(Mutation_Status_Nonsilent = if_else(is.na(Mutation_Status_Nonsilent), "Other", Mutation_Status_Nonsilent))
# Summarize number of mutant and Other cell lines
crispr_muts_summ <- crispr_muts %>% group_by(Hugo_Symbol) %>%
summarize(N_Nonsilent_Other = sum(Mutation_Status_Nonsilent == "Other"),
N_Nonsilent_Mutant = sum(Mutation_Status_Nonsilent == "Mutant"))
# Merge test results back into full dataset, which restores information lost in the summarization
crispr_data <- merge(crispr_muts_summ, crispr_muts, by = "Hugo_Symbol")
# Add Color columns
crispr_data$Color_Nonsilent <- ifelse(crispr_data$Mutation_Status_Nonsilent == "Other", "thistle", "darkorchid")
crispr_data$Color_Nonsilent <- factor(crispr_data$Color_Nonsilent)
# Cell line lineages
crispr_data <- merge(crispr_data, ccl_converter, by = c("CCLE_Name", "Broad_ID"), all.x = TRUE)
levels(crispr_data$lineage_name) <- sort(levels(crispr_data$lineage_name), decreasing = TRUE)
# Copy number
crispr_data <- merge(crispr_data, cn_melt, by = c("Hugo_Symbol", "Broad_ID"), all.x = TRUE)
# Gene expression (RPKM)
ge_filt <- filter(ge_melt, Hugo_Symbol %in% unique(crispr_data$Hugo_Symbol) & Broad_ID %in% unique(crispr_data$Broad_ID))
crispr_data <- merge(crispr_data, ge_filt, by = c("Hugo_Symbol", "Broad_ID", "CCLE_Name"), all.x = TRUE)
crispr_data$RPKM_log2 <- log2(crispr_data$RPKM + 0.0001)
saveRDS(crispr_data, "./../crispr_lineages_giant_files/crispr_data_18Q3.rds", compress = "xz")
crispr_data <- readRDS("./../crispr_lineages_giant_files/crispr_data_18Q3.rds")
crispr_data_ptmuts <- filter(crispr_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
crispr_data_ptmuts$Keep_PtMut_Tests <- ifelse(crispr_data_ptmuts$Reference_Allele_Length == 1 | is.na(crispr_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(crispr_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
crispr_data_ptmuts <- filter(crispr_data_ptmuts, Keep_PtMut_Tests == TRUE)
# Filter CRISPR for G2P genes in G2P
crispr_data_g2p <- filter(crispr_data_ptmuts, Hugo_Symbol %in% g2p_genes)
crispr_data_g2p$Hugo_Symbol <- factor(crispr_data_g2p$Hugo_Symbol, levels = g2p_genes)
# Drug metadata
drug_meta <- read.delim("./data_munging/drug_id_drug_name_table_10_12_2018.tsv", sep = "\t", header = FALSE)
colnames(drug_meta) <- c("CID", "Drug")
drug_meta$Drug <- tolower(drug_meta$Drug)
maf_df_g2p <- filter(maf_df, Hugo_Symbol %in% g2p_genes)
# CCLE
ccle <- read.delim("./data_munging/data_drug_auc_ccle_10_12_2018.csv", sep = "\t", header = TRUE, row.names = 1, check.names = FALSE)
ccle <- merge(drug_meta, ccle, by = "CID")
ccle_melt <- melt(ccle, id.vars = c("CID", "Drug"), measure.vars = colnames(ccle)[3:ncol(ccle)], variable.name = "accession_id", value.name = "AUC")
ccle_grid <- expand.grid("accession_id" = unique(ccle_melt$accession_id), "Hugo_Symbol" = g2p_genes)
ccle_data <- merge(ccle_grid, ccle_melt, by = "accession_id", all.x = TRUE)
ccle_data <- merge(ccle_data, ccl_converter, by = "accession_id", all.x = TRUE)
ccle_data <- merge(ccle_data, maf_df_g2p, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
ccle_data$Mutation_Status_Nonsilent <- ifelse(is.na(ccle_data$Mutation_Status_Nonsilent), "Other", ccle_data$Mutation_Status_Nonsilent)
ccle_data$Hugo_Symbol <- factor(ccle_data$Hugo_Symbol)
ccle_data$AUC <- as.numeric(ccle_data$AUC)
ccle_data$Color_Nonsilent <- ifelse(ccle_data$Mutation_Status_Nonsilent == "Other", "palegreen3", "springgreen4")
ccle_data$Color_Nonsilent <- factor(ccle_data$Color_Nonsilent)
ccle_data <- filter(ccle_data, !is.na(ccle_data$AUC))
ccle_data$Drug_Gene <- paste0(ccle_data$Drug, "_", ccle_data$Hugo_Symbol)
saveRDS(ccle_data, "./data_munging/rds/ccle_data_18Q3_g2pgenes.rds", compress = "xz")
# CTRP
ctrp <- read.delim("./data_munging/data_drug_auc_ctrp_10_12_2018.csv", sep = "\t", header = TRUE, row.names = 1, check.names = FALSE)
ctrp <- merge(drug_meta, ctrp, by = "CID")
ctrp_melt <- melt(ctrp, id.vars = c("CID", "Drug"), measure.vars = colnames(ctrp)[3:ncol(ctrp)], variable.name = "accession_id", value.name = "AUC")
ctrp_grid <- expand.grid("accession_id" = unique(ctrp_melt$accession_id), "Hugo_Symbol" = g2p_genes)
ctrp_data <- merge(ctrp_grid, ctrp_melt, by = "accession_id", all.x = TRUE)
ctrp_data <- merge(ctrp_data, ccl_converter, by = "accession_id", all.x = TRUE)
ctrp_data <- merge(ctrp_data, maf_df_g2p, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
ctrp_data$Mutation_Status_Nonsilent <- ifelse(is.na(ctrp_data$Mutation_Status_Nonsilent), "Other", ctrp_data$Mutation_Status_Nonsilent)
ctrp_data$Hugo_Symbol <- factor(ctrp_data$Hugo_Symbol)
ctrp_data$AUC <- as.numeric(ctrp_data$AUC)
ctrp_data$Color_Nonsilent <- ifelse(ctrp_data$Mutation_Status_Nonsilent == "Other", "slategray3", "steelblue4")
ctrp_data$Color_Nonsilent <- factor(ctrp_data$Color_Nonsilent)
ctrp_data <- filter(ctrp_data, !is.na(ctrp_data$AUC))
ctrp_data$Drug_Gene <- paste0(ctrp_data$Drug, "_", ctrp_data$Hugo_Symbol)
saveRDS(ctrp_data, "./data_munging/rds/ctrp_data_18Q3_g2pgenes.rds", compress = "xz")
# GDSC
gdsc <- read.delim("./data_munging/data_drug_auc_gdsc_10_12_2018.csv", sep = "\t", header = TRUE, row.names = 1, check.names = FALSE)
gdsc <- merge(drug_meta, gdsc, by = "CID")
gdsc_melt <- melt(gdsc, id.vars = c("CID", "Drug"), measure.vars = colnames(gdsc)[3:ncol(gdsc)], variable.name = "accession_id", value.name = "AUC")
gdsc_grid <- expand.grid("accession_id" = unique(gdsc_melt$accession_id), "Hugo_Symbol" = g2p_genes)
gdsc_data <- merge(gdsc_grid, gdsc_melt, by = "accession_id", all.x = TRUE)
gdsc_data <- merge(gdsc_data, ccl_converter, by = "accession_id", all.x = TRUE)
gdsc_data <- merge(gdsc_data, maf_df_g2p, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
gdsc_data$Mutation_Status_Nonsilent <- ifelse(is.na(gdsc_data$Mutation_Status_Nonsilent), "Other", gdsc_data$Mutation_Status_Nonsilent)
gdsc_data$Hugo_Symbol <- factor(gdsc_data$Hugo_Symbol)
gdsc_data$AUC <- as.numeric(gdsc_data$AUC)
gdsc_data$Color_Nonsilent <- ifelse(gdsc_data$Mutation_Status_Nonsilent == "Other", "paleturquoise3", "turquoise4")
gdsc_data$Color_Nonsilent <- factor(gdsc_data$Color_Nonsilent)
gdsc_data <- filter(gdsc_data, !is.na(gdsc_data$AUC))
gdsc_data$Drug_Gene <- paste0(gdsc_data$Drug, "_", gdsc_data$Hugo_Symbol)
saveRDS(gdsc_data, "./data_munging/rds/gdsc_data_18Q3_g2pgenes.rds", compress = "xz")
ccle_data <- readRDS("./data_munging/rds/ccle_data_18Q3_g2pgenes.rds")
ccle_data_ptmuts <- filter(ccle_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
ccle_data_ptmuts$Keep_PtMut_Tests <- ifelse(ccle_data_ptmuts$Reference_Allele_Length == 1 | is.na(ccle_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(ccle_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
ccle_data_ptmuts <- filter(ccle_data_ptmuts, Keep_PtMut_Tests == TRUE)
ctrp_data <- readRDS("./data_munging/rds/ctrp_data_18Q3_g2pgenes.rds")
ctrp_data_ptmuts <- filter(ctrp_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
ctrp_data_ptmuts$Keep_PtMut_Tests <- ifelse(ctrp_data_ptmuts$Reference_Allele_Length == 1 | is.na(ctrp_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(ctrp_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
ctrp_data_ptmuts <- filter(ctrp_data_ptmuts, Keep_PtMut_Tests == TRUE)
gdsc_data <- readRDS("./data_munging/rds/gdsc_data_18Q3_g2pgenes.rds")
gdsc_data_ptmuts <- filter(gdsc_data, Reference_Allele_Length == 1 | Reference_Allele_Length == 0 | is.na(Reference_Allele_Length))
gdsc_data_ptmuts$Keep_PtMut_Tests <- ifelse(gdsc_data_ptmuts$Reference_Allele_Length == 1 | is.na(gdsc_data_ptmuts$Reference_Allele_Length), TRUE, ifelse(gdsc_data_ptmuts$Tumor_Seq_Allele1_Length == 1, TRUE, FALSE))
gdsc_data_ptmuts <- filter(gdsc_data_ptmuts, Keep_PtMut_Tests == TRUE)
# Filter drug screen datasets for G2P drug-gene associations
ccle_data_g2p <- filter(ccle_data_ptmuts, Drug_Gene %in% g2p_drug_genes)
ctrp_data_g2p <- filter(ctrp_data_ptmuts, Drug_Gene %in% g2p_drug_genes)
gdsc_data_g2p <- filter(gdsc_data_ptmuts, Drug_Gene %in% g2p_drug_genes)
# Filter drug screen datasets for G2P genes in drug-gene associations
ccle_data_g2p_genesfilt <- filter(ccle_data_ptmuts, Hugo_Symbol %in% g2p_genes)
ccle_data_g2p_genesfilt$Hugo_Symbol <- ordered(ccle_data_g2p_genesfilt$Hugo_Symbol, levels = g2p_genes)
ctrp_data_g2p_genesfilt <- filter(ctrp_data_ptmuts, Hugo_Symbol %in% g2p_genes)
ctrp_data_g2p_genesfilt$Hugo_Symbol <- ordered(ctrp_data_g2p_genesfilt$Hugo_Symbol, levels = g2p_genes)
gdsc_data_g2p_genesfilt <- filter(gdsc_data_ptmuts, Hugo_Symbol %in% g2p_genes)
gdsc_data_g2p_genesfilt$Hugo_Symbol <- ordered(gdsc_data_g2p_genesfilt$Hugo_Symbol, levels = g2p_genes)
crispr_signif_g2p_gene <- compare_means(Score ~ Mutation_Status_Nonsilent, group.by = c("Hugo_Symbol"), data = crispr_data_g2p, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_g2p_gene <- adj_signif(crispr_signif_g2p_gene)
crispr_signif_g2p_gene <- crispr_signif_g2p_gene[order(crispr_signif_g2p_gene$p),]
saveRDS(crispr_signif_g2p_gene, "./data_munging/rds/crispr_signif_g2p_gene.rds")
crispr_signif_g2p_gene <- readRDS("./data_munging/rds/crispr_signif_g2p_gene.rds")
crispr_signif_g2p_20gene <- as.character(crispr_signif_g2p_gene$Hugo_Symbol[0:20])
knitr::kable(crispr_signif_g2p_gene[, c("Hugo_Symbol", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results for Level A point mutations (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|
| KRAS | 0.0000000 | 0.0000000 | <2e-16 | **** | **** |
| BRAF | 0.0000000 | 0.0000000 | <2e-16 | **** | **** |
| TSC2 | 0.0123492 | 0.1145397 | 0.012 |
|
NA |
| JAK2 | 0.0164691 | 0.1145397 | 0.016 |
|
NA |
| UGT1A1 | 0.0173545 | 0.1145397 | 0.017 |
|
NA |
| CYP19A1 | 0.0266336 | 0.1464846 | 0.027 |
|
NA |
| DPYD | 0.0395906 | 0.1866413 | 0.040 |
|
NA |
| ERBB2 | 0.2205184 | 0.7187459 | 0.221 | NA | NA |
| BRCA2 | 0.2325878 | 0.7187459 | 0.233 | NA | NA |
| RET | 0.2906604 | 0.7187459 | 0.291 | NA | NA |
| ALK | 0.2998088 | 0.7187459 | 0.300 | NA | NA |
| PDGFRA | 0.3319033 | 0.7187459 | 0.332 | NA | NA |
| BRCA1 | 0.3510923 | 0.7187459 | 0.351 | NA | NA |
| EGFR | 0.3543454 | 0.7187459 | 0.354 | NA | NA |
| NPM1 | 0.3647284 | 0.7187459 | 0.365 | NA | NA |
| MYD88 | 0.3819214 | 0.7187459 | 0.382 | NA | NA |
| ROS1 | 0.3825781 | 0.7187459 | 0.383 | NA | NA |
| PDGFRB | 0.3945583 | 0.7187459 | 0.395 | NA | NA |
| PTCH1 | 0.4615402 | 0.7187459 | 0.462 | NA | NA |
| ESR1 | 0.4662732 | 0.7187459 | 0.466 | NA | NA |
| PDGFB | 0.4681793 | 0.7187459 | 0.468 | NA | NA |
| MGMT | 0.4791639 | 0.7187459 | 0.479 | NA | NA |
| MET | 0.6731081 | 0.8828534 | 0.673 | NA | NA |
| DNMT3A | 0.6819627 | 0.8828534 | 0.682 | NA | NA |
| TSC1 | 0.6872265 | 0.8828534 | 0.687 | NA | NA |
| FLT3 | 0.6955814 | 0.8828534 | 0.696 | NA | NA |
| IDH2 | 0.7750457 | 0.9120325 | 0.775 | NA | NA |
| PML | 0.7843574 | 0.9120325 | 0.784 | NA | NA |
| ERBB3 | 0.8014831 | 0.9120325 | 0.801 | NA | NA |
| ABL1 | 0.8737848 | 0.9611633 | 0.874 | NA | NA |
| KIT | 0.9113147 | 0.9690846 | 0.911 | NA | NA |
| AKT1 | 0.9397184 | 0.9690846 | 0.940 | NA | NA |
| TPMT | 0.9768760 | 0.9768760 | 0.977 | NA | NA |
crispr_data_signif_g2p_gene_filt <- filter(crispr_data_ptmuts, Hugo_Symbol %in% crispr_signif_g2p_20gene)
crispr_data_signif_g2p_gene <- merge(crispr_data_signif_g2p_gene_filt, crispr_signif_g2p_gene, by = "Hugo_Symbol")
crispr_data_signif_g2p_gene$Hugo_Symbol <- ordered(crispr_data_signif_g2p_gene$Hugo_Symbol, levels = crispr_signif_g2p_20gene)
crispr_data_signif_g2p_gene_color <- as.character(crispr_data_signif_g2p_gene$Color_Nonsilent)
names(crispr_data_signif_g2p_gene_color) <- crispr_data_signif_g2p_gene$Mutation_Status_Nonsilent
crispr_data_signif_g2p_gene <- merge(crispr_data_signif_g2p_gene, crispr_data_signif_g2p_gene %>% group_by(Hugo_Symbol) %>% summarize(Text_y = max(Score)), by = "Hugo_Symbol")
crispr_data_signif_g2p_gene_text <- unique(data.frame(p.signif = crispr_data_signif_g2p_gene$p.signif, p.signif.adj = crispr_data_signif_g2p_gene$p.signif.adj, Hugo_Symbol = crispr_data_signif_g2p_gene$Hugo_Symbol, Text_y = crispr_data_signif_g2p_gene$Text_y))
crispr_data_signif_g2p_gene_plot <- ggplot(data = crispr_data_signif_g2p_gene, aes(x = Mutation_Status_Nonsilent, y = Score)) +
facet_wrap(~ Hugo_Symbol, drop = FALSE, nrow = 2, scales = "free_y") +
geom_jitter(aes(color = Mutation_Status_Nonsilent), alpha = 0.5, width = 0.3) +
geom_boxplot(color = "black", fill = NA, outlier.shape = NA) +
geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
scale_color_manual(values = crispr_data_signif_g2p_gene_color) +
geom_text(data = crispr_data_signif_g2p_gene_text, mapping = aes(x = 1.5, y = Text_y, label = p.signif), nudge_y = 0.2) +
theme(legend.position = "top", axis.text.x = element_blank(), axis.ticks.x = element_blank(), axis.title.x = element_blank()) +
labs(y = "CERES Score",
color = "Mutation Status",
title = "CERES scores for select Level A G2P genes",
subtitle = "Genes are sorted by increasing p-value.")
crispr_data_signif_g2p_gene_plot
# ggsave("./plots_18Q3/manuscript/crispr_data_signif_g2p_gene_plot.png", crispr_data_signif_g2p_gene_plot, width = 12, height = 7, units = "in")
crispr_signif_g2p_lineage <- compare_means(Score ~ Mutation_Status_Nonsilent, group.by = c("Hugo_Symbol", "group_general_lineage_name"), data = crispr_data_g2p, method = "wilcox.test", p.adjust.method = "BH")
crispr_signif_g2p_lineage <- adj_signif(crispr_signif_g2p_lineage)
crispr_signif_g2p_lineage <- crispr_signif_g2p_lineage[order(crispr_signif_g2p_lineage$p),]
saveRDS(crispr_signif_g2p_lineage, "./data_munging/rds/crispr_signif_g2p_lineage.rds")
# write.table(crispr_signif_g2p_lineage, file = "~/Desktop/crispr_signif_g2p_lineage.csv", quote = FALSE, sep = ",", row.names = FALSE)
crispr_signif_g2p_lineage <- readRDS("./data_munging/rds/crispr_signif_g2p_lineage.rds")
knitr::kable(filter(crispr_signif_g2p_lineage, p < 0.1)[, c("Hugo_Symbol", "group_general_lineage_name", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "Wilcoxon test results comparing non-silent mutant vs other cell lines by lineage, p < 0.1 (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | group_general_lineage_name | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|---|
| KRAS | lung cancer | 0.0000000 | 0.0000009 | 2.5e-09 | **** | **** |
| KRAS | ovarian cancer | 0.0001488 | 0.0266283 | 0.00015 | *** |
|
| KRAS | colorectal cancer | 0.0010547 | 0.1258600 | 0.00105 | ** | NA |
| KRAS | stomach cancer | 0.0040001 | 0.3580128 | 0.00400 | ** | NA |
| BRAF | skin cancer | 0.0054870 | 0.3928703 | 0.00549 | ** | NA |
| BRAF | ovarian cancer | 0.0107679 | 0.6424844 | 0.01077 |
|
NA |
| BRAF | breast cancer | 0.0136283 | 0.6969908 | 0.01363 |
|
NA |
| PDGFRA | uterine cancer | 0.0224142 | 0.7800150 | 0.02241 |
|
NA |
| KRAS | breast cancer | 0.0237414 | 0.7800150 | 0.02374 |
|
NA |
| ROS1 | esophageal cancer | 0.0292725 | 0.7800150 | 0.02927 |
|
NA |
| BRAF | cancer | 0.0294387 | 0.7800150 | 0.02944 |
|
NA |
| BRCA1 | breast cancer | 0.0312722 | 0.7800150 | 0.03127 |
|
NA |
| ERBB3 | lung cancer | 0.0336500 | 0.7800150 | 0.03365 |
|
NA |
| KRAS | leukemia | 0.0360247 | 0.7800150 | 0.03602 |
|
NA |
| ROS1 | head and neck cancer | 0.0363586 | 0.7800150 | 0.03636 |
|
NA |
| MGMT | colorectal cancer | 0.0372425 | 0.7800150 | 0.03724 |
|
NA |
| PDGFRA | colorectal cancer | 0.0491408 | 0.7800150 | 0.04914 |
|
NA |
| DNMT3A | uterine cancer | 0.0572376 | 0.7800150 | 0.05724 | NA | NA |
| BRCA1 | colorectal cancer | 0.0587865 | 0.7800150 | 0.05879 | NA | NA |
| ALK | peripheral nervous system neoplasm | 0.0607704 | 0.7800150 | 0.06077 | NA | NA |
| FLT3 | liver cancer | 0.0678603 | 0.7800150 | 0.06786 | NA | NA |
| DPYD | skin cancer | 0.0714670 | 0.7800150 | 0.07147 | NA | NA |
| BRCA2 | ovarian cancer | 0.0816592 | 0.7800150 | 0.08166 | NA | NA |
| TSC1 | uterine cancer | 0.0966619 | 0.7800150 | 0.09666 | NA | NA |
| ROS1 | kidney cancer | 0.0977184 | 0.7800150 | 0.09772 | NA | NA |
| DPYD | central nervous system cancer | 0.0978273 | 0.7800150 | 0.09783 | NA | NA |
| EGFR | uterine cancer | 0.0984998 | 0.7800150 | 0.09850 | NA | NA |
crispr_data_signif_g2p_lineage <- merge(crispr_data_signif_g2p_gene_filt, crispr_signif_g2p_lineage, by = c("Hugo_Symbol", "group_general_lineage_name"))
crispr_data_signif_g2p_lineage$Hugo_Symbol <- ordered(crispr_data_signif_g2p_lineage$Hugo_Symbol, levels = crispr_signif_g2p_20gene)
crispr_data_signif_g2p_lineage_color <- as.character(crispr_data_signif_g2p_lineage$Color_Nonsilent)
names(crispr_data_signif_g2p_lineage_color) <- crispr_data_signif_g2p_lineage$Mutation_Status_Nonsilent
crispr_data_signif_g2p_lineage <- merge(crispr_data_signif_g2p_lineage, crispr_data_signif_g2p_lineage %>% group_by(Hugo_Symbol) %>% summarize(Text_y = max(Score)), by = "Hugo_Symbol")
crispr_data_signif_g2p_lineage_text <- unique(data.frame(p.signif = crispr_data_signif_g2p_lineage$p.signif, p.signif.adj = crispr_data_signif_g2p_lineage$p.signif.adj, group_general_lineage_name = crispr_data_signif_g2p_lineage$group_general_lineage_name, Hugo_Symbol = crispr_data_signif_g2p_lineage$Hugo_Symbol, Text_y = crispr_data_signif_g2p_lineage$Text_y))
crispr_data_signif_g2p_lineage_plot <- ggplot(data = crispr_data_signif_g2p_lineage, aes(x = group_general_lineage_name, y = Score)) +
facet_wrap(~ Hugo_Symbol, nrow = 4, scales = "free_y") +
geom_point(aes(color = Mutation_Status_Nonsilent), alpha = 0.5) +
geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
scale_color_manual(values = crispr_data_signif_g2p_lineage_color) +
geom_text(data = crispr_data_signif_g2p_lineage_text, mapping = aes(x = group_general_lineage_name, y = Text_y, label = p.signif), angle = 90, vjust = 0.8, nudge_y = 0.1) +
theme(legend.position = "top", axis.text.x = element_text(angle = 90, hjust = 1, vjust = 0.4, size = 10)) +
labs(y = "CERES Score",
x = "Lineage",
color = "Mutation Status",
title = "CERES score by cell line lineage for significant Level A G2P genes",
subtitle = "* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001\nGenes are sorted by increasing lineage-agnostic p-value.")
crispr_data_signif_g2p_lineage_plot
# ggsave("./plots_18Q3/manuscript/crispr_crispr_data_signif_g2p_lineage_plot.png", crispr_data_signif_g2p_lineage_plot, width = 12, height = 15, units = "in")
crispr_data_signif_g2p_lineage_summ <- crispr_data_signif_g2p_lineage %>% group_by(Hugo_Symbol, group_general_lineage_name, Mutation_Status_Nonsilent) %>% tally()
# write.table(crispr_data_signif_g2p_lineage_summ, file = "~/Desktop/crispr_data_signif_g2p_lineage_summ_20181005.tsv", quote = FALSE, sep = "\t")
knitr::kable(crispr_data_signif_g2p_lineage_summ, caption = "Mutant/Other counts for gene-lineage combinations") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | group_general_lineage_name | Mutation_Status_Nonsilent | n |
|---|---|---|---|
| KRAS | bone cancer | Mutant | 1 |
| KRAS | bone cancer | Other | 15 |
| KRAS | breast cancer | Mutant | 2 |
| KRAS | breast cancer | Other | 24 |
| KRAS | colorectal cancer | Mutant | 14 |
| KRAS | colorectal cancer | Other | 13 |
| KRAS | esophageal cancer | Mutant | 1 |
| KRAS | esophageal cancer | Other | 13 |
| KRAS | leukemia | Mutant | 2 |
| KRAS | leukemia | Other | 19 |
| KRAS | lung cancer | Mutant | 22 |
| KRAS | lung cancer | Other | 48 |
| KRAS | multiple myeloma | Mutant | 4 |
| KRAS | multiple myeloma | Other | 12 |
| KRAS | ovarian cancer | Mutant | 9 |
| KRAS | ovarian cancer | Other | 26 |
| KRAS | pancreatic cancer | Mutant | 23 |
| KRAS | pancreatic cancer | Other | 1 |
| KRAS | stomach cancer | Mutant | 5 |
| KRAS | stomach cancer | Other | 10 |
| KRAS | urinary bladder cancer | Mutant | 2 |
| KRAS | urinary bladder cancer | Other | 19 |
| KRAS | uterine cancer | Mutant | 7 |
| KRAS | uterine cancer | Other | 11 |
| BRAF | bone cancer | Mutant | 1 |
| BRAF | bone cancer | Other | 14 |
| BRAF | breast cancer | Mutant | 3 |
| BRAF | breast cancer | Other | 22 |
| BRAF | cancer | Mutant | 2 |
| BRAF | cancer | Other | 16 |
| BRAF | central nervous system cancer | Mutant | 2 |
| BRAF | central nervous system cancer | Other | 43 |
| BRAF | colorectal cancer | Mutant | 13 |
| BRAF | colorectal cancer | Other | 15 |
| BRAF | esophageal cancer | Mutant | 2 |
| BRAF | esophageal cancer | Other | 12 |
| BRAF | liver cancer | Mutant | 1 |
| BRAF | liver cancer | Other | 15 |
| BRAF | lung cancer | Mutant | 3 |
| BRAF | lung cancer | Other | 66 |
| BRAF | multiple myeloma | Mutant | 2 |
| BRAF | multiple myeloma | Other | 14 |
| BRAF | ovarian cancer | Mutant | 3 |
| BRAF | ovarian cancer | Other | 31 |
| BRAF | pancreatic cancer | Mutant | 2 |
| BRAF | pancreatic cancer | Other | 21 |
| BRAF | peripheral nervous system neoplasm | Mutant | 1 |
| BRAF | peripheral nervous system neoplasm | Other | 12 |
| BRAF | skin cancer | Mutant | 23 |
| BRAF | skin cancer | Other | 8 |
| BRAF | stomach cancer | Mutant | 1 |
| BRAF | stomach cancer | Other | 14 |
| BRAF | thyroid cancer | Mutant | 1 |
| BRAF | thyroid cancer | Other | 2 |
| BRAF | urinary bladder cancer | Mutant | 1 |
| BRAF | urinary bladder cancer | Other | 20 |
| BRAF | uterine cancer | Mutant | 5 |
| BRAF | uterine cancer | Other | 14 |
| TSC2 | breast cancer | Mutant | 1 |
| TSC2 | breast cancer | Other | 25 |
| TSC2 | cancer | Mutant | 1 |
| TSC2 | cancer | Other | 17 |
| TSC2 | central nervous system cancer | Mutant | 1 |
| TSC2 | central nervous system cancer | Other | 43 |
| TSC2 | colorectal cancer | Mutant | 5 |
| TSC2 | colorectal cancer | Other | 22 |
| TSC2 | esophageal cancer | Mutant | 1 |
| TSC2 | esophageal cancer | Other | 13 |
| TSC2 | kidney cancer | Mutant | 1 |
| TSC2 | kidney cancer | Other | 21 |
| TSC2 | leukemia | Mutant | 2 |
| TSC2 | leukemia | Other | 19 |
| TSC2 | liver cancer | Mutant | 2 |
| TSC2 | liver cancer | Other | 14 |
| TSC2 | lymphoma | Mutant | 2 |
| TSC2 | lymphoma | Other | 9 |
| TSC2 | multiple myeloma | Mutant | 2 |
| TSC2 | multiple myeloma | Other | 14 |
| TSC2 | pancreatic cancer | Mutant | 2 |
| TSC2 | pancreatic cancer | Other | 21 |
| TSC2 | peripheral nervous system neoplasm | Mutant | 1 |
| TSC2 | peripheral nervous system neoplasm | Other | 12 |
| TSC2 | rhabdomyosarcoma | Mutant | 1 |
| TSC2 | rhabdomyosarcoma | Other | 6 |
| TSC2 | stomach cancer | Mutant | 2 |
| TSC2 | stomach cancer | Other | 13 |
| TSC2 | uterine cancer | Mutant | 9 |
| TSC2 | uterine cancer | Other | 10 |
| JAK2 | colorectal cancer | Mutant | 1 |
| JAK2 | colorectal cancer | Other | 27 |
| JAK2 | esophageal cancer | Mutant | 1 |
| JAK2 | esophageal cancer | Other | 13 |
| JAK2 | leukemia | Mutant | 1 |
| JAK2 | leukemia | Other | 20 |
| JAK2 | lung cancer | Mutant | 2 |
| JAK2 | lung cancer | Other | 67 |
| JAK2 | lymphoma | Mutant | 1 |
| JAK2 | lymphoma | Other | 10 |
| JAK2 | ovarian cancer | Mutant | 1 |
| JAK2 | ovarian cancer | Other | 34 |
| JAK2 | urinary bladder cancer | Mutant | 2 |
| JAK2 | urinary bladder cancer | Other | 19 |
| JAK2 | uterine cancer | Mutant | 5 |
| JAK2 | uterine cancer | Other | 13 |
| UGT1A1 | bone cancer | Mutant | 2 |
| UGT1A1 | bone cancer | Other | 14 |
| UGT1A1 | colorectal cancer | Mutant | 1 |
| UGT1A1 | colorectal cancer | Other | 25 |
| UGT1A1 | esophageal cancer | Mutant | 1 |
| UGT1A1 | esophageal cancer | Other | 13 |
| UGT1A1 | kidney cancer | Mutant | 1 |
| UGT1A1 | kidney cancer | Other | 21 |
| UGT1A1 | lung cancer | Mutant | 2 |
| UGT1A1 | lung cancer | Other | 67 |
| UGT1A1 | skin cancer | Mutant | 2 |
| UGT1A1 | skin cancer | Other | 28 |
| UGT1A1 | stomach cancer | Mutant | 1 |
| UGT1A1 | stomach cancer | Other | 14 |
| UGT1A1 | uterine cancer | Mutant | 3 |
| UGT1A1 | uterine cancer | Other | 16 |
| CYP19A1 | breast cancer | Mutant | 1 |
| CYP19A1 | breast cancer | Other | 25 |
| CYP19A1 | esophageal cancer | Mutant | 1 |
| CYP19A1 | esophageal cancer | Other | 13 |
| CYP19A1 | lymphoma | Mutant | 1 |
| CYP19A1 | lymphoma | Other | 10 |
| CYP19A1 | peripheral nervous system neoplasm | Mutant | 1 |
| CYP19A1 | peripheral nervous system neoplasm | Other | 12 |
| CYP19A1 | stomach cancer | Mutant | 1 |
| CYP19A1 | stomach cancer | Other | 14 |
| CYP19A1 | urinary bladder cancer | Mutant | 1 |
| CYP19A1 | urinary bladder cancer | Other | 20 |
| CYP19A1 | uterine cancer | Mutant | 2 |
| CYP19A1 | uterine cancer | Other | 16 |
| DPYD | bone cancer | Mutant | 1 |
| DPYD | bone cancer | Other | 15 |
| DPYD | breast cancer | Mutant | 2 |
| DPYD | breast cancer | Other | 24 |
| DPYD | central nervous system cancer | Mutant | 1 |
| DPYD | central nervous system cancer | Other | 44 |
| DPYD | colorectal cancer | Mutant | 4 |
| DPYD | colorectal cancer | Other | 24 |
| DPYD | head and neck cancer | Mutant | 1 |
| DPYD | head and neck cancer | Other | 14 |
| DPYD | kidney cancer | Mutant | 2 |
| DPYD | kidney cancer | Other | 20 |
| DPYD | leukemia | Mutant | 1 |
| DPYD | leukemia | Other | 21 |
| DPYD | liver cancer | Mutant | 1 |
| DPYD | liver cancer | Other | 15 |
| DPYD | lung cancer | Mutant | 4 |
| DPYD | lung cancer | Other | 65 |
| DPYD | lymphoma | Mutant | 1 |
| DPYD | lymphoma | Other | 10 |
| DPYD | multiple myeloma | Mutant | 1 |
| DPYD | multiple myeloma | Other | 15 |
| DPYD | ovarian cancer | Mutant | 2 |
| DPYD | ovarian cancer | Other | 33 |
| DPYD | rhabdomyosarcoma | Mutant | 1 |
| DPYD | rhabdomyosarcoma | Other | 6 |
| DPYD | skin cancer | Mutant | 4 |
| DPYD | skin cancer | Other | 25 |
| DPYD | urinary bladder cancer | Mutant | 1 |
| DPYD | urinary bladder cancer | Other | 20 |
| DPYD | uterine cancer | Mutant | 2 |
| DPYD | uterine cancer | Other | 16 |
| ERBB2 | breast cancer | Mutant | 1 |
| ERBB2 | breast cancer | Other | 25 |
| ERBB2 | colorectal cancer | Mutant | 3 |
| ERBB2 | colorectal cancer | Other | 25 |
| ERBB2 | head and neck cancer | Mutant | 1 |
| ERBB2 | head and neck cancer | Other | 14 |
| ERBB2 | kidney cancer | Mutant | 1 |
| ERBB2 | kidney cancer | Other | 21 |
| ERBB2 | leukemia | Mutant | 1 |
| ERBB2 | leukemia | Other | 20 |
| ERBB2 | lung cancer | Mutant | 3 |
| ERBB2 | lung cancer | Other | 66 |
| ERBB2 | ovarian cancer | Mutant | 2 |
| ERBB2 | ovarian cancer | Other | 33 |
| ERBB2 | stomach cancer | Mutant | 2 |
| ERBB2 | stomach cancer | Other | 13 |
| ERBB2 | urinary bladder cancer | Mutant | 2 |
| ERBB2 | urinary bladder cancer | Other | 20 |
| ERBB2 | uterine cancer | Mutant | 5 |
| ERBB2 | uterine cancer | Other | 14 |
| BRCA2 | bone cancer | Mutant | 1 |
| BRCA2 | bone cancer | Other | 15 |
| BRCA2 | breast cancer | Mutant | 5 |
| BRCA2 | breast cancer | Other | 21 |
| BRCA2 | cancer | Mutant | 3 |
| BRCA2 | cancer | Other | 15 |
| BRCA2 | central nervous system cancer | Mutant | 2 |
| BRCA2 | central nervous system cancer | Other | 43 |
| BRCA2 | colorectal cancer | Mutant | 7 |
| BRCA2 | colorectal cancer | Other | 22 |
| BRCA2 | esophageal cancer | Mutant | 2 |
| BRCA2 | esophageal cancer | Other | 12 |
| BRCA2 | kidney cancer | Mutant | 2 |
| BRCA2 | kidney cancer | Other | 20 |
| BRCA2 | leukemia | Mutant | 3 |
| BRCA2 | leukemia | Other | 18 |
| BRCA2 | liver cancer | Mutant | 1 |
| BRCA2 | liver cancer | Other | 15 |
| BRCA2 | lung cancer | Mutant | 6 |
| BRCA2 | lung cancer | Other | 63 |
| BRCA2 | multiple myeloma | Mutant | 1 |
| BRCA2 | multiple myeloma | Other | 15 |
| BRCA2 | ovarian cancer | Mutant | 2 |
| BRCA2 | ovarian cancer | Other | 33 |
| BRCA2 | pancreatic cancer | Mutant | 1 |
| BRCA2 | pancreatic cancer | Other | 22 |
| BRCA2 | skin cancer | Mutant | 6 |
| BRCA2 | skin cancer | Other | 23 |
| BRCA2 | stomach cancer | Mutant | 2 |
| BRCA2 | stomach cancer | Other | 13 |
| BRCA2 | uterine cancer | Mutant | 7 |
| BRCA2 | uterine cancer | Other | 15 |
| RET | bone cancer | Mutant | 1 |
| RET | bone cancer | Other | 15 |
| RET | cancer | Mutant | 2 |
| RET | cancer | Other | 16 |
| RET | central nervous system cancer | Mutant | 1 |
| RET | central nervous system cancer | Other | 44 |
| RET | colorectal cancer | Mutant | 2 |
| RET | colorectal cancer | Other | 25 |
| RET | esophageal cancer | Mutant | 1 |
| RET | esophageal cancer | Other | 13 |
| RET | kidney cancer | Mutant | 1 |
| RET | kidney cancer | Other | 21 |
| RET | leukemia | Mutant | 1 |
| RET | leukemia | Other | 20 |
| RET | lung cancer | Mutant | 5 |
| RET | lung cancer | Other | 64 |
| RET | ovarian cancer | Mutant | 2 |
| RET | ovarian cancer | Other | 33 |
| RET | skin cancer | Mutant | 2 |
| RET | skin cancer | Other | 27 |
| RET | uterine cancer | Mutant | 2 |
| RET | uterine cancer | Other | 16 |
| ALK | breast cancer | Mutant | 2 |
| ALK | breast cancer | Other | 24 |
| ALK | cancer | Mutant | 2 |
| ALK | cancer | Other | 16 |
| ALK | colorectal cancer | Mutant | 8 |
| ALK | colorectal cancer | Other | 20 |
| ALK | esophageal cancer | Mutant | 2 |
| ALK | esophageal cancer | Other | 12 |
| ALK | leukemia | Mutant | 3 |
| ALK | leukemia | Other | 18 |
| ALK | liver cancer | Mutant | 1 |
| ALK | liver cancer | Other | 15 |
| ALK | lung cancer | Mutant | 7 |
| ALK | lung cancer | Other | 63 |
| ALK | lymphoma | Mutant | 1 |
| ALK | lymphoma | Other | 10 |
| ALK | ovarian cancer | Mutant | 2 |
| ALK | ovarian cancer | Other | 33 |
| ALK | pancreatic cancer | Mutant | 1 |
| ALK | pancreatic cancer | Other | 22 |
| ALK | peripheral nervous system neoplasm | Mutant | 2 |
| ALK | peripheral nervous system neoplasm | Other | 11 |
| ALK | skin cancer | Mutant | 3 |
| ALK | skin cancer | Other | 26 |
| ALK | uterine cancer | Mutant | 3 |
| ALK | uterine cancer | Other | 16 |
| PDGFRA | breast cancer | Mutant | 1 |
| PDGFRA | breast cancer | Other | 25 |
| PDGFRA | cancer | Mutant | 1 |
| PDGFRA | cancer | Other | 17 |
| PDGFRA | central nervous system cancer | Mutant | 1 |
| PDGFRA | central nervous system cancer | Other | 44 |
| PDGFRA | colorectal cancer | Mutant | 3 |
| PDGFRA | colorectal cancer | Other | 24 |
| PDGFRA | esophageal cancer | Mutant | 1 |
| PDGFRA | esophageal cancer | Other | 13 |
| PDGFRA | kidney cancer | Mutant | 1 |
| PDGFRA | kidney cancer | Other | 21 |
| PDGFRA | leukemia | Mutant | 3 |
| PDGFRA | leukemia | Other | 18 |
| PDGFRA | lung cancer | Mutant | 8 |
| PDGFRA | lung cancer | Other | 63 |
| PDGFRA | ovarian cancer | Mutant | 1 |
| PDGFRA | ovarian cancer | Other | 34 |
| PDGFRA | pancreatic cancer | Mutant | 1 |
| PDGFRA | pancreatic cancer | Other | 22 |
| PDGFRA | skin cancer | Mutant | 3 |
| PDGFRA | skin cancer | Other | 26 |
| PDGFRA | urinary bladder cancer | Mutant | 2 |
| PDGFRA | urinary bladder cancer | Other | 19 |
| PDGFRA | uterine cancer | Mutant | 4 |
| PDGFRA | uterine cancer | Other | 14 |
| BRCA1 | breast cancer | Mutant | 2 |
| BRCA1 | breast cancer | Other | 23 |
| BRCA1 | colorectal cancer | Mutant | 5 |
| BRCA1 | colorectal cancer | Other | 23 |
| BRCA1 | head and neck cancer | Mutant | 1 |
| BRCA1 | head and neck cancer | Other | 14 |
| BRCA1 | liver cancer | Mutant | 2 |
| BRCA1 | liver cancer | Other | 14 |
| BRCA1 | lung cancer | Mutant | 4 |
| BRCA1 | lung cancer | Other | 65 |
| BRCA1 | lymphoma | Mutant | 1 |
| BRCA1 | lymphoma | Other | 10 |
| BRCA1 | ovarian cancer | Mutant | 3 |
| BRCA1 | ovarian cancer | Other | 32 |
| BRCA1 | pancreatic cancer | Mutant | 1 |
| BRCA1 | pancreatic cancer | Other | 22 |
| BRCA1 | peripheral nervous system neoplasm | Mutant | 1 |
| BRCA1 | peripheral nervous system neoplasm | Other | 12 |
| BRCA1 | skin cancer | Mutant | 2 |
| BRCA1 | skin cancer | Other | 27 |
| BRCA1 | stomach cancer | Mutant | 2 |
| BRCA1 | stomach cancer | Other | 13 |
| BRCA1 | urinary bladder cancer | Mutant | 2 |
| BRCA1 | urinary bladder cancer | Other | 19 |
| BRCA1 | uterine cancer | Mutant | 5 |
| BRCA1 | uterine cancer | Other | 13 |
| EGFR | bone cancer | Mutant | 1 |
| EGFR | bone cancer | Other | 15 |
| EGFR | breast cancer | Mutant | 1 |
| EGFR | breast cancer | Other | 25 |
| EGFR | central nervous system cancer | Mutant | 4 |
| EGFR | central nervous system cancer | Other | 41 |
| EGFR | colorectal cancer | Mutant | 3 |
| EGFR | colorectal cancer | Other | 26 |
| EGFR | esophageal cancer | Mutant | 4 |
| EGFR | esophageal cancer | Other | 11 |
| EGFR | leukemia | Mutant | 2 |
| EGFR | leukemia | Other | 19 |
| EGFR | liver cancer | Mutant | 1 |
| EGFR | liver cancer | Other | 15 |
| EGFR | lung cancer | Mutant | 7 |
| EGFR | lung cancer | Other | 60 |
| EGFR | lymphoma | Mutant | 1 |
| EGFR | lymphoma | Other | 10 |
| EGFR | multiple myeloma | Mutant | 2 |
| EGFR | multiple myeloma | Other | 14 |
| EGFR | ovarian cancer | Mutant | 2 |
| EGFR | ovarian cancer | Other | 33 |
| EGFR | skin cancer | Mutant | 1 |
| EGFR | skin cancer | Other | 28 |
| EGFR | stomach cancer | Mutant | 1 |
| EGFR | stomach cancer | Other | 14 |
| EGFR | uterine cancer | Mutant | 8 |
| EGFR | uterine cancer | Other | 11 |
| NPM1 | central nervous system cancer | Mutant | 2 |
| NPM1 | central nervous system cancer | Other | 43 |
| NPM1 | ovarian cancer | Mutant | 1 |
| NPM1 | ovarian cancer | Other | 34 |
| NPM1 | urinary bladder cancer | Mutant | 1 |
| NPM1 | urinary bladder cancer | Other | 20 |
| NPM1 | uterine cancer | Mutant | 1 |
| NPM1 | uterine cancer | Other | 17 |
| MYD88 | bone cancer | Mutant | 1 |
| MYD88 | bone cancer | Other | 15 |
| MYD88 | breast cancer | Mutant | 1 |
| MYD88 | breast cancer | Other | 25 |
| MYD88 | colorectal cancer | Mutant | 1 |
| MYD88 | colorectal cancer | Other | 26 |
| MYD88 | leukemia | Mutant | 1 |
| MYD88 | leukemia | Other | 20 |
| MYD88 | multiple myeloma | Mutant | 1 |
| MYD88 | multiple myeloma | Other | 15 |
| MYD88 | pancreatic cancer | Mutant | 1 |
| MYD88 | pancreatic cancer | Other | 22 |
| MYD88 | urinary bladder cancer | Mutant | 1 |
| MYD88 | urinary bladder cancer | Other | 20 |
| MYD88 | uterine cancer | Mutant | 3 |
| MYD88 | uterine cancer | Other | 15 |
| ROS1 | bone cancer | Mutant | 1 |
| ROS1 | bone cancer | Other | 15 |
| ROS1 | breast cancer | Mutant | 2 |
| ROS1 | breast cancer | Other | 24 |
| ROS1 | cancer | Mutant | 2 |
| ROS1 | cancer | Other | 16 |
| ROS1 | central nervous system cancer | Mutant | 3 |
| ROS1 | central nervous system cancer | Other | 42 |
| ROS1 | colorectal cancer | Mutant | 4 |
| ROS1 | colorectal cancer | Other | 22 |
| ROS1 | esophageal cancer | Mutant | 3 |
| ROS1 | esophageal cancer | Other | 11 |
| ROS1 | head and neck cancer | Mutant | 3 |
| ROS1 | head and neck cancer | Other | 12 |
| ROS1 | kidney cancer | Mutant | 2 |
| ROS1 | kidney cancer | Other | 20 |
| ROS1 | leukemia | Mutant | 1 |
| ROS1 | leukemia | Other | 20 |
| ROS1 | liver cancer | Mutant | 5 |
| ROS1 | liver cancer | Other | 11 |
| ROS1 | lung cancer | Mutant | 3 |
| ROS1 | lung cancer | Other | 66 |
| ROS1 | lymphoma | Mutant | 2 |
| ROS1 | lymphoma | Other | 9 |
| ROS1 | ovarian cancer | Mutant | 1 |
| ROS1 | ovarian cancer | Other | 34 |
| ROS1 | pancreatic cancer | Mutant | 1 |
| ROS1 | pancreatic cancer | Other | 22 |
| ROS1 | peripheral nervous system neoplasm | Mutant | 1 |
| ROS1 | peripheral nervous system neoplasm | Other | 12 |
| ROS1 | skin cancer | Mutant | 5 |
| ROS1 | skin cancer | Other | 25 |
| ROS1 | urinary bladder cancer | Mutant | 1 |
| ROS1 | urinary bladder cancer | Other | 20 |
| ROS1 | uterine cancer | Mutant | 7 |
| ROS1 | uterine cancer | Other | 12 |
| PDGFRB | breast cancer | Mutant | 4 |
| PDGFRB | breast cancer | Other | 22 |
| PDGFRB | cancer | Mutant | 2 |
| PDGFRB | cancer | Other | 16 |
| PDGFRB | central nervous system cancer | Mutant | 1 |
| PDGFRB | central nervous system cancer | Other | 44 |
| PDGFRB | colorectal cancer | Mutant | 3 |
| PDGFRB | colorectal cancer | Other | 24 |
| PDGFRB | kidney cancer | Mutant | 1 |
| PDGFRB | kidney cancer | Other | 21 |
| PDGFRB | leukemia | Mutant | 1 |
| PDGFRB | leukemia | Other | 20 |
| PDGFRB | lung cancer | Mutant | 5 |
| PDGFRB | lung cancer | Other | 64 |
| PDGFRB | ovarian cancer | Mutant | 2 |
| PDGFRB | ovarian cancer | Other | 33 |
| PDGFRB | rhabdomyosarcoma | Mutant | 1 |
| PDGFRB | rhabdomyosarcoma | Other | 6 |
| PDGFRB | skin cancer | Mutant | 2 |
| PDGFRB | skin cancer | Other | 27 |
| PDGFRB | urinary bladder cancer | Mutant | 1 |
| PDGFRB | urinary bladder cancer | Other | 20 |
| PDGFRB | uterine cancer | Mutant | 4 |
| PDGFRB | uterine cancer | Other | 16 |
| PTCH1 | breast cancer | Mutant | 4 |
| PTCH1 | breast cancer | Other | 22 |
| PTCH1 | colorectal cancer | Mutant | 4 |
| PTCH1 | colorectal cancer | Other | 24 |
| PTCH1 | esophageal cancer | Mutant | 1 |
| PTCH1 | esophageal cancer | Other | 13 |
| PTCH1 | kidney cancer | Mutant | 1 |
| PTCH1 | kidney cancer | Other | 21 |
| PTCH1 | leukemia | Mutant | 1 |
| PTCH1 | leukemia | Other | 21 |
| PTCH1 | liver cancer | Mutant | 1 |
| PTCH1 | liver cancer | Other | 15 |
| PTCH1 | lung cancer | Mutant | 2 |
| PTCH1 | lung cancer | Other | 67 |
| PTCH1 | lymphoma | Mutant | 1 |
| PTCH1 | lymphoma | Other | 11 |
| PTCH1 | ovarian cancer | Mutant | 3 |
| PTCH1 | ovarian cancer | Other | 32 |
| PTCH1 | skin cancer | Mutant | 1 |
| PTCH1 | skin cancer | Other | 28 |
| PTCH1 | stomach cancer | Mutant | 1 |
| PTCH1 | stomach cancer | Other | 14 |
| PTCH1 | urinary bladder cancer | Mutant | 2 |
| PTCH1 | urinary bladder cancer | Other | 19 |
| PTCH1 | uterine cancer | Mutant | 5 |
| PTCH1 | uterine cancer | Other | 14 |
| ESR1 | colorectal cancer | Mutant | 1 |
| ESR1 | colorectal cancer | Other | 26 |
| ESR1 | esophageal cancer | Mutant | 1 |
| ESR1 | esophageal cancer | Other | 13 |
| ESR1 | head and neck cancer | Mutant | 1 |
| ESR1 | head and neck cancer | Other | 14 |
| ESR1 | leukemia | Mutant | 3 |
| ESR1 | leukemia | Other | 18 |
| ESR1 | liver cancer | Mutant | 1 |
| ESR1 | liver cancer | Other | 15 |
| ESR1 | lung cancer | Mutant | 3 |
| ESR1 | lung cancer | Other | 66 |
| ESR1 | stomach cancer | Mutant | 2 |
| ESR1 | stomach cancer | Other | 13 |
| ESR1 | uterine cancer | Mutant | 2 |
| ESR1 | uterine cancer | Other | 16 |
ccle_signif_g2p <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = "Drug_Gene", data = ccle_data_g2p, method = "wilcox.test", p.adjust.method = "BH")
ccle_signif_g2p <- adj_signif(ccle_signif_g2p)
ccle_signif_g2p <- ccle_signif_g2p[order(ccle_signif_g2p$p),]
saveRDS(ccle_signif_g2p, "./data_munging/rds/ccle_signif_g2p_gene.rds")
ccle_signif_g2p_ByDrug <- lapply(unique(ccle_data_g2p_genesfilt$Drug), WilcoxonByDrug, dataset = ccle_data_g2p_genesfilt, data_name = "ccle")
names(ccle_signif_g2p_ByDrug) <- unique(ccle_data_g2p_genesfilt$Drug)
saveRDS(ccle_signif_g2p_ByDrug, "./data_munging/rds/ccle_signif_g2p_ByDrug.rds")
ccle_signif_g2p <- readRDS("./data_munging/rds/ccle_signif_g2p_gene.rds")
knitr::kable(ccle_signif_g2p[, c("Drug_Gene", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CCLE: Wilcoxon test results for level A G2P drug-gene associations (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Drug_Gene | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|
| selumetinib_KRAS | 0.0004853 | 0.0043681 | 0.00049 | *** | ** |
| lapatinib_ERBB2 | 0.0500292 | 0.1724797 | 0.05003 | NA | NA |
| nilotinib_UGT1A1 | 0.0574932 | 0.1724797 | 0.05749 | NA | NA |
| erlotinib_MET | 0.1724618 | 0.3880391 | 0.17246 | NA | NA |
| erlotinib_KRAS | 0.3430622 | 0.4860797 | 0.34306 | NA | NA |
| lapatinib_KRAS | 0.3717079 | 0.4860797 | 0.37171 | NA | NA |
| erlotinib_EGFR | 0.3780620 | 0.4860797 | 0.37806 | NA | NA |
| irinotecan_UGT1A1 | 0.8309879 | 0.9348613 | 0.83099 | NA | NA |
| nilotinib_ABL1 | 0.9989982 | 0.9989982 | 0.99900 | NA | NA |
ccle_signif_g2p_ByDrug <- readRDS("./data_munging/rds/ccle_signif_g2p_ByDrug.rds")
ccle_signif_g2p_ByDrug_all <- rbindlist(ccle_signif_g2p_ByDrug, use.names = TRUE)
ccle_signif_g2p_ByDrug_all <- ccle_signif_g2p_ByDrug_all[order(ccle_signif_g2p_ByDrug_all$p),]
knitr::kable(ccle_signif_g2p_ByDrug_all[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CCLE: By-drug Wilcoxon test results for point mutations in level A G2P genes (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | Drug | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|---|
| BRAF | selumetinib | 0.0000000 | 0.0000016 | 4.8e-08 | **** | **** |
| KRAS | selumetinib | 0.0004853 | 0.0082509 | 0.00049 | *** | ** |
| KRAS | irinotecan | 0.0107870 | 0.2265486 | 0.011 |
|
NA |
| ERBB3 | lapatinib | 0.0129696 | 0.4409649 | 0.013 |
|
NA |
| FLT3 | irinotecan | 0.0133264 | 0.2265486 | 0.013 |
|
NA |
| ERBB3 | nilotinib | 0.0219026 | 0.7446883 | 0.022 |
|
NA |
| BRAF | erlotinib | 0.0224018 | 0.4604309 | 0.022 |
|
NA |
| KIT | lapatinib | 0.0299886 | 0.4872398 | 0.030 |
|
NA |
| ERBB2 | erlotinib | 0.0361008 | 0.4604309 | 0.036 |
|
NA |
| PDGFB | erlotinib | 0.0406263 | 0.4604309 | 0.041 |
|
NA |
| TSC2 | irinotecan | 0.0425134 | 0.4818182 | 0.043 |
|
NA |
| ERBB2 | lapatinib | 0.0500292 | 0.4872398 | 0.050 | NA | NA |
| UGT1A1 | nilotinib | 0.0574932 | 0.8315963 | 0.057 | NA | NA |
| ROS1 | lapatinib | 0.0638294 | 0.4872398 | 0.064 | NA | NA |
| JAK2 | irinotecan | 0.0704563 | 0.5988785 | 0.070 | NA | NA |
| MGMT | lapatinib | 0.0716529 | 0.4872398 | 0.072 | NA | NA |
| BRCA2 | selumetinib | 0.0801455 | 0.6177935 | 0.08015 | NA | NA |
| BRAF | nilotinib | 0.0823341 | 0.8315963 | 0.082 | NA | NA |
| G6PD | selumetinib | 0.0848649 | 0.6177935 | 0.08486 | NA | NA |
| DNMT3A | lapatinib | 0.0910216 | 0.4905489 | 0.091 | NA | NA |
| IDH2 | selumetinib | 0.0923191 | 0.6177935 | 0.09232 | NA | NA |
| ROS1 | erlotinib | 0.0964090 | 0.7043128 | 0.096 | NA | NA |
| G6PD | nilotinib | 0.0978349 | 0.8315963 | 0.098 | NA | NA |
| AKT1 | irinotecan | 0.0995560 | 0.6555760 | 0.100 | NA | NA |
| PTCH1 | selumetinib | 0.1105610 | 0.6177935 | 0.11056 | NA | NA |
| BRAF | irinotecan | 0.1223433 | 0.6555760 | 0.122 | NA | NA |
| PDGFRA | selumetinib | 0.1271928 | 0.6177935 | 0.12719 | NA | NA |
| AKT1 | nilotinib | 0.1319214 | 0.8961394 | 0.132 | NA | NA |
| TSC2 | lapatinib | 0.1353477 | 0.4905489 | 0.135 | NA | NA |
| BRCA2 | lapatinib | 0.1454060 | 0.4905489 | 0.145 | NA | NA |
| DNMT3A | selumetinib | 0.1475871 | 0.6272450 | 0.14759 | NA | NA |
| PDGFRA | erlotinib | 0.1494369 | 0.7043128 | 0.149 | NA | NA |
| ERBB3 | erlotinib | 0.1517945 | 0.7043128 | 0.152 | NA | NA |
| PDGFRA | lapatinib | 0.1524894 | 0.4905489 | 0.152 | NA | NA |
| BRAF | lapatinib | 0.1535431 | 0.4905489 | 0.154 | NA | NA |
| MGMT | erlotinib | 0.1554862 | 0.7043128 | 0.155 | NA | NA |
| RET | lapatinib | 0.1587070 | 0.4905489 | 0.159 | NA | NA |
| ESR1 | irinotecan | 0.1628356 | 0.6555760 | 0.163 | NA | NA |
| DPYD | nilotinib | 0.1716871 | 0.8961394 | 0.172 | NA | NA |
| MET | erlotinib | 0.1724618 | 0.7043128 | 0.172 | NA | NA |
| JAK2 | selumetinib | 0.1725059 | 0.6516888 | 0.17251 | NA | NA |
| TPMT | irinotecan | 0.1771488 | 0.6555760 | 0.177 | NA | NA |
| IDH2 | nilotinib | 0.1844993 | 0.8961394 | 0.184 | NA | NA |
| PDGFB | lapatinib | 0.1902003 | 0.5389009 | 0.190 | NA | NA |
| JAK2 | erlotinib | 0.2076226 | 0.7043128 | 0.208 | NA | NA |
| IDH2 | erlotinib | 0.2087321 | 0.7043128 | 0.209 | NA | NA |
| PDGFRB | irinotecan | 0.2131484 | 0.6555760 | 0.213 | NA | NA |
| EGFR | irinotecan | 0.2306603 | 0.6555760 | 0.231 | NA | NA |
| MGMT | irinotecan | 0.2444998 | 0.6555760 | 0.244 | NA | NA |
| ERBB2 | nilotinib | 0.2469369 | 0.9412676 | 0.247 | NA | NA |
| JAK2 | lapatinib | 0.2481605 | 0.6059107 | 0.248 | NA | NA |
| BRCA2 | irinotecan | 0.2519045 | 0.6555760 | 0.252 | NA | NA |
| DPYD | irinotecan | 0.2565617 | 0.6555760 | 0.257 | NA | NA |
| PDGFB | nilotinib | 0.2614178 | 0.9412676 | 0.261 | NA | NA |
| NPM1 | lapatinib | 0.2652151 | 0.6059107 | 0.265 | NA | NA |
| PML | lapatinib | 0.2673135 | 0.6059107 | 0.267 | NA | NA |
| DNMT3A | irinotecan | 0.2699431 | 0.6555760 | 0.270 | NA | NA |
| BRCA2 | erlotinib | 0.2904280 | 0.7043128 | 0.290 | NA | NA |
| KRAS | nilotinib | 0.2905710 | 0.9412676 | 0.291 | NA | NA |
| TSC1 | selumetinib | 0.3026265 | 0.9776385 | 0.30263 | NA | NA |
| PML | erlotinib | 0.3071538 | 0.7043128 | 0.307 | NA | NA |
| RET | selumetinib | 0.3162948 | 0.9776385 | 0.31629 | NA | NA |
| JAK2 | nilotinib | 0.3242397 | 0.9412676 | 0.324 | NA | NA |
| CYP19A1 | irinotecan | 0.3281397 | 0.7321035 | 0.328 | NA | NA |
| KRAS | erlotinib | 0.3430622 | 0.7043128 | 0.343 | NA | NA |
| MET | irinotecan | 0.3595819 | 0.7321035 | 0.360 | NA | NA |
| CYP19A1 | nilotinib | 0.3614358 | 0.9412676 | 0.361 | NA | NA |
| BRCA1 | erlotinib | 0.3656704 | 0.7043128 | 0.366 | NA | NA |
| CYP19A1 | selumetinib | 0.3657355 | 0.9863877 | 0.36574 | NA | NA |
| MYD88 | irinotecan | 0.3660517 | 0.7321035 | 0.366 | NA | NA |
| KRAS | lapatinib | 0.3717079 | 0.7898793 | 0.372 | NA | NA |
| MET | nilotinib | 0.3749787 | 0.9412676 | 0.375 | NA | NA |
| RET | erlotinib | 0.3769409 | 0.7043128 | 0.377 | NA | NA |
| EGFR | erlotinib | 0.3780620 | 0.7043128 | 0.378 | NA | NA |
| KIT | erlotinib | 0.3945572 | 0.7043128 | 0.395 | NA | NA |
| NPM1 | erlotinib | 0.4081068 | 0.7043128 | 0.408 | NA | NA |
| AKT1 | erlotinib | 0.4089836 | 0.7043128 | 0.409 | NA | NA |
| TSC2 | erlotinib | 0.4143017 | 0.7043128 | 0.414 | NA | NA |
| ALK | irinotecan | 0.4159284 | 0.7856426 | 0.416 | NA | NA |
| KIT | selumetinib | 0.4291048 | 0.9863877 | 0.42910 | NA | NA |
| BRCA2 | nilotinib | 0.4329522 | 0.9412676 | 0.433 | NA | NA |
| DNMT3A | nilotinib | 0.4393202 | 0.9412676 | 0.439 | NA | NA |
| ABL1 | lapatinib | 0.4453225 | 0.8186706 | 0.445 | NA | NA |
| FLT3 | erlotinib | 0.4536996 | 0.7345612 | 0.454 | NA | NA |
| ESR1 | selumetinib | 0.4556101 | 0.9863877 | 0.45561 | NA | NA |
| MYD88 | lapatinib | 0.4587151 | 0.8186706 | 0.459 | NA | NA |
| ALK | lapatinib | 0.4609038 | 0.8186706 | 0.461 | NA | NA |
| PDGFRB | nilotinib | 0.4795241 | 0.9412676 | 0.480 | NA | NA |
| ROS1 | irinotecan | 0.4834670 | 0.8355783 | 0.483 | NA | NA |
| TPMT | erlotinib | 0.4842070 | 0.7483199 | 0.484 | NA | NA |
| DPYD | lapatinib | 0.4951753 | 0.8186706 | 0.495 | NA | NA |
| PDGFB | irinotecan | 0.5117862 | 0.8355783 | 0.512 | NA | NA |
| ESR1 | nilotinib | 0.5209092 | 0.9412676 | 0.521 | NA | NA |
| NPM1 | nilotinib | 0.5225901 | 0.9412676 | 0.523 | NA | NA |
| BRCA1 | lapatinib | 0.5346294 | 0.8186706 | 0.535 | NA | NA |
| IDH2 | irinotecan | 0.5383687 | 0.8355783 | 0.538 | NA | NA |
| ESR1 | erlotinib | 0.5463206 | 0.8076043 | 0.546 | NA | NA |
| MET | lapatinib | 0.5678884 | 0.8186706 | 0.568 | NA | NA |
| CYP19A1 | erlotinib | 0.5725012 | 0.8110433 | 0.573 | NA | NA |
| EGFR | selumetinib | 0.5763443 | 0.9863877 | 0.57634 | NA | NA |
| PDGFRB | lapatinib | 0.5810825 | 0.8186706 | 0.581 | NA | NA |
| UGT1A1 | lapatinib | 0.5880643 | 0.8186706 | 0.588 | NA | NA |
| FLT3 | nilotinib | 0.5913464 | 0.9412676 | 0.591 | NA | NA |
| PDGFRA | irinotecan | 0.5925752 | 0.8355783 | 0.593 | NA | NA |
| RET | nilotinib | 0.5975829 | 0.9412676 | 0.598 | NA | NA |
| TSC1 | irinotecan | 0.6014923 | 0.8355783 | 0.601 | NA | NA |
| AKT1 | lapatinib | 0.6019637 | 0.8186706 | 0.602 | NA | NA |
| TSC2 | selumetinib | 0.6111574 | 0.9863877 | 0.61116 | NA | NA |
| ERBB2 | irinotecan | 0.6286426 | 0.8355783 | 0.629 | NA | NA |
| PML | irinotecan | 0.6294330 | 0.8355783 | 0.629 | NA | NA |
| G6PD | lapatinib | 0.6332410 | 0.8280844 | 0.633 | NA | NA |
| RET | irinotecan | 0.6389716 | 0.8355783 | 0.639 | NA | NA |
| TSC1 | erlotinib | 0.6505989 | 0.8848145 | 0.651 | NA | NA |
| MET | selumetinib | 0.6524774 | 0.9863877 | 0.65248 | NA | NA |
| KIT | nilotinib | 0.6606331 | 0.9412676 | 0.661 | NA | NA |
| ABL1 | selumetinib | 0.6628862 | 0.9863877 | 0.66289 | NA | NA |
| PDGFRB | selumetinib | 0.6645199 | 0.9863877 | 0.66452 | NA | NA |
| ABL1 | irinotecan | 0.6660281 | 0.8387021 | 0.666 | NA | NA |
| TPMT | nilotinib | 0.6679929 | 0.9412676 | 0.668 | NA | NA |
| ROS1 | nilotinib | 0.6819122 | 0.9412676 | 0.682 | NA | NA |
| DPYD | erlotinib | 0.6840148 | 0.8944809 | 0.684 | NA | NA |
| DPYD | selumetinib | 0.6868738 | 0.9863877 | 0.68687 | NA | NA |
| MYD88 | nilotinib | 0.6912056 | 0.9412676 | 0.691 | NA | NA |
| TSC2 | nilotinib | 0.6921085 | 0.9412676 | 0.692 | NA | NA |
| CYP19A1 | lapatinib | 0.6950890 | 0.8752973 | 0.695 | NA | NA |
| PTCH1 | irinotecan | 0.7162618 | 0.8697465 | 0.716 | NA | NA |
| MYD88 | selumetinib | 0.7246756 | 0.9863877 | 0.72468 | NA | NA |
| PTCH1 | erlotinib | 0.7302464 | 0.9195695 | 0.730 | NA | NA |
| TSC1 | lapatinib | 0.7401698 | 0.8933363 | 0.740 | NA | NA |
| PDGFB | selumetinib | 0.7634636 | 0.9863877 | 0.76346 | NA | NA |
| G6PD | erlotinib | 0.7787902 | 0.9278477 | 0.779 | NA | NA |
| PTCH1 | lapatinib | 0.7871784 | 0.8933363 | 0.787 | NA | NA |
| EGFR | lapatinib | 0.7947247 | 0.8933363 | 0.795 | NA | NA |
| ALK | nilotinib | 0.7983903 | 0.9829706 | 0.798 | NA | NA |
| TSC1 | nilotinib | 0.7988924 | 0.9829706 | 0.799 | NA | NA |
| IDH2 | lapatinib | 0.8145125 | 0.8933363 | 0.815 | NA | NA |
| BRCA1 | irinotecan | 0.8210965 | 0.9114060 | 0.821 | NA | NA |
| ERBB2 | selumetinib | 0.8218228 | 0.9863877 | 0.82182 | NA | NA |
| UGT1A1 | erlotinib | 0.8238031 | 0.9278477 | 0.824 | NA | NA |
| G6PD | irinotecan | 0.8254252 | 0.9114060 | 0.825 | NA | NA |
| ROS1 | selumetinib | 0.8271911 | 0.9863877 | 0.82719 | NA | NA |
| ALK | selumetinib | 0.8278795 | 0.9863877 | 0.82788 | NA | NA |
| PDGFRB | erlotinib | 0.8279937 | 0.9278477 | 0.828 | NA | NA |
| MGMT | nilotinib | 0.8301945 | 0.9829706 | 0.830 | NA | NA |
| UGT1A1 | irinotecan | 0.8309879 | 0.9114060 | 0.831 | NA | NA |
| ABL1 | erlotinib | 0.8522490 | 0.9278477 | 0.852 | NA | NA |
| FLT3 | selumetinib | 0.8527746 | 0.9863877 | 0.85277 | NA | NA |
| FLT3 | lapatinib | 0.8614733 | 0.9153153 | 0.861 | NA | NA |
| PDGFRA | nilotinib | 0.8621321 | 0.9829706 | 0.862 | NA | NA |
| ERBB3 | selumetinib | 0.8669447 | 0.9863877 | 0.86694 | NA | NA |
| NPM1 | selumetinib | 0.8832243 | 0.9863877 | 0.88322 | NA | NA |
| KIT | irinotecan | 0.8862231 | 0.9200633 | 0.886 | NA | NA |
| MYD88 | erlotinib | 0.8885739 | 0.9278477 | 0.889 | NA | NA |
| UGT1A1 | selumetinib | 0.8917738 | 0.9863877 | 0.89177 | NA | NA |
| NPM1 | irinotecan | 0.8930026 | 0.9200633 | 0.893 | NA | NA |
| DNMT3A | erlotinib | 0.9005581 | 0.9278477 | 0.901 | NA | NA |
| TPMT | lapatinib | 0.9089736 | 0.9365183 | 0.909 | NA | NA |
| PML | nilotinib | 0.9170484 | 0.9829706 | 0.917 | NA | NA |
| AKT1 | selumetinib | 0.9187209 | 0.9863877 | 0.91872 | NA | NA |
| MGMT | selumetinib | 0.9254057 | 0.9863877 | 0.92541 | NA | NA |
| ALK | erlotinib | 0.9492432 | 0.9492432 | 0.949 | NA | NA |
| PML | selumetinib | 0.9504098 | 0.9863877 | 0.95041 | NA | NA |
| BRCA1 | nilotinib | 0.9506540 | 0.9829706 | 0.951 | NA | NA |
| PTCH1 | nilotinib | 0.9525059 | 0.9829706 | 0.953 | NA | NA |
| EGFR | nilotinib | 0.9540597 | 0.9829706 | 0.954 | NA | NA |
| BRCA1 | selumetinib | 0.9592240 | 0.9863877 | 0.95922 | NA | NA |
| ESR1 | lapatinib | 0.9641363 | 0.9641363 | 0.964 | NA | NA |
| ERBB3 | irinotecan | 0.9705439 | 0.9705439 | 0.971 | NA | NA |
| TPMT | selumetinib | 0.9863877 | 0.9863877 | 0.98639 | NA | NA |
| ABL1 | nilotinib | 0.9989982 | 0.9989982 | 0.999 | NA | NA |
ctrp_signif_g2p <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = "Drug_Gene", data = ctrp_data_g2p, method = "wilcox.test", p.adjust.method = "BH")
ctrp_signif_g2p <- adj_signif(ctrp_signif_g2p)
ctrp_signif_g2p <- ctrp_signif_g2p[order(ctrp_signif_g2p$p),]
saveRDS(ctrp_signif_g2p, "./data_munging/rds/ctrp_signif_g2p_gene.rds")
ctrp_signif_g2p_ByDrug <- lapply(unique(ctrp_data_g2p_genesfilt$Drug), WilcoxonByDrug, dataset = ctrp_data_g2p_genesfilt, data_name = "CTRP")
names(ctrp_signif_g2p_ByDrug) <- unique(ctrp_data_g2p_genesfilt$Drug)
saveRDS(ctrp_signif_g2p_ByDrug, "./data_munging/rds/ctrp_signif_g2p_ByDrug.rds")
ctrp_signif_g2p <- readRDS("./data_munging/rds/ctrp_signif_g2p_gene.rds")
knitr::kable(ctrp_signif_g2p[, c("Drug_Gene", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CTRP: Wilcoxon test results for level A G2P drug-gene associations (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Drug_Gene | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|
| vemurafenib_BRAF | 0.0000005 | 0.0000236 | 4.9e-07 | **** | **** |
| lapatinib_KRAS | 0.0000056 | 0.0001343 | 5.6e-06 | **** | *** |
| selumetinib_KRAS | 0.0002012 | 0.0032190 | 0.00020 | *** | ** |
| dabrafenib_BRAF | 0.0002722 | 0.0032664 | 0.00027 | *** | ** |
| gefitinib_KRAS | 0.0040210 | 0.0386011 | 0.00402 | ** |
|
| imatinib_PDGFRB | 0.0054451 | 0.0435604 | 0.00545 | ** |
|
| trametinib_BRAF | 0.0064941 | 0.0445309 | 0.00649 | ** |
|
| cyclophosphamide_ERBB2 | 0.0089622 | 0.0537731 | 0.00896 | ** | NA |
| afatinib_KRAS | 0.0107829 | 0.0575089 | 0.01078 |
|
NA |
| azd_KRAS | 0.0127676 | 0.0612847 | 0.01277 |
|
NA |
| pazopanib_UGT1A1 | 0.0341719 | 0.1491138 | 0.03417 |
|
NA |
| crizotinib_MET | 0.0436200 | 0.1744801 | 0.04362 |
|
NA |
| crizotinib_ALK | 0.0595488 | 0.2048823 | 0.05955 | NA | NA |
| fulvestrant_ERBB2 | 0.0667862 | 0.2048823 | 0.06679 | NA | NA |
| crizotinib_ROS1 | 0.0682314 | 0.2048823 | 0.06823 | NA | NA |
| gefitinib_MET | 0.0682941 | 0.2048823 | 0.06829 | NA | NA |
| dabrafenib_G6PD | 0.0952173 | 0.2688489 | 0.09522 | NA | NA |
| sunitinib_PDGFRA | 0.1625269 | 0.4059909 | 0.16253 | NA | NA |
| temozolomide_MGMT | 0.1678755 | 0.4059909 | 0.16788 | NA | NA |
| vandetanib_RET | 0.1691629 | 0.4059909 | 0.16916 | NA | NA |
| afatinib_ERBB2 | 0.1962848 | 0.4486509 | 0.19628 | NA | NA |
| neratinib_ERBB2 | 0.2066706 | 0.4509176 | 0.20667 | NA | NA |
| azd_EGFR | 0.2197291 | 0.4585650 | 0.21973 | NA | NA |
| afatinib_EGFR | 0.2518397 | 0.5036794 | 0.25184 | NA | NA |
| ibrutinib_MYD88 | 0.3177454 | 0.5850208 | 0.31775 | NA | NA |
| regorafenib_PDGFRA | 0.3247031 | 0.5850208 | 0.32470 | NA | NA |
| imatinib_PDGFB | 0.3290742 | 0.5850208 | 0.32907 | NA | NA |
| regorafenib_KIT | 0.4759780 | 0.8159623 | 0.47598 | NA | NA |
| olaparib_BRCA2 | 0.5281161 | 0.8473422 | 0.52812 | NA | NA |
| sunitinib_KIT | 0.5322976 | 0.8473422 | 0.53230 | NA | NA |
| erlotinib_EGFR | 0.5472418 | 0.8473422 | 0.54724 | NA | NA |
| imatinib_ABL1 | 0.5818558 | 0.8613135 | 0.58186 | NA | NA |
| cabozantinib_RET | 0.6089852 | 0.8613135 | 0.60899 | NA | NA |
| nilotinib_ABL1 | 0.6182260 | 0.8613135 | 0.61823 | NA | NA |
| imatinib_KIT | 0.6429646 | 0.8613135 | 0.64296 | NA | NA |
| erlotinib_MET | 0.6459851 | 0.8613135 | 0.64599 | NA | NA |
| fulvestrant_ESR1 | 0.6748204 | 0.8754427 | 0.67482 | NA | NA |
| afatinib_ERBB3 | 0.6959010 | 0.8790329 | 0.69590 | NA | NA |
| nilotinib_UGT1A1 | 0.7429748 | 0.8953061 | 0.74297 | NA | NA |
| fluorouracil_DPYD | 0.7693491 | 0.8953061 | 0.76935 | NA | NA |
| dasatinib_ABL1 | 0.7801253 | 0.8953061 | 0.78013 | NA | NA |
| olaparib_BRCA1 | 0.8126710 | 0.8953061 | 0.81267 | NA | NA |
| erlotinib_KRAS | 0.8197849 | 0.8953061 | 0.81978 | NA | NA |
| ruxolitinib_JAK2 | 0.8206972 | 0.8953061 | 0.82070 | NA | NA |
| imatinib_PDGFRA | 0.8550665 | 0.9120709 | 0.85507 | NA | NA |
| gefitinib_EGFR | 0.8875800 | 0.9156890 | 0.88758 | NA | NA |
| lapatinib_ERBB2 | 0.8966122 | 0.9156890 | 0.89661 | NA | NA |
| belinostat_UGT1A1 | 0.9223455 | 0.9223455 | 0.92235 | NA | NA |
ctrp_signif_g2p_ByDrug <- readRDS("./data_munging/rds/ctrp_signif_g2p_ByDrug.rds")
ctrp_signif_g2p_ByDrug_all <- rbindlist(ctrp_signif_g2p_ByDrug, use.names = TRUE)
ctrp_signif_g2p_ByDrug_all <- ctrp_signif_g2p_ByDrug_all[order(ctrp_signif_g2p_ByDrug_all$p),]
knitr::kable(ctrp_signif_g2p_ByDrug_all[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CTRP: By-drug Wilcoxon test results for point mutations in level A G2P genes (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | Drug | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|---|
| BRAF | vemurafenib | 0.0000005 | 0.0000167 | 4.9e-07 | **** | **** |
| KRAS | lapatinib | 0.0000056 | 0.0001902 | 5.6e-06 | **** | *** |
| KRAS | trametinib | 0.0000123 | 0.0004073 | 1.2e-05 | **** | *** |
| KRAS | pazopanib | 0.0000172 | 0.0005849 | 1.7e-05 | **** | *** |
| KRAS | ibrutinib | 0.0000293 | 0.0009955 | 2.9e-05 | **** | *** |
| MYD88 | vemurafenib | 0.0000321 | 0.0005454 | 3.2e-05 | **** | *** |
| KRAS | selumetinib | 0.0002012 | 0.0035372 | 0.00020 | *** | ** |
| BRAF | selumetinib | 0.0002081 | 0.0035372 | 0.00021 | *** | ** |
| BRAF | olaparib | 0.0002505 | 0.0085179 | 0.00025 | *** | ** |
| BRAF | dabrafenib | 0.0002722 | 0.0089827 | 0.00027 | *** | ** |
| KRAS | sunitinib | 0.0004277 | 0.0145425 | 0.00043 | *** |
|
| KRAS | neratinib | 0.0004366 | 0.0148460 | 0.00044 | *** |
|
| EGFR | vemurafenib | 0.0006405 | 0.0072593 | 0.00064 | *** | ** |
| BRAF | afatinib | 0.0008985 | 0.0305482 | 0.0009 | *** |
|
| KRAS | vandetanib | 0.0012628 | 0.0296819 | 0.0013 | ** |
|
| DNMT3A | vandetanib | 0.0017460 | 0.0296819 | 0.0017 | ** |
|
| KRAS | cabozantinib | 0.0020791 | 0.0706877 | 0.0021 | ** | NA |
| DNMT3A | lapatinib | 0.0028992 | 0.0492861 | 0.0029 | ** |
|
| CYP19A1 | vemurafenib | 0.0034645 | 0.0294485 | 0.00346 | ** |
|
| KRAS | olaparib | 0.0035982 | 0.0611698 | 0.00360 | ** | NA |
| KRAS | gefitinib | 0.0040210 | 0.1367124 | 0.004 | ** | NA |
| BRAF | neratinib | 0.0041088 | 0.0698503 | 0.00411 | ** | NA |
| BRAF | pazopanib | 0.0041184 | 0.0700128 | 0.0041 | ** | NA |
| BRAF | ibrutinib | 0.0051142 | 0.0869422 | 0.0051 | ** | NA |
| DNMT3A | selumetinib | 0.0054340 | 0.0615849 | 0.00543 | ** | NA |
| PDGFRB | imatinib | 0.0054451 | 0.1851319 | 0.0054 | ** | NA |
| PML | fulvestrant | 0.0061906 | 0.2104795 | 0.0062 | ** | NA |
| BRAF | ruxolitinib | 0.0062716 | 0.2132360 | 0.0063 | ** | NA |
| PDGFRB | cabozantinib | 0.0062762 | 0.1066960 | 0.0063 | ** | NA |
| BRAF | trametinib | 0.0064941 | 0.1071526 | 0.0065 | ** | NA |
| DNMT3A | gefitinib | 0.0080435 | 0.1367399 | 0.008 | ** | NA |
| ERBB2 | cyclophosphamide | 0.0089622 | 0.3047143 | 0.009 | ** | NA |
| KRAS | regorafenib | 0.0098050 | 0.1882113 | 0.0098 | ** | NA |
| ERBB2 | cabozantinib | 0.0100336 | 0.1091138 | 0.0100 |
|
NA |
| KRAS | afatinib | 0.0107829 | 0.1699989 | 0.0108 |
|
NA |
| PML | crizotinib | 0.0111785 | 0.3800698 | 0.011 |
|
NA |
| KRAS | vemurafenib | 0.0119766 | 0.0814412 | 0.01198 |
|
NA |
| MYD88 | vandetanib | 0.0123446 | 0.1399058 | 0.0123 |
|
NA |
| KRAS | azd | 0.0127676 | 0.2040480 | 0.013 |
|
NA |
| ERBB3 | cabozantinib | 0.0128369 | 0.1091138 | 0.0128 |
|
NA |
| BRAF | temozolomide | 0.0137195 | 0.4000874 | 0.014 |
|
NA |
| KIT | ibrutinib | 0.0142737 | 0.1617685 | 0.0143 |
|
NA |
| TPMT | sunitinib | 0.0149004 | 0.2533066 | 0.01490 |
|
NA |
| DNMT3A | afatinib | 0.0149999 | 0.1699989 | 0.0150 |
|
NA |
| PML | fluorouracil | 0.0155734 | 0.5294946 | 0.016 |
|
NA |
| RET | azd | 0.0156276 | 0.2040480 | 0.016 |
|
NA |
| PTCH1 | trametinib | 0.0159153 | 0.1750680 | 0.0159 |
|
NA |
| ROS1 | pazopanib | 0.0165094 | 0.1871070 | 0.0165 |
|
NA |
| PDGFB | regorafenib | 0.0165670 | 0.1882113 | 0.0166 |
|
NA |
| CYP19A1 | regorafenib | 0.0166069 | 0.1882113 | 0.0166 |
|
NA |
| UGT1A1 | azd | 0.0180042 | 0.2040480 | 0.018 |
|
NA |
| BRAF | cyclophosphamide | 0.0222337 | 0.3779730 | 0.022 |
|
NA |
| ALK | neratinib | 0.0230681 | 0.2614389 | 0.02307 |
|
NA |
| DNMT3A | trametinib | 0.0232930 | 0.1921671 | 0.0233 |
|
NA |
| ESR1 | imatinib | 0.0245120 | 0.4167035 | 0.0245 |
|
NA |
| BRCA1 | fulvestrant | 0.0266668 | 0.4533360 | 0.0267 |
|
NA |
| JAK2 | temozolomide | 0.0271063 | 0.4000874 | 0.027 |
|
NA |
| DNMT3A | crizotinib | 0.0276455 | 0.3866447 | 0.028 |
|
NA |
| BRAF | dasatinib | 0.0300319 | 0.7302743 | 0.030 |
|
NA |
| BRAF | lapatinib | 0.0305016 | 0.3456843 | 0.0305 |
|
NA |
| PML | selumetinib | 0.0317252 | 0.2169061 | 0.03173 |
|
NA |
| PDGFRA | ibrutinib | 0.0333483 | 0.2315548 | 0.0333 |
|
NA |
| DNMT3A | ibrutinib | 0.0340522 | 0.2315548 | 0.0341 |
|
NA |
| UGT1A1 | pazopanib | 0.0341719 | 0.2904612 | 0.0342 |
|
NA |
| TSC2 | vemurafenib | 0.0345796 | 0.1751927 | 0.03458 |
|
NA |
| DPYD | selumetinib | 0.0356352 | 0.2169061 | 0.03564 |
|
NA |
| DNMT3A | neratinib | 0.0356380 | 0.3029234 | 0.03564 |
|
NA |
| MET | vemurafenib | 0.0360691 | 0.1751927 | 0.03607 |
|
NA |
| KIT | cabozantinib | 0.0362427 | 0.1752370 | 0.0362 |
|
NA |
| PDGFRB | afatinib | 0.0366997 | 0.2708095 | 0.0367 |
|
NA |
| ROS1 | gefitinib | 0.0380067 | 0.3938390 | 0.038 |
|
NA |
| TPMT | selumetinib | 0.0382776 | 0.2169061 | 0.03828 |
|
NA |
| TSC2 | cabozantinib | 0.0383320 | 0.1752370 | 0.0383 |
|
NA |
| ROS1 | cabozantinib | 0.0390533 | 0.1752370 | 0.0391 |
|
NA |
| BRAF | fluorouracil | 0.0393299 | 0.5857145 | 0.039 |
|
NA |
| KIT | afatinib | 0.0398249 | 0.2708095 | 0.0398 |
|
NA |
| FLT3 | cabozantinib | 0.0412322 | 0.1752370 | 0.0412 |
|
NA |
| MET | sunitinib | 0.0414057 | 0.3813132 | 0.04141 |
|
NA |
| BRAF | azd | 0.0415725 | 0.3045006 | 0.042 |
|
NA |
| DNMT3A | erlotinib | 0.0426319 | 0.4945308 | 0.043 |
|
NA |
| CYP19A1 | imatinib | 0.0430959 | 0.4184794 | 0.0431 |
|
NA |
| FLT3 | olaparib | 0.0434999 | 0.3890797 | 0.04350 |
|
NA |
| MET | crizotinib | 0.0436200 | 0.3866447 | 0.044 |
|
NA |
| ROS1 | azd | 0.0447795 | 0.3045006 | 0.045 |
|
NA |
| ROS1 | olaparib | 0.0457741 | 0.3890797 | 0.04577 |
|
NA |
| TSC1 | nilotinib | 0.0489600 | 0.4507292 | 0.049 |
|
NA |
| BRCA1 | belinostat | 0.0497327 | 0.9332615 | 0.05 |
|
NA |
| PDGFRB | regorafenib | 0.0500392 | 0.3550591 | 0.0500 | NA | NA |
| ALK | dasatinib | 0.0501428 | 0.7302743 | 0.050 | NA | NA |
| MET | selumetinib | 0.0507587 | 0.2252140 | 0.05076 | NA | NA |
| KRAS | crizotinib | 0.0508005 | 0.3866447 | 0.051 | NA | NA |
| PTCH1 | regorafenib | 0.0522146 | 0.3550591 | 0.0522 | NA | NA |
| PTCH1 | vemurafenib | 0.0527029 | 0.2006954 | 0.05270 | NA | NA |
| RET | selumetinib | 0.0529915 | 0.2252140 | 0.05299 | NA | NA |
| BRCA1 | vemurafenib | 0.0531252 | 0.2006954 | 0.05313 | NA | NA |
| ALK | vandetanib | 0.0531880 | 0.4520980 | 0.0532 | NA | NA |
| PDGFRA | gefitinib | 0.0538638 | 0.3938390 | 0.054 | NA | NA |
| MET | nilotinib | 0.0553000 | 0.4507292 | 0.055 | NA | NA |
| JAK2 | nilotinib | 0.0558396 | 0.4507292 | 0.056 | NA | NA |
| TPMT | imatinib | 0.0564058 | 0.4184794 | 0.0564 | NA | NA |
| BRCA2 | temozolomide | 0.0567584 | 0.4000874 | 0.057 | NA | NA |
| MYD88 | temozolomide | 0.0574402 | 0.4000874 | 0.057 | NA | NA |
| NPM1 | lapatinib | 0.0576027 | 0.4247950 | 0.0576 | NA | NA |
| MGMT | dabrafenib | 0.0578528 | 0.6995857 | 0.05785 | NA | NA |
| IDH2 | olaparib | 0.0581368 | 0.3953299 | 0.05814 | NA | NA |
| PTCH1 | temozolomide | 0.0588364 | 0.4000874 | 0.059 | NA | NA |
| ALK | crizotinib | 0.0595488 | 0.3866447 | 0.060 | NA | NA |
| JAK2 | cabozantinib | 0.0601835 | 0.1902348 | 0.0602 | NA | NA |
| ABL1 | cyclophosphamide | 0.0608027 | 0.6890967 | 0.061 | NA | NA |
| PDGFRB | sunitinib | 0.0609026 | 0.3813132 | 0.06090 | NA | NA |
| PTCH1 | imatinib | 0.0615411 | 0.4184794 | 0.0615 | NA | NA |
| DPYD | neratinib | 0.0622681 | 0.4234232 | 0.06227 | NA | NA |
| PDGFRA | lapatinib | 0.0624698 | 0.4247950 | 0.0625 | NA | NA |
| PTCH1 | erlotinib | 0.0624883 | 0.4945308 | 0.062 | NA | NA |
| MET | cabozantinib | 0.0628214 | 0.1902348 | 0.0628 | NA | NA |
| CYP19A1 | dasatinib | 0.0644360 | 0.7302743 | 0.064 | NA | NA |
| PTCH1 | sunitinib | 0.0653514 | 0.3813132 | 0.06535 | NA | NA |
| UGT1A1 | cabozantinib | 0.0659861 | 0.1902348 | 0.0660 | NA | NA |
| ERBB2 | fulvestrant | 0.0667862 | 0.7405746 | 0.0668 | NA | NA |
| AKT1 | cabozantinib | 0.0671417 | 0.1902348 | 0.0671 | NA | NA |
| DNMT3A | sunitinib | 0.0672906 | 0.3813132 | 0.06729 | NA | NA |
| EGFR | regorafenib | 0.0674563 | 0.3598309 | 0.0675 | NA | NA |
| ROS1 | crizotinib | 0.0682314 | 0.3866447 | 0.068 | NA | NA |
| MET | gefitinib | 0.0682941 | 0.3938390 | 0.068 | NA | NA |
| ROS1 | erlotinib | 0.0687863 | 0.4945308 | 0.069 | NA | NA |
| JAK2 | erlotinib | 0.0694206 | 0.4945308 | 0.069 | NA | NA |
| JAK2 | gefitinib | 0.0695010 | 0.3938390 | 0.070 | NA | NA |
| KRAS | ruxolitinib | 0.0698118 | 0.9314078 | 0.0698 | NA | NA |
| KRAS | nilotinib | 0.0700538 | 0.4507292 | 0.070 | NA | NA |
| TPMT | afatinib | 0.0710783 | 0.3521922 | 0.0711 | NA | NA |
| DPYD | azd | 0.0712184 | 0.4035707 | 0.071 | NA | NA |
| ALK | afatinib | 0.0725102 | 0.3521922 | 0.0725 | NA | NA |
| PDGFRA | vemurafenib | 0.0735826 | 0.2190817 | 0.07358 | NA | NA |
| G6PD | regorafenib | 0.0740828 | 0.3598309 | 0.0741 | NA | NA |
| KIT | selumetinib | 0.0746874 | 0.2821523 | 0.07469 | NA | NA |
| NPM1 | pazopanib | 0.0750765 | 0.5105199 | 0.0751 | NA | NA |
| TPMT | cabozantinib | 0.0751475 | 0.1965396 | 0.0751 | NA | NA |
| TSC1 | vemurafenib | 0.0759962 | 0.2190817 | 0.07600 | NA | NA |
| PML | vemurafenib | 0.0789218 | 0.2190817 | 0.07892 | NA | NA |
| TSC1 | fluorouracil | 0.0794633 | 0.5857145 | 0.079 | NA | NA |
| UGT1A1 | sunitinib | 0.0800633 | 0.3888788 | 0.08006 | NA | NA |
| DNMT3A | fluorouracil | 0.0810167 | 0.5857145 | 0.081 | NA | NA |
| G6PD | nilotinib | 0.0817599 | 0.4507292 | 0.082 | NA | NA |
| PDGFRA | erlotinib | 0.0818940 | 0.4945308 | 0.082 | NA | NA |
| ERBB2 | dabrafenib | 0.0822127 | 0.6995857 | 0.08221 | NA | NA |
| RET | afatinib | 0.0832455 | 0.3537932 | 0.0832 | NA | NA |
| PDGFRB | trametinib | 0.0837396 | 0.4658024 | 0.0837 | NA | NA |
| BRCA2 | vemurafenib | 0.0837665 | 0.2190817 | 0.08377 | NA | NA |
| MYD88 | nilotinib | 0.0840035 | 0.4507292 | 0.084 | NA | NA |
| BRCA1 | azd | 0.0871239 | 0.4231730 | 0.087 | NA | NA |
| TPMT | crizotinib | 0.0889926 | 0.4322498 | 0.089 | NA | NA |
| KIT | trametinib | 0.0892804 | 0.4658024 | 0.0893 | NA | NA |
| RET | fluorouracil | 0.0904485 | 0.5857145 | 0.090 | NA | NA |
| BRCA2 | pazopanib | 0.0923309 | 0.5232086 | 0.0923 | NA | NA |
| TPMT | dasatinib | 0.0925509 | 0.7866823 | 0.093 | NA | NA |
| ROS1 | nilotinib | 0.0927972 | 0.4507292 | 0.093 | NA | NA |
| PDGFRA | temozolomide | 0.0937160 | 0.5310575 | 0.094 | NA | NA |
| G6PD | dabrafenib | 0.0952173 | 0.6995857 | 0.09522 | NA | NA |
| RET | cyclophosphamide | 0.0968718 | 0.8234099 | 0.097 | NA | NA |
| DNMT3A | olaparib | 0.0996068 | 0.5644383 | 0.09961 | NA | NA |
| DPYD | afatinib | 0.1034804 | 0.3909259 | 0.1035 | NA | NA |
| ABL1 | trametinib | 0.1038508 | 0.4658024 | 0.1039 | NA | NA |
| MGMT | imatinib | 0.1047274 | 0.5934553 | 0.1047 | NA | NA |
| DPYD | vandetanib | 0.1050806 | 0.6681475 | 0.1051 | NA | NA |
| PDGFB | ibrutinib | 0.1088089 | 0.5415524 | 0.1088 | NA | NA |
| MGMT | erlotinib | 0.1093037 | 0.4945308 | 0.109 | NA | NA |
| AKT1 | crizotinib | 0.1095589 | 0.4656252 | 0.110 | NA | NA |
| AKT1 | azd | 0.1125486 | 0.4576031 | 0.113 | NA | NA |
| RET | trametinib | 0.1129218 | 0.4658024 | 0.1129 | NA | NA |
| UGT1A1 | dabrafenib | 0.1142522 | 0.6995857 | 0.11425 | NA | NA |
| ESR1 | fluorouracil | 0.1147435 | 0.5857145 | 0.115 | NA | NA |
| DNMT3A | pazopanib | 0.1153640 | 0.5603392 | 0.1154 | NA | NA |
| PDGFB | vemurafenib | 0.1163543 | 0.2825748 | 0.11635 | NA | NA |
| PTCH1 | lapatinib | 0.1167103 | 0.6029902 | 0.1167 | NA | NA |
| AKT1 | sunitinib | 0.1198936 | 0.4988051 | 0.11989 | NA | NA |
| PDGFRA | azd | 0.1211302 | 0.4576031 | 0.121 | NA | NA |
| BRCA1 | nilotinib | 0.1242641 | 0.4564231 | 0.124 | NA | NA |
| TPMT | neratinib | 0.1244008 | 0.6384596 | 0.12440 | NA | NA |
| TSC1 | cabozantinib | 0.1252422 | 0.3041597 | 0.1252 | NA | NA |
| PML | gefitinib | 0.1255530 | 0.6098289 | 0.126 | NA | NA |
| ERBB2 | fluorouracil | 0.1257464 | 0.5857145 | 0.126 | NA | NA |
| CYP19A1 | ibrutinib | 0.1269984 | 0.5415524 | 0.1270 | NA | NA |
| CYP19A1 | dabrafenib | 0.1271974 | 0.6995857 | 0.12720 | NA | NA |
| ALK | ibrutinib | 0.1274241 | 0.5415524 | 0.1274 | NA | NA |
| PTCH1 | nilotinib | 0.1277181 | 0.4564231 | 0.128 | NA | NA |
| NPM1 | erlotinib | 0.1307567 | 0.4945308 | 0.131 | NA | NA |
| EGFR | trametinib | 0.1316155 | 0.4825901 | 0.1316 | NA | NA |
| NPM1 | sunitinib | 0.1320366 | 0.4988051 | 0.13204 | NA | NA |
| ROS1 | regorafenib | 0.1323222 | 0.5623696 | 0.1323 | NA | NA |
| JAK2 | vemurafenib | 0.1329072 | 0.3012562 | 0.13291 | NA | NA |
| BRAF | imatinib | 0.1350841 | 0.6561226 | 0.1351 | NA | NA |
| BRCA2 | neratinib | 0.1369451 | 0.6384596 | 0.13695 | NA | NA |
| PTCH1 | olaparib | 0.1376429 | 0.6685514 | 0.13764 | NA | NA |
| TPMT | ruxolitinib | 0.1408874 | 0.9314078 | 0.1409 | NA | NA |
| UGT1A1 | selumetinib | 0.1423368 | 0.4163122 | 0.14234 | NA | NA |
| MGMT | fluorouracil | 0.1432551 | 0.5857145 | 0.143 | NA | NA |
| BRCA2 | erlotinib | 0.1458082 | 0.4945308 | 0.146 | NA | NA |
| ALK | erlotinib | 0.1462901 | 0.4945308 | 0.146 | NA | NA |
| FLT3 | nilotinib | 0.1476259 | 0.4564231 | 0.148 | NA | NA |
| DPYD | nilotinib | 0.1476663 | 0.4564231 | 0.148 | NA | NA |
| G6PD | trametinib | 0.1496537 | 0.4938571 | 0.1497 | NA | NA |
| TSC1 | sunitinib | 0.1518085 | 0.5023558 | 0.15181 | NA | NA |
| AKT1 | neratinib | 0.1528627 | 0.6384596 | 0.15286 | NA | NA |
| DPYD | fulvestrant | 0.1532097 | 0.7405746 | 0.1532 | NA | NA |
| ERBB2 | erlotinib | 0.1533325 | 0.4945308 | 0.153 | NA | NA |
| G6PD | selumetinib | 0.1551003 | 0.4163122 | 0.15510 | NA | NA |
| PDGFRB | selumetinib | 0.1562725 | 0.4163122 | 0.15627 | NA | NA |
| ALK | azd | 0.1572449 | 0.5346326 | 0.157 | NA | NA |
| FLT3 | vemurafenib | 0.1577275 | 0.3259020 | 0.15773 | NA | NA |
| NPM1 | crizotinib | 0.1583886 | 0.5983568 | 0.158 | NA | NA |
| CYP19A1 | fluorouracil | 0.1588485 | 0.5857145 | 0.159 | NA | NA |
| DNMT3A | dasatinib | 0.1589015 | 0.8981810 | 0.159 | NA | NA |
| ALK | selumetinib | 0.1591782 | 0.4163122 | 0.15918 | NA | NA |
| KIT | erlotinib | 0.1599953 | 0.4945308 | 0.160 | NA | NA |
| CYP19A1 | belinostat | 0.1605668 | 0.9332615 | 0.16 | NA | NA |
| UGT1A1 | olaparib | 0.1608514 | 0.6836186 | 0.16085 | NA | NA |
| ABL1 | ruxolitinib | 0.1623760 | 0.9314078 | 0.1624 | NA | NA |
| PDGFRA | sunitinib | 0.1625269 | 0.5023558 | 0.16253 | NA | NA |
| AKT1 | vemurafenib | 0.1629510 | 0.3259020 | 0.16295 | NA | NA |
| CYP19A1 | nilotinib | 0.1633178 | 0.4627337 | 0.163 | NA | NA |
| RET | lapatinib | 0.1635140 | 0.6029902 | 0.1635 | NA | NA |
| ROS1 | ruxolitinib | 0.1652562 | 0.9314078 | 0.1653 | NA | NA |
| TPMT | gefitinib | 0.1653865 | 0.6634491 | 0.165 | NA | NA |
| CYP19A1 | cyclophosphamide | 0.1664216 | 0.8874508 | 0.166 | NA | NA |
| MET | cyclophosphamide | 0.1671638 | 0.8874508 | 0.167 | NA | NA |
| MGMT | temozolomide | 0.1678755 | 0.7065822 | 0.168 | NA | NA |
| ERBB2 | dasatinib | 0.1679727 | 0.8981810 | 0.168 | NA | NA |
| TSC1 | neratinib | 0.1690040 | 0.6384596 | 0.16900 | NA | NA |
| RET | vandetanib | 0.1691629 | 0.6681475 | 0.1692 | NA | NA |
| ROS1 | afatinib | 0.1715284 | 0.5539450 | 0.1715 | NA | NA |
| ALK | fluorouracil | 0.1722690 | 0.5857145 | 0.172 | NA | NA |
| IDH2 | fulvestrant | 0.1760724 | 0.7405746 | 0.1761 | NA | NA |
| BRCA2 | selumetinib | 0.1762300 | 0.4279871 | 0.17623 | NA | NA |
| IDH2 | imatinib | 0.1770530 | 0.6851658 | 0.1771 | NA | NA |
| TSC1 | dabrafenib | 0.1796741 | 0.8398900 | 0.17967 | NA | NA |
| ABL1 | belinostat | 0.1800207 | 0.9332615 | 0.18 | NA | NA |
| G6PD | gefitinib | 0.1809687 | 0.6634491 | 0.181 | NA | NA |
| PDGFRB | pazopanib | 0.1809713 | 0.6888301 | 0.1810 | NA | NA |
| ALK | lapatinib | 0.1820481 | 0.6029902 | 0.1820 | NA | NA |
| KIT | pazopanib | 0.1823374 | 0.6888301 | 0.1823 | NA | NA |
| UGT1A1 | cyclophosphamide | 0.1827105 | 0.8874508 | 0.183 | NA | NA |
| ESR1 | trametinib | 0.1839575 | 0.5233822 | 0.1840 | NA | NA |
| CYP19A1 | sunitinib | 0.1840148 | 0.5213753 | 0.18401 | NA | NA |
| RET | ruxolitinib | 0.1851983 | 0.9314078 | 0.1852 | NA | NA |
| MET | fulvestrant | 0.1858576 | 0.7405746 | 0.1859 | NA | NA |
| ALK | temozolomide | 0.1882566 | 0.7065822 | 0.188 | NA | NA |
| PDGFRA | trametinib | 0.1903208 | 0.5233822 | 0.1903 | NA | NA |
| MGMT | vandetanib | 0.1909706 | 0.6681475 | 0.1910 | NA | NA |
| JAK2 | azd | 0.1912155 | 0.5910299 | 0.191 | NA | NA |
| ERBB2 | afatinib | 0.1962848 | 0.5539450 | 0.1963 | NA | NA |
| DPYD | vemurafenib | 0.1972116 | 0.3725107 | 0.19721 | NA | NA |
| BRCA1 | cabozantinib | 0.1984399 | 0.4341695 | 0.1984 | NA | NA |
| IDH2 | afatinib | 0.2002219 | 0.5539450 | 0.2002 | NA | NA |
| BRCA1 | sunitinib | 0.2029629 | 0.5308261 | 0.20296 | NA | NA |
| PTCH1 | cabozantinib | 0.2043150 | 0.4341695 | 0.2043 | NA | NA |
| KRAS | temozolomide | 0.2044885 | 0.7065822 | 0.204 | NA | NA |
| RET | gefitinib | 0.2049189 | 0.6634491 | 0.205 | NA | NA |
| JAK2 | vandetanib | 0.2056568 | 0.6681475 | 0.2057 | NA | NA |
| TPMT | lapatinib | 0.2063631 | 0.6029902 | 0.2064 | NA | NA |
| ERBB2 | neratinib | 0.2066706 | 0.7012154 | 0.20667 | NA | NA |
| ABL1 | temozolomide | 0.2078183 | 0.7065822 | 0.208 | NA | NA |
| G6PD | vandetanib | 0.2082743 | 0.6681475 | 0.2083 | NA | NA |
| PDGFB | ruxolitinib | 0.2112854 | 0.9314078 | 0.2113 | NA | NA |
| JAK2 | regorafenib | 0.2116803 | 0.7996810 | 0.2117 | NA | NA |
| MGMT | afatinib | 0.2118025 | 0.5539450 | 0.2118 | NA | NA |
| TSC1 | ibrutinib | 0.2141178 | 0.7299037 | 0.2141 | NA | NA |
| RET | erlotinib | 0.2156089 | 0.5141116 | 0.216 | NA | NA |
| MET | trametinib | 0.2171377 | 0.5469503 | 0.2171 | NA | NA |
| TPMT | olaparib | 0.2193329 | 0.6914387 | 0.21933 | NA | NA |
| MET | vandetanib | 0.2195544 | 0.6681475 | 0.2196 | NA | NA |
| EGFR | azd | 0.2197291 | 0.5979347 | 0.220 | NA | NA |
| UGT1A1 | crizotinib | 0.2205241 | 0.6987047 | 0.221 | NA | NA |
| PDGFRA | cabozantinib | 0.2210144 | 0.4420288 | 0.2210 | NA | NA |
| AKT1 | erlotinib | 0.2216745 | 0.5141116 | 0.222 | NA | NA |
| ROS1 | lapatinib | 0.2232310 | 0.6029902 | 0.2232 | NA | NA |
| AKT1 | vandetanib | 0.2252466 | 0.6681475 | 0.2252 | NA | NA |
| DPYD | erlotinib | 0.2260758 | 0.5141116 | 0.226 | NA | NA |
| IDH2 | erlotinib | 0.2268140 | 0.5141116 | 0.227 | NA | NA |
| KIT | neratinib | 0.2272109 | 0.7012154 | 0.22721 | NA | NA |
| TSC1 | azd | 0.2297525 | 0.5979347 | 0.230 | NA | NA |
| NPM1 | fulvestrant | 0.2309231 | 0.7405746 | 0.2309 | NA | NA |
| MGMT | dasatinib | 0.2320758 | 0.8981810 | 0.232 | NA | NA |
| FLT3 | ibrutinib | 0.2324658 | 0.7299037 | 0.2325 | NA | NA |
| ROS1 | fulvestrant | 0.2343543 | 0.7405746 | 0.2344 | NA | NA |
| TPMT | vandetanib | 0.2358167 | 0.6681475 | 0.2358 | NA | NA |
| DPYD | gefitinib | 0.2382705 | 0.6634491 | 0.238 | NA | NA |
| RET | crizotinib | 0.2389903 | 0.6987047 | 0.239 | NA | NA |
| MGMT | lapatinib | 0.2397677 | 0.6029902 | 0.2398 | NA | NA |
| ROS1 | trametinib | 0.2403793 | 0.5469503 | 0.2404 | NA | NA |
| MYD88 | dabrafenib | 0.2408578 | 0.8398900 | 0.24086 | NA | NA |
| AKT1 | lapatinib | 0.2447114 | 0.6029902 | 0.2447 | NA | NA |
| PML | nilotinib | 0.2462058 | 0.6439228 | 0.246 | NA | NA |
| KIT | crizotinib | 0.2466017 | 0.6987047 | 0.247 | NA | NA |
| PDGFB | pazopanib | 0.2466642 | 0.7489184 | 0.2467 | NA | NA |
| RET | neratinib | 0.2474878 | 0.7012154 | 0.24749 | NA | NA |
| PDGFB | azd | 0.2475165 | 0.5979347 | 0.248 | NA | NA |
| MGMT | vemurafenib | 0.2488404 | 0.4452933 | 0.24884 | NA | NA |
| MGMT | gefitinib | 0.2498351 | 0.6634491 | 0.250 | NA | NA |
| MET | olaparib | 0.2511607 | 0.6914387 | 0.25116 | NA | NA |
| G6PD | sunitinib | 0.2518013 | 0.5738528 | 0.25180 | NA | NA |
| EGFR | afatinib | 0.2518397 | 0.6116107 | 0.2518 | NA | NA |
| TPMT | trametinib | 0.2520717 | 0.5469503 | 0.2521 | NA | NA |
| JAK2 | cyclophosphamide | 0.2532387 | 0.9645613 | 0.253 | NA | NA |
| TSC2 | cyclophosphamide | 0.2553250 | 0.9645613 | 0.255 | NA | NA |
| UGT1A1 | regorafenib | 0.2573217 | 0.8332306 | 0.2573 | NA | NA |
| MGMT | ruxolitinib | 0.2579077 | 0.9314078 | 0.2579 | NA | NA |
| NPM1 | ibrutinib | 0.2580132 | 0.7299037 | 0.2580 | NA | NA |
| PDGFRB | ibrutinib | 0.2584041 | 0.7299037 | 0.2584 | NA | NA |
| TPMT | pazopanib | 0.2589317 | 0.7489184 | 0.2589 | NA | NA |
| AKT1 | olaparib | 0.2619009 | 0.6914387 | 0.26190 | NA | NA |
| IDH2 | lapatinib | 0.2631941 | 0.6029902 | 0.2632 | NA | NA |
| PML | olaparib | 0.2632816 | 0.6914387 | 0.26328 | NA | NA |
| MET | pazopanib | 0.2643242 | 0.7489184 | 0.2643 | NA | NA |
| TSC2 | azd | 0.2666255 | 0.5979347 | 0.267 | NA | NA |
| TSC1 | dasatinib | 0.2684477 | 0.8981810 | 0.268 | NA | NA |
| MYD88 | cabozantinib | 0.2705198 | 0.5109818 | 0.2705 | NA | NA |
| AKT1 | gefitinib | 0.2710276 | 0.6634491 | 0.271 | NA | NA |
| MYD88 | lapatinib | 0.2727428 | 0.6029902 | 0.2727 | NA | NA |
| JAK2 | fulvestrant | 0.2731170 | 0.7405746 | 0.2731 | NA | NA |
| CYP19A1 | lapatinib | 0.2738891 | 0.6029902 | 0.2739 | NA | NA |
| ERBB2 | gefitinib | 0.2741193 | 0.6634491 | 0.274 | NA | NA |
| PDGFRA | selumetinib | 0.2749493 | 0.6232184 | 0.27495 | NA | NA |
| KRAS | fulvestrant | 0.2766131 | 0.7405746 | 0.2766 | NA | NA |
| TSC1 | imatinib | 0.2772743 | 0.6851658 | 0.2773 | NA | NA |
| MGMT | trametinib | 0.2783193 | 0.5469503 | 0.2783 | NA | NA |
| ALK | imatinib | 0.2787671 | 0.6851658 | 0.2788 | NA | NA |
| MGMT | fulvestrant | 0.2788073 | 0.7405746 | 0.2788 | NA | NA |
| AKT1 | ibrutinib | 0.2790808 | 0.7299037 | 0.2791 | NA | NA |
| ROS1 | sunitinib | 0.2791187 | 0.5738528 | 0.27912 | NA | NA |
| FLT3 | dabrafenib | 0.2794287 | 0.8398900 | 0.27943 | NA | NA |
| ABL1 | fulvestrant | 0.2803031 | 0.7405746 | 0.2803 | NA | NA |
| TSC2 | sunitinib | 0.2822305 | 0.5738528 | 0.28223 | NA | NA |
| ERBB2 | trametinib | 0.2825628 | 0.5469503 | 0.2826 | NA | NA |
| CYP19A1 | fulvestrant | 0.2831609 | 0.7405746 | 0.2832 | NA | NA |
| BRCA1 | lapatinib | 0.2837601 | 0.6029902 | 0.2838 | NA | NA |
| EGFR | vandetanib | 0.2853916 | 0.6968774 | 0.2854 | NA | NA |
| PTCH1 | dasatinib | 0.2856356 | 0.8981810 | 0.286 | NA | NA |
| ERBB3 | sunitinib | 0.2869264 | 0.5738528 | 0.28693 | NA | NA |
| ESR1 | olaparib | 0.2881802 | 0.6914387 | 0.28818 | NA | NA |
| TPMT | fluorouracil | 0.2892300 | 0.8392181 | 0.289 | NA | NA |
| MET | regorafenib | 0.2896133 | 0.8332306 | 0.2896 | NA | NA |
| PDGFRB | neratinib | 0.2911880 | 0.7411173 | 0.29119 | NA | NA |
| IDH2 | vandetanib | 0.2935755 | 0.6968774 | 0.2936 | NA | NA |
| ERBB2 | imatinib | 0.2961755 | 0.6851658 | 0.2962 | NA | NA |
| NPM1 | azd | 0.2976666 | 0.5979347 | 0.298 | NA | NA |
| DPYD | belinostat | 0.2978744 | 0.9332615 | 0.30 | NA | NA |
| UGT1A1 | ruxolitinib | 0.2979995 | 0.9314078 | 0.2980 | NA | NA |
| TSC2 | dasatinib | 0.2997123 | 0.8981810 | 0.300 | NA | NA |
| MGMT | nilotinib | 0.3000538 | 0.6835150 | 0.300 | NA | NA |
| NPM1 | cabozantinib | 0.3013980 | 0.5150108 | 0.3014 | NA | NA |
| ABL1 | crizotinib | 0.3022158 | 0.7904106 | 0.302 | NA | NA |
| PTCH1 | azd | 0.3023110 | 0.5979347 | 0.302 | NA | NA |
| ABL1 | cabozantinib | 0.3029475 | 0.5150108 | 0.3029 | NA | NA |
| CYP19A1 | olaparib | 0.3043830 | 0.6914387 | 0.30438 | NA | NA |
| ESR1 | gefitinib | 0.3045810 | 0.6634491 | 0.305 | NA | NA |
| PDGFB | neratinib | 0.3051659 | 0.7411173 | 0.30517 | NA | NA |
| ALK | vemurafenib | 0.3064787 | 0.5210137 | 0.30648 | NA | NA |
| PDGFRA | vandetanib | 0.3074459 | 0.6968774 | 0.3074 | NA | NA |
| AKT1 | afatinib | 0.3079994 | 0.6638151 | 0.3080 | NA | NA |
| BRAF | belinostat | 0.3085030 | 0.9332615 | 0.31 | NA | NA |
| TSC1 | selumetinib | 0.3094377 | 0.6575550 | 0.30944 | NA | NA |
| DNMT3A | imatinib | 0.3100619 | 0.6851658 | 0.3101 | NA | NA |
| TPMT | erlotinib | 0.3109754 | 0.6608228 | 0.311 | NA | NA |
| PML | trametinib | 0.3122459 | 0.5469503 | 0.3122 | NA | NA |
| ALK | trametinib | 0.3149108 | 0.5469503 | 0.3149 | NA | NA |
| RET | dasatinib | 0.3153187 | 0.8981810 | 0.315 | NA | NA |
| UGT1A1 | imatinib | 0.3163786 | 0.6851658 | 0.3164 | NA | NA |
| MYD88 | gefitinib | 0.3170349 | 0.6634491 | 0.317 | NA | NA |
| EGFR | olaparib | 0.3170528 | 0.6914387 | 0.31705 | NA | NA |
| MYD88 | ibrutinib | 0.3177454 | 0.7476014 | 0.3177 | NA | NA |
| FLT3 | pazopanib | 0.3190784 | 0.8345127 | 0.3191 | NA | NA |
| ROS1 | temozolomide | 0.3206533 | 0.7644487 | 0.321 | NA | NA |
| TSC2 | nilotinib | 0.3227612 | 0.6835150 | 0.323 | NA | NA |
| BRCA1 | temozolomide | 0.3234468 | 0.7644487 | 0.323 | NA | NA |
| PDGFRA | regorafenib | 0.3247031 | 0.8332306 | 0.3247 | NA | NA |
| G6PD | cabozantinib | 0.3251186 | 0.5263825 | 0.3251 | NA | NA |
| ALK | olaparib | 0.3253829 | 0.6914387 | 0.32538 | NA | NA |
| IDH2 | dabrafenib | 0.3256308 | 0.8398900 | 0.32563 | NA | NA |
| PDGFRB | ruxolitinib | 0.3271325 | 0.9314078 | 0.3271 | NA | NA |
| PDGFB | imatinib | 0.3290742 | 0.6851658 | 0.3291 | NA | NA |
| BRCA1 | regorafenib | 0.3293828 | 0.8332306 | 0.3294 | NA | NA |
| ABL1 | fluorouracil | 0.3296373 | 0.8392181 | 0.330 | NA | NA |
| UGT1A1 | ibrutinib | 0.3298241 | 0.7476014 | 0.3298 | NA | NA |
| ERBB3 | imatinib | 0.3301067 | 0.6851658 | 0.3301 | NA | NA |
| ESR1 | lapatinib | 0.3306838 | 0.6259186 | 0.3307 | NA | NA |
| TPMT | azd | 0.3307900 | 0.5979347 | 0.331 | NA | NA |
| MET | lapatinib | 0.3313687 | 0.6259186 | 0.3314 | NA | NA |
| KIT | gefitinib | 0.3317245 | 0.6634491 | 0.332 | NA | NA |
| MYD88 | afatinib | 0.3320613 | 0.6638151 | 0.3321 | NA | NA |
| PDGFRA | fluorouracil | 0.3334048 | 0.8392181 | 0.333 | NA | NA |
| IDH2 | neratinib | 0.3337619 | 0.7446930 | 0.33376 | NA | NA |
| MYD88 | azd | 0.3389331 | 0.5979347 | 0.339 | NA | NA |
| PML | imatinib | 0.3392370 | 0.6851658 | 0.3392 | NA | NA |
| ERBB2 | selumetinib | 0.3397053 | 0.6794106 | 0.33971 | NA | NA |
| ABL1 | afatinib | 0.3423060 | 0.6638151 | 0.3423 | NA | NA |
| KRAS | imatinib | 0.3425829 | 0.6851658 | 0.3426 | NA | NA |
| TSC1 | regorafenib | 0.3430949 | 0.8332306 | 0.3431 | NA | NA |
| ESR1 | nilotinib | 0.3452748 | 0.6835150 | 0.345 | NA | NA |
| NPM1 | fluorouracil | 0.3455604 | 0.8392181 | 0.346 | NA | NA |
| BRAF | nilotinib | 0.3473234 | 0.6835150 | 0.347 | NA | NA |
| ERBB3 | belinostat | 0.3479934 | 0.9332615 | 0.35 | NA | NA |
| IDH2 | cabozantinib | 0.3499020 | 0.5407576 | 0.3499 | NA | NA |
| NPM1 | neratinib | 0.3504438 | 0.7446930 | 0.35044 | NA | NA |
| TSC2 | afatinib | 0.3514315 | 0.6638151 | 0.3514 | NA | NA |
| KRAS | dasatinib | 0.3522956 | 0.8981810 | 0.352 | NA | NA |
| ERBB3 | cyclophosphamide | 0.3561490 | 0.9793614 | 0.356 | NA | NA |
| IDH2 | azd | 0.3568667 | 0.5979347 | 0.357 | NA | NA |
| PDGFB | dasatinib | 0.3571989 | 0.8981810 | 0.357 | NA | NA |
| NPM1 | dabrafenib | 0.3577714 | 0.8398900 | 0.35777 | NA | NA |
| BRAF | fulvestrant | 0.3578334 | 0.8690240 | 0.3578 | NA | NA |
| ALK | gefitinib | 0.3595266 | 0.6791058 | 0.360 | NA | NA |
| NPM1 | temozolomide | 0.3616494 | 0.7644487 | 0.362 | NA | NA |
| PDGFB | nilotinib | 0.3618609 | 0.6835150 | 0.362 | NA | NA |
| UGT1A1 | temozolomide | 0.3627228 | 0.7644487 | 0.363 | NA | NA |
| MET | dabrafenib | 0.3629609 | 0.8398900 | 0.36296 | NA | NA |
| PDGFRB | belinostat | 0.3636843 | 0.9332615 | 0.36 | NA | NA |
| ERBB3 | lapatinib | 0.3667711 | 0.6475307 | 0.3668 | NA | NA |
| IDH2 | vemurafenib | 0.3678300 | 0.5955342 | 0.36783 | NA | NA |
| TPMT | regorafenib | 0.3679816 | 0.8340916 | 0.3680 | NA | NA |
| ERBB3 | azd | 0.3693126 | 0.5979347 | 0.369 | NA | NA |
| JAK2 | afatinib | 0.3737944 | 0.6674950 | 0.3738 | NA | NA |
| FLT3 | temozolomide | 0.3743174 | 0.7644487 | 0.374 | NA | NA |
| ROS1 | cyclophosphamide | 0.3774686 | 0.9793614 | 0.377 | NA | NA |
| ABL1 | ibrutinib | 0.3777841 | 0.8027912 | 0.3778 | NA | NA |
| PDGFRA | pazopanib | 0.3783240 | 0.9187869 | 0.3783 | NA | NA |
| EGFR | lapatinib | 0.3809004 | 0.6475307 | 0.3809 | NA | NA |
| PML | sunitinib | 0.3810854 | 0.7198280 | 0.38109 | NA | NA |
| BRCA2 | trametinib | 0.3821071 | 0.6252529 | 0.3821 | NA | NA |
| EGFR | ruxolitinib | 0.3825743 | 0.9314078 | 0.3826 | NA | NA |
| PML | dasatinib | 0.3857611 | 0.8981810 | 0.386 | NA | NA |
| MGMT | neratinib | 0.3926360 | 0.7852720 | 0.39264 | NA | NA |
| PML | afatinib | 0.3926441 | 0.6674950 | 0.3926 | NA | NA |
| BRAF | cabozantinib | 0.3934771 | 0.5686724 | 0.3935 | NA | NA |
| ROS1 | vemurafenib | 0.3937304 | 0.6084924 | 0.39373 | NA | NA |
| ERBB3 | dabrafenib | 0.3967421 | 0.8398900 | 0.39674 | NA | NA |
| TPMT | cyclophosphamide | 0.3978413 | 0.9793614 | 0.398 | NA | NA |
| RET | belinostat | 0.3979105 | 0.9332615 | 0.40 | NA | NA |
| ALK | dabrafenib | 0.3998459 | 0.8398900 | 0.39985 | NA | NA |
| PDGFRA | dasatinib | 0.4012694 | 0.8981810 | 0.401 | NA | NA |
| NPM1 | vandetanib | 0.4033915 | 0.8222586 | 0.4034 | NA | NA |
| PML | ruxolitinib | 0.4077983 | 0.9314078 | 0.4078 | NA | NA |
| AKT1 | trametinib | 0.4079935 | 0.6252529 | 0.4080 | NA | NA |
| KIT | dabrafenib | 0.4097454 | 0.8398900 | 0.40975 | NA | NA |
| RET | regorafenib | 0.4107421 | 0.8471493 | 0.4107 | NA | NA |
| ERBB3 | vandetanib | 0.4111293 | 0.8222586 | 0.4111 | NA | NA |
| KRAS | dabrafenib | 0.4111914 | 0.8398900 | 0.41119 | NA | NA |
| DPYD | temozolomide | 0.4129554 | 0.7644487 | 0.413 | NA | NA |
| FLT3 | lapatinib | 0.4146955 | 0.6714118 | 0.4147 | NA | NA |
| ESR1 | temozolomide | 0.4151428 | 0.7644487 | 0.415 | NA | NA |
| BRCA2 | cabozantinib | 0.4162945 | 0.5686724 | 0.4163 | NA | NA |
| TSC2 | trametinib | 0.4168352 | 0.6252529 | 0.4168 | NA | NA |
| PML | erlotinib | 0.4170584 | 0.8218115 | 0.417 | NA | NA |
| CYP19A1 | cabozantinib | 0.4181415 | 0.5686724 | 0.4181 | NA | NA |
| JAK2 | crizotinib | 0.4182454 | 0.9896386 | 0.418 | NA | NA |
| ALK | fulvestrant | 0.4191815 | 0.9110805 | 0.4192 | NA | NA |
| PTCH1 | selumetinib | 0.4194027 | 0.7472482 | 0.41940 | NA | NA |
| EGFR | dasatinib | 0.4226734 | 0.8981810 | 0.423 | NA | NA |
| BRCA2 | azd | 0.4237037 | 0.6548149 | 0.424 | NA | NA |
| KIT | cyclophosphamide | 0.4256579 | 0.9793614 | 0.426 | NA | NA |
| ESR1 | ibrutinib | 0.4291778 | 0.8107592 | 0.4292 | NA | NA |
| EGFR | ibrutinib | 0.4292255 | 0.8107592 | 0.4292 | NA | NA |
| NPM1 | selumetinib | 0.4302455 | 0.7472482 | 0.43025 | NA | NA |
| PML | pazopanib | 0.4313542 | 0.9261994 | 0.4314 | NA | NA |
| TPMT | dabrafenib | 0.4326706 | 0.8398900 | 0.43267 | NA | NA |
| PDGFRB | fluorouracil | 0.4341969 | 0.8677771 | 0.434 | NA | NA |
| PML | temozolomide | 0.4354604 | 0.7644487 | 0.435 | NA | NA |
| ESR1 | cabozantinib | 0.4356954 | 0.5697555 | 0.4357 | NA | NA |
| ERBB3 | ruxolitinib | 0.4364470 | 0.9314078 | 0.4364 | NA | NA |
| MYD88 | fulvestrant | 0.4383092 | 0.9110805 | 0.4383 | NA | NA |
| CYP19A1 | temozolomide | 0.4385706 | 0.7644487 | 0.439 | NA | NA |
| IDH2 | trametinib | 0.4390903 | 0.6262131 | 0.4391 | NA | NA |
| ESR1 | sunitinib | 0.4399411 | 0.7545287 | 0.43994 | NA | NA |
| BRCA2 | vandetanib | 0.4404474 | 0.8272351 | 0.4404 | NA | NA |
| IDH2 | selumetinib | 0.4434340 | 0.7472482 | 0.44343 | NA | NA |
| ALK | nilotinib | 0.4451309 | 0.7927775 | 0.445 | NA | NA |
| TSC2 | neratinib | 0.4493579 | 0.8334472 | 0.44936 | NA | NA |
| MET | temozolomide | 0.4496757 | 0.7644487 | 0.450 | NA | NA |
| ERBB3 | pazopanib | 0.4547800 | 0.9261994 | 0.4548 | NA | NA |
| IDH2 | dasatinib | 0.4572773 | 0.9092193 | 0.457 | NA | NA |
| ESR1 | erlotinib | 0.4580536 | 0.8218115 | 0.458 | NA | NA |
| BRAF | erlotinib | 0.4592476 | 0.8218115 | 0.459 | NA | NA |
| G6PD | vemurafenib | 0.4602214 | 0.6539778 | 0.46022 | NA | NA |
| ESR1 | vemurafenib | 0.4616314 | 0.6539778 | 0.46163 | NA | NA |
| BRAF | vandetanib | 0.4622785 | 0.8272351 | 0.4623 | NA | NA |
| PDGFB | fluorouracil | 0.4641195 | 0.8677771 | 0.464 | NA | NA |
| MGMT | sunitinib | 0.4645056 | 0.7545287 | 0.46451 | NA | NA |
| JAK2 | sunitinib | 0.4660324 | 0.7545287 | 0.46603 | NA | NA |
| FLT3 | regorafenib | 0.4660591 | 0.8471493 | 0.4661 | NA | NA |
| G6PD | fluorouracil | 0.4661924 | 0.8677771 | 0.466 | NA | NA |
| ABL1 | gefitinib | 0.4664039 | 0.8346175 | 0.466 | NA | NA |
| AKT1 | ruxolitinib | 0.4679864 | 0.9314078 | 0.4680 | NA | NA |
| TPMT | ibrutinib | 0.4703605 | 0.8416977 | 0.4704 | NA | NA |
| DNMT3A | cabozantinib | 0.4741169 | 0.5970360 | 0.4741 | NA | NA |
| ERBB2 | azd | 0.4751190 | 0.6739725 | 0.475 | NA | NA |
| CYP19A1 | azd | 0.4757453 | 0.6739725 | 0.476 | NA | NA |
| KIT | regorafenib | 0.4759780 | 0.8471493 | 0.4760 | NA | NA |
| CYP19A1 | selumetinib | 0.4763756 | 0.7472482 | 0.47638 | NA | NA |
| UGT1A1 | fluorouracil | 0.4767219 | 0.8677771 | 0.477 | NA | NA |
| BRCA2 | afatinib | 0.4780707 | 0.7569737 | 0.4781 | NA | NA |
| MYD88 | trametinib | 0.4783281 | 0.6262131 | 0.4783 | NA | NA |
| BRCA2 | crizotinib | 0.4789637 | 0.9896386 | 0.479 | NA | NA |
| BRCA1 | neratinib | 0.4793342 | 0.8334472 | 0.47933 | NA | NA |
| BRCA1 | imatinib | 0.4803511 | 0.9073299 | 0.4804 | NA | NA |
| G6PD | dasatinib | 0.4813514 | 0.9092193 | 0.481 | NA | NA |
| EGFR | dabrafenib | 0.4817681 | 0.8681874 | 0.48177 | NA | NA |
| JAK2 | trametinib | 0.4825043 | 0.6262131 | 0.4825 | NA | NA |
| G6PD | lapatinib | 0.4825811 | 0.7270249 | 0.4826 | NA | NA |
| IDH2 | pazopanib | 0.4829493 | 0.9261994 | 0.4829 | NA | NA |
| ABL1 | selumetinib | 0.4835135 | 0.7472482 | 0.48351 | NA | NA |
| MGMT | belinostat | 0.4836415 | 0.9332615 | 0.48 | NA | NA |
| BRCA2 | belinostat | 0.4837494 | 0.9332615 | 0.48 | NA | NA |
| FLT3 | belinostat | 0.4844586 | 0.9332615 | 0.48 | NA | NA |
| BRCA1 | fluorouracil | 0.4849343 | 0.8677771 | 0.485 | NA | NA |
| DNMT3A | temozolomide | 0.4872219 | 0.7776868 | 0.487 | NA | NA |
| ALK | regorafenib | 0.4873433 | 0.8471493 | 0.4873 | NA | NA |
| DPYD | ruxolitinib | 0.4879108 | 0.9314078 | 0.4879 | NA | NA |
| MET | afatinib | 0.4898065 | 0.7569737 | 0.4898 | NA | NA |
| PDGFRA | neratinib | 0.4902631 | 0.8334472 | 0.49026 | NA | NA |
| MGMT | crizotinib | 0.4938707 | 0.9896386 | 0.494 | NA | NA |
| TSC1 | vandetanib | 0.4950385 | 0.8415654 | 0.4950 | NA | NA |
| DPYD | lapatinib | 0.4952434 | 0.7270249 | 0.4952 | NA | NA |
| PTCH1 | pazopanib | 0.4968297 | 0.9261994 | 0.4968 | NA | NA |
| TSC1 | temozolomide | 0.5032091 | 0.7776868 | 0.503 | NA | NA |
| DPYD | cyclophosphamide | 0.5045811 | 0.9793614 | 0.505 | NA | NA |
| RET | sunitinib | 0.5118218 | 0.7868747 | 0.51182 | NA | NA |
| DPYD | trametinib | 0.5123073 | 0.6262131 | 0.5123 | NA | NA |
| UGT1A1 | trametinib | 0.5123562 | 0.6262131 | 0.5124 | NA | NA |
| PML | lapatinib | 0.5131940 | 0.7270249 | 0.5132 | NA | NA |
| MET | neratinib | 0.5169277 | 0.8369306 | 0.51693 | NA | NA |
| RET | pazopanib | 0.5175936 | 0.9261994 | 0.5176 | NA | NA |
| TSC2 | ruxolitinib | 0.5176922 | 0.9314078 | 0.5177 | NA | NA |
| DPYD | dabrafenib | 0.5177549 | 0.8681874 | 0.51775 | NA | NA |
| BRCA1 | gefitinib | 0.5187110 | 0.8466777 | 0.519 | NA | NA |
| PDGFRA | nilotinib | 0.5194411 | 0.7927775 | 0.519 | NA | NA |
| ABL1 | regorafenib | 0.5196255 | 0.8471493 | 0.5196 | NA | NA |
| NPM1 | gefitinib | 0.5229480 | 0.8466777 | 0.523 | NA | NA |
| DPYD | regorafenib | 0.5244529 | 0.8471493 | 0.5245 | NA | NA |
| BRCA2 | olaparib | 0.5281161 | 0.9728161 | 0.52812 | NA | NA |
| DNMT3A | nilotinib | 0.5289852 | 0.7927775 | 0.529 | NA | NA |
| AKT1 | cyclophosphamide | 0.5303222 | 0.9793614 | 0.530 | NA | NA |
| PDGFRA | ruxolitinib | 0.5303811 | 0.9314078 | 0.5304 | NA | NA |
| KIT | sunitinib | 0.5322976 | 0.7868747 | 0.53230 | NA | NA |
| FLT3 | dasatinib | 0.5331194 | 0.9367075 | 0.533 | NA | NA |
| G6PD | cyclophosphamide | 0.5360224 | 0.9793614 | 0.536 | NA | NA |
| ERBB3 | crizotinib | 0.5361343 | 0.9896386 | 0.536 | NA | NA |
| MYD88 | imatinib | 0.5393201 | 0.9425360 | 0.5393 | NA | NA |
| TSC1 | lapatinib | 0.5398720 | 0.7342259 | 0.5399 | NA | NA |
| RET | vemurafenib | 0.5409337 | 0.7294806 | 0.54093 | NA | NA |
| BRCA2 | dabrafenib | 0.5419188 | 0.8681874 | 0.54192 | NA | NA |
| TSC2 | crizotinib | 0.5427013 | 0.9896386 | 0.543 | NA | NA |
| PTCH1 | fulvestrant | 0.5427377 | 0.9110805 | 0.5427 | NA | NA |
| BRCA2 | cyclophosphamide | 0.5442614 | 0.9793614 | 0.544 | NA | NA |
| NPM1 | nilotinib | 0.5448245 | 0.7927775 | 0.545 | NA | NA |
| EGFR | erlotinib | 0.5472418 | 0.8891239 | 0.547 | NA | NA |
| EGFR | nilotinib | 0.5479716 | 0.7927775 | 0.548 | NA | NA |
| ESR1 | regorafenib | 0.5481555 | 0.8471493 | 0.5482 | NA | NA |
| TSC2 | erlotinib | 0.5491647 | 0.8891239 | 0.549 | NA | NA |
| ERBB3 | selumetinib | 0.5514235 | 0.8151478 | 0.55142 | NA | NA |
| MGMT | azd | 0.5517454 | 0.7386733 | 0.552 | NA | NA |
| TSC2 | temozolomide | 0.5520727 | 0.8087434 | 0.552 | NA | NA |
| MYD88 | neratinib | 0.5522299 | 0.8534462 | 0.55223 | NA | NA |
| JAK2 | dabrafenib | 0.5524829 | 0.8681874 | 0.55248 | NA | NA |
| IDH2 | ruxolitinib | 0.5558028 | 0.9314078 | 0.5558 | NA | NA |
| PDGFRB | fulvestrant | 0.5559160 | 0.9110805 | 0.5559 | NA | NA |
| PDGFB | gefitinib | 0.5559298 | 0.8546038 | 0.556 | NA | NA |
| ERBB2 | vemurafenib | 0.5578381 | 0.7294806 | 0.55784 | NA | NA |
| TSC2 | vandetanib | 0.5599331 | 0.8665251 | 0.5599 | NA | NA |
| ERBB2 | vandetanib | 0.5606927 | 0.8665251 | 0.5607 | NA | NA |
| PDGFRB | nilotinib | 0.5622570 | 0.7927775 | 0.562 | NA | NA |
| JAK2 | ibrutinib | 0.5688103 | 0.9669776 | 0.5688 | NA | NA |
| RET | fulvestrant | 0.5689282 | 0.9110805 | 0.5689 | NA | NA |
| MGMT | olaparib | 0.5699313 | 0.9728161 | 0.56993 | NA | NA |
| PDGFB | olaparib | 0.5706892 | 0.9728161 | 0.57069 | NA | NA |
| FLT3 | fulvestrant | 0.5722357 | 0.9110805 | 0.5722 | NA | NA |
| KRAS | cyclophosphamide | 0.5770737 | 0.9793614 | 0.577 | NA | NA |
| PML | belinostat | 0.5778444 | 0.9332615 | 0.58 | NA | NA |
| PDGFRB | gefitinib | 0.5781143 | 0.8546038 | 0.578 | NA | NA |
| DPYD | sunitinib | 0.5784482 | 0.8194683 | 0.57845 | NA | NA |
| MYD88 | pazopanib | 0.5788620 | 0.9261994 | 0.5789 | NA | NA |
| UGT1A1 | afatinib | 0.5812670 | 0.8592643 | 0.5813 | NA | NA |
| ABL1 | imatinib | 0.5818558 | 0.9425360 | 0.5819 | NA | NA |
| FLT3 | imatinib | 0.5821546 | 0.9425360 | 0.5822 | NA | NA |
| ERBB3 | nilotinib | 0.5829246 | 0.7927775 | 0.583 | NA | NA |
| DNMT3A | cyclophosphamide | 0.5843537 | 0.9793614 | 0.584 | NA | NA |
| PML | cabozantinib | 0.5847529 | 0.6901833 | 0.5848 | NA | NA |
| ROS1 | belinostat | 0.5877641 | 0.9332615 | 0.59 | NA | NA |
| AKT1 | temozolomide | 0.5884213 | 0.8087434 | 0.588 | NA | NA |
| KIT | lapatinib | 0.5885275 | 0.7696129 | 0.5885 | NA | NA |
| ERBB3 | fulvestrant | 0.5897197 | 0.9110805 | 0.5897 | NA | NA |
| KIT | azd | 0.5928965 | 0.7386733 | 0.593 | NA | NA |
| PDGFRB | temozolomide | 0.5946643 | 0.8087434 | 0.595 | NA | NA |
| DPYD | cabozantinib | 0.5989674 | 0.6901833 | 0.5990 | NA | NA |
| G6PD | ibrutinib | 0.6023586 | 0.9736731 | 0.6024 | NA | NA |
| DNMT3A | vemurafenib | 0.6061305 | 0.7525336 | 0.60613 | NA | NA |
| MET | azd | 0.6072926 | 0.7386733 | 0.607 | NA | NA |
| G6PD | azd | 0.6083192 | 0.7386733 | 0.608 | NA | NA |
| MGMT | cyclophosphamide | 0.6089169 | 0.9793614 | 0.609 | NA | NA |
| RET | cabozantinib | 0.6089852 | 0.6901833 | 0.6090 | NA | NA |
| PDGFB | erlotinib | 0.6129494 | 0.9151456 | 0.613 | NA | NA |
| MYD88 | ruxolitinib | 0.6181728 | 0.9314078 | 0.6182 | NA | NA |
| ABL1 | nilotinib | 0.6182260 | 0.8084494 | 0.618 | NA | NA |
| CYP19A1 | vandetanib | 0.6183456 | 0.8720434 | 0.6183 | NA | NA |
| TSC1 | trametinib | 0.6186725 | 0.7291497 | 0.6187 | NA | NA |
| ERBB2 | temozolomide | 0.6194974 | 0.8101120 | 0.619 | NA | NA |
| PDGFRB | vemurafenib | 0.6197336 | 0.7525336 | 0.61973 | NA | NA |
| TSC1 | olaparib | 0.6197994 | 0.9728161 | 0.61980 | NA | NA |
| BRCA1 | pazopanib | 0.6211989 | 0.9261994 | 0.6212 | NA | NA |
| PDGFRA | dabrafenib | 0.6212605 | 0.9318907 | 0.62126 | NA | NA |
| BRCA1 | dasatinib | 0.6214626 | 0.9367075 | 0.621 | NA | NA |
| NPM1 | ruxolitinib | 0.6223011 | 0.9314078 | 0.6223 | NA | NA |
| TSC2 | lapatinib | 0.6258155 | 0.7879401 | 0.6258 | NA | NA |
| CYP19A1 | ruxolitinib | 0.6276320 | 0.9314078 | 0.6276 | NA | NA |
| ERBB2 | ruxolitinib | 0.6293981 | 0.9314078 | 0.6294 | NA | NA |
| DNMT3A | ruxolitinib | 0.6300700 | 0.9314078 | 0.6301 | NA | NA |
| KIT | vandetanib | 0.6306055 | 0.8720434 | 0.6306 | NA | NA |
| AKT1 | regorafenib | 0.6309258 | 0.9326729 | 0.6309 | NA | NA |
| AKT1 | fluorouracil | 0.6312805 | 0.9561079 | 0.631 | NA | NA |
| RET | imatinib | 0.6313687 | 0.9504694 | 0.6314 | NA | NA |
| ESR1 | azd | 0.6359850 | 0.7424789 | 0.636 | NA | NA |
| IDH2 | crizotinib | 0.6363824 | 0.9896386 | 0.636 | NA | NA |
| TSC1 | erlotinib | 0.6364596 | 0.9151456 | 0.636 | NA | NA |
| ERBB3 | gefitinib | 0.6397928 | 0.8848141 | 0.640 | NA | NA |
| TSC1 | crizotinib | 0.6420105 | 0.9896386 | 0.642 | NA | NA |
| KIT | imatinib | 0.6429646 | 0.9504694 | 0.6430 | NA | NA |
| AKT1 | pazopanib | 0.6440994 | 0.9261994 | 0.6441 | NA | NA |
| PDGFB | selumetinib | 0.6445370 | 0.8818646 | 0.64454 | NA | NA |
| MET | erlotinib | 0.6459851 | 0.9151456 | 0.646 | NA | NA |
| BRCA1 | selumetinib | 0.6484298 | 0.8818646 | 0.64843 | NA | NA |
| PDGFRA | afatinib | 0.6518163 | 0.8631215 | 0.6518 | NA | NA |
| DNMT3A | azd | 0.6551284 | 0.7424789 | 0.655 | NA | NA |
| MYD88 | fluorouracil | 0.6552215 | 0.9561079 | 0.655 | NA | NA |
| IDH2 | cyclophosphamide | 0.6554963 | 0.9793614 | 0.655 | NA | NA |
| UGT1A1 | neratinib | 0.6590084 | 0.9509752 | 0.65901 | NA | NA |
| BRCA2 | ibrutinib | 0.6602730 | 0.9736731 | 0.6603 | NA | NA |
| PTCH1 | belinostat | 0.6603291 | 0.9332615 | 0.66 | NA | NA |
| UGT1A1 | lapatinib | 0.6619661 | 0.7879401 | 0.6620 | NA | NA |
| TSC1 | pazopanib | 0.6622597 | 0.9261994 | 0.6623 | NA | NA |
| BRAF | regorafenib | 0.6631522 | 0.9394657 | 0.6632 | NA | NA |
| AKT1 | dasatinib | 0.6650170 | 0.9367075 | 0.665 | NA | NA |
| ALK | belinostat | 0.6654501 | 0.9332615 | 0.67 | NA | NA |
| G6PD | afatinib | 0.6656317 | 0.8631215 | 0.6656 | NA | NA |
| PDGFRA | fulvestrant | 0.6659409 | 0.9110805 | 0.6659 | NA | NA |
| PML | dabrafenib | 0.6659420 | 0.9324432 | 0.66594 | NA | NA |
| RET | nilotinib | 0.6667141 | 0.8395660 | 0.667 | NA | NA |
| BRCA2 | lapatinib | 0.6720665 | 0.7879401 | 0.6721 | NA | NA |
| NPM1 | cyclophosphamide | 0.6729128 | 0.9793614 | 0.673 | NA | NA |
| G6PD | fulvestrant | 0.6741823 | 0.9110805 | 0.6742 | NA | NA |
| PDGFRB | crizotinib | 0.6743149 | 0.9896386 | 0.674 | NA | NA |
| ESR1 | fulvestrant | 0.6748204 | 0.9110805 | 0.6748 | NA | NA |
| KIT | olaparib | 0.6772410 | 0.9728161 | 0.67724 | NA | NA |
| ESR1 | neratinib | 0.6776713 | 0.9509752 | 0.67767 | NA | NA |
| PTCH1 | dabrafenib | 0.6781405 | 0.9324432 | 0.67814 | NA | NA |
| ABL1 | azd | 0.6783940 | 0.7440450 | 0.678 | NA | NA |
| ABL1 | olaparib | 0.6795493 | 0.9728161 | 0.67955 | NA | NA |
| EGFR | cabozantinib | 0.6800714 | 0.7458848 | 0.6801 | NA | NA |
| ALK | ruxolitinib | 0.6822022 | 0.9664531 | 0.6822 | NA | NA |
| UGT1A1 | gefitinib | 0.6824391 | 0.8848141 | 0.682 | NA | NA |
| ABL1 | vandetanib | 0.6832739 | 0.8720434 | 0.6833 | NA | NA |
| TSC1 | fulvestrant | 0.6874271 | 0.9110805 | 0.6874 | NA | NA |
| PTCH1 | fluorouracil | 0.6889362 | 0.9561079 | 0.689 | NA | NA |
| PTCH1 | crizotinib | 0.6896847 | 0.9896386 | 0.690 | NA | NA |
| ERBB2 | belinostat | 0.6914232 | 0.9332615 | 0.69 | NA | NA |
| CYP19A1 | afatinib | 0.6916918 | 0.8631215 | 0.6917 | NA | NA |
| JAK2 | olaparib | 0.6925765 | 0.9728161 | 0.69258 | NA | NA |
| PML | regorafenib | 0.6943881 | 0.9410069 | 0.6944 | NA | NA |
| ERBB3 | afatinib | 0.6959010 | 0.8631215 | 0.6959 | NA | NA |
| EGFR | fulvestrant | 0.6967086 | 0.9110805 | 0.6967 | NA | NA |
| BRCA2 | dasatinib | 0.6990595 | 0.9367075 | 0.699 | NA | NA |
| TSC2 | fluorouracil | 0.7001121 | 0.9561079 | 0.700 | NA | NA |
| G6PD | pazopanib | 0.7046983 | 0.9261994 | 0.7047 | NA | NA |
| KRAS | belinostat | 0.7060390 | 0.9332615 | 0.71 | NA | NA |
| PDGFRB | azd | 0.7069233 | 0.7511060 | 0.707 | NA | NA |
| BRCA2 | imatinib | 0.7069599 | 0.9654406 | 0.7070 | NA | NA |
| BRCA1 | vandetanib | 0.7073522 | 0.8720434 | 0.7074 | NA | NA |
| UGT1A1 | erlotinib | 0.7111266 | 0.9491271 | 0.711 | NA | NA |
| FLT3 | gefitinib | 0.7182420 | 0.8848141 | 0.718 | NA | NA |
| TSC1 | belinostat | 0.7219457 | 0.9332615 | 0.72 | NA | NA |
| ROS1 | vandetanib | 0.7251785 | 0.8720434 | 0.7252 | NA | NA |
| FLT3 | erlotinib | 0.7258031 | 0.9491271 | 0.726 | NA | NA |
| PDGFB | vandetanib | 0.7261157 | 0.8720434 | 0.7261 | NA | NA |
| MET | fluorouracil | 0.7280738 | 0.9561079 | 0.728 | NA | NA |
| FLT3 | trametinib | 0.7282232 | 0.8286678 | 0.7282 | NA | NA |
| ROS1 | ibrutinib | 0.7285250 | 0.9736731 | 0.7285 | NA | NA |
| PML | cyclophosphamide | 0.7303617 | 0.9793614 | 0.730 | NA | NA |
| TSC1 | ruxolitinib | 0.7316331 | 0.9851643 | 0.7316 | NA | NA |
| AKT1 | imatinib | 0.7320299 | 0.9654406 | 0.7320 | NA | NA |
| TSC2 | gefitinib | 0.7322403 | 0.8848141 | 0.732 | NA | NA |
| PTCH1 | afatinib | 0.7324281 | 0.8631215 | 0.7324 | NA | NA |
| ERBB3 | neratinib | 0.7332982 | 0.9509752 | 0.73330 | NA | NA |
| FLT3 | selumetinib | 0.7342484 | 0.8927666 | 0.73425 | NA | NA |
| ERBB3 | fluorouracil | 0.7345804 | 0.9561079 | 0.735 | NA | NA |
| ERBB2 | nilotinib | 0.7346282 | 0.8710739 | 0.735 | NA | NA |
| TSC1 | afatinib | 0.7361919 | 0.8631215 | 0.7362 | NA | NA |
| PDGFB | sunitinib | 0.7395816 | 0.9565998 | 0.73958 | NA | NA |
| PDGFRA | crizotinib | 0.7420103 | 0.9896386 | 0.742 | NA | NA |
| UGT1A1 | nilotinib | 0.7429748 | 0.8710739 | 0.743 | NA | NA |
| MGMT | selumetinib | 0.7434177 | 0.8927666 | 0.74342 | NA | NA |
| PML | vandetanib | 0.7438018 | 0.8720434 | 0.7438 | NA | NA |
| G6PD | olaparib | 0.7455081 | 0.9728161 | 0.74551 | NA | NA |
| BRCA2 | gefitinib | 0.7477970 | 0.8848141 | 0.748 | NA | NA |
| TSC2 | imatinib | 0.7480994 | 0.9654406 | 0.7481 | NA | NA |
| JAK2 | selumetinib | 0.7485902 | 0.8927666 | 0.74859 | NA | NA |
| DPYD | crizotinib | 0.7496551 | 0.9896386 | 0.750 | NA | NA |
| MYD88 | crizotinib | 0.7508273 | 0.9896386 | 0.751 | NA | NA |
| PDGFRB | dasatinib | 0.7535038 | 0.9367075 | 0.754 | NA | NA |
| PTCH1 | gefitinib | 0.7546944 | 0.8848141 | 0.755 | NA | NA |
| PDGFRB | dabrafenib | 0.7547325 | 0.9480461 | 0.75473 | NA | NA |
| NPM1 | olaparib | 0.7587867 | 0.9728161 | 0.75879 | NA | NA |
| G6PD | temozolomide | 0.7612249 | 0.9585795 | 0.761 | NA | NA |
| PDGFRB | lapatinib | 0.7618885 | 0.8634737 | 0.7619 | NA | NA |
| BRCA2 | regorafenib | 0.7635037 | 0.9410069 | 0.7635 | NA | NA |
| DPYD | imatinib | 0.7666734 | 0.9654406 | 0.7667 | NA | NA |
| TSC2 | olaparib | 0.7680842 | 0.9728161 | 0.76808 | NA | NA |
| EGFR | sunitinib | 0.7681397 | 0.9565998 | 0.76814 | NA | NA |
| DPYD | fluorouracil | 0.7693491 | 0.9561079 | 0.769 | NA | NA |
| FLT3 | sunitinib | 0.7714998 | 0.9565998 | 0.77150 | NA | NA |
| MYD88 | dasatinib | 0.7715129 | 0.9367075 | 0.772 | NA | NA |
| EGFR | fluorouracil | 0.7720863 | 0.9561079 | 0.772 | NA | NA |
| ERBB2 | ibrutinib | 0.7726805 | 0.9736731 | 0.7727 | NA | NA |
| PDGFRB | vandetanib | 0.7728525 | 0.8735853 | 0.7729 | NA | NA |
| TSC2 | belinostat | 0.7739206 | 0.9332615 | 0.77 | NA | NA |
| UGT1A1 | vemurafenib | 0.7774617 | 0.9065616 | 0.77746 | NA | NA |
| ESR1 | dasatinib | 0.7776986 | 0.9367075 | 0.778 | NA | NA |
| KIT | dasatinib | 0.7790279 | 0.9367075 | 0.779 | NA | NA |
| MYD88 | regorafenib | 0.7798439 | 0.9410069 | 0.7798 | NA | NA |
| ABL1 | dasatinib | 0.7801253 | 0.9367075 | 0.780 | NA | NA |
| ROS1 | dasatinib | 0.7804679 | 0.9367075 | 0.780 | NA | NA |
| BRCA1 | erlotinib | 0.7809136 | 0.9494085 | 0.781 | NA | NA |
| MYD88 | selumetinib | 0.7817427 | 0.8927666 | 0.78174 | NA | NA |
| RET | ibrutinib | 0.7824502 | 0.9736731 | 0.7825 | NA | NA |
| EGFR | belinostat | 0.7834615 | 0.9332615 | 0.78 | NA | NA |
| CYP19A1 | neratinib | 0.7845031 | 0.9509752 | 0.78450 | NA | NA |
| MET | belinostat | 0.7848683 | 0.9332615 | 0.78 | NA | NA |
| PDGFRB | cyclophosphamide | 0.7850095 | 0.9793614 | 0.785 | NA | NA |
| MGMT | cabozantinib | 0.7880782 | 0.8373331 | 0.7881 | NA | NA |
| BRCA1 | trametinib | 0.7902084 | 0.8422588 | 0.7902 | NA | NA |
| ALK | pazopanib | 0.7907566 | 0.9261994 | 0.7908 | NA | NA |
| NPM1 | trametinib | 0.7912128 | 0.8422588 | 0.7912 | NA | NA |
| MYD88 | sunitinib | 0.7948466 | 0.9565998 | 0.79485 | NA | NA |
| FLT3 | fluorouracil | 0.7949588 | 0.9561079 | 0.795 | NA | NA |
| BRCA2 | fulvestrant | 0.7961724 | 0.9582702 | 0.7962 | NA | NA |
| ESR1 | vandetanib | 0.7965042 | 0.8735853 | 0.7965 | NA | NA |
| IDH2 | belinostat | 0.7972643 | 0.9332615 | 0.80 | NA | NA |
| NPM1 | regorafenib | 0.8002281 | 0.9410069 | 0.8002 | NA | NA |
| ROS1 | dabrafenib | 0.8003190 | 0.9480461 | 0.80032 | NA | NA |
| CYP19A1 | erlotinib | 0.8021724 | 0.9494085 | 0.802 | NA | NA |
| TSC2 | dabrafenib | 0.8039511 | 0.9480461 | 0.80395 | NA | NA |
| ERBB2 | pazopanib | 0.8041509 | 0.9261994 | 0.8042 | NA | NA |
| EGFR | imatinib | 0.8043300 | 0.9690754 | 0.8043 | NA | NA |
| ERBB3 | vemurafenib | 0.8058873 | 0.9065616 | 0.80589 | NA | NA |
| IDH2 | gefitinib | 0.8069304 | 0.9145211 | 0.807 | NA | NA |
| AKT1 | fulvestrant | 0.8069482 | 0.9582702 | 0.8069 | NA | NA |
| TPMT | temozolomide | 0.8089661 | 0.9600068 | 0.809 | NA | NA |
| NPM1 | dasatinib | 0.8123866 | 0.9367075 | 0.812 | NA | NA |
| BRCA1 | olaparib | 0.8126710 | 0.9728161 | 0.81267 | NA | NA |
| FLT3 | afatinib | 0.8136811 | 0.9017076 | 0.8137 | NA | NA |
| TSC2 | pazopanib | 0.8156658 | 0.9261994 | 0.8157 | NA | NA |
| EGFR | selumetinib | 0.8175946 | 0.8927666 | 0.81759 | NA | NA |
| KRAS | fluorouracil | 0.8178870 | 0.9561079 | 0.818 | NA | NA |
| DNMT3A | dabrafenib | 0.8196290 | 0.9480461 | 0.81963 | NA | NA |
| KRAS | erlotinib | 0.8197849 | 0.9494085 | 0.820 | NA | NA |
| JAK2 | ruxolitinib | 0.8206972 | 0.9851643 | 0.8207 | NA | NA |
| ABL1 | neratinib | 0.8209775 | 0.9509752 | 0.82098 | NA | NA |
| JAK2 | pazopanib | 0.8212255 | 0.9261994 | 0.8212 | NA | NA |
| ESR1 | afatinib | 0.8221452 | 0.9017076 | 0.8221 | NA | NA |
| AKT1 | selumetinib | 0.8255265 | 0.8927666 | 0.82553 | NA | NA |
| ERBB3 | dasatinib | 0.8265066 | 0.9367075 | 0.827 | NA | NA |
| ERBB3 | regorafenib | 0.8265906 | 0.9410069 | 0.8266 | NA | NA |
| G6PD | belinostat | 0.8270727 | 0.9332615 | 0.83 | NA | NA |
| BRCA2 | sunitinib | 0.8280670 | 0.9565998 | 0.82807 | NA | NA |
| TSC2 | regorafenib | 0.8307456 | 0.9410069 | 0.8307 | NA | NA |
| ABL1 | dabrafenib | 0.8331314 | 0.9480461 | 0.83313 | NA | NA |
| JAK2 | imatinib | 0.8347277 | 0.9690754 | 0.8347 | NA | NA |
| ABL1 | pazopanib | 0.8358559 | 0.9261994 | 0.8359 | NA | NA |
| TPMT | nilotinib | 0.8378567 | 0.9337740 | 0.838 | NA | NA |
| BRCA2 | ruxolitinib | 0.8386749 | 0.9851643 | 0.8387 | NA | NA |
| TPMT | fulvestrant | 0.8400737 | 0.9582702 | 0.8401 | NA | NA |
| KIT | belinostat | 0.8435673 | 0.9332615 | 0.84 | NA | NA |
| ABL1 | sunitinib | 0.8440587 | 0.9565998 | 0.84406 | NA | NA |
| EGFR | cyclophosphamide | 0.8442118 | 0.9793614 | 0.844 | NA | NA |
| TPMT | belinostat | 0.8445547 | 0.9332615 | 0.84 | NA | NA |
| PDGFRB | erlotinib | 0.8448409 | 0.9494085 | 0.845 | NA | NA |
| PML | azd | 0.8448624 | 0.8704643 | 0.845 | NA | NA |
| PDGFB | fulvestrant | 0.8455325 | 0.9582702 | 0.8455 | NA | NA |
| DNMT3A | belinostat | 0.8463546 | 0.9332615 | 0.85 | NA | NA |
| ALK | cabozantinib | 0.8474970 | 0.8731787 | 0.8475 | NA | NA |
| JAK2 | belinostat | 0.8481782 | 0.9332615 | 0.85 | NA | NA |
| ESR1 | ruxolitinib | 0.8489985 | 0.9851643 | 0.8490 | NA | NA |
| MGMT | pazopanib | 0.8490601 | 0.9261994 | 0.8491 | NA | NA |
| PDGFB | afatinib | 0.8499921 | 0.9031166 | 0.8500 | NA | NA |
| BRCA1 | ibrutinib | 0.8510774 | 0.9736731 | 0.8511 | NA | NA |
| IDH2 | nilotinib | 0.8513822 | 0.9337740 | 0.851 | NA | NA |
| CYP19A1 | pazopanib | 0.8533966 | 0.9261994 | 0.8534 | NA | NA |
| PDGFRA | imatinib | 0.8550665 | 0.9690754 | 0.8551 | NA | NA |
| PDGFB | crizotinib | 0.8558808 | 0.9896386 | 0.856 | NA | NA |
| PTCH1 | neratinib | 0.8565156 | 0.9509752 | 0.85652 | NA | NA |
| G6PD | neratinib | 0.8580742 | 0.9509752 | 0.85807 | NA | NA |
| ERBB3 | temozolomide | 0.8609254 | 0.9600068 | 0.861 | NA | NA |
| FLT3 | neratinib | 0.8622113 | 0.9509752 | 0.86221 | NA | NA |
| ERBB3 | trametinib | 0.8637892 | 0.8907826 | 0.8638 | NA | NA |
| ROS1 | selumetinib | 0.8640047 | 0.8927666 | 0.86400 | NA | NA |
| MET | ruxolitinib | 0.8650705 | 0.9851643 | 0.8651 | NA | NA |
| TSC2 | selumetinib | 0.8665087 | 0.8927666 | 0.86651 | NA | NA |
| BRCA1 | cyclophosphamide | 0.8713387 | 0.9793614 | 0.871 | NA | NA |
| ALK | cyclophosphamide | 0.8716671 | 0.9793614 | 0.872 | NA | NA |
| ERBB2 | regorafenib | 0.8725903 | 0.9410069 | 0.8726 | NA | NA |
| EGFR | temozolomide | 0.8736252 | 0.9600068 | 0.874 | NA | NA |
| PML | ibrutinib | 0.8740839 | 0.9736731 | 0.8741 | NA | NA |
| MET | ibrutinib | 0.8773082 | 0.9736731 | 0.8773 | NA | NA |
| G6PD | erlotinib | 0.8787499 | 0.9494085 | 0.879 | NA | NA |
| PDGFB | cabozantinib | 0.8796954 | 0.8796954 | 0.8797 | NA | NA |
| BRCA1 | ruxolitinib | 0.8813093 | 0.9851643 | 0.8813 | NA | NA |
| ERBB3 | olaparib | 0.8819557 | 0.9728161 | 0.88196 | NA | NA |
| NPM1 | vemurafenib | 0.8824014 | 0.9065616 | 0.88240 | NA | NA |
| ESR1 | pazopanib | 0.8825243 | 0.9261994 | 0.8825 | NA | NA |
| ABL1 | vemurafenib | 0.8828642 | 0.9065616 | 0.88286 | NA | NA |
| KIT | vemurafenib | 0.8838594 | 0.9065616 | 0.88386 | NA | NA |
| BRAF | crizotinib | 0.8847422 | 0.9896386 | 0.885 | NA | NA |
| MGMT | regorafenib | 0.8856536 | 0.9410069 | 0.8857 | NA | NA |
| FLT3 | azd | 0.8863568 | 0.8863568 | 0.886 | NA | NA |
| TSC2 | fulvestrant | 0.8866945 | 0.9688694 | 0.8867 | NA | NA |
| RET | temozolomide | 0.8870447 | 0.9600068 | 0.887 | NA | NA |
| EGFR | gefitinib | 0.8875800 | 0.9734748 | 0.888 | NA | NA |
| MET | dasatinib | 0.8890135 | 0.9662257 | 0.889 | NA | NA |
| PML | neratinib | 0.8916365 | 0.9509752 | 0.89164 | NA | NA |
| ABL1 | erlotinib | 0.8935609 | 0.9494085 | 0.894 | NA | NA |
| KIT | nilotinib | 0.8943017 | 0.9501956 | 0.894 | NA | NA |
| MGMT | ibrutinib | 0.8947146 | 0.9736731 | 0.8947 | NA | NA |
| JAK2 | lapatinib | 0.8953005 | 0.9427410 | 0.8953 | NA | NA |
| MET | imatinib | 0.8955374 | 0.9790505 | 0.8955 | NA | NA |
| ERBB2 | lapatinib | 0.8966122 | 0.9427410 | 0.8966 | NA | NA |
| BRCA2 | fluorouracil | 0.8966696 | 0.9561079 | 0.897 | NA | NA |
| MYD88 | belinostat | 0.8969609 | 0.9332615 | 0.90 | NA | NA |
| CYP19A1 | crizotinib | 0.8996262 | 0.9896386 | 0.900 | NA | NA |
| IDH2 | sunitinib | 0.9001651 | 0.9857115 | 0.90017 | NA | NA |
| FLT3 | cyclophosphamide | 0.9009165 | 0.9793614 | 0.901 | NA | NA |
| NPM1 | belinostat | 0.9011013 | 0.9332615 | 0.90 | NA | NA |
| IDH2 | temozolomide | 0.9035358 | 0.9600068 | 0.904 | NA | NA |
| TPMT | vemurafenib | 0.9065616 | 0.9065616 | 0.90656 | NA | NA |
| ESR1 | crizotinib | 0.9085657 | 0.9896386 | 0.909 | NA | NA |
| JAK2 | dasatinib | 0.9093889 | 0.9662257 | 0.909 | NA | NA |
| ESR1 | cyclophosphamide | 0.9094059 | 0.9793614 | 0.909 | NA | NA |
| RET | olaparib | 0.9112727 | 0.9728161 | 0.91127 | NA | NA |
| DNMT3A | fulvestrant | 0.9118771 | 0.9688694 | 0.9119 | NA | NA |
| PTCH1 | vandetanib | 0.9121958 | 0.9305740 | 0.9122 | NA | NA |
| JAK2 | fluorouracil | 0.9122887 | 0.9561079 | 0.912 | NA | NA |
| PTCH1 | ruxolitinib | 0.9145576 | 0.9851643 | 0.9146 | NA | NA |
| PDGFB | lapatinib | 0.9150133 | 0.9427410 | 0.9150 | NA | NA |
| AKT1 | dabrafenib | 0.9165171 | 0.9896121 | 0.91652 | NA | NA |
| DPYD | pazopanib | 0.9171346 | 0.9261994 | 0.9171 | NA | NA |
| ROS1 | fluorouracil | 0.9179969 | 0.9561079 | 0.918 | NA | NA |
| PDGFRA | olaparib | 0.9187781 | 0.9728161 | 0.91878 | NA | NA |
| EGFR | neratinib | 0.9192244 | 0.9509752 | 0.91922 | NA | NA |
| PTCH1 | cyclophosphamide | 0.9194906 | 0.9793614 | 0.919 | NA | NA |
| TSC2 | ibrutinib | 0.9206937 | 0.9736731 | 0.9207 | NA | NA |
| PDGFB | cyclophosphamide | 0.9213531 | 0.9793614 | 0.921 | NA | NA |
| ESR1 | selumetinib | 0.9216779 | 0.9216779 | 0.92168 | NA | NA |
| MYD88 | cyclophosphamide | 0.9220687 | 0.9793614 | 0.922 | NA | NA |
| CYP19A1 | trametinib | 0.9221480 | 0.9221480 | 0.9221 | NA | NA |
| UGT1A1 | belinostat | 0.9223455 | 0.9332615 | 0.92 | NA | NA |
| JAK2 | neratinib | 0.9230054 | 0.9509752 | 0.92301 | NA | NA |
| ESR1 | belinostat | 0.9247735 | 0.9332615 | 0.92 | NA | NA |
| PDGFRA | belinostat | 0.9258624 | 0.9332615 | 0.93 | NA | NA |
| EGFR | pazopanib | 0.9261994 | 0.9261994 | 0.9262 | NA | NA |
| BRCA2 | nilotinib | 0.9267694 | 0.9548533 | 0.927 | NA | NA |
| UGT1A1 | vandetanib | 0.9276534 | 0.9305740 | 0.9277 | NA | NA |
| FLT3 | vandetanib | 0.9305740 | 0.9305740 | 0.9306 | NA | NA |
| AKT1 | belinostat | 0.9332615 | 0.9332615 | 0.93 | NA | NA |
| BRCA1 | afatinib | 0.9350732 | 0.9634087 | 0.9351 | NA | NA |
| ERBB3 | ibrutinib | 0.9351931 | 0.9736731 | 0.9352 | NA | NA |
| IDH2 | ibrutinib | 0.9361769 | 0.9736731 | 0.9362 | NA | NA |
| EGFR | crizotinib | 0.9363173 | 0.9896386 | 0.936 | NA | NA |
| IDH2 | fluorouracil | 0.9380996 | 0.9561079 | 0.938 | NA | NA |
| MYD88 | olaparib | 0.9407553 | 0.9728161 | 0.94076 | NA | NA |
| ERBB2 | sunitinib | 0.9415781 | 0.9857115 | 0.94158 | NA | NA |
| FLT3 | ruxolitinib | 0.9427873 | 0.9851643 | 0.9428 | NA | NA |
| IDH2 | regorafenib | 0.9449361 | 0.9661684 | 0.9449 | NA | NA |
| CYP19A1 | gefitinib | 0.9492185 | 0.9871832 | 0.949 | NA | NA |
| ROS1 | neratinib | 0.9510033 | 0.9510033 | 0.95100 | NA | NA |
| NPM1 | imatinib | 0.9542718 | 0.9790505 | 0.9543 | NA | NA |
| KIT | fluorouracil | 0.9561079 | 0.9561079 | 0.956 | NA | NA |
| G6PD | ruxolitinib | 0.9561889 | 0.9851643 | 0.9562 | NA | NA |
| PDGFRB | olaparib | 0.9563573 | 0.9728161 | 0.95636 | NA | NA |
| ABL1 | lapatinib | 0.9564785 | 0.9564785 | 0.9565 | NA | NA |
| ALK | sunitinib | 0.9567200 | 0.9857115 | 0.95672 | NA | NA |
| PDGFB | temozolomide | 0.9628530 | 0.9895199 | 0.963 | NA | NA |
| MYD88 | erlotinib | 0.9646182 | 0.9832344 | 0.965 | NA | NA |
| PTCH1 | ibrutinib | 0.9649617 | 0.9736731 | 0.9650 | NA | NA |
| TSC1 | cyclophosphamide | 0.9655074 | 0.9793614 | 0.966 | NA | NA |
| ESR1 | dabrafenib | 0.9659108 | 0.9896121 | 0.96591 | NA | NA |
| DNMT3A | regorafenib | 0.9661684 | 0.9661684 | 0.9662 | NA | NA |
| BRCA1 | dabrafenib | 0.9666621 | 0.9896121 | 0.96666 | NA | NA |
| KIT | fulvestrant | 0.9667212 | 0.9765345 | 0.9667 | NA | NA |
| ERBB2 | olaparib | 0.9669476 | 0.9728161 | 0.96695 | NA | NA |
| AKT1 | nilotinib | 0.9672155 | 0.9672155 | 0.967 | NA | NA |
| ROS1 | imatinib | 0.9684583 | 0.9790505 | 0.9685 | NA | NA |
| ERBB2 | crizotinib | 0.9689644 | 0.9896386 | 0.969 | NA | NA |
| TSC1 | gefitinib | 0.9708568 | 0.9871832 | 0.971 | NA | NA |
| DPYD | olaparib | 0.9728161 | 0.9728161 | 0.97282 | NA | NA |
| DPYD | ibrutinib | 0.9736731 | 0.9736731 | 0.9737 | NA | NA |
| G6PD | crizotinib | 0.9756109 | 0.9896386 | 0.976 | NA | NA |
| UGT1A1 | fulvestrant | 0.9765345 | 0.9765345 | 0.9765 | NA | NA |
| DPYD | dasatinib | 0.9779403 | 0.9980158 | 0.978 | NA | NA |
| G6PD | imatinib | 0.9790505 | 0.9790505 | 0.9791 | NA | NA |
| PDGFRA | cyclophosphamide | 0.9793614 | 0.9793614 | 0.979 | NA | NA |
| ERBB3 | erlotinib | 0.9832344 | 0.9832344 | 0.983 | NA | NA |
| BRAF | gefitinib | 0.9871832 | 0.9871832 | 0.987 | NA | NA |
| BRCA1 | crizotinib | 0.9886434 | 0.9896386 | 0.989 | NA | NA |
| KIT | temozolomide | 0.9895199 | 0.9895199 | 0.990 | NA | NA |
| RET | dabrafenib | 0.9896121 | 0.9896121 | 0.98961 | NA | NA |
| FLT3 | crizotinib | 0.9896386 | 0.9896386 | 0.990 | NA | NA |
| BRAF | sunitinib | 0.9897961 | 0.9897961 | 0.98980 | NA | NA |
| NPM1 | afatinib | 0.9954026 | 0.9954026 | 0.9954 | NA | NA |
| KIT | ruxolitinib | 0.9977843 | 0.9977843 | 0.9978 | NA | NA |
| UGT1A1 | dasatinib | 0.9980158 | 0.9980158 | 0.998 | NA | NA |
gdsc_signif_g2p <- compare_means(AUC ~ Mutation_Status_Nonsilent, group.by = "Drug_Gene", data = gdsc_data_g2p, method = "wilcox.test", p.adjust.method = "BH")
gdsc_signif_g2p <- adj_signif(gdsc_signif_g2p)
gdsc_signif_g2p <- gdsc_signif_g2p[order(gdsc_signif_g2p$p),]
saveRDS(gdsc_signif_g2p, "./data_munging/rds/gdsc_signif_g2p_gene.rds")
gdsc_signif_g2p_ByDrug <- lapply(unique(gdsc_data_g2p_genesfilt$Drug), WilcoxonByDrug, dataset = gdsc_data_g2p_genesfilt, data_name = "gdsc")
names(gdsc_signif_g2p_ByDrug) <- unique(gdsc_data_g2p_genesfilt$Drug)
saveRDS(gdsc_signif_g2p_ByDrug, "./data_munging/rds/gdsc_signif_g2p_ByDrug.rds")
gdsc_signif_g2p <- readRDS("./data_munging/rds/gdsc_signif_g2p_gene.rds")
knitr::kable(gdsc_signif_g2p[, c("Drug_Gene", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "GDSC: Wilcoxon test results for level A G2P drug-gene associations (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Drug_Gene | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|
| dabrafenib_BRAF | 0.0001234 | 0.0034674 | 0.00012 | *** | ** |
| trametinib_BRAF | 0.0001576 | 0.0034674 | 0.00016 | *** | ** |
| afatinib_ERBB2 | 0.0171962 | 0.2522113 | 0.01720 |
|
NA |
| ponatinib_ABL1 | 0.0614896 | 0.6763861 | 0.06149 | NA | NA |
| lapatinib_ERBB2 | 0.1230985 | 0.8133548 | 0.12310 | NA | NA |
| erlotinib_MET | 0.1281272 | 0.8133548 | 0.12813 | NA | NA |
| crizotinib_MET | 0.1305419 | 0.8133548 | 0.13054 | NA | NA |
| gefitinib_EGFR | 0.1651667 | 0.8133548 | 0.16517 | NA | NA |
| afatinib_KRAS | 0.1838668 | 0.8133548 | 0.18387 | NA | NA |
| alectinib_ROS1 | 0.2335276 | 0.8133548 | 0.23353 | NA | NA |
| dabrafenib_G6PD | 0.2443393 | 0.8133548 | 0.24434 | NA | NA |
| imatinib_PDGFB | 0.2502352 | 0.8133548 | 0.25024 | NA | NA |
| rucaparib_BRCA2 | 0.3140675 | 0.8133548 | 0.31407 | NA | NA |
| imatinib_PDGFRA | 0.3143676 | 0.8133548 | 0.31437 | NA | NA |
| crizotinib_ALK | 0.3700920 | 0.8133548 | 0.37009 | NA | NA |
| gefitinib_MET | 0.3977576 | 0.8133548 | 0.39776 | NA | NA |
| pazopanib_UGT1A1 | 0.3984406 | 0.8133548 | 0.39844 | NA | NA |
| belinostat_UGT1A1 | 0.4041103 | 0.8133548 | 0.40411 | NA | NA |
| tretinoin_PML | 0.4081601 | 0.8133548 | 0.40816 | NA | NA |
| dasatinib_ABL1 | 0.4250747 | 0.8133548 | 0.42507 | NA | NA |
| afatinib_EGFR | 0.4594260 | 0.8133548 | 0.45943 | NA | NA |
| imatinib_ABL1 | 0.4679914 | 0.8133548 | 0.46799 | NA | NA |
| imatinib_PDGFRB | 0.4699331 | 0.8133548 | 0.46993 | NA | NA |
| erlotinib_KRAS | 0.4886809 | 0.8133548 | 0.48868 | NA | NA |
| nilotinib_UGT1A1 | 0.4918297 | 0.8133548 | 0.49183 | NA | NA |
| sunitinib_PDGFRA | 0.4989956 | 0.8133548 | 0.49900 | NA | NA |
| cabozantinib_RET | 0.4991041 | 0.8133548 | 0.49910 | NA | NA |
| afatinib_ERBB3 | 0.5614904 | 0.8250718 | 0.56149 | NA | NA |
| rucaparib_BRCA1 | 0.5768966 | 0.8250718 | 0.57690 | NA | NA |
| gefitinib_KRAS | 0.6235545 | 0.8250718 | 0.62355 | NA | NA |
| lapatinib_KRAS | 0.6456344 | 0.8250718 | 0.64563 | NA | NA |
| midostaurin_FLT3 | 0.6526579 | 0.8250718 | 0.65266 | NA | NA |
| sunitinib_KIT | 0.6583214 | 0.8250718 | 0.65832 | NA | NA |
| temozolomide_MGMT | 0.6634570 | 0.8250718 | 0.66346 | NA | NA |
| alectinib_ALK | 0.6916060 | 0.8250718 | 0.69161 | NA | NA |
| docetaxel_ERBB2 | 0.7052502 | 0.8250718 | 0.70525 | NA | NA |
| palbociclib_ERBB2 | 0.7083268 | 0.8250718 | 0.70833 | NA | NA |
| vismodegib_PTCH1 | 0.7198241 | 0.8250718 | 0.71982 | NA | NA |
| nilotinib_ABL1 | 0.7313136 | 0.8250718 | 0.73131 | NA | NA |
| imatinib_KIT | 0.7505218 | 0.8255740 | 0.75052 | NA | NA |
| bosutinib monohydrate_ABL1 | 0.7708229 | 0.8272245 | 0.77082 | NA | NA |
| ruxolitinib_JAK2 | 0.8523436 | 0.8929314 | 0.85234 | NA | NA |
| crizotinib_ROS1 | 0.9055984 | 0.9218958 | 0.90560 | NA | NA |
| erlotinib_EGFR | 0.9218958 | 0.9218958 | 0.92190 | NA | NA |
gdsc_signif_g2p_ByDrug <- readRDS("./data_munging/rds/gdsc_signif_g2p_ByDrug.rds")
gdsc_signif_g2p_ByDrug_all <- rbindlist(gdsc_signif_g2p_ByDrug, use.names = TRUE)
gdsc_signif_g2p_ByDrug_all <- gdsc_signif_g2p_ByDrug_all[order(gdsc_signif_g2p_ByDrug_all$p),]
knitr::kable(gdsc_signif_g2p_ByDrug_all[, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "GDSC: by-drug Wilcoxon test results for point mutations in level A G2P genes (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | Drug | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|---|
| KRAS | trametinib | 0.0000000 | 0.0000003 | 8.5e-09 | **** | **** |
| BRAF | dabrafenib | 0.0001234 | 0.0041947 | 0.00012 | *** | ** |
| BRAF | trametinib | 0.0001576 | 0.0026794 | 0.00016 | *** | ** |
| PDGFRB | cabozantinib | 0.0005036 | 0.0171218 | 0.0005 | *** |
|
| KRAS | palbociclib | 0.0017081 | 0.0580770 | 0.0017 | ** | NA |
| PDGFRB | tretinoin | 0.0032063 | 0.1090147 | 0.0032 | ** | NA |
| ROS1 | cabozantinib | 0.0037056 | 0.0629948 | 0.0037 | ** | NA |
| KRAS | pazopanib | 0.0043870 | 0.1308570 | 0.0044 | ** | NA |
| BRCA2 | midostaurin | 0.0058907 | 0.2002841 | 0.0059 | ** | NA |
| TSC1 | temozolomide | 0.0073262 | 0.2490920 | 0.0073 | ** | NA |
| ABL1 | pazopanib | 0.0076975 | 0.1308570 | 0.0077 | ** | NA |
| ALK | palbociclib | 0.0089754 | 0.1525816 | 0.0090 | ** | NA |
| ROS1 | trametinib | 0.0160528 | 0.1819317 | 0.01605 |
|
NA |
| DNMT3A | temozolomide | 0.0163008 | 0.2771142 | 0.0163 |
|
NA |
| BRCA1 | tretinoin | 0.0170421 | 0.2897149 | 0.0170 |
|
NA |
| ERBB2 | afatinib | 0.0171962 | 0.5609625 | 0.017 |
|
NA |
| BRAF | bosutinib monohydrate | 0.0181741 | 0.3173957 | 0.018 |
|
NA |
| KIT | bosutinib monohydrate | 0.0186703 | 0.3173957 | 0.019 |
|
NA |
| ABL1 | gefitinib | 0.0196537 | 0.6682274 | 0.020 |
|
NA |
| BRCA2 | erlotinib | 0.0208851 | 0.6683217 | 0.021 |
|
NA |
| DPYD | lapatinib | 0.0212882 | 0.6812223 | 0.021 |
|
NA |
| TPMT | cabozantinib | 0.0218657 | 0.2413818 | 0.0219 |
|
NA |
| MGMT | docetaxel | 0.0241785 | 0.6845085 | 0.024 |
|
NA |
| UGT1A1 | trametinib | 0.0274916 | 0.2336787 | 0.02749 |
|
NA |
| KRAS | dabrafenib | 0.0278924 | 0.3904427 | 0.02789 |
|
NA |
| FLT3 | cabozantinib | 0.0283979 | 0.2413818 | 0.0284 |
|
NA |
| TSC1 | sunitinib | 0.0300384 | 0.5453213 | 0.030 |
|
NA |
| ERBB3 | ponatinib | 0.0344904 | 0.9972326 | 0.034 |
|
NA |
| NPM1 | tretinoin | 0.0355459 | 0.3525943 | 0.0355 |
|
NA |
| JAK2 | dabrafenib | 0.0362699 | 0.3904427 | 0.03627 |
|
NA |
| FLT3 | crizotinib | 0.0371049 | 0.3575404 | 0.037 |
|
NA |
| UGT1A1 | afatinib | 0.0384529 | 0.5609625 | 0.038 |
|
NA |
| UGT1A1 | midostaurin | 0.0385592 | 0.6011299 | 0.0386 |
|
NA |
| ERBB3 | temozolomide | 0.0387034 | 0.4275924 | 0.0387 |
|
NA |
| ESR1 | imatinib | 0.0394429 | 0.7846892 | 0.039 |
|
NA |
| TSC1 | crizotinib | 0.0396633 | 0.3575404 | 0.040 |
|
NA |
| BRCA2 | crizotinib | 0.0408902 | 0.3575404 | 0.041 |
|
NA |
| TSC1 | tretinoin | 0.0414817 | 0.3525943 | 0.0415 |
|
NA |
| ABL1 | cabozantinib | 0.0433477 | 0.2947646 | 0.0433 |
|
NA |
| DNMT3A | sunitinib | 0.0480660 | 0.5453213 | 0.048 |
|
NA |
| TPMT | temozolomide | 0.0503050 | 0.4275924 | 0.0503 | NA | NA |
| TSC1 | rucaparib | 0.0503265 | 0.8376438 | 0.050 | NA | NA |
| NPM1 | dabrafenib | 0.0506987 | 0.3904427 | 0.05070 | NA | NA |
| ABL1 | afatinib | 0.0507264 | 0.5609625 | 0.051 | NA | NA |
| KIT | nilotinib | 0.0509383 | 0.7074000 | 0.051 | NA | NA |
| RET | sunitinib | 0.0511239 | 0.5453213 | 0.051 | NA | NA |
| ERBB3 | dabrafenib | 0.0574180 | 0.3904427 | 0.05742 | NA | NA |
| TSC1 | bosutinib monohydrate | 0.0576889 | 0.6538081 | 0.058 | NA | NA |
| DNMT3A | crizotinib | 0.0577322 | 0.3575404 | 0.058 | NA | NA |
| PML | crizotinib | 0.0605225 | 0.3575404 | 0.061 | NA | NA |
| RET | alectinib | 0.0609957 | 0.6998836 | 0.061 | NA | NA |
| ABL1 | ponatinib | 0.0614896 | 0.9972326 | 0.061 | NA | NA |
| PDGFRA | alectinib | 0.0638924 | 0.6998836 | 0.064 | NA | NA |
| PTCH1 | cabozantinib | 0.0650780 | 0.3687756 | 0.0651 | NA | NA |
| PDGFB | ruxolitinib | 0.0653257 | 0.7847293 | 0.065 | NA | NA |
| TPMT | belinostat | 0.0656977 | 0.6734824 | 0.066 | NA | NA |
| ABL1 | ruxolitinib | 0.0661262 | 0.7847293 | 0.066 | NA | NA |
| PDGFRB | belinostat | 0.0666829 | 0.6734824 | 0.067 | NA | NA |
| CYP19A1 | ruxolitinib | 0.0692408 | 0.7847293 | 0.069 | NA | NA |
| DNMT3A | docetaxel | 0.0692678 | 0.6845085 | 0.069 | NA | NA |
| BRCA2 | lapatinib | 0.0716745 | 0.7620951 | 0.072 | NA | NA |
| KIT | trametinib | 0.0733706 | 0.4303556 | 0.07337 | NA | NA |
| TPMT | dabrafenib | 0.0737570 | 0.4179561 | 0.07376 | NA | NA |
| BRAF | belinostat | 0.0744959 | 0.6734824 | 0.074 | NA | NA |
| PDGFRB | dasatinib | 0.0763115 | 0.9447103 | 0.076 | NA | NA |
| DPYD | crizotinib | 0.0771266 | 0.3575404 | 0.077 | NA | NA |
| TSC1 | nilotinib | 0.0779898 | 0.7074000 | 0.078 | NA | NA |
| ERBB2 | crizotinib | 0.0782120 | 0.3575404 | 0.078 | NA | NA |
| ALK | gefitinib | 0.0794375 | 0.7564295 | 0.079 | NA | NA |
| FLT3 | erlotinib | 0.0848216 | 0.6714960 | 0.085 | NA | NA |
| AKT1 | nilotinib | 0.0856959 | 0.7074000 | 0.086 | NA | NA |
| PDGFRB | midostaurin | 0.0887296 | 0.6011299 | 0.0887 | NA | NA |
| JAK2 | trametinib | 0.0900127 | 0.4303556 | 0.09001 | NA | NA |
| UGT1A1 | tretinoin | 0.0911112 | 0.3862972 | 0.0911 | NA | NA |
| BRCA2 | tretinoin | 0.0916313 | 0.3862972 | 0.0916 | NA | NA |
| ABL1 | docetaxel | 0.0918631 | 0.6845085 | 0.092 | NA | NA |
| BRCA2 | dasatinib | 0.0931223 | 0.9447103 | 0.093 | NA | NA |
| IDH2 | cabozantinib | 0.0934140 | 0.4267811 | 0.0934 | NA | NA |
| TPMT | alectinib | 0.0935866 | 0.6998836 | 0.094 | NA | NA |
| ROS1 | erlotinib | 0.0943399 | 0.6714960 | 0.094 | NA | NA |
| MYD88 | ruxolitinib | 0.0954788 | 0.8115699 | 0.095 | NA | NA |
| NPM1 | dasatinib | 0.0957018 | 0.9447103 | 0.096 | NA | NA |
| TPMT | tretinoin | 0.0957413 | 0.3862972 | 0.0957 | NA | NA |
| MET | lapatinib | 0.0972319 | 0.7620951 | 0.097 | NA | NA |
| DNMT3A | rucaparib | 0.0975186 | 0.8376438 | 0.098 | NA | NA |
| RET | palbociclib | 0.0983382 | 0.7307299 | 0.0983 | NA | NA |
| ERBB2 | gefitinib | 0.0989296 | 0.7564295 | 0.099 | NA | NA |
| FLT3 | imatinib | 0.0990080 | 0.7846892 | 0.099 | NA | NA |
| JAK2 | cabozantinib | 0.1004191 | 0.4267811 | 0.1004 | NA | NA |
| BRCA2 | palbociclib | 0.1027690 | 0.7307299 | 0.1028 | NA | NA |
| MYD88 | trametinib | 0.1042757 | 0.4303556 | 0.10428 | NA | NA |
| PML | midostaurin | 0.1046555 | 0.6011299 | 0.1047 | NA | NA |
| TSC2 | tretinoin | 0.1061419 | 0.3862972 | 0.1061 | NA | NA |
| ABL1 | trametinib | 0.1069974 | 0.4303556 | 0.10700 | NA | NA |
| PDGFRA | gefitinib | 0.1077698 | 0.7564295 | 0.108 | NA | NA |
| CYP19A1 | imatinib | 0.1086620 | 0.7846892 | 0.109 | NA | NA |
| ERBB3 | midostaurin | 0.1104412 | 0.6011299 | 0.1104 | NA | NA |
| TSC2 | dabrafenib | 0.1118016 | 0.4630570 | 0.11180 | NA | NA |
| BRAF | palbociclib | 0.1131136 | 0.7307299 | 0.1131 | NA | NA |
| ROS1 | tretinoin | 0.1136424 | 0.3862972 | 0.1136 | NA | NA |
| ROS1 | ponatinib | 0.1143242 | 0.9972326 | 0.114 | NA | NA |
| ESR1 | temozolomide | 0.1154649 | 0.6370529 | 0.1155 | NA | NA |
| G6PD | bosutinib monohydrate | 0.1162560 | 0.8517410 | 0.116 | NA | NA |
| BRCA2 | imatinib | 0.1174800 | 0.7846892 | 0.117 | NA | NA |
| PDGFRA | tretinoin | 0.1216752 | 0.3862972 | 0.1217 | NA | NA |
| MGMT | afatinib | 0.1228036 | 0.5609625 | 0.123 | NA | NA |
| ERBB2 | lapatinib | 0.1230985 | 0.7620951 | 0.123 | NA | NA |
| TPMT | ruxolitinib | 0.1231531 | 0.8374409 | 0.123 | NA | NA |
| ERBB2 | midostaurin | 0.1231748 | 0.6011299 | 0.1232 | NA | NA |
| IDH2 | belinostat | 0.1232427 | 0.6734824 | 0.123 | NA | NA |
| KIT | tretinoin | 0.1249785 | 0.3862972 | 0.1250 | NA | NA |
| UGT1A1 | bosutinib monohydrate | 0.1252560 | 0.8517410 | 0.125 | NA | NA |
| ALK | dabrafenib | 0.1254923 | 0.4630570 | 0.12549 | NA | NA |
| MYD88 | docetaxel | 0.1258052 | 0.6845085 | 0.126 | NA | NA |
| MGMT | gefitinib | 0.1263998 | 0.7564295 | 0.126 | NA | NA |
| PTCH1 | midostaurin | 0.1266216 | 0.6011299 | 0.1266 | NA | NA |
| MET | erlotinib | 0.1281272 | 0.6714960 | 0.128 | NA | NA |
| MGMT | erlotinib | 0.1288089 | 0.6714960 | 0.129 | NA | NA |
| MET | crizotinib | 0.1305419 | 0.5221677 | 0.131 | NA | NA |
| ERBB2 | temozolomide | 0.1311049 | 0.6370529 | 0.1311 | NA | NA |
| IDH2 | temozolomide | 0.1311580 | 0.6370529 | 0.1312 | NA | NA |
| TSC2 | nilotinib | 0.1328358 | 0.7074000 | 0.133 | NA | NA |
| PDGFRA | afatinib | 0.1332170 | 0.5609625 | 0.133 | NA | NA |
| PTCH1 | gefitinib | 0.1346354 | 0.7564295 | 0.135 | NA | NA |
| PDGFRA | nilotinib | 0.1346957 | 0.7074000 | 0.135 | NA | NA |
| MET | belinostat | 0.1348014 | 0.6734824 | 0.135 | NA | NA |
| EGFR | dabrafenib | 0.1350723 | 0.4630570 | 0.13507 | NA | NA |
| PDGFRA | trametinib | 0.1350935 | 0.4303556 | 0.13509 | NA | NA |
| MET | dabrafenib | 0.1361932 | 0.4630570 | 0.13619 | NA | NA |
| JAK2 | vismodegib | 0.1385135 | 0.8104430 | 0.14 | NA | NA |
| ALK | trametinib | 0.1385711 | 0.4303556 | 0.13857 | NA | NA |
| TSC2 | trametinib | 0.1392327 | 0.4303556 | 0.13923 | NA | NA |
| PDGFRA | cabozantinib | 0.1407290 | 0.4442478 | 0.1407 | NA | NA |
| UGT1A1 | lapatinib | 0.1409522 | 0.7620951 | 0.141 | NA | NA |
| BRAF | rucaparib | 0.1413053 | 0.8376438 | 0.141 | NA | NA |
| AKT1 | midostaurin | 0.1419954 | 0.6011299 | 0.1420 | NA | NA |
| ALK | lapatinib | 0.1428928 | 0.7620951 | 0.143 | NA | NA |
| KIT | cabozantinib | 0.1434514 | 0.4442478 | 0.1435 | NA | NA |
| KRAS | cabozantinib | 0.1437272 | 0.4442478 | 0.1437 | NA | NA |
| PDGFB | erlotinib | 0.1449924 | 0.6714960 | 0.145 | NA | NA |
| ERBB3 | imatinib | 0.1453832 | 0.7846892 | 0.145 | NA | NA |
| UGT1A1 | erlotinib | 0.1468898 | 0.6714960 | 0.147 | NA | NA |
| RET | docetaxel | 0.1477981 | 0.6845085 | 0.148 | NA | NA |
| G6PD | alectinib | 0.1491983 | 0.6998836 | 0.149 | NA | NA |
| NPM1 | belinostat | 0.1498150 | 0.6734824 | 0.150 | NA | NA |
| IDH2 | rucaparib | 0.1502920 | 0.8376438 | 0.150 | NA | NA |
| MET | imatinib | 0.1511805 | 0.7846892 | 0.151 | NA | NA |
| AKT1 | bosutinib monohydrate | 0.1516806 | 0.8595235 | 0.152 | NA | NA |
| BRAF | alectinib | 0.1526449 | 0.6998836 | 0.153 | NA | NA |
| FLT3 | nilotinib | 0.1535908 | 0.7074000 | 0.154 | NA | NA |
| TSC2 | afatinib | 0.1594651 | 0.5609625 | 0.159 | NA | NA |
| BRAF | vismodegib | 0.1624273 | 0.8104430 | 0.16 | NA | NA |
| IDH2 | afatinib | 0.1625545 | 0.5609625 | 0.163 | NA | NA |
| TSC2 | temozolomide | 0.1628876 | 0.6854745 | 0.1629 | NA | NA |
| EGFR | gefitinib | 0.1651667 | 0.7564295 | 0.165 | NA | NA |
| BRCA1 | midostaurin | 0.1683042 | 0.6011299 | 0.1683 | NA | NA |
| ROS1 | docetaxel | 0.1704250 | 0.6845085 | 0.170 | NA | NA |
| TSC1 | trametinib | 0.1714196 | 0.4856889 | 0.17142 | NA | NA |
| PDGFB | tretinoin | 0.1722109 | 0.4533977 | 0.1722 | NA | NA |
| PTCH1 | tretinoin | 0.1733580 | 0.4533977 | 0.1734 | NA | NA |
| TSC2 | crizotinib | 0.1757036 | 0.6247240 | 0.176 | NA | NA |
| ESR1 | nilotinib | 0.1779167 | 0.7074000 | 0.178 | NA | NA |
| NPM1 | cabozantinib | 0.1781069 | 0.5046363 | 0.1781 | NA | NA |
| JAK2 | docetaxel | 0.1783666 | 0.6845085 | 0.178 | NA | NA |
| ERBB2 | belinostat | 0.1805478 | 0.6734824 | 0.181 | NA | NA |
| G6PD | docetaxel | 0.1822668 | 0.6845085 | 0.182 | NA | NA |
| MYD88 | afatinib | 0.1823685 | 0.5609625 | 0.182 | NA | NA |
| KRAS | afatinib | 0.1838668 | 0.5609625 | 0.184 | NA | NA |
| MET | afatinib | 0.1841947 | 0.5609625 | 0.184 | NA | NA |
| ABL1 | belinostat | 0.1850848 | 0.6734824 | 0.185 | NA | NA |
| DNMT3A | nilotinib | 0.1870610 | 0.7074000 | 0.187 | NA | NA |
| PTCH1 | bosutinib monohydrate | 0.1879013 | 0.8678254 | 0.188 | NA | NA |
| BRCA2 | alectinib | 0.1881297 | 0.6998836 | 0.188 | NA | NA |
| ALK | sunitinib | 0.1882759 | 0.8777619 | 0.188 | NA | NA |
| ALK | afatinib | 0.1885392 | 0.5609625 | 0.189 | NA | NA |
| TSC2 | sunitinib | 0.1886391 | 0.8777619 | 0.189 | NA | NA |
| PDGFRB | dabrafenib | 0.1895855 | 0.5719432 | 0.18959 | NA | NA |
| TSC1 | midostaurin | 0.1925940 | 0.6011299 | 0.1926 | NA | NA |
| NPM1 | imatinib | 0.1935911 | 0.7846892 | 0.194 | NA | NA |
| NPM1 | midostaurin | 0.1944832 | 0.6011299 | 0.1945 | NA | NA |
| MGMT | cabozantinib | 0.1946541 | 0.5090952 | 0.1947 | NA | NA |
| PML | alectinib | 0.1950849 | 0.6998836 | 0.195 | NA | NA |
| FLT3 | rucaparib | 0.1971116 | 0.8376438 | 0.197 | NA | NA |
| BRAF | ruxolitinib | 0.1976786 | 0.9414093 | 0.198 | NA | NA |
| TSC2 | docetaxel | 0.1988212 | 0.6845085 | 0.199 | NA | NA |
| JAK2 | gefitinib | 0.1997501 | 0.7564295 | 0.200 | NA | NA |
| ESR1 | gefitinib | 0.2002313 | 0.7564295 | 0.200 | NA | NA |
| UGT1A1 | palbociclib | 0.2007621 | 0.7307299 | 0.2008 | NA | NA |
| PML | palbociclib | 0.2018104 | 0.7307299 | 0.2018 | NA | NA |
| KIT | dabrafenib | 0.2027554 | 0.5719432 | 0.20276 | NA | NA |
| PDGFRB | erlotinib | 0.2028937 | 0.7675082 | 0.203 | NA | NA |
| IDH2 | vismodegib | 0.2041835 | 0.8104430 | 0.20 | NA | NA |
| TSC2 | ponatinib | 0.2051961 | 0.9972326 | 0.205 | NA | NA |
| FLT3 | dasatinib | 0.2059686 | 0.9447103 | 0.206 | NA | NA |
| JAK2 | temozolomide | 0.2108300 | 0.6854745 | 0.2108 | NA | NA |
| G6PD | afatinib | 0.2109900 | 0.5609625 | 0.211 | NA | NA |
| EGFR | crizotinib | 0.2113667 | 0.6763734 | 0.211 | NA | NA |
| ABL1 | palbociclib | 0.2122468 | 0.7307299 | 0.2122 | NA | NA |
| ESR1 | palbociclib | 0.2146985 | 0.7307299 | 0.2147 | NA | NA |
| NPM1 | erlotinib | 0.2158617 | 0.7675082 | 0.216 | NA | NA |
| PTCH1 | temozolomide | 0.2167760 | 0.6854745 | 0.2168 | NA | NA |
| ESR1 | belinostat | 0.2186179 | 0.6734824 | 0.219 | NA | NA |
| MYD88 | belinostat | 0.2195610 | 0.6734824 | 0.220 | NA | NA |
| BRCA1 | vismodegib | 0.2203270 | 0.8104430 | 0.22 | NA | NA |
| PML | temozolomide | 0.2217712 | 0.6854745 | 0.2218 | NA | NA |
| PDGFB | vismodegib | 0.2233811 | 0.8104430 | 0.22 | NA | NA |
| ROS1 | belinostat | 0.2235080 | 0.6734824 | 0.224 | NA | NA |
| KRAS | tretinoin | 0.2237016 | 0.5432753 | 0.2237 | NA | NA |
| NPM1 | alectinib | 0.2246258 | 0.6998836 | 0.225 | NA | NA |
| DNMT3A | dasatinib | 0.2260896 | 0.9447103 | 0.226 | NA | NA |
| ALK | ruxolitinib | 0.2294413 | 0.9414093 | 0.229 | NA | NA |
| PDGFB | afatinib | 0.2297013 | 0.5609625 | 0.230 | NA | NA |
| DPYD | ponatinib | 0.2315390 | 0.9972326 | 0.232 | NA | NA |
| G6PD | ruxolitinib | 0.2325984 | 0.9414093 | 0.233 | NA | NA |
| KIT | vismodegib | 0.2326739 | 0.8104430 | 0.23 | NA | NA |
| ROS1 | alectinib | 0.2335276 | 0.6998836 | 0.234 | NA | NA |
| ABL1 | lapatinib | 0.2342922 | 0.8759947 | 0.234 | NA | NA |
| PTCH1 | belinostat | 0.2376997 | 0.6734824 | 0.238 | NA | NA |
| JAK2 | alectinib | 0.2385373 | 0.6998836 | 0.239 | NA | NA |
| MGMT | palbociclib | 0.2389195 | 0.7307299 | 0.2389 | NA | NA |
| TSC2 | alectinib | 0.2393143 | 0.6998836 | 0.239 | NA | NA |
| CYP19A1 | trametinib | 0.2426959 | 0.5652949 | 0.24270 | NA | NA |
| G6PD | dabrafenib | 0.2443393 | 0.5719432 | 0.24434 | NA | NA |
| DPYD | trametinib | 0.2458254 | 0.5652949 | 0.24583 | NA | NA |
| G6PD | vismodegib | 0.2460143 | 0.8104430 | 0.25 | NA | NA |
| ABL1 | alectinib | 0.2470177 | 0.6998836 | 0.247 | NA | NA |
| TSC1 | vismodegib | 0.2476631 | 0.8104430 | 0.25 | NA | NA |
| IDH2 | bosutinib monohydrate | 0.2477175 | 0.8678254 | 0.248 | NA | NA |
| ERBB3 | tretinoin | 0.2487626 | 0.5613501 | 0.2488 | NA | NA |
| NPM1 | docetaxel | 0.2488101 | 0.6845085 | 0.249 | NA | NA |
| RET | trametinib | 0.2493948 | 0.5652949 | 0.24939 | NA | NA |
| KRAS | ponatinib | 0.2496849 | 0.9972326 | 0.250 | NA | NA |
| PDGFB | imatinib | 0.2502352 | 0.7846892 | 0.250 | NA | NA |
| MGMT | lapatinib | 0.2514271 | 0.8759947 | 0.251 | NA | NA |
| ERBB2 | dabrafenib | 0.2521562 | 0.5719432 | 0.25216 | NA | NA |
| PML | dabrafenib | 0.2532744 | 0.5719432 | 0.25327 | NA | NA |
| EGFR | dasatinib | 0.2539632 | 0.9447103 | 0.254 | NA | NA |
| BRCA1 | bosutinib monohydrate | 0.2550079 | 0.8678254 | 0.255 | NA | NA |
| BRCA2 | afatinib | 0.2553180 | 0.5609625 | 0.255 | NA | NA |
| PML | sunitinib | 0.2560406 | 0.8777619 | 0.256 | NA | NA |
| TSC2 | palbociclib | 0.2593090 | 0.7307299 | 0.2593 | NA | NA |
| IDH2 | ponatinib | 0.2610616 | 0.9972326 | 0.261 | NA | NA |
| PTCH1 | ponatinib | 0.2619913 | 0.9972326 | 0.262 | NA | NA |
| UGT1A1 | crizotinib | 0.2625570 | 0.7638022 | 0.263 | NA | NA |
| TPMT | docetaxel | 0.2626723 | 0.6845085 | 0.263 | NA | NA |
| PTCH1 | afatinib | 0.2628105 | 0.5609625 | 0.263 | NA | NA |
| PDGFB | lapatinib | 0.2633229 | 0.8759947 | 0.263 | NA | NA |
| DNMT3A | afatinib | 0.2639824 | 0.5609625 | 0.264 | NA | NA |
| TPMT | vismodegib | 0.2650075 | 0.8104430 | 0.27 | NA | NA |
| BRAF | docetaxel | 0.2666895 | 0.6845085 | 0.267 | NA | NA |
| MGMT | midostaurin | 0.2670503 | 0.7109289 | 0.2671 | NA | NA |
| DNMT3A | cabozantinib | 0.2687536 | 0.6476573 | 0.2688 | NA | NA |
| DPYD | dabrafenib | 0.2691497 | 0.5719432 | 0.26915 | NA | NA |
| JAK2 | tretinoin | 0.2702044 | 0.5613501 | 0.2702 | NA | NA |
| EGFR | alectinib | 0.2707820 | 0.7081991 | 0.271 | NA | NA |
| ALK | belinostat | 0.2712457 | 0.7094119 | 0.271 | NA | NA |
| AKT1 | vismodegib | 0.2724738 | 0.8104430 | 0.27 | NA | NA |
| KRAS | docetaxel | 0.2725554 | 0.6845085 | 0.273 | NA | NA |
| NPM1 | lapatinib | 0.2737483 | 0.8759947 | 0.274 | NA | NA |
| TPMT | nilotinib | 0.2737875 | 0.7074000 | 0.274 | NA | NA |
| PDGFRB | nilotinib | 0.2738696 | 0.7074000 | 0.274 | NA | NA |
| ERBB2 | trametinib | 0.2740267 | 0.5823067 | 0.27403 | NA | NA |
| NPM1 | temozolomide | 0.2747200 | 0.7783735 | 0.2747 | NA | NA |
| PDGFB | nilotinib | 0.2752114 | 0.7074000 | 0.275 | NA | NA |
| JAK2 | rucaparib | 0.2799799 | 0.8376438 | 0.280 | NA | NA |
| KIT | ruxolitinib | 0.2812051 | 0.9414093 | 0.281 | NA | NA |
| PDGFRB | docetaxel | 0.2818564 | 0.6845085 | 0.282 | NA | NA |
| PDGFRA | midostaurin | 0.2883532 | 0.7109289 | 0.2884 | NA | NA |
| ERBB3 | cabozantinib | 0.2887403 | 0.6476573 | 0.2887 | NA | NA |
| MET | palbociclib | 0.2900431 | 0.7307299 | 0.2900 | NA | NA |
| MET | vismodegib | 0.2900560 | 0.8104430 | 0.29 | NA | NA |
| BRCA2 | bosutinib monohydrate | 0.2907814 | 0.8678254 | 0.291 | NA | NA |
| KRAS | midostaurin | 0.2927354 | 0.7109289 | 0.2927 | NA | NA |
| PTCH1 | pazopanib | 0.2950783 | 0.9239682 | 0.2951 | NA | NA |
| AKT1 | alectinib | 0.2956410 | 0.7179852 | 0.296 | NA | NA |
| UGT1A1 | imatinib | 0.2957214 | 0.7846892 | 0.296 | NA | NA |
| ROS1 | bosutinib monohydrate | 0.2963370 | 0.8678254 | 0.296 | NA | NA |
| FLT3 | trametinib | 0.2977892 | 0.5955784 | 0.29779 | NA | NA |
| ERBB2 | tretinoin | 0.3012993 | 0.5613501 | 0.3013 | NA | NA |
| AKT1 | ruxolitinib | 0.3044779 | 0.9414093 | 0.304 | NA | NA |
| TSC1 | ruxolitinib | 0.3045736 | 0.9414093 | 0.305 | NA | NA |
| DPYD | cabozantinib | 0.3047799 | 0.6476573 | 0.3048 | NA | NA |
| IDH2 | pazopanib | 0.3050404 | 0.9239682 | 0.3050 | NA | NA |
| PTCH1 | nilotinib | 0.3093982 | 0.7074000 | 0.309 | NA | NA |
| BRAF | tretinoin | 0.3097622 | 0.5613501 | 0.3098 | NA | NA |
| DPYD | afatinib | 0.3107947 | 0.6215893 | 0.311 | NA | NA |
| TSC1 | imatinib | 0.3108496 | 0.7846892 | 0.311 | NA | NA |
| MGMT | rucaparib | 0.3112521 | 0.8376438 | 0.311 | NA | NA |
| TPMT | gefitinib | 0.3116629 | 0.8402334 | 0.312 | NA | NA |
| ERBB2 | dasatinib | 0.3121664 | 0.9447103 | 0.312 | NA | NA |
| MET | tretinoin | 0.3136957 | 0.5613501 | 0.3137 | NA | NA |
| BRCA2 | rucaparib | 0.3140675 | 0.8376438 | 0.314 | NA | NA |
| PDGFRA | imatinib | 0.3143676 | 0.7846892 | 0.314 | NA | NA |
| ESR1 | rucaparib | 0.3155348 | 0.8376438 | 0.316 | NA | NA |
| KRAS | belinostat | 0.3158051 | 0.7166062 | 0.316 | NA | NA |
| ERBB2 | imatinib | 0.3160344 | 0.7846892 | 0.316 | NA | NA |
| CYP19A1 | belinostat | 0.3161498 | 0.7166062 | 0.316 | NA | NA |
| KIT | rucaparib | 0.3176892 | 0.8376438 | 0.318 | NA | NA |
| PTCH1 | palbociclib | 0.3180803 | 0.7307299 | 0.3181 | NA | NA |
| NPM1 | nilotinib | 0.3197255 | 0.7074000 | 0.320 | NA | NA |
| ROS1 | rucaparib | 0.3210092 | 0.8376438 | 0.321 | NA | NA |
| DPYD | vismodegib | 0.3255816 | 0.8104430 | 0.33 | NA | NA |
| IDH2 | gefitinib | 0.3258316 | 0.8402334 | 0.326 | NA | NA |
| FLT3 | gefitinib | 0.3274937 | 0.8402334 | 0.327 | NA | NA |
| MGMT | dabrafenib | 0.3282216 | 0.6564431 | 0.32822 | NA | NA |
| IDH2 | docetaxel | 0.3288933 | 0.7454914 | 0.329 | NA | NA |
| TSC2 | lapatinib | 0.3311360 | 0.8842093 | 0.331 | NA | NA |
| EGFR | midostaurin | 0.3312793 | 0.7508998 | 0.3313 | NA | NA |
| ERBB2 | nilotinib | 0.3322155 | 0.7074000 | 0.332 | NA | NA |
| PDGFB | palbociclib | 0.3327587 | 0.7307299 | 0.3328 | NA | NA |
| ROS1 | nilotinib | 0.3339538 | 0.7074000 | 0.334 | NA | NA |
| ERBB3 | gefitinib | 0.3353927 | 0.8402334 | 0.335 | NA | NA |
| BRAF | imatinib | 0.3365852 | 0.7846892 | 0.337 | NA | NA |
| MET | pazopanib | 0.3375577 | 0.9239682 | 0.3376 | NA | NA |
| ERBB3 | bosutinib monohydrate | 0.3381914 | 0.8678254 | 0.338 | NA | NA |
| RET | vismodegib | 0.3393340 | 0.8104430 | 0.34 | NA | NA |
| ERBB2 | pazopanib | 0.3398016 | 0.9239682 | 0.3398 | NA | NA |
| PDGFRB | rucaparib | 0.3399009 | 0.8376438 | 0.340 | NA | NA |
| MYD88 | rucaparib | 0.3422485 | 0.8376438 | 0.342 | NA | NA |
| PDGFRB | vismodegib | 0.3432087 | 0.8104430 | 0.34 | NA | NA |
| DPYD | rucaparib | 0.3449122 | 0.8376438 | 0.345 | NA | NA |
| DPYD | dasatinib | 0.3450704 | 0.9447103 | 0.345 | NA | NA |
| BRCA1 | alectinib | 0.3475727 | 0.7403839 | 0.348 | NA | NA |
| MET | bosutinib monohydrate | 0.3480988 | 0.8678254 | 0.348 | NA | NA |
| IDH2 | tretinoin | 0.3482943 | 0.5921004 | 0.3483 | NA | NA |
| BRCA2 | belinostat | 0.3501637 | 0.7440979 | 0.350 | NA | NA |
| G6PD | ponatinib | 0.3562978 | 0.9972326 | 0.356 | NA | NA |
| CYP19A1 | alectinib | 0.3564980 | 0.7403839 | 0.356 | NA | NA |
| DNMT3A | vismodegib | 0.3575484 | 0.8104430 | 0.36 | NA | NA |
| PTCH1 | docetaxel | 0.3578141 | 0.7603550 | 0.358 | NA | NA |
| BRAF | nilotinib | 0.3579029 | 0.7074000 | 0.358 | NA | NA |
| KIT | afatinib | 0.3580267 | 0.6762727 | 0.358 | NA | NA |
| MET | sunitinib | 0.3589333 | 0.8777619 | 0.359 | NA | NA |
| BRAF | pazopanib | 0.3592410 | 0.9239682 | 0.3592 | NA | NA |
| PDGFB | gefitinib | 0.3627861 | 0.8402334 | 0.363 | NA | NA |
| BRCA2 | pazopanib | 0.3630866 | 0.9239682 | 0.3631 | NA | NA |
| PDGFRB | lapatinib | 0.3673411 | 0.8842093 | 0.367 | NA | NA |
| TSC1 | lapatinib | 0.3673411 | 0.8842093 | 0.367 | NA | NA |
| TSC1 | pazopanib | 0.3683895 | 0.9239682 | 0.3684 | NA | NA |
| ALK | crizotinib | 0.3700920 | 0.8464147 | 0.370 | NA | NA |
| TSC1 | palbociclib | 0.3704875 | 0.7307299 | 0.3705 | NA | NA |
| NPM1 | crizotinib | 0.3719543 | 0.8464147 | 0.372 | NA | NA |
| G6PD | palbociclib | 0.3728013 | 0.7307299 | 0.3728 | NA | NA |
| ERBB2 | ruxolitinib | 0.3785733 | 0.9526741 | 0.379 | NA | NA |
| PDGFB | dasatinib | 0.3792939 | 0.9447103 | 0.379 | NA | NA |
| KRAS | dasatinib | 0.3806744 | 0.9447103 | 0.381 | NA | NA |
| NPM1 | bosutinib monohydrate | 0.3813570 | 0.8678254 | 0.381 | NA | NA |
| G6PD | nilotinib | 0.3817505 | 0.7074000 | 0.382 | NA | NA |
| DPYD | temozolomide | 0.3822258 | 0.8360585 | 0.3822 | NA | NA |
| ERBB2 | bosutinib monohydrate | 0.3828642 | 0.8678254 | 0.383 | NA | NA |
| PTCH1 | alectinib | 0.3832319 | 0.7403839 | 0.383 | NA | NA |
| BRCA2 | gefitinib | 0.3852457 | 0.8402334 | 0.385 | NA | NA |
| RET | imatinib | 0.3884249 | 0.7846892 | 0.388 | NA | NA |
| ERBB3 | belinostat | 0.3891061 | 0.7587223 | 0.389 | NA | NA |
| BRCA1 | dasatinib | 0.3928660 | 0.9447103 | 0.393 | NA | NA |
| ESR1 | vismodegib | 0.3942862 | 0.8378583 | 0.39 | NA | NA |
| AKT1 | tretinoin | 0.3944562 | 0.6307930 | 0.3945 | NA | NA |
| ALK | dasatinib | 0.3952274 | 0.9447103 | 0.395 | NA | NA |
| TSC1 | alectinib | 0.3956481 | 0.7403839 | 0.396 | NA | NA |
| AKT1 | palbociclib | 0.3961746 | 0.7307299 | 0.3962 | NA | NA |
| CYP19A1 | nilotinib | 0.3966596 | 0.7074000 | 0.397 | NA | NA |
| MET | gefitinib | 0.3977576 | 0.8402334 | 0.398 | NA | NA |
| UGT1A1 | pazopanib | 0.3984406 | 0.9239682 | 0.3984 | NA | NA |
| UGT1A1 | sunitinib | 0.3992388 | 0.8777619 | 0.399 | NA | NA |
| NPM1 | palbociclib | 0.3996308 | 0.7307299 | 0.3996 | NA | NA |
| ALK | temozolomide | 0.4005886 | 0.8360585 | 0.4006 | NA | NA |
| KIT | erlotinib | 0.4010455 | 0.8537089 | 0.401 | NA | NA |
| IDH2 | crizotinib | 0.4011464 | 0.8464147 | 0.401 | NA | NA |
| PDGFRA | rucaparib | 0.4016231 | 0.8467310 | 0.402 | NA | NA |
| UGT1A1 | belinostat | 0.4041103 | 0.7587223 | 0.404 | NA | NA |
| BRCA1 | erlotinib | 0.4046403 | 0.8537089 | 0.405 | NA | NA |
| PDGFB | docetaxel | 0.4060325 | 0.8036630 | 0.406 | NA | NA |
| PML | tretinoin | 0.4081601 | 0.6307930 | 0.4082 | NA | NA |
| DNMT3A | ruxolitinib | 0.4082055 | 0.9526741 | 0.408 | NA | NA |
| PDGFRA | palbociclib | 0.4083491 | 0.7307299 | 0.4083 | NA | NA |
| IDH2 | trametinib | 0.4108540 | 0.7083580 | 0.41085 | NA | NA |
| RET | lapatinib | 0.4130391 | 0.8842093 | 0.413 | NA | NA |
| BRCA1 | trametinib | 0.4159320 | 0.7083580 | 0.41593 | NA | NA |
| DNMT3A | trametinib | 0.4166812 | 0.7083580 | 0.41668 | NA | NA |
| PDGFRA | bosutinib monohydrate | 0.4175132 | 0.8678810 | 0.418 | NA | NA |
| MYD88 | alectinib | 0.4215902 | 0.7403839 | 0.422 | NA | NA |
| BRCA1 | nilotinib | 0.4230452 | 0.7074000 | 0.423 | NA | NA |
| JAK2 | belinostat | 0.4239919 | 0.7587223 | 0.424 | NA | NA |
| ABL1 | dasatinib | 0.4250747 | 0.9447103 | 0.425 | NA | NA |
| ESR1 | docetaxel | 0.4254686 | 0.8036630 | 0.425 | NA | NA |
| ERBB2 | erlotinib | 0.4285389 | 0.8537089 | 0.429 | NA | NA |
| KIT | gefitinib | 0.4300536 | 0.8402334 | 0.430 | NA | NA |
| BRCA1 | ponatinib | 0.4319743 | 0.9972326 | 0.432 | NA | NA |
| UGT1A1 | dasatinib | 0.4335809 | 0.9447103 | 0.434 | NA | NA |
| PDGFB | temozolomide | 0.4372281 | 0.8360585 | 0.4372 | NA | NA |
| DNMT3A | imatinib | 0.4384088 | 0.7846892 | 0.438 | NA | NA |
| FLT3 | temozolomide | 0.4398840 | 0.8360585 | 0.4399 | NA | NA |
| IDH2 | lapatinib | 0.4399819 | 0.8842093 | 0.440 | NA | NA |
| CYP19A1 | midostaurin | 0.4400719 | 0.7825538 | 0.4401 | NA | NA |
| ABL1 | rucaparib | 0.4411690 | 0.8467310 | 0.441 | NA | NA |
| ABL1 | dabrafenib | 0.4415642 | 0.7445082 | 0.44156 | NA | NA |
| KIT | lapatinib | 0.4421047 | 0.8842093 | 0.442 | NA | NA |
| FLT3 | pazopanib | 0.4421181 | 0.9239682 | 0.4421 | NA | NA |
| TSC2 | pazopanib | 0.4425985 | 0.9239682 | 0.4426 | NA | NA |
| MYD88 | nilotinib | 0.4453090 | 0.7074000 | 0.445 | NA | NA |
| ERBB2 | alectinib | 0.4455420 | 0.7403839 | 0.446 | NA | NA |
| ESR1 | crizotinib | 0.4487601 | 0.8464147 | 0.449 | NA | NA |
| AKT1 | dabrafenib | 0.4490980 | 0.7445082 | 0.44910 | NA | NA |
| PDGFRA | dabrafenib | 0.4498286 | 0.7445082 | 0.44983 | NA | NA |
| RET | afatinib | 0.4515995 | 0.7810241 | 0.452 | NA | NA |
| G6PD | tretinoin | 0.4531080 | 0.6698118 | 0.4531 | NA | NA |
| CYP19A1 | dasatinib | 0.4547296 | 0.9447103 | 0.455 | NA | NA |
| PML | bosutinib monohydrate | 0.4556704 | 0.8678810 | 0.456 | NA | NA |
| KRAS | vismodegib | 0.4564329 | 0.8556940 | 0.46 | NA | NA |
| PDGFB | alectinib | 0.4572960 | 0.7403839 | 0.457 | NA | NA |
| CYP19A1 | erlotinib | 0.4583847 | 0.8537089 | 0.458 | NA | NA |
| MYD88 | temozolomide | 0.4590388 | 0.8360585 | 0.4590 | NA | NA |
| EGFR | afatinib | 0.4594260 | 0.7810241 | 0.459 | NA | NA |
| DPYD | bosutinib monohydrate | 0.4594664 | 0.8678810 | 0.459 | NA | NA |
| KIT | temozolomide | 0.4596217 | 0.8360585 | 0.4596 | NA | NA |
| PML | imatinib | 0.4608455 | 0.7846892 | 0.461 | NA | NA |
| JAK2 | nilotinib | 0.4609294 | 0.7074000 | 0.461 | NA | NA |
| DNMT3A | erlotinib | 0.4620527 | 0.8537089 | 0.462 | NA | NA |
| MET | nilotinib | 0.4620552 | 0.7074000 | 0.462 | NA | NA |
| BRCA1 | belinostat | 0.4653768 | 0.7769514 | 0.465 | NA | NA |
| BRAF | erlotinib | 0.4662981 | 0.8537089 | 0.466 | NA | NA |
| PTCH1 | sunitinib | 0.4664159 | 0.8777619 | 0.466 | NA | NA |
| ABL1 | imatinib | 0.4679914 | 0.7846892 | 0.468 | NA | NA |
| BRCA2 | ponatinib | 0.4687534 | 0.9972326 | 0.469 | NA | NA |
| PDGFRB | imatinib | 0.4699331 | 0.7846892 | 0.470 | NA | NA |
| PTCH1 | dasatinib | 0.4723552 | 0.9447103 | 0.472 | NA | NA |
| ERBB3 | palbociclib | 0.4724268 | 0.8031255 | 0.4724 | NA | NA |
| MGMT | trametinib | 0.4735520 | 0.7350776 | 0.47355 | NA | NA |
| TSC2 | vismodegib | 0.4749053 | 0.8556940 | 0.47 | NA | NA |
| PTCH1 | trametinib | 0.4756384 | 0.7350776 | 0.47564 | NA | NA |
| PDGFRB | ruxolitinib | 0.4765472 | 0.9526741 | 0.477 | NA | NA |
| MYD88 | tretinoin | 0.4774785 | 0.6757916 | 0.4775 | NA | NA |
| PDGFRA | vismodegib | 0.4781819 | 0.8556940 | 0.48 | NA | NA |
| BRCA1 | ruxolitinib | 0.4788739 | 0.9526741 | 0.479 | NA | NA |
| G6PD | belinostat | 0.4798818 | 0.7769514 | 0.480 | NA | NA |
| NPM1 | ruxolitinib | 0.4817234 | 0.9526741 | 0.482 | NA | NA |
| PDGFB | ponatinib | 0.4821695 | 0.9972326 | 0.482 | NA | NA |
| G6PD | pazopanib | 0.4835225 | 0.9239682 | 0.4835 | NA | NA |
| ERBB2 | sunitinib | 0.4842706 | 0.8777619 | 0.484 | NA | NA |
| CYP19A1 | docetaxel | 0.4847190 | 0.8413401 | 0.485 | NA | NA |
| PDGFRB | afatinib | 0.4872986 | 0.7852762 | 0.487 | NA | NA |
| KRAS | erlotinib | 0.4886809 | 0.8537089 | 0.489 | NA | NA |
| TSC2 | erlotinib | 0.4915604 | 0.8537089 | 0.492 | NA | NA |
| UGT1A1 | nilotinib | 0.4918297 | 0.7074000 | 0.492 | NA | NA |
| CYP19A1 | lapatinib | 0.4937490 | 0.8940161 | 0.494 | NA | NA |
| PDGFB | dabrafenib | 0.4964153 | 0.7445082 | 0.49642 | NA | NA |
| RET | tretinoin | 0.4969056 | 0.6757916 | 0.4969 | NA | NA |
| ALK | midostaurin | 0.4971993 | 0.7825538 | 0.4972 | NA | NA |
| MYD88 | cabozantinib | 0.4985291 | 0.9262331 | 0.4985 | NA | NA |
| PDGFRA | sunitinib | 0.4989956 | 0.8777619 | 0.499 | NA | NA |
| RET | cabozantinib | 0.4991041 | 0.9262331 | 0.4991 | NA | NA |
| EGFR | nilotinib | 0.4993412 | 0.7074000 | 0.499 | NA | NA |
| ERBB3 | lapatinib | 0.5028840 | 0.8940161 | 0.503 | NA | NA |
| RET | crizotinib | 0.5041789 | 0.8464147 | 0.504 | NA | NA |
| G6PD | imatinib | 0.5046668 | 0.7846892 | 0.505 | NA | NA |
| CYP19A1 | afatinib | 0.5081199 | 0.7852762 | 0.508 | NA | NA |
| DPYD | midostaurin | 0.5086465 | 0.7825538 | 0.5086 | NA | NA |
| ERBB3 | pazopanib | 0.5092517 | 0.9239682 | 0.5093 | NA | NA |
| PDGFRB | sunitinib | 0.5106193 | 0.8777619 | 0.511 | NA | NA |
| BRAF | gefitinib | 0.5109860 | 0.8402334 | 0.511 | NA | NA |
| PML | vismodegib | 0.5118312 | 0.8701130 | 0.51 | NA | NA |
| KIT | palbociclib | 0.5134101 | 0.8071578 | 0.5134 | NA | NA |
| ESR1 | dabrafenib | 0.5138002 | 0.7445082 | 0.51380 | NA | NA |
| PDGFRB | temozolomide | 0.5143244 | 0.8360585 | 0.5143 | NA | NA |
| FLT3 | dabrafenib | 0.5153597 | 0.7445082 | 0.51536 | NA | NA |
| MYD88 | dasatinib | 0.5156798 | 0.9470657 | 0.516 | NA | NA |
| DPYD | ruxolitinib | 0.5165164 | 0.9526741 | 0.517 | NA | NA |
| CYP19A1 | sunitinib | 0.5166344 | 0.8777619 | 0.517 | NA | NA |
| DPYD | docetaxel | 0.5183010 | 0.8413401 | 0.518 | NA | NA |
| MET | docetaxel | 0.5196512 | 0.8413401 | 0.520 | NA | NA |
| DPYD | imatinib | 0.5204070 | 0.7846892 | 0.520 | NA | NA |
| EGFR | imatinib | 0.5206143 | 0.7846892 | 0.521 | NA | NA |
| DPYD | gefitinib | 0.5210093 | 0.8402334 | 0.521 | NA | NA |
| DNMT3A | palbociclib | 0.5222786 | 0.8071578 | 0.5223 | NA | NA |
| DPYD | alectinib | 0.5225472 | 0.8075729 | 0.523 | NA | NA |
| NPM1 | gefitinib | 0.5227495 | 0.8402334 | 0.523 | NA | NA |
| PDGFB | trametinib | 0.5280206 | 0.7805521 | 0.52802 | NA | NA |
| BRAF | sunitinib | 0.5308225 | 0.8777619 | 0.531 | NA | NA |
| MYD88 | midostaurin | 0.5310291 | 0.7825538 | 0.5310 | NA | NA |
| ABL1 | crizotinib | 0.5320626 | 0.8464147 | 0.532 | NA | NA |
| DNMT3A | midostaurin | 0.5328652 | 0.7825538 | 0.5329 | NA | NA |
| G6PD | erlotinib | 0.5348254 | 0.8537089 | 0.535 | NA | NA |
| ERBB3 | nilotinib | 0.5371710 | 0.7305525 | 0.537 | NA | NA |
| TSC2 | imatinib | 0.5394738 | 0.7846892 | 0.539 | NA | NA |
| ABL1 | midostaurin | 0.5402282 | 0.7825538 | 0.5402 | NA | NA |
| PTCH1 | dabrafenib | 0.5410696 | 0.7445082 | 0.54107 | NA | NA |
| BRCA2 | temozolomide | 0.5416844 | 0.8360585 | 0.5417 | NA | NA |
| TSC2 | midostaurin | 0.5433441 | 0.7825538 | 0.5433 | NA | NA |
| AKT1 | cabozantinib | 0.5467795 | 0.9262331 | 0.5468 | NA | NA |
| UGT1A1 | dabrafenib | 0.5474325 | 0.7445082 | 0.54743 | NA | NA |
| PDGFB | midostaurin | 0.5477164 | 0.7825538 | 0.5477 | NA | NA |
| UGT1A1 | temozolomide | 0.5500430 | 0.8360585 | 0.5500 | NA | NA |
| MGMT | crizotinib | 0.5501355 | 0.8464147 | 0.550 | NA | NA |
| RET | bosutinib monohydrate | 0.5509591 | 0.9571596 | 0.551 | NA | NA |
| ROS1 | gefitinib | 0.5511895 | 0.8402334 | 0.551 | NA | NA |
| KIT | midostaurin | 0.5523909 | 0.7825538 | 0.5524 | NA | NA |
| CYP19A1 | pazopanib | 0.5523979 | 0.9239682 | 0.5524 | NA | NA |
| ERBB3 | alectinib | 0.5530430 | 0.8175419 | 0.553 | NA | NA |
| MGMT | ponatinib | 0.5540759 | 0.9972326 | 0.554 | NA | NA |
| AKT1 | belinostat | 0.5547454 | 0.8458949 | 0.555 | NA | NA |
| CYP19A1 | tretinoin | 0.5549899 | 0.7257560 | 0.5550 | NA | NA |
| TSC2 | dasatinib | 0.5568736 | 0.9470657 | 0.557 | NA | NA |
| MYD88 | erlotinib | 0.5580136 | 0.8537089 | 0.558 | NA | NA |
| ALK | pazopanib | 0.5581192 | 0.9239682 | 0.5581 | NA | NA |
| RET | ruxolitinib | 0.5597886 | 0.9526741 | 0.560 | NA | NA |
| ERBB3 | afatinib | 0.5614904 | 0.7959129 | 0.561 | NA | NA |
| JAK2 | crizotinib | 0.5623793 | 0.8464147 | 0.562 | NA | NA |
| PML | pazopanib | 0.5629739 | 0.9239682 | 0.5630 | NA | NA |
| TSC1 | erlotinib | 0.5633547 | 0.8537089 | 0.563 | NA | NA |
| ESR1 | sunitinib | 0.5643768 | 0.8777619 | 0.564 | NA | NA |
| G6PD | rucaparib | 0.5646292 | 0.8467310 | 0.565 | NA | NA |
| RET | gefitinib | 0.5658382 | 0.8402334 | 0.566 | NA | NA |
| PDGFB | sunitinib | 0.5660424 | 0.8777619 | 0.566 | NA | NA |
| FLT3 | sunitinib | 0.5660424 | 0.8777619 | 0.566 | NA | NA |
| EGFR | temozolomide | 0.5669345 | 0.8360585 | 0.5669 | NA | NA |
| JAK2 | palbociclib | 0.5675682 | 0.8390139 | 0.5676 | NA | NA |
| FLT3 | lapatinib | 0.5679419 | 0.9537394 | 0.568 | NA | NA |
| CYP19A1 | gefitinib | 0.5683932 | 0.8402334 | 0.568 | NA | NA |
| JAK2 | erlotinib | 0.5702807 | 0.8537089 | 0.570 | NA | NA |
| TSC2 | cabozantinib | 0.5710996 | 0.9262331 | 0.5711 | NA | NA |
| TSC1 | docetaxel | 0.5725527 | 0.8563752 | 0.573 | NA | NA |
| BRCA1 | rucaparib | 0.5768966 | 0.8467310 | 0.577 | NA | NA |
| MGMT | belinostat | 0.5789471 | 0.8458949 | 0.579 | NA | NA |
| ALK | cabozantinib | 0.5795396 | 0.9262331 | 0.5795 | NA | NA |
| ABL1 | sunitinib | 0.5802023 | 0.8777619 | 0.580 | NA | NA |
| ROS1 | midostaurin | 0.5814725 | 0.7908026 | 0.5815 | NA | NA |
| ALK | rucaparib | 0.5819295 | 0.8467310 | 0.582 | NA | NA |
| TSC2 | ruxolitinib | 0.5824296 | 0.9526741 | 0.582 | NA | NA |
| PDGFRA | docetaxel | 0.5828922 | 0.8563752 | 0.583 | NA | NA |
| PTCH1 | ruxolitinib | 0.5835921 | 0.9526741 | 0.584 | NA | NA |
| RET | ponatinib | 0.5838741 | 0.9972326 | 0.584 | NA | NA |
| RET | nilotinib | 0.5840052 | 0.7528214 | 0.584 | NA | NA |
| TSC2 | rucaparib | 0.5851976 | 0.8467310 | 0.585 | NA | NA |
| NPM1 | ponatinib | 0.5854791 | 0.9972326 | 0.585 | NA | NA |
| BRCA1 | afatinib | 0.5859699 | 0.7959129 | 0.586 | NA | NA |
| EGFR | ponatinib | 0.5861711 | 0.9972326 | 0.586 | NA | NA |
| PDGFRA | temozolomide | 0.5883211 | 0.8360585 | 0.5883 | NA | NA |
| EGFR | tretinoin | 0.5940328 | 0.7480413 | 0.5940 | NA | NA |
| KIT | pazopanib | 0.5948891 | 0.9239682 | 0.5949 | NA | NA |
| PML | rucaparib | 0.5950165 | 0.8467310 | 0.595 | NA | NA |
| EGFR | lapatinib | 0.5960871 | 0.9537394 | 0.596 | NA | NA |
| ESR1 | ruxolitinib | 0.5973766 | 0.9526741 | 0.597 | NA | NA |
| MGMT | nilotinib | 0.5978288 | 0.7528214 | 0.598 | NA | NA |
| MYD88 | vismodegib | 0.5979041 | 0.9680352 | 0.60 | NA | NA |
| ABL1 | erlotinib | 0.5985108 | 0.8537089 | 0.599 | NA | NA |
| IDH2 | sunitinib | 0.6010327 | 0.8777619 | 0.601 | NA | NA |
| CYP19A1 | cabozantinib | 0.6024929 | 0.9262331 | 0.6025 | NA | NA |
| BRAF | crizotinib | 0.6026642 | 0.8464147 | 0.603 | NA | NA |
| TPMT | trametinib | 0.6050220 | 0.8571145 | 0.60502 | NA | NA |
| ROS1 | sunitinib | 0.6060667 | 0.8777619 | 0.606 | NA | NA |
| BRCA2 | docetaxel | 0.6116514 | 0.8563752 | 0.612 | NA | NA |
| TSC1 | ponatinib | 0.6125905 | 0.9972326 | 0.613 | NA | NA |
| MET | ponatinib | 0.6159349 | 0.9972326 | 0.616 | NA | NA |
| PML | ponatinib | 0.6178115 | 0.9972326 | 0.618 | NA | NA |
| AKT1 | pazopanib | 0.6189835 | 0.9239682 | 0.6190 | NA | NA |
| CYP19A1 | crizotinib | 0.6190452 | 0.8464147 | 0.619 | NA | NA |
| JAK2 | afatinib | 0.6195384 | 0.7959129 | 0.620 | NA | NA |
| G6PD | sunitinib | 0.6213525 | 0.8777619 | 0.621 | NA | NA |
| MGMT | bosutinib monohydrate | 0.6222029 | 0.9571596 | 0.622 | NA | NA |
| KRAS | gefitinib | 0.6235545 | 0.8503583 | 0.624 | NA | NA |
| DNMT3A | tretinoin | 0.6240726 | 0.7578025 | 0.6241 | NA | NA |
| PDGFB | belinostat | 0.6267736 | 0.8458949 | 0.627 | NA | NA |
| MYD88 | pazopanib | 0.6271722 | 0.9239682 | 0.6272 | NA | NA |
| ROS1 | afatinib | 0.6282804 | 0.7959129 | 0.628 | NA | NA |
| TPMT | afatinib | 0.6320485 | 0.7959129 | 0.632 | NA | NA |
| AKT1 | trametinib | 0.6346674 | 0.8631476 | 0.63467 | NA | NA |
| EGFR | sunitinib | 0.6347395 | 0.8777619 | 0.635 | NA | NA |
| PML | erlotinib | 0.6360548 | 0.8537089 | 0.636 | NA | NA |
| PDGFRB | alectinib | 0.6381495 | 0.8897754 | 0.638 | NA | NA |
| KRAS | imatinib | 0.6424818 | 0.8938878 | 0.642 | NA | NA |
| MGMT | sunitinib | 0.6441449 | 0.8777619 | 0.644 | NA | NA |
| EGFR | ruxolitinib | 0.6447588 | 0.9526741 | 0.645 | NA | NA |
| NPM1 | rucaparib | 0.6448258 | 0.8467310 | 0.645 | NA | NA |
| DNMT3A | ponatinib | 0.6448404 | 0.9972326 | 0.645 | NA | NA |
| KRAS | lapatinib | 0.6456344 | 0.9838238 | 0.646 | NA | NA |
| UGT1A1 | gefitinib | 0.6466857 | 0.8503583 | 0.647 | NA | NA |
| PDGFB | rucaparib | 0.6469333 | 0.8467310 | 0.647 | NA | NA |
| ALK | docetaxel | 0.6482988 | 0.8563752 | 0.648 | NA | NA |
| FLT3 | midostaurin | 0.6526579 | 0.8534757 | 0.6527 | NA | NA |
| ERBB3 | ruxolitinib | 0.6532068 | 0.9526741 | 0.653 | NA | NA |
| TSC2 | gefitinib | 0.6534622 | 0.8503583 | 0.653 | NA | NA |
| UGT1A1 | alectinib | 0.6542466 | 0.8897754 | 0.654 | NA | NA |
| TSC2 | bosutinib monohydrate | 0.6543872 | 0.9571596 | 0.654 | NA | NA |
| KIT | sunitinib | 0.6583214 | 0.8777619 | 0.658 | NA | NA |
| PTCH1 | crizotinib | 0.6605698 | 0.8464147 | 0.661 | NA | NA |
| PDGFRB | pazopanib | 0.6626651 | 0.9239682 | 0.6627 | NA | NA |
| IDH2 | erlotinib | 0.6634451 | 0.8537089 | 0.663 | NA | NA |
| MGMT | temozolomide | 0.6634570 | 0.8360585 | 0.6635 | NA | NA |
| ALK | vismodegib | 0.6657344 | 0.9773105 | 0.67 | NA | NA |
| MYD88 | palbociclib | 0.6675616 | 0.8695381 | 0.6676 | NA | NA |
| FLT3 | belinostat | 0.6686147 | 0.8458949 | 0.669 | NA | NA |
| FLT3 | ponatinib | 0.6691061 | 0.9972326 | 0.669 | NA | NA |
| PDGFB | crizotinib | 0.6714054 | 0.8464147 | 0.671 | NA | NA |
| DNMT3A | dabrafenib | 0.6722330 | 0.8621835 | 0.67223 | NA | NA |
| FLT3 | docetaxel | 0.6723654 | 0.8563752 | 0.672 | NA | NA |
| MET | ruxolitinib | 0.6724758 | 0.9526741 | 0.672 | NA | NA |
| ROS1 | pazopanib | 0.6730661 | 0.9239682 | 0.6731 | NA | NA |
| BRCA2 | nilotinib | 0.6739857 | 0.8184112 | 0.674 | NA | NA |
| ROS1 | temozolomide | 0.6751390 | 0.8360585 | 0.6751 | NA | NA |
| PML | gefitinib | 0.6752846 | 0.8503583 | 0.675 | NA | NA |
| AKT1 | rucaparib | 0.6766724 | 0.8467310 | 0.677 | NA | NA |
| EGFR | belinostat | 0.6783585 | 0.8458949 | 0.678 | NA | NA |
| ESR1 | dasatinib | 0.6806688 | 0.9470657 | 0.681 | NA | NA |
| ERBB2 | rucaparib | 0.6813788 | 0.8467310 | 0.681 | NA | NA |
| ESR1 | lapatinib | 0.6823352 | 0.9878187 | 0.682 | NA | NA |
| PDGFRA | erlotinib | 0.6824019 | 0.8537089 | 0.682 | NA | NA |
| PDGFRA | ponatinib | 0.6831311 | 0.9972326 | 0.683 | NA | NA |
| ESR1 | midostaurin | 0.6835330 | 0.8607452 | 0.6835 | NA | NA |
| ESR1 | tretinoin | 0.6845216 | 0.8025426 | 0.6845 | NA | NA |
| BRCA1 | dabrafenib | 0.6846752 | 0.8621835 | 0.68468 | NA | NA |
| KRAS | rucaparib | 0.6847697 | 0.8467310 | 0.685 | NA | NA |
| BRCA1 | palbociclib | 0.6850052 | 0.8695381 | 0.6850 | NA | NA |
| RET | belinostat | 0.6890334 | 0.8458949 | 0.689 | NA | NA |
| MYD88 | crizotinib | 0.6896981 | 0.8464147 | 0.690 | NA | NA |
| CYP19A1 | bosutinib monohydrate | 0.6902719 | 0.9571596 | 0.690 | NA | NA |
| MGMT | pazopanib | 0.6911734 | 0.9239682 | 0.6912 | NA | NA |
| ALK | alectinib | 0.6916060 | 0.9044078 | 0.692 | NA | NA |
| MET | temozolomide | 0.6917583 | 0.8360585 | 0.6918 | NA | NA |
| ESR1 | pazopanib | 0.6922709 | 0.9239682 | 0.6923 | NA | NA |
| PML | cabozantinib | 0.6926459 | 0.9262331 | 0.6926 | NA | NA |
| PDGFB | cabozantinib | 0.6931930 | 0.9262331 | 0.6932 | NA | NA |
| ESR1 | trametinib | 0.6962680 | 0.9060078 | 0.69627 | NA | NA |
| ABL1 | temozolomide | 0.6987934 | 0.8360585 | 0.6988 | NA | NA |
| BRCA1 | docetaxel | 0.7001716 | 0.8563752 | 0.700 | NA | NA |
| BRCA1 | crizotinib | 0.7017863 | 0.8464147 | 0.702 | NA | NA |
| PML | dasatinib | 0.7028188 | 0.9470657 | 0.703 | NA | NA |
| TSC1 | dasatinib | 0.7033301 | 0.9470657 | 0.703 | NA | NA |
| G6PD | crizotinib | 0.7040235 | 0.8464147 | 0.704 | NA | NA |
| ERBB2 | docetaxel | 0.7052502 | 0.8563752 | 0.705 | NA | NA |
| UGT1A1 | ponatinib | 0.7062488 | 0.9972326 | 0.706 | NA | NA |
| ROS1 | vismodegib | 0.7075936 | 0.9773105 | 0.71 | NA | NA |
| ERBB2 | palbociclib | 0.7083268 | 0.8695381 | 0.7083 | NA | NA |
| TSC2 | belinostat | 0.7089749 | 0.8458949 | 0.709 | NA | NA |
| IDH2 | dasatinib | 0.7090830 | 0.9470657 | 0.709 | NA | NA |
| ALK | erlotinib | 0.7099827 | 0.8537089 | 0.710 | NA | NA |
| JAK2 | dasatinib | 0.7103203 | 0.9470657 | 0.710 | NA | NA |
| RET | dabrafenib | 0.7105653 | 0.8628293 | 0.71057 | NA | NA |
| KRAS | ruxolitinib | 0.7137147 | 0.9613264 | 0.714 | NA | NA |
| RET | dasatinib | 0.7148163 | 0.9470657 | 0.715 | NA | NA |
| KRAS | temozolomide | 0.7150718 | 0.8360585 | 0.7151 | NA | NA |
| ESR1 | cabozantinib | 0.7161231 | 0.9262331 | 0.7161 | NA | NA |
| EGFR | trametinib | 0.7194767 | 0.9060078 | 0.71948 | NA | NA |
| PTCH1 | vismodegib | 0.7198241 | 0.9773105 | 0.72 | NA | NA |
| ERBB3 | erlotinib | 0.7203169 | 0.8537089 | 0.720 | NA | NA |
| PDGFRB | ponatinib | 0.7240517 | 0.9972326 | 0.724 | NA | NA |
| ERBB3 | rucaparib | 0.7263040 | 0.8467310 | 0.726 | NA | NA |
| DPYD | pazopanib | 0.7284979 | 0.9239682 | 0.7285 | NA | NA |
| PDGFRB | palbociclib | 0.7303977 | 0.8695381 | 0.7304 | NA | NA |
| ABL1 | nilotinib | 0.7313136 | 0.8564973 | 0.731 | NA | NA |
| BRAF | temozolomide | 0.7335771 | 0.8360585 | 0.7336 | NA | NA |
| EGFR | docetaxel | 0.7346881 | 0.8613585 | 0.735 | NA | NA |
| PML | ruxolitinib | 0.7351319 | 0.9613264 | 0.735 | NA | NA |
| CYP19A1 | temozolomide | 0.7376987 | 0.8360585 | 0.7377 | NA | NA |
| PDGFRA | crizotinib | 0.7390621 | 0.8464147 | 0.739 | NA | NA |
| KIT | dasatinib | 0.7398951 | 0.9470657 | 0.740 | NA | NA |
| ERBB3 | crizotinib | 0.7406129 | 0.8464147 | 0.741 | NA | NA |
| AKT1 | afatinib | 0.7407741 | 0.8995114 | 0.741 | NA | NA |
| DPYD | sunitinib | 0.7414533 | 0.8823886 | 0.741 | NA | NA |
| KRAS | bosutinib monohydrate | 0.7414809 | 0.9571596 | 0.741 | NA | NA |
| TSC1 | cabozantinib | 0.7417760 | 0.9262331 | 0.7418 | NA | NA |
| CYP19A1 | ponatinib | 0.7421820 | 0.9972326 | 0.742 | NA | NA |
| PDGFRB | bosutinib monohydrate | 0.7429860 | 0.9571596 | 0.743 | NA | NA |
| IDH2 | imatinib | 0.7435570 | 0.9237192 | 0.744 | NA | NA |
| PDGFRA | belinostat | 0.7450686 | 0.8458949 | 0.745 | NA | NA |
| TPMT | midostaurin | 0.7460273 | 0.9058903 | 0.7460 | NA | NA |
| PML | belinostat | 0.7463779 | 0.8458949 | 0.746 | NA | NA |
| BRCA1 | imatinib | 0.7500850 | 0.9237192 | 0.750 | NA | NA |
| KIT | imatinib | 0.7505218 | 0.9237192 | 0.751 | NA | NA |
| EGFR | palbociclib | 0.7514260 | 0.8695381 | 0.7514 | NA | NA |
| DNMT3A | bosutinib monohydrate | 0.7551741 | 0.9571596 | 0.755 | NA | NA |
| PDGFRA | pazopanib | 0.7583124 | 0.9239682 | 0.7583 | NA | NA |
| DNMT3A | alectinib | 0.7613631 | 0.9273034 | 0.761 | NA | NA |
| TPMT | rucaparib | 0.7619662 | 0.8467310 | 0.762 | NA | NA |
| AKT1 | gefitinib | 0.7625117 | 0.8968173 | 0.763 | NA | NA |
| G6PD | trametinib | 0.7631155 | 0.9266403 | 0.76312 | NA | NA |
| EGFR | pazopanib | 0.7631271 | 0.9239682 | 0.7631 | NA | NA |
| MGMT | alectinib | 0.7636616 | 0.9273034 | 0.764 | NA | NA |
| PDGFB | bosutinib monohydrate | 0.7637526 | 0.9571596 | 0.764 | NA | NA |
| KRAS | sunitinib | 0.7642647 | 0.8823886 | 0.764 | NA | NA |
| PDGFRB | gefitinib | 0.7649324 | 0.8968173 | 0.765 | NA | NA |
| TPMT | palbociclib | 0.7668585 | 0.8695381 | 0.7669 | NA | NA |
| CYP19A1 | palbociclib | 0.7672395 | 0.8695381 | 0.7672 | NA | NA |
| ABL1 | bosutinib monohydrate | 0.7708229 | 0.9571596 | 0.771 | NA | NA |
| ALK | tretinoin | 0.7717427 | 0.8561605 | 0.7717 | NA | NA |
| PDGFRA | lapatinib | 0.7718304 | 0.9878187 | 0.772 | NA | NA |
| PDGFB | pazopanib | 0.7722360 | 0.9239682 | 0.7722 | NA | NA |
| ERBB2 | vismodegib | 0.7739594 | 0.9773105 | 0.77 | NA | NA |
| KIT | docetaxel | 0.7747007 | 0.8752363 | 0.775 | NA | NA |
| PML | nilotinib | 0.7777017 | 0.8564973 | 0.778 | NA | NA |
| DPYD | tretinoin | 0.7806169 | 0.8561605 | 0.7806 | NA | NA |
| EGFR | rucaparib | 0.7812134 | 0.8467310 | 0.781 | NA | NA |
| MET | rucaparib | 0.7852325 | 0.8467310 | 0.785 | NA | NA |
| MYD88 | sunitinib | 0.7863908 | 0.8823886 | 0.786 | NA | NA |
| NPM1 | pazopanib | 0.7880905 | 0.9239682 | 0.7881 | NA | NA |
| MYD88 | imatinib | 0.7889569 | 0.9350600 | 0.789 | NA | NA |
| BRAF | ponatinib | 0.7903167 | 0.9972326 | 0.790 | NA | NA |
| BRCA1 | gefitinib | 0.7929047 | 0.8986254 | 0.793 | NA | NA |
| FLT3 | alectinib | 0.7941809 | 0.9311087 | 0.794 | NA | NA |
| BRAF | midostaurin | 0.7943467 | 0.9164533 | 0.7943 | NA | NA |
| PTCH1 | rucaparib | 0.7952280 | 0.8467310 | 0.795 | NA | NA |
| PML | docetaxel | 0.7980096 | 0.8752363 | 0.798 | NA | NA |
| NPM1 | vismodegib | 0.8004491 | 0.9773105 | 0.80 | NA | NA |
| PDGFRB | crizotinib | 0.8019048 | 0.8848604 | 0.802 | NA | NA |
| ERBB3 | trametinib | 0.8021031 | 0.9403967 | 0.80210 | NA | NA |
| FLT3 | afatinib | 0.8043606 | 0.9430434 | 0.804 | NA | NA |
| JAK2 | sunitinib | 0.8046870 | 0.8823886 | 0.805 | NA | NA |
| KRAS | nilotinib | 0.8058237 | 0.8564973 | 0.806 | NA | NA |
| IDH2 | nilotinib | 0.8061151 | 0.8564973 | 0.806 | NA | NA |
| IDH2 | ruxolitinib | 0.8073056 | 0.9802461 | 0.807 | NA | NA |
| FLT3 | tretinoin | 0.8076478 | 0.8581257 | 0.8076 | NA | NA |
| DPYD | belinostat | 0.8079628 | 0.8861528 | 0.808 | NA | NA |
| ESR1 | bosutinib monohydrate | 0.8080005 | 0.9571596 | 0.808 | NA | NA |
| DPYD | palbociclib | 0.8111267 | 0.8753990 | 0.8111 | NA | NA |
| RET | temozolomide | 0.8158960 | 0.8948536 | 0.8159 | NA | NA |
| BRCA1 | sunitinib | 0.8165800 | 0.8823886 | 0.817 | NA | NA |
| ERBB3 | dasatinib | 0.8180600 | 0.9608776 | 0.818 | NA | NA |
| G6PD | gefitinib | 0.8202116 | 0.8995869 | 0.820 | NA | NA |
| FLT3 | palbociclib | 0.8239049 | 0.8753990 | 0.8239 | NA | NA |
| EGFR | bosutinib monohydrate | 0.8249647 | 0.9571596 | 0.825 | NA | NA |
| BRCA1 | pazopanib | 0.8251732 | 0.9335674 | 0.8252 | NA | NA |
| MET | alectinib | 0.8262519 | 0.9364188 | 0.826 | NA | NA |
| G6PD | cabozantinib | 0.8264953 | 0.9262331 | 0.8265 | NA | NA |
| ERBB3 | sunitinib | 0.8272393 | 0.8823886 | 0.827 | NA | NA |
| TSC1 | dabrafenib | 0.8273766 | 0.9700277 | 0.82738 | NA | NA |
| G6PD | midostaurin | 0.8281741 | 0.9164533 | 0.8282 | NA | NA |
| FLT3 | ruxolitinib | 0.8312495 | 0.9802461 | 0.831 | NA | NA |
| MET | trametinib | 0.8326323 | 0.9436500 | 0.83263 | NA | NA |
| BRCA1 | cabozantinib | 0.8333837 | 0.9262331 | 0.8334 | NA | NA |
| MGMT | tretinoin | 0.8349168 | 0.8602173 | 0.8349 | NA | NA |
| CYP19A1 | rucaparib | 0.8350834 | 0.8467310 | 0.835 | NA | NA |
| MET | midostaurin | 0.8355898 | 0.9164533 | 0.8356 | NA | NA |
| RET | rucaparib | 0.8423514 | 0.8467310 | 0.842 | NA | NA |
| BRAF | cabozantinib | 0.8425783 | 0.9262331 | 0.8426 | NA | NA |
| UGT1A1 | rucaparib | 0.8467310 | 0.8467310 | 0.847 | NA | NA |
| ERBB2 | cabozantinib | 0.8477762 | 0.9262331 | 0.8478 | NA | NA |
| DNMT3A | gefitinib | 0.8493836 | 0.9024701 | 0.849 | NA | NA |
| TPMT | pazopanib | 0.8511938 | 0.9335674 | 0.8512 | NA | NA |
| KRAS | crizotinib | 0.8512775 | 0.8966708 | 0.851 | NA | NA |
| MET | cabozantinib | 0.8512783 | 0.9262331 | 0.8513 | NA | NA |
| JAK2 | imatinib | 0.8521878 | 0.9739289 | 0.852 | NA | NA |
| JAK2 | ruxolitinib | 0.8523436 | 0.9802461 | 0.852 | NA | NA |
| UGT1A1 | docetaxel | 0.8542969 | 0.9076904 | 0.854 | NA | NA |
| MET | dasatinib | 0.8543593 | 0.9608776 | 0.854 | NA | NA |
| MYD88 | ponatinib | 0.8552763 | 0.9972326 | 0.855 | NA | NA |
| DPYD | erlotinib | 0.8604995 | 0.9307227 | 0.860 | NA | NA |
| ROS1 | palbociclib | 0.8627523 | 0.8888963 | 0.8628 | NA | NA |
| NPM1 | afatinib | 0.8655570 | 0.9518372 | 0.866 | NA | NA |
| UGT1A1 | vismodegib | 0.8657073 | 0.9773105 | 0.87 | NA | NA |
| NPM1 | trametinib | 0.8672776 | 0.9512077 | 0.86728 | NA | NA |
| G6PD | dasatinib | 0.8682306 | 0.9608776 | 0.868 | NA | NA |
| KIT | crizotinib | 0.8686498 | 0.8966708 | 0.869 | NA | NA |
| ESR1 | ponatinib | 0.8695576 | 0.9972326 | 0.870 | NA | NA |
| FLT3 | bosutinib monohydrate | 0.8695733 | 0.9571596 | 0.870 | NA | NA |
| DNMT3A | lapatinib | 0.8744953 | 0.9878187 | 0.874 | NA | NA |
| ERBB3 | vismodegib | 0.8804120 | 0.9773105 | 0.88 | NA | NA |
| TPMT | ponatinib | 0.8811769 | 0.9972326 | 0.881 | NA | NA |
| JAK2 | midostaurin | 0.8847197 | 0.9400146 | 0.8847 | NA | NA |
| BRCA2 | ruxolitinib | 0.8869414 | 0.9802461 | 0.887 | NA | NA |
| MYD88 | bosutinib monohydrate | 0.8892270 | 0.9571596 | 0.889 | NA | NA |
| JAK2 | pazopanib | 0.8907594 | 0.9464319 | 0.8908 | NA | NA |
| BRCA2 | cabozantinib | 0.8957636 | 0.9262331 | 0.8958 | NA | NA |
| ROS1 | ruxolitinib | 0.8966205 | 0.9802461 | 0.897 | NA | NA |
| PML | trametinib | 0.8969530 | 0.9530125 | 0.89695 | NA | NA |
| MGMT | dasatinib | 0.8989855 | 0.9608776 | 0.899 | NA | NA |
| ALK | bosutinib monohydrate | 0.9008561 | 0.9571596 | 0.901 | NA | NA |
| BRAF | afatinib | 0.9011510 | 0.9518372 | 0.901 | NA | NA |
| ROS1 | crizotinib | 0.9055984 | 0.9055984 | 0.906 | NA | NA |
| TSC1 | belinostat | 0.9061702 | 0.9585223 | 0.906 | NA | NA |
| ERBB3 | docetaxel | 0.9076995 | 0.9352056 | 0.908 | NA | NA |
| AKT1 | temozolomide | 0.9094399 | 0.9462406 | 0.9094 | NA | NA |
| CYP19A1 | dabrafenib | 0.9107211 | 0.9949724 | 0.91072 | NA | NA |
| ESR1 | erlotinib | 0.9133687 | 0.9307227 | 0.913 | NA | NA |
| BRCA1 | lapatinib | 0.9142372 | 0.9878187 | 0.914 | NA | NA |
| EGFR | cabozantinib | 0.9149328 | 0.9262331 | 0.9149 | NA | NA |
| BRCA2 | sunitinib | 0.9151190 | 0.9216497 | 0.915 | NA | NA |
| TSC1 | gefitinib | 0.9156569 | 0.9283678 | 0.916 | NA | NA |
| ROS1 | imatinib | 0.9157097 | 1.0000000 | 0.916 | NA | NA |
| ERBB2 | ponatinib | 0.9158815 | 0.9972326 | 0.916 | NA | NA |
| BRAF | dasatinib | 0.9161548 | 0.9608776 | 0.916 | NA | NA |
| BRCA2 | dabrafenib | 0.9168207 | 0.9949724 | 0.91682 | NA | NA |
| G6PD | temozolomide | 0.9184100 | 0.9462406 | 0.9184 | NA | NA |
| JAK2 | lapatinib | 0.9210478 | 0.9878187 | 0.921 | NA | NA |
| NPM1 | sunitinib | 0.9216497 | 0.9216497 | 0.922 | NA | NA |
| EGFR | erlotinib | 0.9218958 | 0.9307227 | 0.922 | NA | NA |
| ROS1 | lapatinib | 0.9246091 | 0.9878187 | 0.925 | NA | NA |
| PDGFRA | ruxolitinib | 0.9248089 | 0.9802461 | 0.925 | NA | NA |
| KIT | ponatinib | 0.9257639 | 0.9972326 | 0.926 | NA | NA |
| UGT1A1 | cabozantinib | 0.9262331 | 0.9262331 | 0.9262 | NA | NA |
| PTCH1 | erlotinib | 0.9275623 | 0.9307227 | 0.928 | NA | NA |
| MYD88 | gefitinib | 0.9283678 | 0.9283678 | 0.928 | NA | NA |
| TSC1 | afatinib | 0.9300086 | 0.9518372 | 0.930 | NA | NA |
| KIT | belinostat | 0.9303304 | 0.9585223 | 0.930 | NA | NA |
| RET | erlotinib | 0.9307227 | 0.9307227 | 0.931 | NA | NA |
| MYD88 | lapatinib | 0.9323054 | 0.9878187 | 0.932 | NA | NA |
| MGMT | vismodegib | 0.9400649 | 0.9773105 | 0.94 | NA | NA |
| BRCA2 | trametinib | 0.9421624 | 0.9707128 | 0.94216 | NA | NA |
| IDH2 | alectinib | 0.9437117 | 0.9851623 | 0.944 | NA | NA |
| IDH2 | palbociclib | 0.9443484 | 0.9443484 | 0.9443 | NA | NA |
| EGFR | vismodegib | 0.9448114 | 0.9773105 | 0.94 | NA | NA |
| IDH2 | midostaurin | 0.9477169 | 0.9563247 | 0.9477 | NA | NA |
| ABL1 | vismodegib | 0.9494533 | 0.9773105 | 0.95 | NA | NA |
| ESR1 | afatinib | 0.9503087 | 0.9518372 | 0.950 | NA | NA |
| ROS1 | dasatinib | 0.9512458 | 0.9608776 | 0.951 | NA | NA |
| UGT1A1 | ruxolitinib | 0.9514154 | 0.9802461 | 0.951 | NA | NA |
| PML | afatinib | 0.9518372 | 0.9518372 | 0.952 | NA | NA |
| BRCA1 | temozolomide | 0.9526259 | 0.9526259 | 0.9526 | NA | NA |
| ALK | ponatinib | 0.9561548 | 0.9972326 | 0.956 | NA | NA |
| RET | midostaurin | 0.9563247 | 0.9563247 | 0.9563 | NA | NA |
| BRAF | lapatinib | 0.9579143 | 0.9878187 | 0.958 | NA | NA |
| RET | pazopanib | 0.9581510 | 0.9871859 | 0.9582 | NA | NA |
| PDGFRA | dasatinib | 0.9608776 | 0.9608776 | 0.961 | NA | NA |
| ALK | imatinib | 0.9639389 | 1.0000000 | 0.964 | NA | NA |
| DPYD | nilotinib | 0.9678380 | 0.9911966 | 0.968 | NA | NA |
| G6PD | lapatinib | 0.9681165 | 0.9878187 | 0.968 | NA | NA |
| IDH2 | dabrafenib | 0.9684328 | 0.9949724 | 0.96843 | NA | NA |
| KIT | alectinib | 0.9692528 | 0.9851623 | 0.969 | NA | NA |
| AKT1 | docetaxel | 0.9695144 | 0.9695144 | 0.970 | NA | NA |
| DNMT3A | belinostat | 0.9723117 | 0.9723117 | 0.972 | NA | NA |
| CYP19A1 | vismodegib | 0.9723531 | 0.9773105 | 0.97 | NA | NA |
| BRCA2 | vismodegib | 0.9733078 | 0.9773105 | 0.97 | NA | NA |
| PML | lapatinib | 0.9738117 | 0.9878187 | 0.974 | NA | NA |
| FLT3 | vismodegib | 0.9773105 | 0.9773105 | 0.98 | NA | NA |
| MYD88 | dabrafenib | 0.9773916 | 0.9949724 | 0.97739 | NA | NA |
| PDGFRB | trametinib | 0.9784811 | 0.9784811 | 0.97848 | NA | NA |
| KRAS | alectinib | 0.9838427 | 0.9851623 | 0.984 | NA | NA |
| TPMT | bosutinib monohydrate | 0.9847665 | 0.9984574 | 0.985 | NA | NA |
| ESR1 | alectinib | 0.9851623 | 0.9851623 | 0.985 | NA | NA |
| PTCH1 | lapatinib | 0.9878187 | 0.9878187 | 0.988 | NA | NA |
| PTCH1 | imatinib | 0.9882665 | 1.0000000 | 0.988 | NA | NA |
| JAK2 | ponatinib | 0.9882767 | 0.9972326 | 0.988 | NA | NA |
| ALK | nilotinib | 0.9911966 | 0.9911966 | 0.991 | NA | NA |
| MGMT | ruxolitinib | 0.9946721 | 0.9946721 | 0.995 | NA | NA |
| ROS1 | dabrafenib | 0.9949724 | 0.9949724 | 0.99497 | NA | NA |
| ABL1 | tretinoin | 0.9968006 | 0.9968006 | 0.9968 | NA | NA |
| AKT1 | ponatinib | 0.9972326 | 0.9972326 | 0.997 | NA | NA |
| JAK2 | bosutinib monohydrate | 0.9984574 | 0.9984574 | 0.998 | NA | NA |
| DNMT3A | pazopanib | 0.9995159 | 0.9995159 | 0.9995 | NA | NA |
| MGMT | imatinib | 1.0000000 | 1.0000000 | 1.000 | NA | NA |
Drug metadata:
drug_meta <- read.delim("./data_munging/drug_id_drug_name_table_10_12_2018.tsv", sep = "\t", header = FALSE)
colnames(drug_meta) <- c("CID", "Drug")
drug_meta$Drug <- tolower(drug_meta$Drug)
CCLE:
user system elapsed 1483.399 262.649 1901.698
ccle <- read.delim("./data_munging/data_drug_auc_ccle_10_12_2018.csv", sep = "\t", header = TRUE, row.names = 1, check.names = FALSE)
ccle <- merge(drug_meta, ccle, by = "CID")
ccle_melt <- melt(ccle, id.vars = c("CID", "Drug"), measure.vars = colnames(ccle)[3:ncol(ccle)], variable.name = "accession_id", value.name = "AUC")
ccle_grid <- expand.grid("accession_id" = unique(ccle_melt$accession_id), "Hugo_Symbol" = as.character(unique(crispr_data$Hugo_Symbol)))
system.time({ ccle_data_allgenes <- WilcoxonByDrugAllGenes(ccle_melt, ccle_grid, "CCLE") })
saveRDS(ccle_data_allgenes, "./data_munging/rds/ccle_data_18Q3_allgenes.rds", compress = "xz")
ccle_data_allgenes <- readRDS("./data_munging/rds/ccle_data_18Q3_allgenes.rds")
ccle_data_allgenes <- ccle_data_allgenes[order(ccle_data_allgenes$p),]
knitr::kable(ccle_data_allgenes[1:1000, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CCLE: by-drug Wilcoxon test results for point mutations in genes targeted in CRISPR screen (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | Drug | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|---|
| BRAF | selumetinib | 0.0000000 | 0.0008120 | 4.8e-08 | **** | *** |
| NRAS | selumetinib | 0.0000274 | 0.2300368 | 2.7e-05 | **** | NA |
| RABGAP1L | irinotecan | 0.0001104 | 0.8246221 | 0.00011 | *** | NA |
| PEX1 | lapatinib | 0.0001436 | 0.8066236 | 0.00014 | *** | NA |
| FOLH1 | irinotecan | 0.0001732 | 0.8246221 | 0.00017 | *** | NA |
| GAB1 | lapatinib | 0.0002666 | 0.8066236 | 0.00027 | *** | NA |
| SGTA | erlotinib | 0.0002996 | 0.8499467 | 0.00030 | *** | NA |
| PEX1 | erlotinib | 0.0003338 | 0.8499467 | 0.00033 | *** | NA |
| KNSTRN | lapatinib | 0.0003433 | 0.8066236 | 0.00034 | *** | NA |
| RAPGEFL1 | lapatinib | 0.0004253 | 0.8066236 | 0.00043 | *** | NA |
| LRP4 | lapatinib | 0.0004426 | 0.8066236 | 0.00044 | *** | NA |
| KRAS | selumetinib | 0.0004853 | 0.9529374 | 0.00049 | *** | NA |
| PM20D1 | lapatinib | 0.0004931 | 0.8066236 | 0.00049 | *** | NA |
| DTHD1 | selumetinib | 0.0005008 | 0.9529374 | 0.00050 | *** | NA |
| ZNF354A | erlotinib | 0.0005094 | 0.8499467 | 0.00051 | *** | NA |
| KLHL17 | irinotecan | 0.0005574 | 0.8246221 | 0.00056 | *** | NA |
| ZNF226 | erlotinib | 0.0005593 | 0.8499467 | 0.00056 | *** | NA |
| PREX1 | lapatinib | 0.0005712 | 0.8066236 | 0.00057 | *** | NA |
| LRRC37A2 | irinotecan | 0.0006426 | 0.8246221 | 0.00064 | *** | NA |
| SMTN | selumetinib | 0.0006605 | 0.9529374 | 0.00066 | *** | NA |
| IRF2BPL | selumetinib | 0.0006651 | 0.9529374 | 0.00067 | *** | NA |
| PCSK7 | lapatinib | 0.0006916 | 0.8066236 | 0.00069 | *** | NA |
| POP1 | selumetinib | 0.0006964 | 0.9529374 | 0.00070 | *** | NA |
| SLC44A3 | irinotecan | 0.0006970 | 0.8246221 | 0.00070 | *** | NA |
| SLC15A1 | lapatinib | 0.0007197 | 0.8066236 | 0.00072 | *** | NA |
| TGFBI | lapatinib | 0.0007397 | 0.8066236 | 0.00074 | *** | NA |
| TOPORS | lapatinib | 0.0007696 | 0.8066236 | 0.00077 | *** | NA |
| MIPOL1 | lapatinib | 0.0008036 | 0.8066236 | 0.00080 | *** | NA |
| LPO | selumetinib | 0.0009174 | 0.9529374 | 0.00092 | *** | NA |
| C20orf195 | lapatinib | 0.0009346 | 0.8066236 | 0.00093 | *** | NA |
| MAP10 | erlotinib | 0.0009792 | 0.8499467 | 0.00098 | *** | NA |
| PM20D1 | erlotinib | 0.0010281 | 0.8499467 | 0.00103 | ** | NA |
| DENND1B | erlotinib | 0.0010534 | 0.8499467 | 0.00105 | ** | NA |
| RTFDC1 | lapatinib | 0.0010911 | 0.8066236 | 0.00109 | ** | NA |
| ASB15 | nilotinib | 0.0010997 | 0.9993215 | 0.0011 | ** | NA |
| KIF11 | irinotecan | 0.0011053 | 0.8246221 | 0.00111 | ** | NA |
| ENAM | lapatinib | 0.0011374 | 0.8066236 | 0.00114 | ** | NA |
| FAM154B | erlotinib | 0.0011487 | 0.8499467 | 0.00115 | ** | NA |
| OR4M2 | irinotecan | 0.0011493 | 0.8246221 | 0.00115 | ** | NA |
| GZMH | erlotinib | 0.0011644 | 0.8499467 | 0.00116 | ** | NA |
| LRP4 | erlotinib | 0.0011988 | 0.8499467 | 0.00120 | ** | NA |
| PUS7 | lapatinib | 0.0012109 | 0.8066236 | 0.00121 | ** | NA |
| TUBA3E | selumetinib | 0.0012119 | 0.9529374 | 0.00121 | ** | NA |
| OR4K15 | lapatinib | 0.0012601 | 0.8066236 | 0.00126 | ** | NA |
| LGALS3BP | lapatinib | 0.0012852 | 0.8066236 | 0.00129 | ** | NA |
| REL | erlotinib | 0.0012883 | 0.8499467 | 0.00129 | ** | NA |
| CBFA2T3 | erlotinib | 0.0013360 | 0.8499467 | 0.00134 | ** | NA |
| PAN3 | irinotecan | 0.0013548 | 0.8246221 | 0.00135 | ** | NA |
| ZSCAN21 | erlotinib | 0.0013669 | 0.8499467 | 0.00137 | ** | NA |
| PRDM9 | erlotinib | 0.0013817 | 0.8499467 | 0.00138 | ** | NA |
| TRPM3 | irinotecan | 0.0013863 | 0.8246221 | 0.00139 | ** | NA |
| SGTA | lapatinib | 0.0013901 | 0.8066236 | 0.00139 | ** | NA |
| ERCC2 | lapatinib | 0.0014506 | 0.8066236 | 0.00145 | ** | NA |
| C1QTNF9 | erlotinib | 0.0014698 | 0.8499467 | 0.00147 | ** | NA |
| MS4A6A | selumetinib | 0.0014716 | 0.9529374 | 0.00147 | ** | NA |
| C1orf56 | erlotinib | 0.0014847 | 0.8499467 | 0.00148 | ** | NA |
| JPH2 | erlotinib | 0.0014979 | 0.8499467 | 0.00150 | ** | NA |
| NES | lapatinib | 0.0015102 | 0.8066236 | 0.00151 | ** | NA |
| KIAA1462 | selumetinib | 0.0015357 | 0.9529374 | 0.00154 | ** | NA |
| SLC35F3 | lapatinib | 0.0015924 | 0.8066236 | 0.00159 | ** | NA |
| MS4A8 | erlotinib | 0.0016519 | 0.8499467 | 0.00165 | ** | NA |
| SLITRK5 | lapatinib | 0.0016662 | 0.8066236 | 0.00167 | ** | NA |
| DLST | selumetinib | 0.0016934 | 0.9529374 | 0.00169 | ** | NA |
| GCAT | lapatinib | 0.0016991 | 0.8066236 | 0.00170 | ** | NA |
| LCK | selumetinib | 0.0017132 | 0.9529374 | 0.00171 | ** | NA |
| AGO4 | lapatinib | 0.0017146 | 0.8066236 | 0.00171 | ** | NA |
| SUN2 | erlotinib | 0.0017415 | 0.8499467 | 0.00174 | ** | NA |
| GIPC3 | lapatinib | 0.0017491 | 0.8066236 | 0.00175 | ** | NA |
| NCAPG2 | irinotecan | 0.0017741 | 0.8246221 | 0.00177 | ** | NA |
| INPP4B | nilotinib | 0.0017783 | 0.9993215 | 0.0018 | ** | NA |
| WDYHV1 | selumetinib | 0.0017802 | 0.9529374 | 0.00178 | ** | NA |
| FCRLA | erlotinib | 0.0018082 | 0.8499467 | 0.00181 | ** | NA |
| ABRA | irinotecan | 0.0018168 | 0.8246221 | 0.00182 | ** | NA |
| DFFA | lapatinib | 0.0018213 | 0.8066236 | 0.00182 | ** | NA |
| CBFA2T3 | lapatinib | 0.0018394 | 0.8066236 | 0.00184 | ** | NA |
| ITPR3 | nilotinib | 0.0018422 | 0.9993215 | 0.0018 | ** | NA |
| POU2F2 | selumetinib | 0.0018601 | 0.9529374 | 0.00186 | ** | NA |
| KCTD11 | irinotecan | 0.0019772 | 0.8246221 | 0.00198 | ** | NA |
| ANO3 | erlotinib | 0.0020105 | 0.8499467 | 0.00201 | ** | NA |
| HDAC7 | selumetinib | 0.0020609 | 0.9529374 | 0.00206 | ** | NA |
| ETV6 | selumetinib | 0.0021320 | 0.9529374 | 0.00213 | ** | NA |
| SLC2A9 | irinotecan | 0.0021647 | 0.8246221 | 0.00216 | ** | NA |
| ERCC2 | erlotinib | 0.0022218 | 0.8499467 | 0.00222 | ** | NA |
| WDYHV1 | lapatinib | 0.0022250 | 0.8066236 | 0.00223 | ** | NA |
| FAM35A | lapatinib | 0.0022812 | 0.8066236 | 0.00228 | ** | NA |
| GRAMD1C | irinotecan | 0.0023123 | 0.8246221 | 0.00231 | ** | NA |
| TPR | lapatinib | 0.0023145 | 0.8066236 | 0.00231 | ** | NA |
| ARHGEF2 | erlotinib | 0.0023552 | 0.8499467 | 0.00236 | ** | NA |
| MEOX2 | erlotinib | 0.0023721 | 0.8499467 | 0.00237 | ** | NA |
| PROM2 | lapatinib | 0.0023864 | 0.8066236 | 0.00239 | ** | NA |
| HADHA | lapatinib | 0.0024247 | 0.8066236 | 0.00242 | ** | NA |
| TP73 | selumetinib | 0.0024287 | 0.9529374 | 0.00243 | ** | NA |
| APOPT1 | erlotinib | 0.0024784 | 0.8499467 | 0.00248 | ** | NA |
| XPOT | selumetinib | 0.0025000 | 0.9529374 | 0.00250 | ** | NA |
| ABCE1 | irinotecan | 0.0025047 | 0.8246221 | 0.00250 | ** | NA |
| PPP4R2 | erlotinib | 0.0025121 | 0.8499467 | 0.00251 | ** | NA |
| CCDC137 | lapatinib | 0.0025383 | 0.8066236 | 0.00254 | ** | NA |
| ANKHD1 | selumetinib | 0.0025644 | 0.9529374 | 0.00256 | ** | NA |
| APBB1IP | irinotecan | 0.0026127 | 0.8246221 | 0.00261 | ** | NA |
| ADAMTSL2 | erlotinib | 0.0026349 | 0.8499467 | 0.00263 | ** | NA |
| SECISBP2 | nilotinib | 0.0027052 | 0.9993215 | 0.0027 | ** | NA |
| PPARGC1A | irinotecan | 0.0027202 | 0.8246221 | 0.00272 | ** | NA |
| MCRS1 | selumetinib | 0.0027255 | 0.9529374 | 0.00273 | ** | NA |
| RICTOR | lapatinib | 0.0027531 | 0.8066236 | 0.00275 | ** | NA |
| IRF2BP1 | erlotinib | 0.0027609 | 0.8499467 | 0.00276 | ** | NA |
| AZIN1 | lapatinib | 0.0027842 | 0.8066236 | 0.00278 | ** | NA |
| WDR45B | erlotinib | 0.0027981 | 0.8499467 | 0.00280 | ** | NA |
| ACSL6 | lapatinib | 0.0028179 | 0.8066236 | 0.00282 | ** | NA |
| TBC1D23 | erlotinib | 0.0028271 | 0.8499467 | 0.00283 | ** | NA |
| SIX4 | erlotinib | 0.0028336 | 0.8499467 | 0.00283 | ** | NA |
| RSPH10B | lapatinib | 0.0028698 | 0.8066236 | 0.00287 | ** | NA |
| CAPNS1 | selumetinib | 0.0028928 | 0.9529374 | 0.00289 | ** | NA |
| MDGA2 | erlotinib | 0.0029270 | 0.8499467 | 0.00293 | ** | NA |
| FERMT2 | lapatinib | 0.0030272 | 0.8066236 | 0.00303 | ** | NA |
| ACACB | lapatinib | 0.0030364 | 0.8066236 | 0.00304 | ** | NA |
| ZNF99 | selumetinib | 0.0030473 | 0.9529374 | 0.00305 | ** | NA |
| RARA | selumetinib | 0.0030492 | 0.9529374 | 0.00305 | ** | NA |
| SLC2A14 | erlotinib | 0.0030651 | 0.8499467 | 0.00307 | ** | NA |
| FSIP1 | irinotecan | 0.0030928 | 0.8246221 | 0.00309 | ** | NA |
| HTRA3 | lapatinib | 0.0031539 | 0.8066236 | 0.00315 | ** | NA |
| ECI1 | lapatinib | 0.0031886 | 0.8066236 | 0.00319 | ** | NA |
| PCDHA12 | selumetinib | 0.0032043 | 0.9529374 | 0.00320 | ** | NA |
| SLC16A6 | irinotecan | 0.0032476 | 0.8246221 | 0.00325 | ** | NA |
| BMP2K | lapatinib | 0.0032875 | 0.8066236 | 0.00329 | ** | NA |
| TMEM117 | lapatinib | 0.0033057 | 0.8066236 | 0.00331 | ** | NA |
| ANXA10 | erlotinib | 0.0033296 | 0.8499467 | 0.00333 | ** | NA |
| ZNF226 | lapatinib | 0.0033324 | 0.8066236 | 0.00333 | ** | NA |
| SPOCK3 | lapatinib | 0.0033562 | 0.8066236 | 0.00336 | ** | NA |
| TBC1D23 | lapatinib | 0.0033587 | 0.8066236 | 0.00336 | ** | NA |
| IDUA | irinotecan | 0.0033599 | 0.8246221 | 0.00336 | ** | NA |
| CDK5RAP1 | lapatinib | 0.0034196 | 0.8066236 | 0.00342 | ** | NA |
| BAZ1B | irinotecan | 0.0034370 | 0.8246221 | 0.00344 | ** | NA |
| HCRTR1 | lapatinib | 0.0034651 | 0.8066236 | 0.00347 | ** | NA |
| HSPD1 | selumetinib | 0.0034668 | 0.9529374 | 0.00347 | ** | NA |
| SMG5 | selumetinib | 0.0034715 | 0.9529374 | 0.00347 | ** | NA |
| AGO4 | erlotinib | 0.0034911 | 0.8499467 | 0.00349 | ** | NA |
| INTS4 | irinotecan | 0.0034962 | 0.8246221 | 0.00350 | ** | NA |
| HAL | selumetinib | 0.0035473 | 0.9529374 | 0.00355 | ** | NA |
| KATNAL1 | selumetinib | 0.0035604 | 0.9529374 | 0.00356 | ** | NA |
| CYP1A1 | erlotinib | 0.0036235 | 0.8499467 | 0.00362 | ** | NA |
| FANCF | erlotinib | 0.0036323 | 0.8499467 | 0.00363 | ** | NA |
| FREM1 | erlotinib | 0.0037088 | 0.8499467 | 0.00371 | ** | NA |
| DICER1 | irinotecan | 0.0037385 | 0.8246221 | 0.00374 | ** | NA |
| FLOT2 | erlotinib | 0.0037527 | 0.8499467 | 0.00375 | ** | NA |
| CCDC144A | nilotinib | 0.0037547 | 0.9993215 | 0.0038 | ** | NA |
| ESRP2 | lapatinib | 0.0037807 | 0.8066236 | 0.00378 | ** | NA |
| PPP3CA | erlotinib | 0.0037903 | 0.8499467 | 0.00379 | ** | NA |
| PCDH17 | lapatinib | 0.0038402 | 0.8066236 | 0.00384 | ** | NA |
| CERS3 | lapatinib | 0.0038458 | 0.8066236 | 0.00385 | ** | NA |
| ZNF461 | irinotecan | 0.0038504 | 0.8246221 | 0.00385 | ** | NA |
| NMT2 | selumetinib | 0.0038634 | 0.9529374 | 0.00386 | ** | NA |
| SHROOM3 | irinotecan | 0.0039148 | 0.8246221 | 0.00391 | ** | NA |
| VSIG8 | erlotinib | 0.0039542 | 0.8499467 | 0.00395 | ** | NA |
| FAM126B | nilotinib | 0.0039781 | 0.9993215 | 0.0040 | ** | NA |
| FRMD6 | irinotecan | 0.0039810 | 0.8246221 | 0.00398 | ** | NA |
| MAP2 | lapatinib | 0.0040094 | 0.8066236 | 0.00401 | ** | NA |
| CNGB3 | selumetinib | 0.0040417 | 0.9529374 | 0.00404 | ** | NA |
| LCP2 | lapatinib | 0.0040425 | 0.8066236 | 0.00404 | ** | NA |
| CD6 | lapatinib | 0.0040439 | 0.8066236 | 0.00404 | ** | NA |
| COL9A2 | irinotecan | 0.0040671 | 0.8246221 | 0.00407 | ** | NA |
| MUS81 | irinotecan | 0.0040752 | 0.8246221 | 0.00408 | ** | NA |
| IL16 | lapatinib | 0.0040892 | 0.8066236 | 0.00409 | ** | NA |
| COQ3 | erlotinib | 0.0041012 | 0.8499467 | 0.00410 | ** | NA |
| MGEA5 | erlotinib | 0.0041248 | 0.8499467 | 0.00412 | ** | NA |
| ZNF107 | irinotecan | 0.0041445 | 0.8246221 | 0.00414 | ** | NA |
| NUDT13 | erlotinib | 0.0041462 | 0.8499467 | 0.00415 | ** | NA |
| ROBO4 | selumetinib | 0.0041520 | 0.9529374 | 0.00415 | ** | NA |
| KLHL2 | selumetinib | 0.0041855 | 0.9529374 | 0.00419 | ** | NA |
| ZNF473 | selumetinib | 0.0041885 | 0.9529374 | 0.00419 | ** | NA |
| HIST1H1D | irinotecan | 0.0042434 | 0.8246221 | 0.00424 | ** | NA |
| CDKN2A | selumetinib | 0.0042499 | 0.9529374 | 0.00425 | ** | NA |
| DMTN | selumetinib | 0.0042656 | 0.9529374 | 0.00427 | ** | NA |
| ADHFE1 | lapatinib | 0.0042820 | 0.8066236 | 0.00428 | ** | NA |
| HELLS | selumetinib | 0.0043297 | 0.9529374 | 0.00433 | ** | NA |
| QPCTL | lapatinib | 0.0043378 | 0.8066236 | 0.00434 | ** | NA |
| USP48 | irinotecan | 0.0043688 | 0.8246221 | 0.00437 | ** | NA |
| SECISBP2 | irinotecan | 0.0043772 | 0.8246221 | 0.00438 | ** | NA |
| PCDH9 | lapatinib | 0.0044051 | 0.8066236 | 0.00441 | ** | NA |
| RHCE | irinotecan | 0.0044191 | 0.8246221 | 0.00442 | ** | NA |
| OR8B2 | lapatinib | 0.0044334 | 0.8066236 | 0.00443 | ** | NA |
| ARID4B | erlotinib | 0.0044434 | 0.8499467 | 0.00444 | ** | NA |
| ANGPTL6 | lapatinib | 0.0044757 | 0.8066236 | 0.00448 | ** | NA |
| MEIS1 | erlotinib | 0.0044837 | 0.8499467 | 0.00448 | ** | NA |
| SCN3A | lapatinib | 0.0044837 | 0.8066236 | 0.00448 | ** | NA |
| FIBP | lapatinib | 0.0044922 | 0.8066236 | 0.00449 | ** | NA |
| EYA3 | irinotecan | 0.0044959 | 0.8246221 | 0.00450 | ** | NA |
| HIST1H1D | erlotinib | 0.0044980 | 0.8499467 | 0.00450 | ** | NA |
| FARP2 | selumetinib | 0.0044980 | 0.9529374 | 0.00450 | ** | NA |
| OR51L1 | lapatinib | 0.0045055 | 0.8066236 | 0.00451 | ** | NA |
| PEX14 | erlotinib | 0.0045642 | 0.8499467 | 0.00456 | ** | NA |
| ARHGAP17 | erlotinib | 0.0045712 | 0.8499467 | 0.00457 | ** | NA |
| ACOX2 | lapatinib | 0.0045799 | 0.8066236 | 0.00458 | ** | NA |
| QPCTL | selumetinib | 0.0045992 | 0.9529374 | 0.00460 | ** | NA |
| CYP2B6 | irinotecan | 0.0046127 | 0.8246221 | 0.00461 | ** | NA |
| SULT4A1 | lapatinib | 0.0046981 | 0.8066236 | 0.00470 | ** | NA |
| BPIFB1 | erlotinib | 0.0047001 | 0.8499467 | 0.00470 | ** | NA |
| PNO1 | lapatinib | 0.0047293 | 0.8066236 | 0.00473 | ** | NA |
| FREM1 | lapatinib | 0.0047570 | 0.8066236 | 0.00476 | ** | NA |
| ASB15 | irinotecan | 0.0047887 | 0.8246221 | 0.00479 | ** | NA |
| SLC2A1 | lapatinib | 0.0048357 | 0.8066236 | 0.00484 | ** | NA |
| C2CD4A | nilotinib | 0.0048492 | 0.9993215 | 0.0048 | ** | NA |
| SLC16A7 | selumetinib | 0.0048970 | 0.9529374 | 0.00490 | ** | NA |
| HNRNPA3 | lapatinib | 0.0049062 | 0.8066236 | 0.00491 | ** | NA |
| PNLIPRP1 | irinotecan | 0.0049122 | 0.8246221 | 0.00491 | ** | NA |
| VWA8 | irinotecan | 0.0049243 | 0.8246221 | 0.00492 | ** | NA |
| XDH | lapatinib | 0.0049633 | 0.8066236 | 0.00496 | ** | NA |
| KCNMA1 | selumetinib | 0.0050099 | 0.9529374 | 0.00501 | ** | NA |
| SORBS3 | selumetinib | 0.0050481 | 0.9529374 | 0.00505 | ** | NA |
| MORF4L1 | erlotinib | 0.0050571 | 0.8499467 | 0.00506 | ** | NA |
| IGFBP2 | selumetinib | 0.0050839 | 0.9529374 | 0.00508 | ** | NA |
| CUL3 | irinotecan | 0.0050894 | 0.8246221 | 0.00509 | ** | NA |
| MCAT | erlotinib | 0.0051029 | 0.8499467 | 0.00510 | ** | NA |
| AIDA | erlotinib | 0.0051188 | 0.8499467 | 0.00512 | ** | NA |
| AP3M2 | irinotecan | 0.0051552 | 0.8246221 | 0.00516 | ** | NA |
| CHURC1 | irinotecan | 0.0051552 | 0.8246221 | 0.00516 | ** | NA |
| VWA1 | nilotinib | 0.0052464 | 0.9993215 | 0.0052 | ** | NA |
| ACTL8 | erlotinib | 0.0052644 | 0.8499467 | 0.00526 | ** | NA |
| TPRN | irinotecan | 0.0052646 | 0.8246221 | 0.00526 | ** | NA |
| PPP4R2 | nilotinib | 0.0052748 | 0.9993215 | 0.0053 | ** | NA |
| LUZP1 | irinotecan | 0.0052905 | 0.8246221 | 0.00529 | ** | NA |
| RP1 | irinotecan | 0.0052916 | 0.8246221 | 0.00529 | ** | NA |
| BBS7 | lapatinib | 0.0052944 | 0.8066236 | 0.00529 | ** | NA |
| ZNF614 | selumetinib | 0.0053238 | 0.9529374 | 0.00532 | ** | NA |
| PDZD3 | erlotinib | 0.0053256 | 0.8499467 | 0.00533 | ** | NA |
| WAPAL | erlotinib | 0.0053379 | 0.8499467 | 0.00534 | ** | NA |
| NPM3 | selumetinib | 0.0053447 | 0.9529374 | 0.00534 | ** | NA |
| DFFA | erlotinib | 0.0053706 | 0.8499467 | 0.00537 | ** | NA |
| ERVV-1 | lapatinib | 0.0053768 | 0.8066236 | 0.00538 | ** | NA |
| KCNK16 | erlotinib | 0.0054018 | 0.8499467 | 0.00540 | ** | NA |
| WDYHV1 | erlotinib | 0.0054342 | 0.8499467 | 0.00543 | ** | NA |
| HDAC1 | lapatinib | 0.0054570 | 0.8066236 | 0.00546 | ** | NA |
| TMEM117 | erlotinib | 0.0055783 | 0.8499467 | 0.00558 | ** | NA |
| LMBRD2 | irinotecan | 0.0055805 | 0.8246221 | 0.00558 | ** | NA |
| MIPOL1 | erlotinib | 0.0055888 | 0.8499467 | 0.00559 | ** | NA |
| SIX4 | lapatinib | 0.0055942 | 0.8066236 | 0.00559 | ** | NA |
| TSKU | irinotecan | 0.0056000 | 0.8246221 | 0.00560 | ** | NA |
| SYPL2 | lapatinib | 0.0056031 | 0.8066236 | 0.00560 | ** | NA |
| RUNX3 | erlotinib | 0.0056416 | 0.8499467 | 0.00564 | ** | NA |
| COL4A3BP | lapatinib | 0.0056619 | 0.8066236 | 0.00566 | ** | NA |
| C10orf55 | lapatinib | 0.0056868 | 0.8066236 | 0.00569 | ** | NA |
| SLC18A1 | lapatinib | 0.0056956 | 0.8066236 | 0.00570 | ** | NA |
| UPF1 | selumetinib | 0.0057067 | 0.9529374 | 0.00571 | ** | NA |
| LEMD1 | lapatinib | 0.0057296 | 0.8066236 | 0.00573 | ** | NA |
| KCNK7 | selumetinib | 0.0057569 | 0.9529374 | 0.00576 | ** | NA |
| PUS7 | erlotinib | 0.0057590 | 0.8499467 | 0.00576 | ** | NA |
| VCAN | selumetinib | 0.0057600 | 0.9529374 | 0.00576 | ** | NA |
| MYBPC3 | lapatinib | 0.0057618 | 0.8066236 | 0.00576 | ** | NA |
| RNMTL1 | irinotecan | 0.0057630 | 0.8246221 | 0.00576 | ** | NA |
| PLD3 | selumetinib | 0.0057946 | 0.9529374 | 0.00579 | ** | NA |
| FAM20A | selumetinib | 0.0058527 | 0.9529374 | 0.00585 | ** | NA |
| FAM135B | irinotecan | 0.0058751 | 0.8246221 | 0.00588 | ** | NA |
| POU1F1 | irinotecan | 0.0059007 | 0.8246221 | 0.00590 | ** | NA |
| NCKAP5 | selumetinib | 0.0059016 | 0.9529374 | 0.00590 | ** | NA |
| ZFYVE9 | erlotinib | 0.0059654 | 0.8499467 | 0.00597 | ** | NA |
| PSMA6 | lapatinib | 0.0059679 | 0.8066236 | 0.00597 | ** | NA |
| USP8 | lapatinib | 0.0060086 | 0.8066236 | 0.00601 | ** | NA |
| CNIH3 | erlotinib | 0.0060106 | 0.8499467 | 0.00601 | ** | NA |
| TOX4 | erlotinib | 0.0060256 | 0.8499467 | 0.00603 | ** | NA |
| BNIP2 | erlotinib | 0.0060659 | 0.8499467 | 0.00607 | ** | NA |
| BBS7 | erlotinib | 0.0060687 | 0.8499467 | 0.00607 | ** | NA |
| ZNF705A | lapatinib | 0.0060746 | 0.8066236 | 0.00607 | ** | NA |
| CREBZF | selumetinib | 0.0060769 | 0.9529374 | 0.00608 | ** | NA |
| ATP12A | irinotecan | 0.0060801 | 0.8246221 | 0.00608 | ** | NA |
| FUZ | erlotinib | 0.0060935 | 0.8499467 | 0.00609 | ** | NA |
| ESPL1 | selumetinib | 0.0061625 | 0.9529374 | 0.00616 | ** | NA |
| ZNF812 | lapatinib | 0.0061717 | 0.8066236 | 0.00617 | ** | NA |
| ZSCAN10 | nilotinib | 0.0061830 | 0.9993215 | 0.0062 | ** | NA |
| GAL3ST1 | selumetinib | 0.0061867 | 0.9529374 | 0.00619 | ** | NA |
| FCN2 | erlotinib | 0.0062034 | 0.8499467 | 0.00620 | ** | NA |
| AK4 | irinotecan | 0.0062043 | 0.8246221 | 0.00620 | ** | NA |
| TMEM100 | lapatinib | 0.0062056 | 0.8066236 | 0.00621 | ** | NA |
| MYBPC3 | erlotinib | 0.0062363 | 0.8499467 | 0.00624 | ** | NA |
| AKR1B10 | erlotinib | 0.0062569 | 0.8499467 | 0.00626 | ** | NA |
| GIPC3 | erlotinib | 0.0062802 | 0.8499467 | 0.00628 | ** | NA |
| SLC7A4 | lapatinib | 0.0062875 | 0.8066236 | 0.00629 | ** | NA |
| CUX2 | selumetinib | 0.0062938 | 0.9529374 | 0.00629 | ** | NA |
| TRPV2 | irinotecan | 0.0062967 | 0.8246221 | 0.00630 | ** | NA |
| CROCC | nilotinib | 0.0063141 | 0.9993215 | 0.0063 | ** | NA |
| CCNA1 | lapatinib | 0.0063613 | 0.8066236 | 0.00636 | ** | NA |
| NPAS2 | selumetinib | 0.0063920 | 0.9529374 | 0.00639 | ** | NA |
| NF2 | erlotinib | 0.0064062 | 0.8499467 | 0.00641 | ** | NA |
| TULP1 | lapatinib | 0.0064768 | 0.8066236 | 0.00648 | ** | NA |
| PCDHA10 | nilotinib | 0.0064790 | 0.9993215 | 0.0065 | ** | NA |
| ELF2 | lapatinib | 0.0064986 | 0.8066236 | 0.00650 | ** | NA |
| BUB1 | irinotecan | 0.0065029 | 0.8246221 | 0.00650 | ** | NA |
| DSC2 | erlotinib | 0.0065145 | 0.8499467 | 0.00651 | ** | NA |
| UBR2 | nilotinib | 0.0065316 | 0.9993215 | 0.0065 | ** | NA |
| CRTAC1 | lapatinib | 0.0065476 | 0.8066236 | 0.00655 | ** | NA |
| ACADS | selumetinib | 0.0065964 | 0.9529374 | 0.00660 | ** | NA |
| ALX4 | lapatinib | 0.0066202 | 0.8066236 | 0.00662 | ** | NA |
| SMG9 | erlotinib | 0.0066552 | 0.8499467 | 0.00666 | ** | NA |
| FANCF | lapatinib | 0.0066708 | 0.8066236 | 0.00667 | ** | NA |
| IL18RAP | irinotecan | 0.0066862 | 0.8246221 | 0.00669 | ** | NA |
| PCED1A | selumetinib | 0.0066987 | 0.9529374 | 0.00670 | ** | NA |
| DDX27 | selumetinib | 0.0067073 | 0.9529374 | 0.00671 | ** | NA |
| VPS37C | nilotinib | 0.0067406 | 0.9993215 | 0.0067 | ** | NA |
| DDX49 | erlotinib | 0.0067444 | 0.8499467 | 0.00674 | ** | NA |
| AGPAT3 | erlotinib | 0.0068057 | 0.8499467 | 0.00681 | ** | NA |
| MS4A8 | lapatinib | 0.0068101 | 0.8066236 | 0.00681 | ** | NA |
| WDR6 | lapatinib | 0.0068206 | 0.8066236 | 0.00682 | ** | NA |
| LCE2B | nilotinib | 0.0068310 | 0.9993215 | 0.0068 | ** | NA |
| PC | lapatinib | 0.0068372 | 0.8066236 | 0.00684 | ** | NA |
| CHAD | erlotinib | 0.0068391 | 0.8499467 | 0.00684 | ** | NA |
| DENND1B | lapatinib | 0.0068862 | 0.8066236 | 0.00689 | ** | NA |
| ASB15 | erlotinib | 0.0069235 | 0.8499467 | 0.00692 | ** | NA |
| CMA1 | lapatinib | 0.0069235 | 0.8066236 | 0.00692 | ** | NA |
| GMPS | irinotecan | 0.0069248 | 0.8246221 | 0.00692 | ** | NA |
| ROPN1L | selumetinib | 0.0069351 | 0.9529374 | 0.00694 | ** | NA |
| ANO3 | lapatinib | 0.0069452 | 0.8066236 | 0.00695 | ** | NA |
| OR6C65 | irinotecan | 0.0069823 | 0.8246221 | 0.00698 | ** | NA |
| PRR14 | lapatinib | 0.0070451 | 0.8066236 | 0.00705 | ** | NA |
| IK | erlotinib | 0.0070506 | 0.8499467 | 0.00705 | ** | NA |
| OR5T2 | selumetinib | 0.0070658 | 0.9529374 | 0.00707 | ** | NA |
| TAS2R41 | nilotinib | 0.0070946 | 0.9993215 | 0.0071 | ** | NA |
| RXFP2 | erlotinib | 0.0070967 | 0.8499467 | 0.00710 | ** | NA |
| TIGD2 | irinotecan | 0.0070969 | 0.8246221 | 0.00710 | ** | NA |
| CDK5R1 | erlotinib | 0.0071148 | 0.8499467 | 0.00711 | ** | NA |
| R3HDML | lapatinib | 0.0071148 | 0.8066236 | 0.00711 | ** | NA |
| MIB2 | nilotinib | 0.0071278 | 0.9993215 | 0.0071 | ** | NA |
| TCP1 | lapatinib | 0.0071350 | 0.8066236 | 0.00713 | ** | NA |
| RPS6KA2 | nilotinib | 0.0071558 | 0.9993215 | 0.0072 | ** | NA |
| PYGO1 | lapatinib | 0.0071848 | 0.8066236 | 0.00718 | ** | NA |
| ZNF444 | lapatinib | 0.0071848 | 0.8066236 | 0.00718 | ** | NA |
| AXDND1 | irinotecan | 0.0072029 | 0.8246221 | 0.00720 | ** | NA |
| CIRH1A | nilotinib | 0.0072063 | 0.9993215 | 0.0072 | ** | NA |
| TMX2 | lapatinib | 0.0072167 | 0.8066236 | 0.00722 | ** | NA |
| FAM63B | nilotinib | 0.0072215 | 0.9993215 | 0.0072 | ** | NA |
| CHD8 | lapatinib | 0.0072461 | 0.8066236 | 0.00725 | ** | NA |
| SH3GL1 | irinotecan | 0.0072694 | 0.8246221 | 0.00727 | ** | NA |
| HPS1 | erlotinib | 0.0073004 | 0.8499467 | 0.00730 | ** | NA |
| PCDHAC1 | selumetinib | 0.0073021 | 0.9529374 | 0.00730 | ** | NA |
| MCHR1 | selumetinib | 0.0073210 | 0.9529374 | 0.00732 | ** | NA |
| HIST1H1D | nilotinib | 0.0073222 | 0.9993215 | 0.0073 | ** | NA |
| NME8 | irinotecan | 0.0073559 | 0.8246221 | 0.00736 | ** | NA |
| A4GNT | lapatinib | 0.0073592 | 0.8066236 | 0.00736 | ** | NA |
| MECR | erlotinib | 0.0073739 | 0.8499467 | 0.00737 | ** | NA |
| SLC12A1 | selumetinib | 0.0073922 | 0.9529374 | 0.00739 | ** | NA |
| RASL11B | erlotinib | 0.0073936 | 0.8499467 | 0.00739 | ** | NA |
| VAV1 | selumetinib | 0.0074105 | 0.9529374 | 0.00741 | ** | NA |
| AKAP6 | lapatinib | 0.0074258 | 0.8066236 | 0.00743 | ** | NA |
| ZNF85 | erlotinib | 0.0074381 | 0.8499467 | 0.00744 | ** | NA |
| JAK1 | irinotecan | 0.0074451 | 0.8246221 | 0.00745 | ** | NA |
| PNO1 | erlotinib | 0.0074703 | 0.8499467 | 0.00747 | ** | NA |
| SEPSECS | erlotinib | 0.0074703 | 0.8499467 | 0.00747 | ** | NA |
| TBC1D30 | lapatinib | 0.0074748 | 0.8066236 | 0.00747 | ** | NA |
| PALLD | selumetinib | 0.0074748 | 0.9529374 | 0.00747 | ** | NA |
| C19orf47 | selumetinib | 0.0074838 | 0.9529374 | 0.00748 | ** | NA |
| PIGV | irinotecan | 0.0075085 | 0.8246221 | 0.00751 | ** | NA |
| CHRNA6 | irinotecan | 0.0075700 | 0.8246221 | 0.00757 | ** | NA |
| KLHL20 | lapatinib | 0.0075859 | 0.8066236 | 0.00759 | ** | NA |
| ATP13A5 | selumetinib | 0.0075926 | 0.9529374 | 0.00759 | ** | NA |
| GYPE | lapatinib | 0.0075933 | 0.8066236 | 0.00759 | ** | NA |
| NOL7 | erlotinib | 0.0076297 | 0.8499467 | 0.00763 | ** | NA |
| FOLR1 | irinotecan | 0.0076355 | 0.8246221 | 0.00764 | ** | NA |
| STX7 | erlotinib | 0.0076414 | 0.8499467 | 0.00764 | ** | NA |
| WBP11 | irinotecan | 0.0076943 | 0.8246221 | 0.00769 | ** | NA |
| SETD1A | lapatinib | 0.0077204 | 0.8066236 | 0.00772 | ** | NA |
| GHR | selumetinib | 0.0077319 | 0.9529374 | 0.00773 | ** | NA |
| PDCD6IP | irinotecan | 0.0077536 | 0.8246221 | 0.00775 | ** | NA |
| ZC2HC1A | irinotecan | 0.0077559 | 0.8246221 | 0.00776 | ** | NA |
| LHX5 | erlotinib | 0.0077696 | 0.8499467 | 0.00777 | ** | NA |
| ZSWIM1 | lapatinib | 0.0077696 | 0.8066236 | 0.00777 | ** | NA |
| SEMA5A | lapatinib | 0.0077944 | 0.8066236 | 0.00779 | ** | NA |
| SLC16A8 | lapatinib | 0.0078053 | 0.8066236 | 0.00781 | ** | NA |
| RGS20 | erlotinib | 0.0078504 | 0.8499467 | 0.00785 | ** | NA |
| UGT2B4 | nilotinib | 0.0078922 | 0.9993215 | 0.0079 | ** | NA |
| ANKS3 | lapatinib | 0.0078951 | 0.8066236 | 0.00790 | ** | NA |
| DNAJC8 | nilotinib | 0.0079155 | 0.9993215 | 0.0079 | ** | NA |
| UVRAG | selumetinib | 0.0079192 | 0.9529374 | 0.00792 | ** | NA |
| AKR1B10 | lapatinib | 0.0079255 | 0.8066236 | 0.00793 | ** | NA |
| FAM43A | erlotinib | 0.0079336 | 0.8499467 | 0.00793 | ** | NA |
| EPB41L5 | erlotinib | 0.0079422 | 0.8499467 | 0.00794 | ** | NA |
| ZNF160 | lapatinib | 0.0079771 | 0.8066236 | 0.00798 | ** | NA |
| ZMYM4 | irinotecan | 0.0079954 | 0.8246221 | 0.00800 | ** | NA |
| OR4K15 | erlotinib | 0.0080004 | 0.8499467 | 0.00800 | ** | NA |
| TRIM32 | lapatinib | 0.0080008 | 0.8066236 | 0.00800 | ** | NA |
| TLE3 | lapatinib | 0.0080073 | 0.8066236 | 0.00801 | ** | NA |
| PSMD2 | lapatinib | 0.0080171 | 0.8066236 | 0.00802 | ** | NA |
| LCP2 | nilotinib | 0.0080735 | 0.9993215 | 0.0081 | ** | NA |
| MLF2 | erlotinib | 0.0081067 | 0.8499467 | 0.00811 | ** | NA |
| FTSJ2 | selumetinib | 0.0081102 | 0.9529374 | 0.00811 | ** | NA |
| BARD1 | erlotinib | 0.0081120 | 0.8499467 | 0.00811 | ** | NA |
| CLDN8 | lapatinib | 0.0081241 | 0.8066236 | 0.00812 | ** | NA |
| RARS | irinotecan | 0.0081466 | 0.8246221 | 0.00815 | ** | NA |
| SIKE1 | selumetinib | 0.0081585 | 0.9529374 | 0.00816 | ** | NA |
| EEF2 | selumetinib | 0.0081729 | 0.9529374 | 0.00817 | ** | NA |
| ANKRD36 | erlotinib | 0.0081879 | 0.8499467 | 0.00819 | ** | NA |
| KCNQ1 | erlotinib | 0.0081884 | 0.8499467 | 0.00819 | ** | NA |
| SLC22A1 | lapatinib | 0.0082008 | 0.8066236 | 0.00820 | ** | NA |
| TAS2R5 | irinotecan | 0.0082033 | 0.8246221 | 0.00820 | ** | NA |
| ZNF823 | irinotecan | 0.0082307 | 0.8246221 | 0.00823 | ** | NA |
| TM9SF1 | lapatinib | 0.0082445 | 0.8066236 | 0.00824 | ** | NA |
| EFTUD1 | irinotecan | 0.0083442 | 0.8246221 | 0.00834 | ** | NA |
| TAOK1 | irinotecan | 0.0083660 | 0.8246221 | 0.00837 | ** | NA |
| NPY4R | lapatinib | 0.0084017 | 0.8066236 | 0.00840 | ** | NA |
| HDAC1 | erlotinib | 0.0084020 | 0.8499467 | 0.00840 | ** | NA |
| MIPOL1 | selumetinib | 0.0084204 | 0.9529374 | 0.00842 | ** | NA |
| COLEC11 | nilotinib | 0.0084280 | 0.9993215 | 0.0084 | ** | NA |
| MSMB | selumetinib | 0.0084504 | 0.9529374 | 0.00845 | ** | NA |
| ZNF317 | lapatinib | 0.0084512 | 0.8066236 | 0.00845 | ** | NA |
| TNKS1BP1 | selumetinib | 0.0084564 | 0.9529374 | 0.00846 | ** | NA |
| NEDD1 | selumetinib | 0.0084616 | 0.9529374 | 0.00846 | ** | NA |
| P2RY13 | lapatinib | 0.0084734 | 0.8066236 | 0.00847 | ** | NA |
| MRE11A | irinotecan | 0.0084883 | 0.8246221 | 0.00849 | ** | NA |
| MCM7 | lapatinib | 0.0085153 | 0.8066236 | 0.00852 | ** | NA |
| LCK | erlotinib | 0.0085223 | 0.8499467 | 0.00852 | ** | NA |
| SLC41A1 | lapatinib | 0.0085424 | 0.8066236 | 0.00854 | ** | NA |
| COLEC11 | lapatinib | 0.0085507 | 0.8066236 | 0.00855 | ** | NA |
| SLC36A3 | erlotinib | 0.0085524 | 0.8499467 | 0.00855 | ** | NA |
| SLC30A10 | irinotecan | 0.0086106 | 0.8246221 | 0.00861 | ** | NA |
| LRRC63 | erlotinib | 0.0086164 | 0.8499467 | 0.00862 | ** | NA |
| MLF2 | lapatinib | 0.0086793 | 0.8066236 | 0.00868 | ** | NA |
| ARHGAP29 | nilotinib | 0.0086939 | 0.9993215 | 0.0087 | ** | NA |
| DDX49 | lapatinib | 0.0087551 | 0.8066236 | 0.00876 | ** | NA |
| LRIF1 | irinotecan | 0.0087695 | 0.8246221 | 0.00877 | ** | NA |
| AP2A2 | lapatinib | 0.0087805 | 0.8066236 | 0.00878 | ** | NA |
| SERPINI1 | irinotecan | 0.0087947 | 0.8246221 | 0.00879 | ** | NA |
| SLC35E4 | nilotinib | 0.0087978 | 0.9993215 | 0.0088 | ** | NA |
| TOPORS | erlotinib | 0.0088286 | 0.8499467 | 0.00883 | ** | NA |
| ARID1B | irinotecan | 0.0088525 | 0.8246221 | 0.00885 | ** | NA |
| CALM3 | selumetinib | 0.0088548 | 0.9529374 | 0.00885 | ** | NA |
| TTC7B | selumetinib | 0.0088770 | 0.9529374 | 0.00888 | ** | NA |
| HCN2 | erlotinib | 0.0088904 | 0.8499467 | 0.00889 | ** | NA |
| ECI1 | erlotinib | 0.0088912 | 0.8499467 | 0.00889 | ** | NA |
| PHIP | irinotecan | 0.0089033 | 0.8246221 | 0.00890 | ** | NA |
| HHIPL2 | erlotinib | 0.0089162 | 0.8499467 | 0.00892 | ** | NA |
| SLU7 | erlotinib | 0.0089304 | 0.8499467 | 0.00893 | ** | NA |
| EXOC3L4 | irinotecan | 0.0089469 | 0.8246221 | 0.00895 | ** | NA |
| TUBA3C | irinotecan | 0.0089469 | 0.8246221 | 0.00895 | ** | NA |
| HS2ST1 | nilotinib | 0.0089560 | 0.9993215 | 0.0090 | ** | NA |
| GPR132 | lapatinib | 0.0089586 | 0.8066236 | 0.00896 | ** | NA |
| ENTPD8 | irinotecan | 0.0089671 | 0.8246221 | 0.00897 | ** | NA |
| NOTCH4 | lapatinib | 0.0090027 | 0.8066236 | 0.00900 | ** | NA |
| VAMP4 | irinotecan | 0.0090327 | 0.8246221 | 0.00903 | ** | NA |
| FBXW7 | irinotecan | 0.0090628 | 0.8246221 | 0.00906 | ** | NA |
| ARHGAP15 | lapatinib | 0.0090656 | 0.8066236 | 0.00907 | ** | NA |
| ATP5SL | lapatinib | 0.0090932 | 0.8066236 | 0.00909 | ** | NA |
| TGM7 | selumetinib | 0.0091052 | 0.9529374 | 0.00911 | ** | NA |
| GPALPP1 | selumetinib | 0.0091178 | 0.9529374 | 0.00912 | ** | NA |
| KIAA1919 | irinotecan | 0.0091606 | 0.8246221 | 0.00916 | ** | NA |
| PTAFR | irinotecan | 0.0091869 | 0.8246221 | 0.00919 | ** | NA |
| MTHFD2L | irinotecan | 0.0092013 | 0.8246221 | 0.00920 | ** | NA |
| PARD6B | irinotecan | 0.0092013 | 0.8246221 | 0.00920 | ** | NA |
| TPCN1 | irinotecan | 0.0092013 | 0.8246221 | 0.00920 | ** | NA |
| ZWILCH | irinotecan | 0.0092317 | 0.8246221 | 0.00923 | ** | NA |
| PTPN4 | erlotinib | 0.0092336 | 0.8499467 | 0.00923 | ** | NA |
| BSN | irinotecan | 0.0092519 | 0.8246221 | 0.00925 | ** | NA |
| OR2C1 | erlotinib | 0.0092524 | 0.8499467 | 0.00925 | ** | NA |
| VSX1 | erlotinib | 0.0092524 | 0.8499467 | 0.00925 | ** | NA |
| SEPT5 | erlotinib | 0.0092602 | 0.8499467 | 0.00926 | ** | NA |
| IRF2BP1 | lapatinib | 0.0092659 | 0.8066236 | 0.00927 | ** | NA |
| FAM155A | irinotecan | 0.0092866 | 0.8246221 | 0.00929 | ** | NA |
| WFDC3 | nilotinib | 0.0092868 | 0.9993215 | 0.0093 | ** | NA |
| VEZT | erlotinib | 0.0093021 | 0.8499467 | 0.00930 | ** | NA |
| CIR1 | irinotecan | 0.0093192 | 0.8246221 | 0.00932 | ** | NA |
| IL12RB2 | selumetinib | 0.0093355 | 0.9529374 | 0.00934 | ** | NA |
| ZNF444 | erlotinib | 0.0093441 | 0.8499467 | 0.00934 | ** | NA |
| KDM4E | erlotinib | 0.0093742 | 0.8499467 | 0.00937 | ** | NA |
| ABLIM2 | lapatinib | 0.0093826 | 0.8066236 | 0.00938 | ** | NA |
| OSBPL5 | lapatinib | 0.0093931 | 0.8066236 | 0.00939 | ** | NA |
| SLC5A6 | erlotinib | 0.0093984 | 0.8499467 | 0.00940 | ** | NA |
| TLE2 | selumetinib | 0.0094071 | 0.9529374 | 0.00941 | ** | NA |
| RUFY2 | irinotecan | 0.0094102 | 0.8246221 | 0.00941 | ** | NA |
| IQCA1 | lapatinib | 0.0094360 | 0.8066236 | 0.00944 | ** | NA |
| CADPS | irinotecan | 0.0094473 | 0.8246221 | 0.00945 | ** | NA |
| PMFBP1 | lapatinib | 0.0094664 | 0.8066236 | 0.00947 | ** | NA |
| C11orf49 | erlotinib | 0.0094872 | 0.8499467 | 0.00949 | ** | NA |
| ARL14EP | lapatinib | 0.0095009 | 0.8066236 | 0.00950 | ** | NA |
| ALX1 | selumetinib | 0.0095130 | 0.9529374 | 0.00951 | ** | NA |
| STXBP1 | selumetinib | 0.0095178 | 0.9529374 | 0.00952 | ** | NA |
| THRAP3 | nilotinib | 0.0095338 | 0.9993215 | 0.0095 | ** | NA |
| FBXL3 | erlotinib | 0.0095358 | 0.8499467 | 0.00954 | ** | NA |
| ELF3 | lapatinib | 0.0095609 | 0.8066236 | 0.00956 | ** | NA |
| C15orf41 | erlotinib | 0.0095770 | 0.8499467 | 0.00958 | ** | NA |
| GPR32 | lapatinib | 0.0095946 | 0.8066236 | 0.00959 | ** | NA |
| DNAJC27 | nilotinib | 0.0096506 | 0.9993215 | 0.0097 | ** | NA |
| PTK6 | nilotinib | 0.0096792 | 0.9993215 | 0.0097 | ** | NA |
| FAM170B | lapatinib | 0.0096798 | 0.8066236 | 0.00968 | ** | NA |
| SLCO5A1 | irinotecan | 0.0097204 | 0.8246221 | 0.00972 | ** | NA |
| C9orf64 | irinotecan | 0.0097239 | 0.8246221 | 0.00972 | ** | NA |
| ZNF100 | irinotecan | 0.0097611 | 0.8246221 | 0.00976 | ** | NA |
| APOBEC4 | lapatinib | 0.0097770 | 0.8066236 | 0.00978 | ** | NA |
| C1QTNF9 | lapatinib | 0.0097882 | 0.8066236 | 0.00979 | ** | NA |
| C1QTNF9B | lapatinib | 0.0098602 | 0.8066236 | 0.00986 | ** | NA |
| MATN1 | lapatinib | 0.0098602 | 0.8066236 | 0.00986 | ** | NA |
| EIF4E | lapatinib | 0.0098752 | 0.8066236 | 0.00988 | ** | NA |
| FBP1 | irinotecan | 0.0099039 | 0.8246221 | 0.00990 | ** | NA |
| TSPAN18 | erlotinib | 0.0099204 | 0.8499467 | 0.00992 | ** | NA |
| UNK | selumetinib | 0.0099205 | 0.9529374 | 0.00992 | ** | NA |
| LSM11 | selumetinib | 0.0099298 | 0.9529374 | 0.00993 | ** | NA |
| FNDC8 | selumetinib | 0.0099544 | 0.9529374 | 0.00995 | ** | NA |
| PRPF8 | selumetinib | 0.0099673 | 0.9529374 | 0.00997 | ** | NA |
| C16orf96 | erlotinib | 0.0100021 | 0.8499467 | 0.01000 |
|
NA |
| KIRREL2 | lapatinib | 0.0100311 | 0.8066236 | 0.01003 |
|
NA |
| GRM6 | lapatinib | 0.0100372 | 0.8066236 | 0.01004 |
|
NA |
| PACS1 | selumetinib | 0.0100379 | 0.9529374 | 0.01004 |
|
NA |
| MDGA2 | lapatinib | 0.0100642 | 0.8066236 | 0.01006 |
|
NA |
| PTPN5 | lapatinib | 0.0100833 | 0.8066236 | 0.01008 |
|
NA |
| TEX101 | irinotecan | 0.0100869 | 0.8246221 | 0.01009 |
|
NA |
| RIMS2 | lapatinib | 0.0101096 | 0.8066236 | 0.01011 |
|
NA |
| SLC16A14 | selumetinib | 0.0101231 | 0.9529374 | 0.01012 |
|
NA |
| TMEM30B | erlotinib | 0.0101259 | 0.8499467 | 0.01013 |
|
NA |
| MED21 | erlotinib | 0.0101297 | 0.8499467 | 0.01013 |
|
NA |
| SIKE1 | erlotinib | 0.0101297 | 0.8499467 | 0.01013 |
|
NA |
| DIAPH3 | irinotecan | 0.0101333 | 0.8246221 | 0.01013 |
|
NA |
| PLCL2 | selumetinib | 0.0101361 | 0.9529374 | 0.01014 |
|
NA |
| EEA1 | nilotinib | 0.0101538 | 0.9993215 | 0.0102 |
|
NA |
| NAA15 | lapatinib | 0.0101661 | 0.8066236 | 0.01017 |
|
NA |
| CDC14B | irinotecan | 0.0101754 | 0.8246221 | 0.01018 |
|
NA |
| NTPCR | irinotecan | 0.0101754 | 0.8246221 | 0.01018 |
|
NA |
| CXXC5 | lapatinib | 0.0101905 | 0.8066236 | 0.01019 |
|
NA |
| P4HA2 | lapatinib | 0.0101934 | 0.8066236 | 0.01019 |
|
NA |
| CYP4Z1 | irinotecan | 0.0101983 | 0.8246221 | 0.01020 |
|
NA |
| ZC3H11A | irinotecan | 0.0102131 | 0.8246221 | 0.01021 |
|
NA |
| HJURP | erlotinib | 0.0102419 | 0.8499467 | 0.01024 |
|
NA |
| NCL | erlotinib | 0.0102569 | 0.8499467 | 0.01026 |
|
NA |
| FBXL4 | irinotecan | 0.0102704 | 0.8246221 | 0.01027 |
|
NA |
| NPHS2 | irinotecan | 0.0102704 | 0.8246221 | 0.01027 |
|
NA |
| TJAP1 | irinotecan | 0.0102704 | 0.8246221 | 0.01027 |
|
NA |
| ZNF423 | erlotinib | 0.0102896 | 0.8499467 | 0.01029 |
|
NA |
| CHST11 | erlotinib | 0.0103178 | 0.8499467 | 0.01032 |
|
NA |
| PPP1R14A | lapatinib | 0.0103238 | 0.8066236 | 0.01032 |
|
NA |
| C14orf2 | lapatinib | 0.0103264 | 0.8066236 | 0.01033 |
|
NA |
| WWP2 | lapatinib | 0.0103793 | 0.8066236 | 0.01038 |
|
NA |
| ZNF473 | erlotinib | 0.0103970 | 0.8499467 | 0.01040 |
|
NA |
| PRDM15 | irinotecan | 0.0104000 | 0.8246221 | 0.01040 |
|
NA |
| LRRIQ1 | irinotecan | 0.0104193 | 0.8246221 | 0.01042 |
|
NA |
| DPP10 | selumetinib | 0.0104311 | 0.9529374 | 0.01043 |
|
NA |
| PBX1 | irinotecan | 0.0104362 | 0.8246221 | 0.01044 |
|
NA |
| LYVE1 | selumetinib | 0.0104373 | 0.9529374 | 0.01044 |
|
NA |
| CDK5R1 | lapatinib | 0.0104428 | 0.8066236 | 0.01044 |
|
NA |
| LRRC4B | lapatinib | 0.0104574 | 0.8066236 | 0.01046 |
|
NA |
| MFSD9 | selumetinib | 0.0104733 | 0.9529374 | 0.01047 |
|
NA |
| PER1 | lapatinib | 0.0104995 | 0.8066236 | 0.01050 |
|
NA |
| IHH | erlotinib | 0.0105015 | 0.8499467 | 0.01050 |
|
NA |
| KATNAL1 | erlotinib | 0.0105034 | 0.8499467 | 0.01050 |
|
NA |
| RAI1 | irinotecan | 0.0105253 | 0.8246221 | 0.01053 |
|
NA |
| SLC22A2 | erlotinib | 0.0105268 | 0.8499467 | 0.01053 |
|
NA |
| MRGPRX1 | selumetinib | 0.0105279 | 0.9529374 | 0.01053 |
|
NA |
| DDRGK1 | nilotinib | 0.0105448 | 0.9993215 | 0.0105 |
|
NA |
| NALCN | lapatinib | 0.0105860 | 0.8066236 | 0.01059 |
|
NA |
| THRAP3 | erlotinib | 0.0105866 | 0.8499467 | 0.01059 |
|
NA |
| SYVN1 | irinotecan | 0.0106002 | 0.8246221 | 0.01060 |
|
NA |
| PAX8 | nilotinib | 0.0106011 | 0.9993215 | 0.0106 |
|
NA |
| EHMT1 | lapatinib | 0.0106267 | 0.8066236 | 0.01063 |
|
NA |
| FECH | erlotinib | 0.0106280 | 0.8499467 | 0.01063 |
|
NA |
| PLEC | irinotecan | 0.0106310 | 0.8246221 | 0.01063 |
|
NA |
| LIPM | selumetinib | 0.0106324 | 0.9529374 | 0.01063 |
|
NA |
| SHC1 | selumetinib | 0.0106324 | 0.9529374 | 0.01063 |
|
NA |
| GSDMC | selumetinib | 0.0106467 | 0.9529374 | 0.01065 |
|
NA |
| CLEC6A | irinotecan | 0.0106539 | 0.8246221 | 0.01065 |
|
NA |
| GCM1 | selumetinib | 0.0106677 | 0.9529374 | 0.01067 |
|
NA |
| FRZB | erlotinib | 0.0106753 | 0.8499467 | 0.01068 |
|
NA |
| CYP27B1 | irinotecan | 0.0107095 | 0.8246221 | 0.01071 |
|
NA |
| HSP90AB1 | lapatinib | 0.0107152 | 0.8066236 | 0.01072 |
|
NA |
| HLA-C | selumetinib | 0.0107160 | 0.9529374 | 0.01072 |
|
NA |
| NIPBL | irinotecan | 0.0107665 | 0.8246221 | 0.01077 |
|
NA |
| PPAP2B | erlotinib | 0.0107808 | 0.8499467 | 0.01078 |
|
NA |
| KRAS | irinotecan | 0.0107870 | 0.8246221 | 0.01079 |
|
NA |
| TMPRSS9 | irinotecan | 0.0107902 | 0.8246221 | 0.01079 |
|
NA |
| ZNF430 | selumetinib | 0.0108018 | 0.9529374 | 0.01080 |
|
NA |
| WDR43 | nilotinib | 0.0108020 | 0.9993215 | 0.0108 |
|
NA |
| TGFBR1 | erlotinib | 0.0108184 | 0.8499467 | 0.01082 |
|
NA |
| CACYBP | selumetinib | 0.0108391 | 0.9529374 | 0.01084 |
|
NA |
| COMMD3 | selumetinib | 0.0108391 | 0.9529374 | 0.01084 |
|
NA |
| RBFOX2 | erlotinib | 0.0108516 | 0.8499467 | 0.01085 |
|
NA |
| PGK2 | lapatinib | 0.0108565 | 0.8066236 | 0.01086 |
|
NA |
| BMP2 | selumetinib | 0.0108566 | 0.9529374 | 0.01086 |
|
NA |
| CDK5RAP1 | nilotinib | 0.0109571 | 0.9993215 | 0.0110 |
|
NA |
| ALG11 | erlotinib | 0.0109633 | 0.8499467 | 0.01096 |
|
NA |
| C2CD4A | lapatinib | 0.0110089 | 0.8066236 | 0.01101 |
|
NA |
| NFATC4 | nilotinib | 0.0110135 | 0.9993215 | 0.0110 |
|
NA |
| PDLIM5 | lapatinib | 0.0110141 | 0.8066236 | 0.01101 |
|
NA |
| ADAM9 | selumetinib | 0.0110361 | 0.9529374 | 0.01104 |
|
NA |
| SPRR1A | lapatinib | 0.0110558 | 0.8066236 | 0.01106 |
|
NA |
| AVPR1B | irinotecan | 0.0110629 | 0.8246221 | 0.01106 |
|
NA |
| RIC8B | erlotinib | 0.0110847 | 0.8499467 | 0.01108 |
|
NA |
| OR6N2 | lapatinib | 0.0111010 | 0.8066236 | 0.01110 |
|
NA |
| ZNF117 | selumetinib | 0.0111208 | 0.9529374 | 0.01112 |
|
NA |
| CHCHD6 | lapatinib | 0.0111474 | 0.8066236 | 0.01115 |
|
NA |
| ASXL1 | selumetinib | 0.0111516 | 0.9529374 | 0.01115 |
|
NA |
| RRP12 | irinotecan | 0.0111562 | 0.8246221 | 0.01116 |
|
NA |
| ANKHD1 | erlotinib | 0.0111753 | 0.8499467 | 0.01118 |
|
NA |
| ANKRD36 | lapatinib | 0.0111890 | 0.8066236 | 0.01119 |
|
NA |
| KCNT2 | irinotecan | 0.0112552 | 0.8246221 | 0.01126 |
|
NA |
| HCFC2 | nilotinib | 0.0112632 | 0.9993215 | 0.0113 |
|
NA |
| TBX3 | irinotecan | 0.0113399 | 0.8246221 | 0.01134 |
|
NA |
| SULT4A1 | erlotinib | 0.0113683 | 0.8499467 | 0.01137 |
|
NA |
| DLG1 | irinotecan | 0.0114031 | 0.8246221 | 0.01140 |
|
NA |
| CLSTN3 | selumetinib | 0.0114122 | 0.9529374 | 0.01141 |
|
NA |
| CREB3L1 | irinotecan | 0.0114124 | 0.8246221 | 0.01141 |
|
NA |
| MAP4K3 | irinotecan | 0.0114208 | 0.8246221 | 0.01142 |
|
NA |
| ACTL8 | lapatinib | 0.0114490 | 0.8066236 | 0.01145 |
|
NA |
| ARMC6 | lapatinib | 0.0114611 | 0.8066236 | 0.01146 |
|
NA |
| WDR78 | irinotecan | 0.0114630 | 0.8246221 | 0.01146 |
|
NA |
| CCDC64 | irinotecan | 0.0114662 | 0.8246221 | 0.01147 |
|
NA |
| PPP1R14A | erlotinib | 0.0114693 | 0.8499467 | 0.01147 |
|
NA |
| KRT18 | lapatinib | 0.0114823 | 0.8066236 | 0.01148 |
|
NA |
| ITGA1 | nilotinib | 0.0114830 | 0.9993215 | 0.0115 |
|
NA |
| NOB1 | irinotecan | 0.0115086 | 0.8246221 | 0.01151 |
|
NA |
| TDRKH | erlotinib | 0.0115491 | 0.8499467 | 0.01155 |
|
NA |
| RASL10A | lapatinib | 0.0115693 | 0.8066236 | 0.01157 |
|
NA |
| HCLS1 | irinotecan | 0.0115698 | 0.8246221 | 0.01157 |
|
NA |
| BTBD7 | erlotinib | 0.0115756 | 0.8499467 | 0.01158 |
|
NA |
| SIGLEC10 | lapatinib | 0.0115927 | 0.8066236 | 0.01159 |
|
NA |
| EML5 | irinotecan | 0.0115964 | 0.8246221 | 0.01160 |
|
NA |
| STK32C | erlotinib | 0.0116002 | 0.8499467 | 0.01160 |
|
NA |
| PPP4R2 | lapatinib | 0.0116264 | 0.8066236 | 0.01163 |
|
NA |
| GALM | erlotinib | 0.0116311 | 0.8499467 | 0.01163 |
|
NA |
| IL1R1 | selumetinib | 0.0116316 | 0.9529374 | 0.01163 |
|
NA |
| KRT39 | nilotinib | 0.0116342 | 0.9993215 | 0.0116 |
|
NA |
| DUSP4 | irinotecan | 0.0116622 | 0.8246221 | 0.01166 |
|
NA |
| FAM43A | selumetinib | 0.0116715 | 0.9529374 | 0.01167 |
|
NA |
| HOXA2 | lapatinib | 0.0116726 | 0.8066236 | 0.01167 |
|
NA |
| IRX4 | lapatinib | 0.0117017 | 0.8066236 | 0.01170 |
|
NA |
| OR2A2 | selumetinib | 0.0117184 | 0.9529374 | 0.01172 |
|
NA |
| SPRR1A | erlotinib | 0.0117323 | 0.8499467 | 0.01173 |
|
NA |
| KCNQ2 | erlotinib | 0.0117367 | 0.8499467 | 0.01174 |
|
NA |
| THBS1 | selumetinib | 0.0117495 | 0.9529374 | 0.01175 |
|
NA |
| ADAM2 | erlotinib | 0.0117573 | 0.8499467 | 0.01176 |
|
NA |
| PKP4 | irinotecan | 0.0117676 | 0.8246221 | 0.01177 |
|
NA |
| SLC1A1 | nilotinib | 0.0117781 | 0.9993215 | 0.0118 |
|
NA |
| DHRS11 | selumetinib | 0.0117803 | 0.9529374 | 0.01178 |
|
NA |
| PIK3C3 | selumetinib | 0.0117982 | 0.9529374 | 0.01180 |
|
NA |
| TEAD3 | lapatinib | 0.0117983 | 0.8066236 | 0.01180 |
|
NA |
| PGAM2 | selumetinib | 0.0118036 | 0.9529374 | 0.01180 |
|
NA |
| ZNF615 | selumetinib | 0.0118059 | 0.9529374 | 0.01181 |
|
NA |
| LCT | lapatinib | 0.0118227 | 0.8066236 | 0.01182 |
|
NA |
| KIAA1467 | lapatinib | 0.0118403 | 0.8066236 | 0.01184 |
|
NA |
| ADAMTS12 | irinotecan | 0.0118405 | 0.8246221 | 0.01184 |
|
NA |
| PPP1R7 | erlotinib | 0.0118616 | 0.8499467 | 0.01186 |
|
NA |
| THOP1 | irinotecan | 0.0118674 | 0.8246221 | 0.01187 |
|
NA |
| DNM1 | irinotecan | 0.0118738 | 0.8246221 | 0.01187 |
|
NA |
| C16orf58 | lapatinib | 0.0118772 | 0.8066236 | 0.01188 |
|
NA |
| OSBPL8 | irinotecan | 0.0118793 | 0.8246221 | 0.01188 |
|
NA |
| RPS9 | nilotinib | 0.0119195 | 0.9993215 | 0.0119 |
|
NA |
| CD2 | lapatinib | 0.0119204 | 0.8066236 | 0.01192 |
|
NA |
| GCAT | erlotinib | 0.0119214 | 0.8499467 | 0.01192 |
|
NA |
| CNTN6 | selumetinib | 0.0119606 | 0.9529374 | 0.01196 |
|
NA |
| PIK3CG | lapatinib | 0.0119750 | 0.8066236 | 0.01198 |
|
NA |
| TSTA3 | nilotinib | 0.0119869 | 0.9993215 | 0.0120 |
|
NA |
| VSX1 | lapatinib | 0.0120312 | 0.8066236 | 0.01203 |
|
NA |
| SSFA2 | lapatinib | 0.0120699 | 0.8066236 | 0.01207 |
|
NA |
| PRDM5 | erlotinib | 0.0120942 | 0.8499467 | 0.01209 |
|
NA |
| SAR1B | erlotinib | 0.0121368 | 0.8499467 | 0.01214 |
|
NA |
| FUZ | lapatinib | 0.0121368 | 0.8066236 | 0.01214 |
|
NA |
| PRX | lapatinib | 0.0121584 | 0.8066236 | 0.01216 |
|
NA |
| ZMYM6 | irinotecan | 0.0121810 | 0.8246221 | 0.01218 |
|
NA |
| TTYH1 | selumetinib | 0.0122006 | 0.9529374 | 0.01220 |
|
NA |
| KEAP1 | lapatinib | 0.0122014 | 0.8066236 | 0.01220 |
|
NA |
| ANKRD36 | selumetinib | 0.0122099 | 0.9529374 | 0.01221 |
|
NA |
| NEURL2 | erlotinib | 0.0122149 | 0.8499467 | 0.01221 |
|
NA |
| LRRTM4 | lapatinib | 0.0122265 | 0.8066236 | 0.01223 |
|
NA |
| TRIP11 | irinotecan | 0.0122320 | 0.8246221 | 0.01223 |
|
NA |
| FAM109B | lapatinib | 0.0122402 | 0.8066236 | 0.01224 |
|
NA |
| B3GNT6 | irinotecan | 0.0122620 | 0.8246221 | 0.01226 |
|
NA |
| INSM1 | nilotinib | 0.0122810 | 0.9993215 | 0.0123 |
|
NA |
| HOXB7 | selumetinib | 0.0123136 | 0.9529374 | 0.01231 |
|
NA |
| WDR72 | lapatinib | 0.0123221 | 0.8066236 | 0.01232 |
|
NA |
| CACNB2 | irinotecan | 0.0123728 | 0.8246221 | 0.01237 |
|
NA |
| FNDC9 | lapatinib | 0.0123883 | 0.8066236 | 0.01239 |
|
NA |
| KRT16 | lapatinib | 0.0124363 | 0.8066236 | 0.01244 |
|
NA |
| SOX12 | erlotinib | 0.0124556 | 0.8499467 | 0.01246 |
|
NA |
| PEX5L | nilotinib | 0.0124777 | 0.9993215 | 0.0125 |
|
NA |
| OR5AP2 | nilotinib | 0.0124779 | 0.9993215 | 0.0125 |
|
NA |
| GNAI1 | selumetinib | 0.0125135 | 0.9529374 | 0.01251 |
|
NA |
| OR9G1 | nilotinib | 0.0125240 | 0.9993215 | 0.0125 |
|
NA |
| SDE2 | selumetinib | 0.0125667 | 0.9529374 | 0.01257 |
|
NA |
| WDR77 | erlotinib | 0.0125776 | 0.8499467 | 0.01258 |
|
NA |
| ZNF862 | irinotecan | 0.0125860 | 0.8246221 | 0.01259 |
|
NA |
| RECQL | lapatinib | 0.0126144 | 0.8066236 | 0.01261 |
|
NA |
| FAM90A1 | erlotinib | 0.0126148 | 0.8499467 | 0.01261 |
|
NA |
| TAMM41 | irinotecan | 0.0126412 | 0.8246221 | 0.01264 |
|
NA |
| TMEM100 | erlotinib | 0.0126412 | 0.8499467 | 0.01264 |
|
NA |
| CNIH3 | lapatinib | 0.0126593 | 0.8066236 | 0.01266 |
|
NA |
| HEXB | lapatinib | 0.0126593 | 0.8066236 | 0.01266 |
|
NA |
| MMP19 | selumetinib | 0.0127185 | 0.9529374 | 0.01272 |
|
NA |
| SRSF4 | erlotinib | 0.0127391 | 0.8499467 | 0.01274 |
|
NA |
| SPATC1L | erlotinib | 0.0127396 | 0.8499467 | 0.01274 |
|
NA |
| OR6Q1 | irinotecan | 0.0127543 | 0.8246221 | 0.01275 |
|
NA |
| ZNF705A | erlotinib | 0.0127667 | 0.8499467 | 0.01277 |
|
NA |
| KCNK13 | irinotecan | 0.0127840 | 0.8246221 | 0.01278 |
|
NA |
| HSP90AB1 | erlotinib | 0.0128173 | 0.8499467 | 0.01282 |
|
NA |
| ATG5 | erlotinib | 0.0128246 | 0.8499467 | 0.01282 |
|
NA |
| NME6 | lapatinib | 0.0128368 | 0.8066236 | 0.01284 |
|
NA |
| TTC4 | erlotinib | 0.0128384 | 0.8499467 | 0.01284 |
|
NA |
| RASL10B | lapatinib | 0.0128790 | 0.8066236 | 0.01288 |
|
NA |
| TMEM30B | lapatinib | 0.0128790 | 0.8066236 | 0.01288 |
|
NA |
| C16orf46 | lapatinib | 0.0128933 | 0.8066236 | 0.01289 |
|
NA |
| TRIM5 | lapatinib | 0.0129052 | 0.8066236 | 0.01291 |
|
NA |
| RLF | irinotecan | 0.0129398 | 0.8246221 | 0.01294 |
|
NA |
| C9orf9 | lapatinib | 0.0129457 | 0.8066236 | 0.01295 |
|
NA |
| CLP1 | erlotinib | 0.0129497 | 0.8499467 | 0.01295 |
|
NA |
| ZNF169 | nilotinib | 0.0129533 | 0.9993215 | 0.0130 |
|
NA |
| VPS51 | selumetinib | 0.0129669 | 0.9529374 | 0.01297 |
|
NA |
| ERBB3 | lapatinib | 0.0129696 | 0.8066236 | 0.01297 |
|
NA |
| PEX16 | irinotecan | 0.0129828 | 0.8246221 | 0.01298 |
|
NA |
| MRAP | lapatinib | 0.0130300 | 0.8066236 | 0.01303 |
|
NA |
| TDRD9 | irinotecan | 0.0130444 | 0.8246221 | 0.01304 |
|
NA |
| SEZ6L | lapatinib | 0.0130519 | 0.8066236 | 0.01305 |
|
NA |
| ADAM28 | selumetinib | 0.0130688 | 0.9529374 | 0.01307 |
|
NA |
| ELF2 | erlotinib | 0.0130759 | 0.8499467 | 0.01308 |
|
NA |
| TMEM194A | selumetinib | 0.0130782 | 0.9529374 | 0.01308 |
|
NA |
| GXYLT1 | selumetinib | 0.0130812 | 0.9529374 | 0.01308 |
|
NA |
| ZNF586 | nilotinib | 0.0130869 | 0.9993215 | 0.0131 |
|
NA |
| MAS1L | lapatinib | 0.0130910 | 0.8066236 | 0.01309 |
|
NA |
| MECR | lapatinib | 0.0130910 | 0.8066236 | 0.01309 |
|
NA |
| PITPNM2 | lapatinib | 0.0131196 | 0.8066236 | 0.01312 |
|
NA |
| LRRC63 | lapatinib | 0.0131290 | 0.8066236 | 0.01313 |
|
NA |
| RNPS1 | lapatinib | 0.0131290 | 0.8066236 | 0.01313 |
|
NA |
| WNT16 | lapatinib | 0.0131501 | 0.8066236 | 0.01315 |
|
NA |
| RSBN1 | irinotecan | 0.0131770 | 0.8246221 | 0.01318 |
|
NA |
| PLA2G4D | erlotinib | 0.0131927 | 0.8499467 | 0.01319 |
|
NA |
| NLRP12 | erlotinib | 0.0132001 | 0.8499467 | 0.01320 |
|
NA |
| SIRPB2 | selumetinib | 0.0132083 | 0.9529374 | 0.01321 |
|
NA |
| ZCCHC9 | irinotecan | 0.0132159 | 0.8246221 | 0.01322 |
|
NA |
| ELL2 | lapatinib | 0.0132165 | 0.8066236 | 0.01322 |
|
NA |
| CNTLN | lapatinib | 0.0132355 | 0.8066236 | 0.01324 |
|
NA |
| DEF6 | selumetinib | 0.0132814 | 0.9529374 | 0.01328 |
|
NA |
| BRICD5 | selumetinib | 0.0132987 | 0.9529374 | 0.01330 |
|
NA |
| TYSND1 | lapatinib | 0.0133153 | 0.8066236 | 0.01332 |
|
NA |
| FLT3 | irinotecan | 0.0133264 | 0.8246221 | 0.01333 |
|
NA |
| KIAA0020 | selumetinib | 0.0133363 | 0.9529374 | 0.01334 |
|
NA |
| TRPA1 | irinotecan | 0.0133784 | 0.8246221 | 0.01338 |
|
NA |
| WNT3 | selumetinib | 0.0133915 | 0.9529374 | 0.01339 |
|
NA |
| HIST1H2BM | erlotinib | 0.0134253 | 0.8499467 | 0.01343 |
|
NA |
| TIMP2 | erlotinib | 0.0134253 | 0.8499467 | 0.01343 |
|
NA |
| EIF2D | selumetinib | 0.0134257 | 0.9529374 | 0.01343 |
|
NA |
| COMMD5 | selumetinib | 0.0134305 | 0.9529374 | 0.01343 |
|
NA |
| NUDT12 | lapatinib | 0.0134392 | 0.8066236 | 0.01344 |
|
NA |
| RTN2 | nilotinib | 0.0134491 | 0.9993215 | 0.0134 |
|
NA |
| DERA | erlotinib | 0.0134610 | 0.8499467 | 0.01346 |
|
NA |
| VPS13A | irinotecan | 0.0134695 | 0.8246221 | 0.01347 |
|
NA |
| TTC30B | lapatinib | 0.0134923 | 0.8066236 | 0.01349 |
|
NA |
| LHX5 | lapatinib | 0.0135007 | 0.8066236 | 0.01350 |
|
NA |
| GPR37L1 | erlotinib | 0.0135356 | 0.8499467 | 0.01354 |
|
NA |
| CLEC7A | lapatinib | 0.0135480 | 0.8066236 | 0.01355 |
|
NA |
| CRIM1 | lapatinib | 0.0135501 | 0.8066236 | 0.01355 |
|
NA |
| TACC2 | lapatinib | 0.0135525 | 0.8066236 | 0.01355 |
|
NA |
| CYP4A11 | lapatinib | 0.0135766 | 0.8066236 | 0.01358 |
|
NA |
| KATNAL2 | selumetinib | 0.0136110 | 0.9529374 | 0.01361 |
|
NA |
| ACTL7B | lapatinib | 0.0136111 | 0.8066236 | 0.01361 |
|
NA |
| ZHX3 | selumetinib | 0.0136323 | 0.9529374 | 0.01363 |
|
NA |
| PHLDB2 | lapatinib | 0.0136456 | 0.8066236 | 0.01365 |
|
NA |
| NBN | erlotinib | 0.0136799 | 0.8499467 | 0.01368 |
|
NA |
| HIST1H1A | selumetinib | 0.0136807 | 0.9529374 | 0.01368 |
|
NA |
| MPND | irinotecan | 0.0136922 | 0.8246221 | 0.01369 |
|
NA |
| CD300E | lapatinib | 0.0137066 | 0.8066236 | 0.01371 |
|
NA |
| TTN | irinotecan | 0.0137217 | 0.8246221 | 0.01372 |
|
NA |
| CEP135 | irinotecan | 0.0137235 | 0.8246221 | 0.01372 |
|
NA |
| RAPGEFL1 | erlotinib | 0.0137328 | 0.8499467 | 0.01373 |
|
NA |
| FAM13A | erlotinib | 0.0137684 | 0.8499467 | 0.01377 |
|
NA |
| CDH1 | selumetinib | 0.0137714 | 0.9529374 | 0.01377 |
|
NA |
| CA1 | lapatinib | 0.0137792 | 0.8066236 | 0.01378 |
|
NA |
| PTPN12 | selumetinib | 0.0137799 | 0.9529374 | 0.01378 |
|
NA |
| TTPAL | irinotecan | 0.0138057 | 0.8246221 | 0.01381 |
|
NA |
| TRAF3IP2 | selumetinib | 0.0138221 | 0.9529374 | 0.01382 |
|
NA |
| PARD6G | erlotinib | 0.0138977 | 0.8499467 | 0.01390 |
|
NA |
| PNKP | irinotecan | 0.0139155 | 0.8246221 | 0.01392 |
|
NA |
| MRPL52 | irinotecan | 0.0139359 | 0.8246221 | 0.01394 |
|
NA |
| OR10G3 | lapatinib | 0.0139729 | 0.8066236 | 0.01397 |
|
NA |
| RREB1 | lapatinib | 0.0139889 | 0.8066236 | 0.01399 |
|
NA |
| ASXL1 | lapatinib | 0.0139893 | 0.8066236 | 0.01399 |
|
NA |
| GMPR | lapatinib | 0.0139937 | 0.8066236 | 0.01399 |
|
NA |
| HJURP | lapatinib | 0.0140138 | 0.8066236 | 0.01401 |
|
NA |
| XRN1 | selumetinib | 0.0140306 | 0.9529374 | 0.01403 |
|
NA |
| RAX | selumetinib | 0.0140412 | 0.9529374 | 0.01404 |
|
NA |
| SERINC4 | irinotecan | 0.0140484 | 0.8246221 | 0.01405 |
|
NA |
| SIPA1L1 | erlotinib | 0.0140664 | 0.8499467 | 0.01407 |
|
NA |
| ZACN | erlotinib | 0.0140814 | 0.8499467 | 0.01408 |
|
NA |
| NPM3 | erlotinib | 0.0141252 | 0.8499467 | 0.01413 |
|
NA |
| EPB41 | selumetinib | 0.0141326 | 0.9529374 | 0.01413 |
|
NA |
| MAP3K12 | erlotinib | 0.0141606 | 0.8499467 | 0.01416 |
|
NA |
| NRXN1 | selumetinib | 0.0142408 | 0.9529374 | 0.01424 |
|
NA |
| DNAH11 | lapatinib | 0.0142409 | 0.8066236 | 0.01424 |
|
NA |
| DCST2 | lapatinib | 0.0142476 | 0.8066236 | 0.01425 |
|
NA |
| ADPRH | erlotinib | 0.0142498 | 0.8499467 | 0.01425 |
|
NA |
| ANK2 | erlotinib | 0.0142622 | 0.8499467 | 0.01426 |
|
NA |
| PDIA5 | selumetinib | 0.0142686 | 0.9529374 | 0.01427 |
|
NA |
| SETD1A | erlotinib | 0.0142934 | 0.8499467 | 0.01429 |
|
NA |
| LRRC6 | erlotinib | 0.0142953 | 0.8499467 | 0.01430 |
|
NA |
| APLP1 | erlotinib | 0.0143098 | 0.8499467 | 0.01431 |
|
NA |
| PNMT | selumetinib | 0.0143120 | 0.9529374 | 0.01431 |
|
NA |
| PPP4R2 | selumetinib | 0.0143168 | 0.9529374 | 0.01432 |
|
NA |
| TCP10 | lapatinib | 0.0143266 | 0.8066236 | 0.01433 |
|
NA |
| GYG1 | erlotinib | 0.0143415 | 0.8499467 | 0.01434 |
|
NA |
| C1QL4 | selumetinib | 0.0143556 | 0.9529374 | 0.01436 |
|
NA |
| TFDP1 | nilotinib | 0.0143583 | 0.9993215 | 0.0144 |
|
NA |
| PGBD2 | irinotecan | 0.0143732 | 0.8246221 | 0.01437 |
|
NA |
| ZSCAN32 | irinotecan | 0.0143736 | 0.8246221 | 0.01437 |
|
NA |
| TSPAN19 | selumetinib | 0.0143738 | 0.9529374 | 0.01437 |
|
NA |
| CACNA1E | erlotinib | 0.0143860 | 0.8499467 | 0.01439 |
|
NA |
| OR10C1 | selumetinib | 0.0144043 | 0.9529374 | 0.01440 |
|
NA |
| EVC2 | lapatinib | 0.0144176 | 0.8066236 | 0.01442 |
|
NA |
| SLC18B1 | irinotecan | 0.0144334 | 0.8246221 | 0.01443 |
|
NA |
| PEX6 | selumetinib | 0.0144452 | 0.9529374 | 0.01445 |
|
NA |
| ACSL5 | selumetinib | 0.0144484 | 0.9529374 | 0.01445 |
|
NA |
| THAP8 | erlotinib | 0.0145357 | 0.8499467 | 0.01454 |
|
NA |
| ACCS | irinotecan | 0.0146088 | 0.8246221 | 0.01461 |
|
NA |
| PIGC | irinotecan | 0.0146088 | 0.8246221 | 0.01461 |
|
NA |
| CLCN7 | selumetinib | 0.0146240 | 0.9529374 | 0.01462 |
|
NA |
| FKRP | selumetinib | 0.0146452 | 0.9529374 | 0.01465 |
|
NA |
| ATG4C | lapatinib | 0.0146507 | 0.8066236 | 0.01465 |
|
NA |
| CORO6 | nilotinib | 0.0146570 | 0.9993215 | 0.0147 |
|
NA |
| ZNF611 | erlotinib | 0.0146703 | 0.8499467 | 0.01467 |
|
NA |
| NLN | erlotinib | 0.0146707 | 0.8499467 | 0.01467 |
|
NA |
| DNAJC27 | selumetinib | 0.0146881 | 0.9529374 | 0.01469 |
|
NA |
| MEDAG | irinotecan | 0.0146904 | 0.8246221 | 0.01469 |
|
NA |
| MPG | nilotinib | 0.0146915 | 0.9993215 | 0.0147 |
|
NA |
| ZAR1L | lapatinib | 0.0147179 | 0.8066236 | 0.01472 |
|
NA |
| NARF | nilotinib | 0.0147350 | 0.9993215 | 0.0147 |
|
NA |
| RC3H1 | nilotinib | 0.0147517 | 0.9993215 | 0.0148 |
|
NA |
| SCCPDH | erlotinib | 0.0147526 | 0.8499467 | 0.01475 |
|
NA |
| RGS22 | lapatinib | 0.0147530 | 0.8066236 | 0.01475 |
|
NA |
| SUOX | selumetinib | 0.0147661 | 0.9529374 | 0.01477 |
|
NA |
| N6AMT1 | nilotinib | 0.0147708 | 0.9993215 | 0.0148 |
|
NA |
| IMPACT | erlotinib | 0.0148181 | 0.8499467 | 0.01482 |
|
NA |
| CCDC172 | nilotinib | 0.0148220 | 0.9993215 | 0.0148 |
|
NA |
| CEP170 | irinotecan | 0.0148339 | 0.8246221 | 0.01483 |
|
NA |
| TBC1D23 | nilotinib | 0.0148353 | 0.9993215 | 0.0148 |
|
NA |
| NEUROD6 | erlotinib | 0.0148643 | 0.8499467 | 0.01486 |
|
NA |
| HCAR3 | erlotinib | 0.0148895 | 0.8499467 | 0.01489 |
|
NA |
| ESCO2 | selumetinib | 0.0149443 | 0.9529374 | 0.01494 |
|
NA |
| ZMYM4 | nilotinib | 0.0149504 | 0.9993215 | 0.0150 |
|
NA |
| GHR | erlotinib | 0.0149527 | 0.8499467 | 0.01495 |
|
NA |
| IRX1 | lapatinib | 0.0149683 | 0.8066236 | 0.01497 |
|
NA |
| CFB | lapatinib | 0.0149905 | 0.8066236 | 0.01499 |
|
NA |
| TPBGL | erlotinib | 0.0149975 | 0.8499467 | 0.01500 |
|
NA |
| TARBP1 | irinotecan | 0.0150028 | 0.8246221 | 0.01500 |
|
NA |
| ZSCAN10 | irinotecan | 0.0150090 | 0.8246221 | 0.01501 |
|
NA |
| AGPAT3 | lapatinib | 0.0150180 | 0.8066236 | 0.01502 |
|
NA |
| PRG4 | irinotecan | 0.0150285 | 0.8246221 | 0.01503 |
|
NA |
| OGDH | erlotinib | 0.0150506 | 0.8499467 | 0.01505 |
|
NA |
| PCDHGA11 | selumetinib | 0.0151325 | 0.9529374 | 0.01513 |
|
NA |
| FCHO2 | erlotinib | 0.0151449 | 0.8499467 | 0.01514 |
|
NA |
| DMRT1 | selumetinib | 0.0151540 | 0.9529374 | 0.01515 |
|
NA |
| C9orf72 | nilotinib | 0.0151544 | 0.9993215 | 0.0152 |
|
NA |
| GMPR | selumetinib | 0.0151690 | 0.9529374 | 0.01517 |
|
NA |
| UBTD1 | selumetinib | 0.0151690 | 0.9529374 | 0.01517 |
|
NA |
| PRKACB | lapatinib | 0.0151797 | 0.8066236 | 0.01518 |
|
NA |
| RNPS1 | erlotinib | 0.0152110 | 0.8499467 | 0.01521 |
|
NA |
| TTC12 | lapatinib | 0.0152345 | 0.8066236 | 0.01523 |
|
NA |
| FLOT2 | selumetinib | 0.0152519 | 0.9529374 | 0.01525 |
|
NA |
| NECAB3 | nilotinib | 0.0152563 | 0.9993215 | 0.0153 |
|
NA |
| DIO3 | lapatinib | 0.0152738 | 0.8066236 | 0.01527 |
|
NA |
| PKMYT1 | selumetinib | 0.0152850 | 0.9529374 | 0.01529 |
|
NA |
| MRPS31 | nilotinib | 0.0152873 | 0.9993215 | 0.0153 |
|
NA |
| ZIC2 | lapatinib | 0.0153063 | 0.8066236 | 0.01531 |
|
NA |
| TMEM64 | nilotinib | 0.0153114 | 0.9993215 | 0.0153 |
|
NA |
| HIPK1 | selumetinib | 0.0153276 | 0.9529374 | 0.01533 |
|
NA |
| MARCO | irinotecan | 0.0153347 | 0.8246221 | 0.01533 |
|
NA |
| RAPH1 | irinotecan | 0.0153475 | 0.8246221 | 0.01535 |
|
NA |
| CENPH | lapatinib | 0.0153519 | 0.8066236 | 0.01535 |
|
NA |
| CDRT1 | nilotinib | 0.0153716 | 0.9993215 | 0.0154 |
|
NA |
| ASB1 | nilotinib | 0.0153785 | 0.9993215 | 0.0154 |
|
NA |
| HEBP2 | erlotinib | 0.0153939 | 0.8499467 | 0.01539 |
|
NA |
| FAM188A | lapatinib | 0.0154116 | 0.8066236 | 0.01541 |
|
NA |
| FAM20C | lapatinib | 0.0154118 | 0.8066236 | 0.01541 |
|
NA |
| ASB5 | irinotecan | 0.0154242 | 0.8246221 | 0.01542 |
|
NA |
| STX7 | lapatinib | 0.0154507 | 0.8066236 | 0.01545 |
|
NA |
| WDR19 | selumetinib | 0.0154520 | 0.9529374 | 0.01545 |
|
NA |
| HMGCS2 | lapatinib | 0.0154526 | 0.8066236 | 0.01545 |
|
NA |
| TRPV1 | lapatinib | 0.0154526 | 0.8066236 | 0.01545 |
|
NA |
| DEGS1 | irinotecan | 0.0154806 | 0.8246221 | 0.01548 |
|
NA |
| DOPEY2 | lapatinib | 0.0154895 | 0.8066236 | 0.01549 |
|
NA |
| URB1 | nilotinib | 0.0154932 | 0.9993215 | 0.0155 |
|
NA |
| CBLN3 | erlotinib | 0.0154997 | 0.8499467 | 0.01550 |
|
NA |
| SLC25A38 | selumetinib | 0.0155055 | 0.9529374 | 0.01551 |
|
NA |
| STAR | selumetinib | 0.0155055 | 0.9529374 | 0.01551 |
|
NA |
| RRP36 | selumetinib | 0.0155331 | 0.9529374 | 0.01553 |
|
NA |
| LRRC6 | irinotecan | 0.0155505 | 0.8246221 | 0.01555 |
|
NA |
| SF3A3 | lapatinib | 0.0155595 | 0.8066236 | 0.01556 |
|
NA |
| SLC35B2 | irinotecan | 0.0155907 | 0.8246221 | 0.01559 |
|
NA |
| DNAH5 | selumetinib | 0.0155968 | 0.9529374 | 0.01560 |
|
NA |
| KIF13B | nilotinib | 0.0156001 | 0.9993215 | 0.0156 |
|
NA |
| EIF3E | lapatinib | 0.0156229 | 0.8066236 | 0.01562 |
|
NA |
| ABCC2 | selumetinib | 0.0156577 | 0.9529374 | 0.01566 |
|
NA |
| ABCG1 | lapatinib | 0.0156643 | 0.8066236 | 0.01566 |
|
NA |
| BTBD7 | lapatinib | 0.0156750 | 0.8066236 | 0.01568 |
|
NA |
| DDR1 | selumetinib | 0.0156790 | 0.9529374 | 0.01568 |
|
NA |
| CECR6 | lapatinib | 0.0156871 | 0.8066236 | 0.01569 |
|
NA |
| EIF4E | erlotinib | 0.0156890 | 0.8499467 | 0.01569 |
|
NA |
| HCAR3 | lapatinib | 0.0157117 | 0.8066236 | 0.01571 |
|
NA |
| ZNF197 | erlotinib | 0.0157370 | 0.8499467 | 0.01574 |
|
NA |
| PHOSPHO2 | lapatinib | 0.0157386 | 0.8066236 | 0.01574 |
|
NA |
| ADHFE1 | erlotinib | 0.0157404 | 0.8499467 | 0.01574 |
|
NA |
| FBXO22 | irinotecan | 0.0157522 | 0.8246221 | 0.01575 |
|
NA |
| FBN3 | lapatinib | 0.0157659 | 0.8066236 | 0.01577 |
|
NA |
| CACNA1E | lapatinib | 0.0157664 | 0.8066236 | 0.01577 |
|
NA |
| TULP1 | erlotinib | 0.0157705 | 0.8499467 | 0.01577 |
|
NA |
| AOAH | selumetinib | 0.0157764 | 0.9529374 | 0.01578 |
|
NA |
| CHUK | selumetinib | 0.0157777 | 0.9529374 | 0.01578 |
|
NA |
| EIF4G2 | irinotecan | 0.0158021 | 0.8246221 | 0.01580 |
|
NA |
| TRIM8 | erlotinib | 0.0158225 | 0.8499467 | 0.01582 |
|
NA |
| ERLIN2 | irinotecan | 0.0158328 | 0.8246221 | 0.01583 |
|
NA |
| TIAL1 | erlotinib | 0.0158427 | 0.8499467 | 0.01584 |
|
NA |
| FICD | irinotecan | 0.0158432 | 0.8246221 | 0.01584 |
|
NA |
| ABI2 | selumetinib | 0.0158444 | 0.9529374 | 0.01584 |
|
NA |
| RPS23 | lapatinib | 0.0159240 | 0.8066236 | 0.01592 |
|
NA |
| OR5B21 | lapatinib | 0.0159287 | 0.8066236 | 0.01593 |
|
NA |
| LCMT2 | selumetinib | 0.0159616 | 0.9529374 | 0.01596 |
|
NA |
| AK9 | irinotecan | 0.0159828 | 0.8246221 | 0.01598 |
|
NA |
| NCR1 | selumetinib | 0.0159951 | 0.9529374 | 0.01600 |
|
NA |
| FOXA1 | erlotinib | 0.0159965 | 0.8499467 | 0.01600 |
|
NA |
| KIAA0907 | erlotinib | 0.0159993 | 0.8499467 | 0.01600 |
|
NA |
| GBP4 | irinotecan | 0.0160280 | 0.8246221 | 0.01603 |
|
NA |
| C8orf58 | nilotinib | 0.0160765 | 0.9993215 | 0.0161 |
|
NA |
| WAPAL | lapatinib | 0.0160771 | 0.8066236 | 0.01608 |
|
NA |
| TMEM2 | irinotecan | 0.0160876 | 0.8246221 | 0.01609 |
|
NA |
| EVI5 | nilotinib | 0.0160908 | 0.9993215 | 0.0161 |
|
NA |
| FAM83A | erlotinib | 0.0161191 | 0.8499467 | 0.01612 |
|
NA |
| CACNA2D4 | lapatinib | 0.0161449 | 0.8066236 | 0.01614 |
|
NA |
| TYR | nilotinib | 0.0161517 | 0.9993215 | 0.0162 |
|
NA |
| ERMARD | irinotecan | 0.0161836 | 0.8246221 | 0.01618 |
|
NA |
| CHURC1 | nilotinib | 0.0161851 | 0.9993215 | 0.0162 |
|
NA |
| C10orf54 | erlotinib | 0.0161924 | 0.8499467 | 0.01619 |
|
NA |
| DUOX2 | lapatinib | 0.0161973 | 0.8066236 | 0.01620 |
|
NA |
| NFE2 | erlotinib | 0.0162000 | 0.8499467 | 0.01620 |
|
NA |
| ARFGEF1 | irinotecan | 0.0162138 | 0.8246221 | 0.01621 |
|
NA |
| MCAT | lapatinib | 0.0162317 | 0.8066236 | 0.01623 |
|
NA |
| PACRG | irinotecan | 0.0162328 | 0.8246221 | 0.01623 |
|
NA |
| OR1M1 | erlotinib | 0.0162440 | 0.8499467 | 0.01624 |
|
NA |
| ITGA4 | lapatinib | 0.0162448 | 0.8066236 | 0.01624 |
|
NA |
| SNX8 | selumetinib | 0.0162503 | 0.9529374 | 0.01625 |
|
NA |
| MAPK12 | selumetinib | 0.0163132 | 0.9529374 | 0.01631 |
|
NA |
| CREB3L1 | nilotinib | 0.0163246 | 0.9993215 | 0.0163 |
|
NA |
| RNF133 | irinotecan | 0.0163374 | 0.8246221 | 0.01634 |
|
NA |
| POLR2H | lapatinib | 0.0163504 | 0.8066236 | 0.01635 |
|
NA |
| NMRK1 | erlotinib | 0.0163547 | 0.8499467 | 0.01635 |
|
NA |
| SLC4A4 | lapatinib | 0.0163672 | 0.8066236 | 0.01637 |
|
NA |
| MAFK | selumetinib | 0.0163758 | 0.9529374 | 0.01638 |
|
NA |
| PUS7L | irinotecan | 0.0163841 | 0.8246221 | 0.01638 |
|
NA |
| BCAR3 | nilotinib | 0.0163909 | 0.9993215 | 0.0164 |
|
NA |
| CECR1 | nilotinib | 0.0163909 | 0.9993215 | 0.0164 |
|
NA |
| RHBDD1 | selumetinib | 0.0164012 | 0.9529374 | 0.01640 |
|
NA |
| OTUD7B | irinotecan | 0.0164336 | 0.8246221 | 0.01643 |
|
NA |
| GAL3ST4 | nilotinib | 0.0164621 | 0.9993215 | 0.0165 |
|
NA |
| ARHGAP44 | selumetinib | 0.0164722 | 0.9529374 | 0.01647 |
|
NA |
| RAB11FIP2 | irinotecan | 0.0164732 | 0.8246221 | 0.01647 |
|
NA |
| MBNL2 | erlotinib | 0.0164762 | 0.8499467 | 0.01648 |
|
NA |
| OR52B2 | erlotinib | 0.0165488 | 0.8499467 | 0.01655 |
|
NA |
| CABLES2 | erlotinib | 0.0165550 | 0.8499467 | 0.01655 |
|
NA |
| MBP | irinotecan | 0.0165570 | 0.8246221 | 0.01656 |
|
NA |
| KIF20B | lapatinib | 0.0165851 | 0.8066236 | 0.01659 |
|
NA |
| RAD9A | lapatinib | 0.0165856 | 0.8066236 | 0.01659 |
|
NA |
| STX12 | irinotecan | 0.0166049 | 0.8246221 | 0.01660 |
|
NA |
| YY1AP1 | selumetinib | 0.0166219 | 0.9529374 | 0.01662 |
|
NA |
| KRT71 | irinotecan | 0.0166489 | 0.8246221 | 0.01665 |
|
NA |
| ZNF683 | nilotinib | 0.0166491 | 0.9993215 | 0.0166 |
|
NA |
| CES1 | irinotecan | 0.0166759 | 0.8246221 | 0.01668 |
|
NA |
| SELE | nilotinib | 0.0166968 | 0.9993215 | 0.0167 |
|
NA |
| NOL7 | lapatinib | 0.0167684 | 0.8066236 | 0.01677 |
|
NA |
| ZNF653 | lapatinib | 0.0167728 | 0.8066236 | 0.01677 |
|
NA |
| SRSF6 | irinotecan | 0.0167771 | 0.8246221 | 0.01678 |
|
NA |
| P2RX4 | irinotecan | 0.0168067 | 0.8246221 | 0.01681 |
|
NA |
| FAM222A | nilotinib | 0.0168189 | 0.9993215 | 0.0168 |
|
NA |
| ELP6 | lapatinib | 0.0168219 | 0.8066236 | 0.01682 |
|
NA |
| CERCAM | irinotecan | 0.0168859 | 0.8246221 | 0.01689 |
|
NA |
| DARS2 | lapatinib | 0.0169008 | 0.8066236 | 0.01690 |
|
NA |
| BAZ2A | lapatinib | 0.0169024 | 0.8066236 | 0.01690 |
|
NA |
| DHRS4 | erlotinib | 0.0169202 | 0.8499467 | 0.01692 |
|
NA |
| WNT16 | erlotinib | 0.0169232 | 0.8499467 | 0.01692 |
|
NA |
| NRIP1 | lapatinib | 0.0169419 | 0.8066236 | 0.01694 |
|
NA |
| ZNF490 | nilotinib | 0.0169423 | 0.9993215 | 0.0169 |
|
NA |
| PER1 | nilotinib | 0.0169779 | 0.9993215 | 0.0170 |
|
NA |
| PNPLA6 | irinotecan | 0.0169895 | 0.8246221 | 0.01699 |
|
NA |
| KDM4A | irinotecan | 0.0170229 | 0.8246221 | 0.01702 |
|
NA |
| UBXN4 | irinotecan | 0.0170285 | 0.8246221 | 0.01703 |
|
NA |
| ADRA1B | irinotecan | 0.0170490 | 0.8246221 | 0.01705 |
|
NA |
| SLC6A5 | nilotinib | 0.0170583 | 0.9993215 | 0.0171 |
|
NA |
| NR5A1 | erlotinib | 0.0170785 | 0.8499467 | 0.01708 |
|
NA |
| GALNT18 | erlotinib | 0.0170799 | 0.8499467 | 0.01708 |
|
NA |
| NAT14 | selumetinib | 0.0170861 | 0.9529374 | 0.01709 |
|
NA |
| PARVG | selumetinib | 0.0170882 | 0.9529374 | 0.01709 |
|
NA |
| ARHGAP5 | lapatinib | 0.0170916 | 0.8066236 | 0.01709 |
|
NA |
| FAM109B | erlotinib | 0.0170964 | 0.8499467 | 0.01710 |
|
NA |
| NEUROD6 | lapatinib | 0.0171355 | 0.8066236 | 0.01714 |
|
NA |
| NHLRC2 | lapatinib | 0.0171458 | 0.8066236 | 0.01715 |
|
NA |
| DNAH11 | erlotinib | 0.0171489 | 0.8499467 | 0.01715 |
|
NA |
| TIAF1 | erlotinib | 0.0171535 | 0.8499467 | 0.01715 |
|
NA |
| ARSG | nilotinib | 0.0171649 | 0.9993215 | 0.0172 |
|
NA |
| MEF2C | erlotinib | 0.0171686 | 0.8499467 | 0.01717 |
|
NA |
| ACSF2 | nilotinib | 0.0171972 | 0.9993215 | 0.0172 |
|
NA |
| RAPGEFL1 | nilotinib | 0.0171972 | 0.9993215 | 0.0172 |
|
NA |
| TIPARP | selumetinib | 0.0172099 | 0.9529374 | 0.01721 |
|
NA |
| SLC15A1 | erlotinib | 0.0172199 | 0.8499467 | 0.01722 |
|
NA |
| TIAL1 | lapatinib | 0.0172248 | 0.8066236 | 0.01722 |
|
NA |
| GLI3 | irinotecan | 0.0172435 | 0.8246221 | 0.01724 |
|
NA |
| CEP104 | nilotinib | 0.0172545 | 0.9993215 | 0.0173 |
|
NA |
| SLC18A1 | erlotinib | 0.0172557 | 0.8499467 | 0.01726 |
|
NA |
| SLX4 | lapatinib | 0.0172586 | 0.8066236 | 0.01726 |
|
NA |
| BASP1 | lapatinib | 0.0172588 | 0.8066236 | 0.01726 |
|
NA |
| NETO2 | irinotecan | 0.0172617 | 0.8246221 | 0.01726 |
|
NA |
| CYP2D6 | selumetinib | 0.0172619 | 0.9529374 | 0.01726 |
|
NA |
| TENC1 | lapatinib | 0.0172752 | 0.8066236 | 0.01728 |
|
NA |
| IGLON5 | erlotinib | 0.0172824 | 0.8499467 | 0.01728 |
|
NA |
| MPL | selumetinib | 0.0172826 | 0.9529374 | 0.01728 |
|
NA |
| HIST1H4D | selumetinib | 0.0172887 | 0.9529374 | 0.01729 |
|
NA |
| DEFB124 | lapatinib | 0.0173015 | 0.8066236 | 0.01730 |
|
NA |
| CEACAM21 | selumetinib | 0.0173077 | 0.9529374 | 0.01731 |
|
NA |
CTRP:
ctrp <- read.delim("./data_munging/data_drug_auc_ctrp_10_12_2018.csv", sep = "\t", header = TRUE, row.names = 1, check.names = FALSE)
ctrp <- merge(drug_meta, ctrp, by = "CID")
ctrp_melt <- melt(ctrp, id.var s = c("CID", "Drug"), measure.vars = colnames(ctrp)[3:ncol(ctrp)], variable.name = "accession_id", value.name = "AUC")
ctrp_grid <- expand.grid("accession_id" = unique(ctrp_melt$accession_id), "Hugo_Symbol" = as.character(unique(crispr_data$Hugo_Symbol)))
ctrp_data_allgenes <- WilcoxonByDrugAllGenes(ctrp_melt, ctrp_grid, "CTRP")
saveRDS(ctrp_data_allgenes, "./data_munging/rds/ctrp_data_18Q3_allgenes.rds", compress = "xz")
ctrp_data_allgenes <- readRDS("./data_munging/rds/ctrp_data_18Q3_allgenes.rds")
ctrp_data_allgenes <- ctrp_data_allgenes[order(ctrp_data_allgenes$p),]
knitr::kable(ctrp_data_allgenes[1:1000, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "CTRP: by-drug Wilcoxon test results for point mutations in genes targeted in CRISPR screen (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | Drug | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|---|
| BRAF | vemurafenib | 0.0000005 | 0.0083931 | 4.9e-07 | **** | ** |
| PTEN | afatinib | 0.0000005 | 0.0084143 | 5.0e-07 | **** | ** |
| KRT3 | vandetanib | 0.0000013 | 0.0216412 | 1.3e-06 | **** |
|
| KRAS | lapatinib | 0.0000056 | 0.0953102 | 5.6e-06 | **** | NA |
| MYO1B | vemurafenib | 0.0000114 | 0.0968555 | 1.1e-05 | **** | NA |
| KRAS | trametinib | 0.0000123 | 0.1904129 | 1.2e-05 | **** | NA |
| KRT3 | neratinib | 0.0000141 | 0.2403292 | 1.4e-05 | **** | NA |
| IL12RB2 | erlotinib | 0.0000169 | 0.1520260 | 1.7e-05 | **** | NA |
| KRAS | pazopanib | 0.0000172 | 0.2934471 | 1.7e-05 | **** | NA |
| KRT3 | erlotinib | 0.0000178 | 0.1520260 | 1.8e-05 | **** | NA |
| KRT3 | afatinib | 0.0000181 | 0.1537573 | 1.8e-05 | **** | NA |
| KRT3 | lapatinib | 0.0000234 | 0.1991097 | 2.3e-05 | **** | NA |
| AXL | vemurafenib | 0.0000280 | 0.1368615 | 2.8e-05 | **** | NA |
| KRAS | ibrutinib | 0.0000293 | 0.4281528 | 2.9e-05 | **** | NA |
| KIF24 | cabozantinib | 0.0000316 | 0.1286957 | 3.2e-05 | **** | NA |
| MYD88 | vemurafenib | 0.0000321 | 0.1368615 | 3.2e-05 | **** | NA |
| SHC4 | erlotinib | 0.0000489 | 0.2780669 | 4.9e-05 | **** | NA |
| PRDM5 | neratinib | 0.0000510 | 0.4354491 | 5.1e-05 | **** | NA |
| SEC14L5 | ibrutinib | 0.0000517 | 0.4281528 | 5.2e-05 | **** | NA |
| BRINP3 | cabozantinib | 0.0000537 | 0.1286957 | 5.4e-05 | **** | NA |
| PTEN | lapatinib | 0.0000569 | 0.3228575 | 5.7e-05 | **** | NA |
| KRT3 | gefitinib | 0.0000607 | 0.8522633 | 6.1e-05 | **** | NA |
| EPHA1 | temozolomide | 0.0000773 | 0.8741265 | 7.7e-05 | **** | NA |
| GOLGA3 | cabozantinib | 0.0000815 | 0.1286957 | 8.1e-05 | **** | NA |
| WNK4 | regorafenib | 0.0000904 | 0.6564110 | 9e-05 | **** | NA |
| DDX59 | cabozantinib | 0.0000951 | 0.1286957 | 9.5e-05 | **** | NA |
| PLOD2 | cabozantinib | 0.0000974 | 0.1286957 | 9.7e-05 | **** | NA |
| AHCTF1 | cabozantinib | 0.0000976 | 0.1286957 | 9.8e-05 | **** | NA |
| COL11A2 | sunitinib | 0.0000988 | 0.6695527 | 9.9e-05 | **** | NA |
| DET1 | gefitinib | 0.0001000 | 0.8522633 | 0.00010 | *** | NA |
| ZBTB47 | cabozantinib | 0.0001022 | 0.1286957 | 0.00010 | *** | NA |
| GAB4 | regorafenib | 0.0001024 | 0.6564110 | 0.00010 | *** | NA |
| AHNAK | cabozantinib | 0.0001039 | 0.1286957 | 0.00010 | *** | NA |
| HADHA | cabozantinib | 0.0001054 | 0.1286957 | 0.00011 | *** | NA |
| TERT | cabozantinib | 0.0001056 | 0.1286957 | 0.00011 | *** | NA |
| ANK3 | nilotinib | 0.0001112 | 0.7820181 | 0.00011 | *** | NA |
| E2F7 | sunitinib | 0.0001191 | 0.6695527 | 0.00012 | *** | NA |
| PPP2R1A | cabozantinib | 0.0001203 | 0.1286957 | 0.00012 | *** | NA |
| MUC16 | cabozantinib | 0.0001209 | 0.1286957 | 0.00012 | *** | NA |
| MYT1 | cabozantinib | 0.0001213 | 0.1286957 | 0.00012 | *** | NA |
| SLC7A14 | imatinib | 0.0001217 | 0.8762527 | 0.00012 | *** | NA |
| PHF21B | imatinib | 0.0001249 | 0.8762527 | 0.00012 | *** | NA |
| SOCS4 | cabozantinib | 0.0001270 | 0.1286957 | 0.00013 | *** | NA |
| NLRC5 | sunitinib | 0.0001311 | 0.6695527 | 0.00013 | *** | NA |
| VPS13B | cabozantinib | 0.0001340 | 0.1286957 | 0.00013 | *** | NA |
| PRDM5 | lapatinib | 0.0001343 | 0.5312630 | 0.00013 | *** | NA |
| EMILIN3 | cabozantinib | 0.0001348 | 0.1286957 | 0.00013 | *** | NA |
| STIM2 | vemurafenib | 0.0001357 | 0.3867723 | 0.00014 | *** | NA |
| SBF2 | cabozantinib | 0.0001385 | 0.1286957 | 0.00014 | *** | NA |
| TTN | pazopanib | 0.0001407 | 0.9778540 | 0.00014 | *** | NA |
| VRK1 | cabozantinib | 0.0001426 | 0.1286957 | 0.00014 | *** | NA |
| CEP290 | regorafenib | 0.0001429 | 0.6564110 | 0.00014 | *** | NA |
| RBM5 | cabozantinib | 0.0001468 | 0.1286957 | 0.00015 | *** | NA |
| ICAM5 | cabozantinib | 0.0001556 | 0.1286957 | 0.00016 | *** | NA |
| CXXC5 | lapatinib | 0.0001559 | 0.5312630 | 0.00016 | *** | NA |
| ATAD5 | erlotinib | 0.0001579 | 0.4689421 | 0.00016 | *** | NA |
| SNX6 | vemurafenib | 0.0001604 | 0.3867723 | 0.00016 | *** | NA |
| TMTC3 | fluorouracil | 0.0001645 | 1.0000000 | 0.00016 | *** | NA |
| SSFA2 | erlotinib | 0.0001677 | 0.4689421 | 0.00017 | *** | NA |
| FAM193B | cabozantinib | 0.0001710 | 0.1286957 | 0.00017 | *** | NA |
| TACC2 | cabozantinib | 0.0001738 | 0.1286957 | 0.00017 | *** | NA |
| MKL1 | cabozantinib | 0.0001742 | 0.1286957 | 0.00017 | *** | NA |
| PTEN | sunitinib | 0.0001751 | 0.6695527 | 0.00018 | *** | NA |
| LRP11 | vemurafenib | 0.0001765 | 0.3867723 | 0.00018 | *** | NA |
| ZNF248 | erlotinib | 0.0001773 | 0.4689421 | 0.00018 | *** | NA |
| SNX14 | cabozantinib | 0.0001832 | 0.1296498 | 0.00018 | *** | NA |
| BRD7 | vemurafenib | 0.0001838 | 0.3867723 | 0.00018 | *** | NA |
| ERMARD | erlotinib | 0.0001923 | 0.4689421 | 0.00019 | *** | NA |
| KRT3 | ibrutinib | 0.0001957 | 0.9136837 | 0.00020 | *** | NA |
| CACNA1C | cabozantinib | 0.0001963 | 0.1312426 | 0.00020 | *** | NA |
| DHTKD1 | vandetanib | 0.0001986 | 0.8963224 | 0.00020 | *** | NA |
| PCYOX1L | cabozantinib | 0.0002009 | 0.1312426 | 0.00020 | *** | NA |
| KRAS | selumetinib | 0.0002012 | 0.9983774 | 0.00020 | *** | NA |
| BRAF | selumetinib | 0.0002081 | 0.9983774 | 0.00021 | *** | NA |
| SRCIN1 | cabozantinib | 0.0002116 | 0.1331394 | 0.00021 | *** | NA |
| PTEN | neratinib | 0.0002153 | 0.9827379 | 0.00022 | *** | NA |
| CACTIN | cabozantinib | 0.0002225 | 0.1350202 | 0.00022 | *** | NA |
| TP53 | olaparib | 0.0002233 | 0.9821538 | 0.00022 | *** | NA |
| KCTD3 | vemurafenib | 0.0002279 | 0.3867723 | 0.00023 | *** | NA |
| ZNF217 | lapatinib | 0.0002453 | 0.6963677 | 0.00025 | *** | NA |
| BRAF | olaparib | 0.0002505 | 0.9821538 | 0.00025 | *** | NA |
| ANKLE1 | cabozantinib | 0.0002608 | 0.1477637 | 0.00026 | *** | NA |
| ENOSF1 | cabozantinib | 0.0002609 | 0.1477637 | 0.00026 | *** | NA |
| GATA3 | cabozantinib | 0.0002714 | 0.1487444 | 0.00027 | *** | NA |
| SHC1 | dasatinib | 0.0002715 | 0.9816837 | 0.00027 | *** | NA |
| BRAF | dabrafenib | 0.0002722 | 0.9104067 | 0.00027 | *** | NA |
| EXT2 | ibrutinib | 0.0002723 | 0.9136837 | 0.00027 | *** | NA |
| TEP1 | cabozantinib | 0.0002862 | 0.1510065 | 0.00029 | *** | NA |
| ZNF467 | cabozantinib | 0.0002933 | 0.1510065 | 0.00029 | *** | NA |
| ZNF804B | pazopanib | 0.0002963 | 0.9778540 | 0.00030 | *** | NA |
| ANKLE1 | sunitinib | 0.0003252 | 0.6695527 | 0.00033 | *** | NA |
| GCC2 | cabozantinib | 0.0003302 | 0.1558899 | 0.00033 | *** | NA |
| CREBBP | dasatinib | 0.0003347 | 0.9816837 | 0.00033 | *** | NA |
| LRRC16A | vemurafenib | 0.0003411 | 0.3867723 | 0.00034 | *** | NA |
| ZNF335 | cabozantinib | 0.0003430 | 0.1558899 | 0.00034 | *** | NA |
| PYGO1 | afatinib | 0.0003533 | 0.8943727 | 0.00035 | *** | NA |
| PAQR8 | neratinib | 0.0003588 | 0.9827379 | 0.00036 | *** | NA |
| DMXL1 | imatinib | 0.0003594 | 0.8762527 | 0.00036 | *** | NA |
| KLHL40 | cabozantinib | 0.0003618 | 0.1558899 | 0.00036 | *** | NA |
| RTFDC1 | afatinib | 0.0003639 | 0.8943727 | 0.00036 | *** | NA |
| SCN1A | fulvestrant | 0.0003688 | 0.9869407 | 0.00037 | *** | NA |
| WNK4 | vemurafenib | 0.0003713 | 0.3867723 | 0.00037 | *** | NA |
| ASTN2 | cabozantinib | 0.0003714 | 0.1558899 | 0.00037 | *** | NA |
| NSA2 | ibrutinib | 0.0003777 | 0.9136837 | 0.00038 | *** | NA |
| MAK16 | cabozantinib | 0.0003884 | 0.1558899 | 0.00039 | *** | NA |
| DMRTA2 | cabozantinib | 0.0003898 | 0.1558899 | 0.00039 | *** | NA |
| URB2 | cabozantinib | 0.0003978 | 0.1558899 | 0.00040 | *** | NA |
| CLIP2 | cabozantinib | 0.0003980 | 0.1558899 | 0.00040 | *** | NA |
| ATP11A | sunitinib | 0.0004107 | 0.6695527 | 0.00041 | *** | NA |
| RUNX1 | regorafenib | 0.0004133 | 0.6564110 | 0.00041 | *** | NA |
| SLC29A4 | nilotinib | 0.0004156 | 0.7820181 | 0.00042 | *** | NA |
| SNX19 | cabozantinib | 0.0004184 | 0.1558899 | 0.00042 | *** | NA |
| ABCF1 | regorafenib | 0.0004243 | 0.6564110 | 0.00042 | *** | NA |
| MEP1A | gefitinib | 0.0004262 | 0.9513640 | 0.00043 | *** | NA |
| ARID3B | gefitinib | 0.0004268 | 0.9513640 | 0.00043 | *** | NA |
| KRAS | sunitinib | 0.0004277 | 0.6695527 | 0.00043 | *** | NA |
| NAIF1 | cabozantinib | 0.0004303 | 0.1558899 | 0.00043 | *** | NA |
| TTN | olaparib | 0.0004307 | 0.9821538 | 0.00043 | *** | NA |
| KRAS | neratinib | 0.0004366 | 0.9827379 | 0.00044 | *** | NA |
| JPH2 | lapatinib | 0.0004376 | 0.8488319 | 0.00044 | *** | NA |
| TSHZ2 | vemurafenib | 0.0004471 | 0.3867723 | 0.00045 | *** | NA |
| ZFP36L2 | regorafenib | 0.0004494 | 0.6564110 | 0.00045 | *** | NA |
| ACTL10 | cabozantinib | 0.0004521 | 0.1558899 | 0.00045 | *** | NA |
| TEK | regorafenib | 0.0004540 | 0.6564110 | 0.00045 | *** | NA |
| PCGF3 | pazopanib | 0.0004551 | 0.9778540 | 0.00046 | *** | NA |
| IFRD2 | vemurafenib | 0.0004566 | 0.3867723 | 0.00046 | *** | NA |
| SORL1 | cabozantinib | 0.0004583 | 0.1558899 | 0.00046 | *** | NA |
| RASEF | afatinib | 0.0004625 | 0.8943727 | 0.00046 | *** | NA |
| P2RX2 | vemurafenib | 0.0004626 | 0.3867723 | 0.00046 | *** | NA |
| CCDC122 | vemurafenib | 0.0004652 | 0.3867723 | 0.00047 | *** | NA |
| PPP3CB | vandetanib | 0.0004707 | 0.8963224 | 0.00047 | *** | NA |
| MSH6 | cabozantinib | 0.0004853 | 0.1558899 | 0.00049 | *** | NA |
| ANKEF1 | regorafenib | 0.0004913 | 0.6564110 | 0.00049 | *** | NA |
| SRPK1 | cabozantinib | 0.0004942 | 0.1558899 | 0.00049 | *** | NA |
| JAKMIP2 | vemurafenib | 0.0004957 | 0.3867723 | 0.00050 | *** | NA |
| AK8 | neratinib | 0.0004999 | 0.9827379 | 0.00050 | *** | NA |
| SEMA5A | cabozantinib | 0.0005006 | 0.1558899 | 0.00050 | *** | NA |
| GJA8 | azd | 0.0005022 | 0.9984655 | 0.00050 | *** | NA |
| C3 | vemurafenib | 0.0005049 | 0.3867723 | 0.00050 | *** | NA |
| KAT6A | cabozantinib | 0.0005081 | 0.1558899 | 0.00051 | *** | NA |
| HLA-B | sunitinib | 0.0005095 | 0.6695527 | 0.00051 | *** | NA |
| ST14 | regorafenib | 0.0005100 | 0.6564110 | 0.00051 | *** | NA |
| PCDH20 | cabozantinib | 0.0005176 | 0.1558899 | 0.00052 | *** | NA |
| C17orf70 | cabozantinib | 0.0005187 | 0.1558899 | 0.00052 | *** | NA |
| CIT | vemurafenib | 0.0005219 | 0.3867723 | 0.00052 | *** | NA |
| NUP107 | cabozantinib | 0.0005314 | 0.1558899 | 0.00053 | *** | NA |
| CLEC4E | vandetanib | 0.0005363 | 0.8963224 | 0.00054 | *** | NA |
| CXXC5 | neratinib | 0.0005366 | 0.9827379 | 0.00054 | *** | NA |
| HSPA13 | cabozantinib | 0.0005375 | 0.1558899 | 0.00054 | *** | NA |
| ZNF248 | cabozantinib | 0.0005408 | 0.1558899 | 0.00054 | *** | NA |
| HDAC3 | cabozantinib | 0.0005468 | 0.1558899 | 0.00055 | *** | NA |
| PRKAG2 | crizotinib | 0.0005484 | 0.9965659 | 0.00055 | *** | NA |
| DNAH14 | nilotinib | 0.0005496 | 0.7820181 | 0.00055 | *** | NA |
| PPP1R26 | olaparib | 0.0005576 | 0.9821538 | 0.00056 | *** | NA |
| UCP1 | sunitinib | 0.0005642 | 0.6695527 | 0.00056 | *** | NA |
| RAD23A | gefitinib | 0.0005652 | 0.9513640 | 0.00057 | *** | NA |
| TSHZ1 | regorafenib | 0.0005665 | 0.6564110 | 0.00057 | *** | NA |
| PCDHA10 | neratinib | 0.0005673 | 0.9827379 | 0.00057 | *** | NA |
| KMT2D | cabozantinib | 0.0005681 | 0.1558899 | 0.00057 | *** | NA |
| APC | erlotinib | 0.0005703 | 0.7436781 | 0.00057 | *** | NA |
| PAX1 | imatinib | 0.0005793 | 0.8762527 | 0.00058 | *** | NA |
| SGCG | lapatinib | 0.0005793 | 0.8488319 | 0.00058 | *** | NA |
| NELFA | sunitinib | 0.0005822 | 0.6695527 | 0.00058 | *** | NA |
| STK35 | cabozantinib | 0.0005881 | 0.1558899 | 0.00059 | *** | NA |
| SYNE4 | cabozantinib | 0.0005946 | 0.1558899 | 0.00059 | *** | NA |
| SLC4A8 | cabozantinib | 0.0005954 | 0.1558899 | 0.00060 | *** | NA |
| ARID3B | erlotinib | 0.0005962 | 0.7436781 | 0.00060 | *** | NA |
| RCC2 | vemurafenib | 0.0006048 | 0.3867723 | 0.00060 | *** | NA |
| LILRA1 | ibrutinib | 0.0006135 | 0.9136837 | 0.00061 | *** | NA |
| IQCE | cabozantinib | 0.0006141 | 0.1558899 | 0.00061 | *** | NA |
| EFCAB3 | vemurafenib | 0.0006144 | 0.3867723 | 0.00061 | *** | NA |
| APBA3 | afatinib | 0.0006175 | 0.8943727 | 0.00062 | *** | NA |
| RAB11FIP3 | lapatinib | 0.0006211 | 0.8488319 | 0.00062 | *** | NA |
| CBLN3 | cabozantinib | 0.0006239 | 0.1558899 | 0.00062 | *** | NA |
| SLC45A2 | cabozantinib | 0.0006261 | 0.1558899 | 0.00063 | *** | NA |
| KYNU | gefitinib | 0.0006263 | 0.9513640 | 0.00063 | *** | NA |
| CHEK2 | erlotinib | 0.0006283 | 0.7436781 | 0.00063 | *** | NA |
| VCAN | azd | 0.0006318 | 0.9984655 | 0.00063 | *** | NA |
| EGFR | vemurafenib | 0.0006405 | 0.3867723 | 0.00064 | *** | NA |
| TP53 | crizotinib | 0.0006495 | 0.9965659 | 0.00065 | *** | NA |
| MRGPRX1 | erlotinib | 0.0006522 | 0.7436781 | 0.00065 | *** | NA |
| DLX4 | cabozantinib | 0.0006567 | 0.1558899 | 0.00066 | *** | NA |
| ADNP | cabozantinib | 0.0006591 | 0.1558899 | 0.00066 | *** | NA |
| MAP7 | vemurafenib | 0.0006626 | 0.3867723 | 0.00066 | *** | NA |
| SLC35F2 | cabozantinib | 0.0006630 | 0.1558899 | 0.00066 | *** | NA |
| SH3BP5L | crizotinib | 0.0006657 | 0.9965659 | 0.00067 | *** | NA |
| DIMT1 | vemurafenib | 0.0006662 | 0.3867723 | 0.00067 | *** | NA |
| TNRC18 | olaparib | 0.0006714 | 0.9821538 | 0.00067 | *** | NA |
| HINFP | cabozantinib | 0.0006784 | 0.1558899 | 0.00068 | *** | NA |
| NME3 | cabozantinib | 0.0006809 | 0.1558899 | 0.00068 | *** | NA |
| ITGA6 | cabozantinib | 0.0006851 | 0.1558899 | 0.00069 | *** | NA |
| ZFP69B | cabozantinib | 0.0006856 | 0.1558899 | 0.00069 | *** | NA |
| MCM3AP | nilotinib | 0.0006880 | 0.7820181 | 0.00069 | *** | NA |
| RANBP3 | cabozantinib | 0.0006949 | 0.1558899 | 0.00069 | *** | NA |
| COL6A2 | afatinib | 0.0006970 | 0.8943727 | 0.00070 | *** | NA |
| RTFDC1 | neratinib | 0.0006971 | 0.9827379 | 0.00070 | *** | NA |
| ADAMTS13 | erlotinib | 0.0006981 | 0.7436781 | 0.00070 | *** | NA |
| OR6C75 | regorafenib | 0.0007051 | 0.6564110 | 0.00071 | *** | NA |
| ARID3B | neratinib | 0.0007102 | 0.9827379 | 0.00071 | *** | NA |
| OR2T27 | imatinib | 0.0007124 | 0.8762527 | 0.00071 | *** | NA |
| ZKSCAN3 | cabozantinib | 0.0007188 | 0.1558899 | 0.00072 | *** | NA |
| GABRR2 | sunitinib | 0.0007199 | 0.6695527 | 0.00072 | *** | NA |
| SEC14L2 | vemurafenib | 0.0007239 | 0.3867723 | 0.00072 | *** | NA |
| WDR11 | vemurafenib | 0.0007255 | 0.3867723 | 0.00073 | *** | NA |
| PAX8 | regorafenib | 0.0007275 | 0.6564110 | 0.00073 | *** | NA |
| BCLAF1 | vandetanib | 0.0007373 | 0.8963224 | 0.00074 | *** | NA |
| CCDC34 | cabozantinib | 0.0007377 | 0.1558899 | 0.00074 | *** | NA |
| FANCM | cabozantinib | 0.0007380 | 0.1558899 | 0.00074 | *** | NA |
| CCDC147 | regorafenib | 0.0007423 | 0.6564110 | 0.00074 | *** | NA |
| SOX11 | cabozantinib | 0.0007426 | 0.1558899 | 0.00074 | *** | NA |
| FAHD2B | cabozantinib | 0.0007434 | 0.1558899 | 0.00074 | *** | NA |
| CALCR | olaparib | 0.0007449 | 0.9821538 | 0.00074 | *** | NA |
| POLQ | nilotinib | 0.0007490 | 0.7820181 | 0.00075 | *** | NA |
| HEATR4 | neratinib | 0.0007513 | 0.9827379 | 0.00075 | *** | NA |
| UBAP2L | regorafenib | 0.0007520 | 0.6564110 | 0.00075 | *** | NA |
| CCDC101 | olaparib | 0.0007540 | 0.9821538 | 0.00075 | *** | NA |
| ZNF471 | nilotinib | 0.0007567 | 0.7820181 | 0.00076 | *** | NA |
| CRIM1 | regorafenib | 0.0007664 | 0.6564110 | 0.00077 | *** | NA |
| KIAA1586 | cabozantinib | 0.0007673 | 0.1558899 | 0.00077 | *** | NA |
| TP53 | cabozantinib | 0.0007688 | 0.1558899 | 0.00077 | *** | NA |
| SRRM1 | olaparib | 0.0007730 | 0.9821538 | 0.00077 | *** | NA |
| DUSP13 | cabozantinib | 0.0007746 | 0.1558899 | 0.00077 | *** | NA |
| DOCK2 | vemurafenib | 0.0007783 | 0.3867723 | 0.00078 | *** | NA |
| TMEM63A | vemurafenib | 0.0007807 | 0.3867723 | 0.00078 | *** | NA |
| GJA8 | sunitinib | 0.0007809 | 0.6695527 | 0.00078 | *** | NA |
| ZNF697 | vemurafenib | 0.0007878 | 0.3867723 | 0.00079 | *** | NA |
| FAT2 | nilotinib | 0.0007897 | 0.7820181 | 0.00079 | *** | NA |
| NME8 | olaparib | 0.0007906 | 0.9821538 | 0.00079 | *** | NA |
| CFI | temozolomide | 0.0007920 | 0.8741265 | 0.00079 | *** | NA |
| KRT83 | vemurafenib | 0.0007933 | 0.3867723 | 0.00079 | *** | NA |
| NTSR2 | cabozantinib | 0.0007941 | 0.1558899 | 0.00079 | *** | NA |
| MEFV | cabozantinib | 0.0007943 | 0.1558899 | 0.00079 | *** | NA |
| GPR110 | temozolomide | 0.0007944 | 0.8741265 | 0.00079 | *** | NA |
| LZTFL1 | crizotinib | 0.0007987 | 0.9965659 | 0.00080 | *** | NA |
| UVSSA | olaparib | 0.0008038 | 0.9821538 | 0.00080 | *** | NA |
| GPR128 | dasatinib | 0.0008067 | 0.9816837 | 0.00081 | *** | NA |
| TAF6 | lapatinib | 0.0008077 | 0.8488319 | 0.00081 | *** | NA |
| GPR110 | regorafenib | 0.0008117 | 0.6564110 | 0.00081 | *** | NA |
| NMUR1 | cabozantinib | 0.0008122 | 0.1558899 | 0.00081 | *** | NA |
| TRPV4 | cabozantinib | 0.0008139 | 0.1558899 | 0.00081 | *** | NA |
| PPP2R5E | cabozantinib | 0.0008178 | 0.1558899 | 0.00082 | *** | NA |
| PNLIPRP1 | nilotinib | 0.0008194 | 0.7820181 | 0.00082 | *** | NA |
| IKZF2 | sunitinib | 0.0008236 | 0.6695527 | 0.00082 | *** | NA |
| GRIK1 | temozolomide | 0.0008293 | 0.8741265 | 0.00083 | *** | NA |
| DHDDS | cabozantinib | 0.0008327 | 0.1558899 | 0.00083 | *** | NA |
| TRIM5 | cabozantinib | 0.0008355 | 0.1558899 | 0.00084 | *** | NA |
| STX17 | cabozantinib | 0.0008356 | 0.1558899 | 0.00084 | *** | NA |
| SYNDIG1 | dasatinib | 0.0008414 | 0.9816837 | 0.00084 | *** | NA |
| TNXB | sunitinib | 0.0008457 | 0.6695527 | 0.00085 | *** | NA |
| ENPP3 | sunitinib | 0.0008489 | 0.6695527 | 0.00085 | *** | NA |
| PAX2 | vemurafenib | 0.0008524 | 0.3867723 | 0.00085 | *** | NA |
| PWWP2B | nilotinib | 0.0008593 | 0.7820181 | 0.00086 | *** | NA |
| KPNB1 | vemurafenib | 0.0008621 | 0.3867723 | 0.00086 | *** | NA |
| TRPM6 | vemurafenib | 0.0008630 | 0.3867723 | 0.00086 | *** | NA |
| GPR4 | cabozantinib | 0.0008646 | 0.1558899 | 0.00086 | *** | NA |
| ZNF587 | dasatinib | 0.0008680 | 0.9816837 | 0.00087 | *** | NA |
| ZNF253 | temozolomide | 0.0008681 | 0.8741265 | 0.00087 | *** | NA |
| TGFB3 | vemurafenib | 0.0008700 | 0.3867723 | 0.00087 | *** | NA |
| TRIML1 | cabozantinib | 0.0008794 | 0.1558899 | 0.00088 | *** | NA |
| OR7D4 | regorafenib | 0.0008827 | 0.6564110 | 0.00088 | *** | NA |
| HOOK2 | fulvestrant | 0.0008831 | 0.9869407 | 0.00088 | *** | NA |
| MAP2K7 | vemurafenib | 0.0008832 | 0.3867723 | 0.00088 | *** | NA |
| NOL7 | sunitinib | 0.0008896 | 0.6695527 | 0.00089 | *** | NA |
| HAND2 | cabozantinib | 0.0008907 | 0.1558899 | 0.00089 | *** | NA |
| THSD7A | temozolomide | 0.0008907 | 0.8741265 | 0.00089 | *** | NA |
| TRA2B | cabozantinib | 0.0008965 | 0.1558899 | 0.00090 | *** | NA |
| RECQL | vemurafenib | 0.0008969 | 0.3867723 | 0.00090 | *** | NA |
| PROSER1 | vandetanib | 0.0008976 | 0.8963224 | 0.00090 | *** | NA |
| BRAF | afatinib | 0.0008985 | 0.8943727 | 0.00090 | *** | NA |
| ZFYVE16 | vemurafenib | 0.0009018 | 0.3867723 | 0.00090 | *** | NA |
| PLCL1 | ibrutinib | 0.0009043 | 0.9136837 | 0.00090 | *** | NA |
| SETD1A | erlotinib | 0.0009046 | 0.7436781 | 0.00090 | *** | NA |
| NCOA7 | cabozantinib | 0.0009047 | 0.1558899 | 0.00090 | *** | NA |
| MUC16 | crizotinib | 0.0009097 | 0.9965659 | 0.00091 | *** | NA |
| GPR128 | vandetanib | 0.0009125 | 0.8963224 | 0.00091 | *** | NA |
| RAD23A | afatinib | 0.0009161 | 0.8943727 | 0.00092 | *** | NA |
| NUAK2 | cabozantinib | 0.0009193 | 0.1558899 | 0.00092 | *** | NA |
| GPAT2 | azd | 0.0009198 | 0.9984655 | 0.00092 | *** | NA |
| ITGAL | cabozantinib | 0.0009198 | 0.1558899 | 0.00092 | *** | NA |
| TOPORS | cabozantinib | 0.0009234 | 0.1558899 | 0.00092 | *** | NA |
| IRX4 | cabozantinib | 0.0009248 | 0.1558899 | 0.00092 | *** | NA |
| FBXO42 | vemurafenib | 0.0009250 | 0.3867723 | 0.00092 | *** | NA |
| TRIM4 | cabozantinib | 0.0009261 | 0.1558899 | 0.00093 | *** | NA |
| NPR3 | regorafenib | 0.0009273 | 0.6564110 | 0.00093 | *** | NA |
| NGFR | cabozantinib | 0.0009365 | 0.1558899 | 0.00094 | *** | NA |
| CCDC68 | lapatinib | 0.0009373 | 0.8488319 | 0.00094 | *** | NA |
| POU6F2 | gefitinib | 0.0009381 | 0.9513640 | 0.00094 | *** | NA |
| ATP11A | cabozantinib | 0.0009410 | 0.1558899 | 0.00094 | *** | NA |
| DYNC1H1 | cabozantinib | 0.0009421 | 0.1558899 | 0.00094 | *** | NA |
| RAD23A | neratinib | 0.0009440 | 0.9827379 | 0.00094 | *** | NA |
| CFHR2 | olaparib | 0.0009453 | 0.9821538 | 0.00095 | *** | NA |
| SLC45A3 | cabozantinib | 0.0009465 | 0.1558899 | 0.00095 | *** | NA |
| CYBRD1 | vemurafenib | 0.0009509 | 0.3867723 | 0.00095 | *** | NA |
| ARMC4 | nilotinib | 0.0009519 | 0.7820181 | 0.00095 | *** | NA |
| SPRED1 | afatinib | 0.0009531 | 0.8943727 | 0.00095 | *** | NA |
| MUM1 | cabozantinib | 0.0009561 | 0.1558899 | 0.00096 | *** | NA |
| MBOAT2 | erlotinib | 0.0009582 | 0.7436781 | 0.00096 | *** | NA |
| TEKT2 | cabozantinib | 0.0009633 | 0.1558899 | 0.00096 | *** | NA |
| THNSL1 | dabrafenib | 0.0009636 | 0.9104067 | 0.00096 | *** | NA |
| DTX3L | vandetanib | 0.0009650 | 0.8963224 | 0.00096 | *** | NA |
| NELFA | cabozantinib | 0.0009689 | 0.1558899 | 0.00097 | *** | NA |
| TRIM72 | nilotinib | 0.0009704 | 0.7820181 | 0.00097 | *** | NA |
| TTC30A | nilotinib | 0.0009749 | 0.7820181 | 0.00097 | *** | NA |
| MYH7B | sunitinib | 0.0009751 | 0.6695527 | 0.00098 | *** | NA |
| GPRIN1 | lapatinib | 0.0009771 | 0.8488319 | 0.00098 | *** | NA |
| POLN | regorafenib | 0.0009782 | 0.6564110 | 0.00098 | *** | NA |
| VENTX | cabozantinib | 0.0009799 | 0.1558899 | 0.00098 | *** | NA |
| TMEM63B | cabozantinib | 0.0009927 | 0.1558899 | 0.00099 | *** | NA |
| ZFR | cabozantinib | 0.0009946 | 0.1558899 | 0.00099 | *** | NA |
| PIK3C2G | cabozantinib | 0.0009996 | 0.1558899 | 0.00100 | *** | NA |
| AP1G2 | ruxolitinib | 0.0010001 | 1.0000000 | 0.0010 | ** | NA |
| NOX5 | cabozantinib | 0.0010026 | 0.1558899 | 0.00100 | ** | NA |
| AK8 | lapatinib | 0.0010032 | 0.8488319 | 0.00100 | ** | NA |
| TGFB3 | regorafenib | 0.0010063 | 0.6564110 | 0.00101 | ** | NA |
| PPFIA4 | cabozantinib | 0.0010164 | 0.1558899 | 0.00102 | ** | NA |
| MPP2 | erlotinib | 0.0010171 | 0.7436781 | 0.00102 | ** | NA |
| CYB5R2 | vemurafenib | 0.0010234 | 0.3867723 | 0.00102 | ** | NA |
| CHTF18 | cabozantinib | 0.0010264 | 0.1558899 | 0.00103 | ** | NA |
| PPP1R21 | regorafenib | 0.0010295 | 0.6564110 | 0.00103 | ** | NA |
| ZIC4 | cabozantinib | 0.0010347 | 0.1558899 | 0.00103 | ** | NA |
| RHOA | olaparib | 0.0010354 | 0.9821538 | 0.00104 | ** | NA |
| SMARCAD1 | vemurafenib | 0.0010360 | 0.3867723 | 0.00104 | ** | NA |
| NOM1 | cabozantinib | 0.0010368 | 0.1558899 | 0.00104 | ** | NA |
| FOXK2 | cabozantinib | 0.0010369 | 0.1558899 | 0.00104 | ** | NA |
| NUP107 | vemurafenib | 0.0010385 | 0.3867723 | 0.00104 | ** | NA |
| ZNF706 | erlotinib | 0.0010390 | 0.7436781 | 0.00104 | ** | NA |
| FOLH1 | erlotinib | 0.0010411 | 0.7436781 | 0.00104 | ** | NA |
| CEP135 | imatinib | 0.0010435 | 0.8762527 | 0.00104 | ** | NA |
| ZNF597 | dabrafenib | 0.0010558 | 0.9104067 | 0.00106 | ** | NA |
| WDR4 | vemurafenib | 0.0010599 | 0.3867723 | 0.00106 | ** | NA |
| TMTC3 | sunitinib | 0.0010615 | 0.6695527 | 0.00106 | ** | NA |
| MGAT4B | erlotinib | 0.0010636 | 0.7436781 | 0.00106 | ** | NA |
| HCFC2 | vemurafenib | 0.0010638 | 0.3867723 | 0.00106 | ** | NA |
| ASB10 | cabozantinib | 0.0010660 | 0.1566523 | 0.00107 | ** | NA |
| DDX28 | vemurafenib | 0.0010708 | 0.3867723 | 0.00107 | ** | NA |
| CCDC175 | cabozantinib | 0.0010719 | 0.1566523 | 0.00107 | ** | NA |
| DLST | selumetinib | 0.0010725 | 0.9983774 | 0.00107 | ** | NA |
| TAF1C | cabozantinib | 0.0010752 | 0.1566523 | 0.00108 | ** | NA |
| PRDM5 | ibrutinib | 0.0010768 | 0.9136837 | 0.00108 | ** | NA |
| THSD7A | cabozantinib | 0.0010789 | 0.1566523 | 0.00108 | ** | NA |
| LIX1 | vemurafenib | 0.0010817 | 0.3867723 | 0.00108 | ** | NA |
| NKX6-2 | selumetinib | 0.0010842 | 0.9983774 | 0.00108 | ** | NA |
| CCDC68 | crizotinib | 0.0010920 | 0.9965659 | 0.00109 | ** | NA |
| PLEKHG4B | gefitinib | 0.0010977 | 0.9513640 | 0.00110 | ** | NA |
| COL16A1 | cabozantinib | 0.0011012 | 0.1583646 | 0.00110 | ** | NA |
| DOCK2 | temozolomide | 0.0011031 | 0.8741265 | 0.00110 | ** | NA |
| PIGW | regorafenib | 0.0011035 | 0.6564110 | 0.00110 | ** | NA |
| VAV1 | temozolomide | 0.0011041 | 0.8741265 | 0.00110 | ** | NA |
| ADCK1 | vandetanib | 0.0011052 | 0.8963224 | 0.00111 | ** | NA |
| PLBD2 | imatinib | 0.0011070 | 0.8762527 | 0.00111 | ** | NA |
| NTN4 | vemurafenib | 0.0011108 | 0.3867723 | 0.00111 | ** | NA |
| ARID3B | lapatinib | 0.0011156 | 0.8488319 | 0.00112 | ** | NA |
| ST6GAL2 | sunitinib | 0.0011178 | 0.6695527 | 0.00112 | ** | NA |
| STYK1 | cabozantinib | 0.0011203 | 0.1583646 | 0.00112 | ** | NA |
| ARHGEF15 | dabrafenib | 0.0011207 | 0.9104067 | 0.00112 | ** | NA |
| SCAP | cabozantinib | 0.0011210 | 0.1583646 | 0.00112 | ** | NA |
| NKD2 | vandetanib | 0.0011240 | 0.8963224 | 0.00112 | ** | NA |
| RTN3 | regorafenib | 0.0011257 | 0.6564110 | 0.00113 | ** | NA |
| TCF7L2 | vemurafenib | 0.0011266 | 0.3867723 | 0.00113 | ** | NA |
| NOC2L | gefitinib | 0.0011312 | 0.9513640 | 0.00113 | ** | NA |
| TRMT13 | cabozantinib | 0.0011328 | 0.1583646 | 0.00113 | ** | NA |
| PPP2R1A | sunitinib | 0.0011339 | 0.6695527 | 0.00113 | ** | NA |
| MYO7B | cyclophosphamide | 0.0011346 | 1.0000000 | 0.0011 | ** | NA |
| CHTF18 | lapatinib | 0.0011356 | 0.8488319 | 0.00114 | ** | NA |
| TNFRSF1B | cabozantinib | 0.0011373 | 0.1583646 | 0.00114 | ** | NA |
| SLCO6A1 | regorafenib | 0.0011379 | 0.6564110 | 0.00114 | ** | NA |
| PAQR8 | lapatinib | 0.0011436 | 0.8488319 | 0.00114 | ** | NA |
| STON1 | imatinib | 0.0011448 | 0.8762527 | 0.00114 | ** | NA |
| ZNF732 | nilotinib | 0.0011451 | 0.7820181 | 0.00115 | ** | NA |
| C10orf120 | nilotinib | 0.0011484 | 0.7820181 | 0.00115 | ** | NA |
| PHF20 | regorafenib | 0.0011590 | 0.6564110 | 0.00116 | ** | NA |
| NET1 | cabozantinib | 0.0011638 | 0.1607308 | 0.00116 | ** | NA |
| PI15 | sunitinib | 0.0011645 | 0.6695527 | 0.00116 | ** | NA |
| ABCA12 | erlotinib | 0.0011647 | 0.7436781 | 0.00116 | ** | NA |
| AKR1A1 | vemurafenib | 0.0011716 | 0.3867723 | 0.00117 | ** | NA |
| TRMT12 | vemurafenib | 0.0011757 | 0.3867723 | 0.00118 | ** | NA |
| TRIM16 | cabozantinib | 0.0011808 | 0.1614970 | 0.00118 | ** | NA |
| INSL3 | vemurafenib | 0.0011818 | 0.3867723 | 0.00118 | ** | NA |
| KAT5 | erlotinib | 0.0011830 | 0.7436781 | 0.00118 | ** | NA |
| LRP4 | regorafenib | 0.0011851 | 0.6564110 | 0.00119 | ** | NA |
| SCAF11 | cabozantinib | 0.0011883 | 0.1614970 | 0.00119 | ** | NA |
| CC2D2B | vemurafenib | 0.0011927 | 0.3867723 | 0.00119 | ** | NA |
| XKR3 | regorafenib | 0.0011928 | 0.6564110 | 0.00119 | ** | NA |
| MAML3 | vemurafenib | 0.0011979 | 0.3867723 | 0.00120 | ** | NA |
| TMC8 | vemurafenib | 0.0012013 | 0.3867723 | 0.00120 | ** | NA |
| PCM1 | imatinib | 0.0012057 | 0.8762527 | 0.00121 | ** | NA |
| ZNF436 | pazopanib | 0.0012094 | 0.9778540 | 0.00121 | ** | NA |
| MAP6 | sunitinib | 0.0012102 | 0.6695527 | 0.00121 | ** | NA |
| TROVE2 | erlotinib | 0.0012238 | 0.7436781 | 0.00122 | ** | NA |
| GPR156 | cabozantinib | 0.0012361 | 0.1618592 | 0.00124 | ** | NA |
| SLC22A8 | temozolomide | 0.0012363 | 0.8741265 | 0.00124 | ** | NA |
| METTL7A | vandetanib | 0.0012515 | 0.8963224 | 0.00125 | ** | NA |
| PDCD1LG2 | sunitinib | 0.0012562 | 0.6695527 | 0.00126 | ** | NA |
| PRPF4B | cabozantinib | 0.0012581 | 0.1618592 | 0.00126 | ** | NA |
| KRAS | vandetanib | 0.0012628 | 0.8963224 | 0.00126 | ** | NA |
| CPEB1 | cabozantinib | 0.0012639 | 0.1618592 | 0.00126 | ** | NA |
| SLC25A29 | cabozantinib | 0.0012651 | 0.1618592 | 0.00127 | ** | NA |
| ZNF653 | fulvestrant | 0.0012684 | 0.9869407 | 0.00127 | ** | NA |
| PHLPP2 | cabozantinib | 0.0012708 | 0.1618592 | 0.00127 | ** | NA |
| PRDM16 | cabozantinib | 0.0012722 | 0.1618592 | 0.00127 | ** | NA |
| ACRBP | gefitinib | 0.0012728 | 0.9513640 | 0.00127 | ** | NA |
| NUAK1 | cabozantinib | 0.0012775 | 0.1618592 | 0.00128 | ** | NA |
| PAPD4 | vemurafenib | 0.0012823 | 0.4051918 | 0.00128 | ** | NA |
| ST6GALNAC5 | cabozantinib | 0.0012833 | 0.1618592 | 0.00128 | ** | NA |
| ALOX5 | vandetanib | 0.0012929 | 0.8963224 | 0.00129 | ** | NA |
| XRCC5 | erlotinib | 0.0012930 | 0.7436781 | 0.00129 | ** | NA |
| RAPGEF1 | cabozantinib | 0.0012937 | 0.1618592 | 0.00129 | ** | NA |
| DNAAF3 | lapatinib | 0.0012952 | 0.8488319 | 0.00130 | ** | NA |
| FERMT2 | regorafenib | 0.0013000 | 0.6564110 | 0.00130 | ** | NA |
| MSI2 | cabozantinib | 0.0013033 | 0.1618592 | 0.00130 | ** | NA |
| DLL1 | nilotinib | 0.0013064 | 0.7820181 | 0.00131 | ** | NA |
| EPHB2 | cabozantinib | 0.0013085 | 0.1618592 | 0.00131 | ** | NA |
| MEP1A | afatinib | 0.0013090 | 0.8943727 | 0.00131 | ** | NA |
| MAP10 | cabozantinib | 0.0013109 | 0.1618592 | 0.00131 | ** | NA |
| ENPP2 | regorafenib | 0.0013138 | 0.6564110 | 0.00131 | ** | NA |
| RNF103 | nilotinib | 0.0013149 | 0.7820181 | 0.00131 | ** | NA |
| FPR3 | cabozantinib | 0.0013149 | 0.1618592 | 0.00131 | ** | NA |
| THOC1 | vemurafenib | 0.0013216 | 0.4054598 | 0.00132 | ** | NA |
| DNAH14 | regorafenib | 0.0013223 | 0.6564110 | 0.00132 | ** | NA |
| ZNF594 | nilotinib | 0.0013236 | 0.7820181 | 0.00132 | ** | NA |
| TMEM117 | gefitinib | 0.0013254 | 0.9513640 | 0.00133 | ** | NA |
| TMEM117 | afatinib | 0.0013255 | 0.8943727 | 0.00133 | ** | NA |
| RAPSN | cabozantinib | 0.0013283 | 0.1618592 | 0.00133 | ** | NA |
| ADORA2A | erlotinib | 0.0013283 | 0.7436781 | 0.00133 | ** | NA |
| ERVV-1 | erlotinib | 0.0013329 | 0.7436781 | 0.00133 | ** | NA |
| CDH4 | cabozantinib | 0.0013339 | 0.1618592 | 0.00133 | ** | NA |
| UBXN11 | olaparib | 0.0013350 | 0.9821538 | 0.00133 | ** | NA |
| GRIA1 | sunitinib | 0.0013445 | 0.6695527 | 0.00134 | ** | NA |
| PNMA2 | cabozantinib | 0.0013467 | 0.1622588 | 0.00135 | ** | NA |
| STARD4 | vemurafenib | 0.0013498 | 0.4054598 | 0.00135 | ** | NA |
| OPCML | ibrutinib | 0.0013513 | 0.9136837 | 0.00135 | ** | NA |
| GRK5 | lapatinib | 0.0013542 | 0.8488319 | 0.00135 | ** | NA |
| SSC5D | vandetanib | 0.0013593 | 0.8963224 | 0.00136 | ** | NA |
| ITGAD | vandetanib | 0.0013600 | 0.8963224 | 0.00136 | ** | NA |
| OR6T1 | regorafenib | 0.0013628 | 0.6564110 | 0.00136 | ** | NA |
| HSD17B12 | regorafenib | 0.0013669 | 0.6564110 | 0.00137 | ** | NA |
| GAPVD1 | cabozantinib | 0.0013683 | 0.1636954 | 0.00137 | ** | NA |
| RTN4RL2 | vandetanib | 0.0013687 | 0.8963224 | 0.00137 | ** | NA |
| PKMYT1 | sunitinib | 0.0013709 | 0.6695527 | 0.00137 | ** | NA |
| IGSF22 | vemurafenib | 0.0013745 | 0.4054598 | 0.00137 | ** | NA |
| SCEL | imatinib | 0.0013773 | 0.8762527 | 0.00138 | ** | NA |
| DNAH9 | sunitinib | 0.0013787 | 0.6695527 | 0.00138 | ** | NA |
| OR10Q1 | sunitinib | 0.0013790 | 0.6695527 | 0.00138 | ** | NA |
| CLEC10A | ruxolitinib | 0.0013845 | 1.0000000 | 0.0014 | ** | NA |
| PSD3 | sunitinib | 0.0013875 | 0.6695527 | 0.00139 | ** | NA |
| MAN1C1 | sunitinib | 0.0013898 | 0.6695527 | 0.00139 | ** | NA |
| LRP1B | pazopanib | 0.0013913 | 0.9778540 | 0.00139 | ** | NA |
| SWT1 | cabozantinib | 0.0013955 | 0.1657823 | 0.00140 | ** | NA |
| ADPRH | erlotinib | 0.0014017 | 0.7436781 | 0.00140 | ** | NA |
| MESP2 | olaparib | 0.0014045 | 0.9821538 | 0.00140 | ** | NA |
| SFRP2 | sunitinib | 0.0014061 | 0.6695527 | 0.00141 | ** | NA |
| EIF3M | vemurafenib | 0.0014077 | 0.4054598 | 0.00141 | ** | NA |
| PAK6 | cabozantinib | 0.0014086 | 0.1657823 | 0.00141 | ** | NA |
| SNX13 | vemurafenib | 0.0014153 | 0.4054598 | 0.00142 | ** | NA |
| SLC22A14 | cabozantinib | 0.0014154 | 0.1657823 | 0.00142 | ** | NA |
| RAD23A | erlotinib | 0.0014158 | 0.7436781 | 0.00142 | ** | NA |
| HDAC3 | regorafenib | 0.0014174 | 0.6564110 | 0.00142 | ** | NA |
| MGAT4B | gefitinib | 0.0014221 | 0.9513640 | 0.00142 | ** | NA |
| DCTN1 | imatinib | 0.0014230 | 0.8762527 | 0.00142 | ** | NA |
| PARP10 | cabozantinib | 0.0014248 | 0.1657823 | 0.00142 | ** | NA |
| POU6F2 | neratinib | 0.0014250 | 0.9827379 | 0.00143 | ** | NA |
| SLC43A3 | vemurafenib | 0.0014257 | 0.4054598 | 0.00143 | ** | NA |
| AGAP6 | afatinib | 0.0014276 | 0.8943727 | 0.00143 | ** | NA |
| EIF3B | gefitinib | 0.0014340 | 0.9513640 | 0.00143 | ** | NA |
| GMDS | imatinib | 0.0014387 | 0.8762527 | 0.00144 | ** | NA |
| ADPRH | afatinib | 0.0014476 | 0.8943727 | 0.00145 | ** | NA |
| NCAPG | gefitinib | 0.0014514 | 0.9513640 | 0.00145 | ** | NA |
| UVRAG | erlotinib | 0.0014553 | 0.7436781 | 0.00146 | ** | NA |
| GLIS1 | lapatinib | 0.0014554 | 0.8488319 | 0.00146 | ** | NA |
| EPHB6 | regorafenib | 0.0014568 | 0.6564110 | 0.00146 | ** | NA |
| PRKAG2 | sunitinib | 0.0014652 | 0.6695527 | 0.00147 | ** | NA |
| SF3A1 | regorafenib | 0.0014668 | 0.6564110 | 0.00147 | ** | NA |
| SNX32 | cabozantinib | 0.0014677 | 0.1686927 | 0.00147 | ** | NA |
| ZNF213 | cabozantinib | 0.0014697 | 0.1686927 | 0.00147 | ** | NA |
| STPG2 | nilotinib | 0.0014704 | 0.7820181 | 0.00147 | ** | NA |
| GORASP2 | vemurafenib | 0.0014712 | 0.4065722 | 0.00147 | ** | NA |
| MSL1 | sunitinib | 0.0014723 | 0.6695527 | 0.00147 | ** | NA |
| ZNF384 | vemurafenib | 0.0014772 | 0.4065722 | 0.00148 | ** | NA |
| POC5 | erlotinib | 0.0014781 | 0.7436781 | 0.00148 | ** | NA |
| FAM193B | imatinib | 0.0014870 | 0.8762527 | 0.00149 | ** | NA |
| CACNA1C | sunitinib | 0.0014910 | 0.6695527 | 0.00149 | ** | NA |
| TTC30A | regorafenib | 0.0014963 | 0.6564110 | 0.00150 | ** | NA |
| SCUBE2 | erlotinib | 0.0014976 | 0.7436781 | 0.00150 | ** | NA |
| ECI1 | nilotinib | 0.0014991 | 0.7820181 | 0.00150 | ** | NA |
| CNNM3 | olaparib | 0.0015004 | 0.9821538 | 0.00150 | ** | NA |
| TMEM223 | lapatinib | 0.0015046 | 0.8488319 | 0.00150 | ** | NA |
| HRC | cabozantinib | 0.0015095 | 0.1720979 | 0.00151 | ** | NA |
| OR6C4 | lapatinib | 0.0015103 | 0.8488319 | 0.00151 | ** | NA |
| FGF21 | fulvestrant | 0.0015129 | 0.9869407 | 0.00151 | ** | NA |
| CXXC5 | erlotinib | 0.0015136 | 0.7436781 | 0.00151 | ** | NA |
| AGPAT9 | erlotinib | 0.0015159 | 0.7436781 | 0.00152 | ** | NA |
| NCEH1 | lapatinib | 0.0015183 | 0.8488319 | 0.00152 | ** | NA |
| CCDC34 | sunitinib | 0.0015194 | 0.6695527 | 0.00152 | ** | NA |
| PHC2 | gefitinib | 0.0015331 | 0.9513640 | 0.00153 | ** | NA |
| FOXP4 | vemurafenib | 0.0015342 | 0.4100629 | 0.00153 | ** | NA |
| SLC18A1 | sunitinib | 0.0015351 | 0.6695527 | 0.00154 | ** | NA |
| FTCD | regorafenib | 0.0015373 | 0.6564110 | 0.00154 | ** | NA |
| HNRNPAB | imatinib | 0.0015405 | 0.8762527 | 0.00154 | ** | NA |
| RCC2 | regorafenib | 0.0015410 | 0.6564110 | 0.00154 | ** | NA |
| KLHL36 | cabozantinib | 0.0015436 | 0.1723805 | 0.00154 | ** | NA |
| SFRP2 | crizotinib | 0.0015448 | 0.9965659 | 0.00154 | ** | NA |
| C8orf82 | crizotinib | 0.0015462 | 0.9965659 | 0.00155 | ** | NA |
| RFC1 | cabozantinib | 0.0015473 | 0.1723805 | 0.00155 | ** | NA |
| SP4 | pazopanib | 0.0015517 | 0.9778540 | 0.00155 | ** | NA |
| DLL1 | regorafenib | 0.0015586 | 0.6564110 | 0.00156 | ** | NA |
| ARHGDIG | cabozantinib | 0.0015587 | 0.1723805 | 0.00156 | ** | NA |
| MUT | vemurafenib | 0.0015617 | 0.4100629 | 0.00156 | ** | NA |
| CCDC88A | sunitinib | 0.0015635 | 0.6695527 | 0.00156 | ** | NA |
| ANKRD9 | lapatinib | 0.0015673 | 0.8488319 | 0.00157 | ** | NA |
| RAD21L1 | selumetinib | 0.0015767 | 0.9983774 | 0.00158 | ** | NA |
| UNK | cabozantinib | 0.0015775 | 0.1723805 | 0.00158 | ** | NA |
| VPS53 | cabozantinib | 0.0015775 | 0.1723805 | 0.00158 | ** | NA |
| PLXNB2 | regorafenib | 0.0015778 | 0.6564110 | 0.00158 | ** | NA |
| BCL9L | cabozantinib | 0.0015807 | 0.1723805 | 0.00158 | ** | NA |
| IKZF4 | erlotinib | 0.0015820 | 0.7436781 | 0.00158 | ** | NA |
| MS4A8 | dasatinib | 0.0015833 | 0.9816837 | 0.00158 | ** | NA |
| ZC3H14 | cabozantinib | 0.0015872 | 0.1723805 | 0.00159 | ** | NA |
| PFDN1 | lapatinib | 0.0015881 | 0.8488319 | 0.00159 | ** | NA |
| CIZ1 | sunitinib | 0.0015897 | 0.6695527 | 0.00159 | ** | NA |
| FCGRT | lapatinib | 0.0015924 | 0.8488319 | 0.00159 | ** | NA |
| HOOK1 | afatinib | 0.0015929 | 0.8943727 | 0.00159 | ** | NA |
| SEC14L5 | neratinib | 0.0015945 | 0.9827379 | 0.00159 | ** | NA |
| GNPTAB | temozolomide | 0.0016008 | 0.8741265 | 0.00160 | ** | NA |
| PROSER1 | erlotinib | 0.0016047 | 0.7436781 | 0.00160 | ** | NA |
| ZSCAN18 | temozolomide | 0.0016048 | 0.8741265 | 0.00160 | ** | NA |
| MINPP1 | regorafenib | 0.0016062 | 0.6564110 | 0.00161 | ** | NA |
| C1orf56 | erlotinib | 0.0016067 | 0.7436781 | 0.00161 | ** | NA |
| ATP6V0A4 | vemurafenib | 0.0016088 | 0.4100629 | 0.00161 | ** | NA |
| PPIF | vemurafenib | 0.0016098 | 0.4100629 | 0.00161 | ** | NA |
| KRT83 | olaparib | 0.0016133 | 0.9821538 | 0.00161 | ** | NA |
| TTBK2 | lapatinib | 0.0016147 | 0.8488319 | 0.00161 | ** | NA |
| CYBRD1 | cabozantinib | 0.0016172 | 0.1723805 | 0.00162 | ** | NA |
| ARHGEF5 | regorafenib | 0.0016186 | 0.6564110 | 0.00162 | ** | NA |
| MYH6 | vemurafenib | 0.0016218 | 0.4100629 | 0.00162 | ** | NA |
| ZBTB21 | cabozantinib | 0.0016252 | 0.1723805 | 0.00163 | ** | NA |
| ZNF479 | temozolomide | 0.0016272 | 0.8741265 | 0.00163 | ** | NA |
| PPP2R2B | temozolomide | 0.0016278 | 0.8741265 | 0.00163 | ** | NA |
| ZSWIM3 | cabozantinib | 0.0016333 | 0.1723805 | 0.00163 | ** | NA |
| CDH15 | neratinib | 0.0016333 | 0.9827379 | 0.00163 | ** | NA |
| TTN | cabozantinib | 0.0016379 | 0.1723805 | 0.00164 | ** | NA |
| SDC3 | cabozantinib | 0.0016385 | 0.1723805 | 0.00164 | ** | NA |
| TRIM13 | sunitinib | 0.0016409 | 0.6695527 | 0.00164 | ** | NA |
| HRAS | sunitinib | 0.0016468 | 0.6695527 | 0.00165 | ** | NA |
| FOXO1 | nilotinib | 0.0016531 | 0.7820181 | 0.00165 | ** | NA |
| ADAMTSL4 | nilotinib | 0.0016534 | 0.7820181 | 0.00165 | ** | NA |
| AP4E1 | sunitinib | 0.0016541 | 0.6695527 | 0.00165 | ** | NA |
| ZNF662 | vemurafenib | 0.0016580 | 0.4100629 | 0.00166 | ** | NA |
| FOXL2 | vemurafenib | 0.0016581 | 0.4100629 | 0.00166 | ** | NA |
| CCDC77 | cabozantinib | 0.0016603 | 0.1723805 | 0.00166 | ** | NA |
| ELK4 | cabozantinib | 0.0016622 | 0.1723805 | 0.00166 | ** | NA |
| DPYSL2 | erlotinib | 0.0016629 | 0.7436781 | 0.00166 | ** | NA |
| PROSER1 | afatinib | 0.0016629 | 0.8943727 | 0.00166 | ** | NA |
| E2F7 | cabozantinib | 0.0016641 | 0.1723805 | 0.00166 | ** | NA |
| SLITRK5 | gefitinib | 0.0016647 | 0.9513640 | 0.00166 | ** | NA |
| ZNF839 | gefitinib | 0.0016733 | 0.9513640 | 0.00167 | ** | NA |
| DENND1A | temozolomide | 0.0016872 | 0.8741265 | 0.00169 | ** | NA |
| MBOAT2 | gefitinib | 0.0016898 | 0.9513640 | 0.00169 | ** | NA |
| MCM7 | sunitinib | 0.0016918 | 0.6695527 | 0.00169 | ** | NA |
| AOX1 | cabozantinib | 0.0016965 | 0.1746693 | 0.00170 | ** | NA |
| E2F3 | azd | 0.0016967 | 0.9984655 | 0.00170 | ** | NA |
| FOXP2 | selumetinib | 0.0016981 | 0.9983774 | 0.00170 | ** | NA |
| OR6C65 | ibrutinib | 0.0017090 | 0.9136837 | 0.00171 | ** | NA |
| BRPF1 | vemurafenib | 0.0017102 | 0.4130491 | 0.00171 | ** | NA |
| ACAD11 | nilotinib | 0.0017105 | 0.7820181 | 0.00171 | ** | NA |
| PRR14 | neratinib | 0.0017155 | 0.9827379 | 0.00172 | ** | NA |
| CSNK1G1 | nilotinib | 0.0017164 | 0.7820181 | 0.00172 | ** | NA |
| KRT20 | sunitinib | 0.0017185 | 0.6695527 | 0.00172 | ** | NA |
| INPP5A | vemurafenib | 0.0017186 | 0.4130491 | 0.00172 | ** | NA |
| APOB | olaparib | 0.0017210 | 0.9821538 | 0.00172 | ** | NA |
| ERG | gefitinib | 0.0017365 | 0.9513640 | 0.00174 | ** | NA |
| MYH10 | cabozantinib | 0.0017451 | 0.1771797 | 0.00175 | ** | NA |
| DNMT3A | vandetanib | 0.0017460 | 0.8963224 | 0.00175 | ** | NA |
| ZNF436 | cabozantinib | 0.0017465 | 0.1771797 | 0.00175 | ** | NA |
| CDK17 | dasatinib | 0.0017484 | 0.9816837 | 0.00175 | ** | NA |
| MEP1A | lapatinib | 0.0017510 | 0.8488319 | 0.00175 | ** | NA |
| ATM | dasatinib | 0.0017548 | 0.9816837 | 0.00175 | ** | NA |
| SLC7A2 | dasatinib | 0.0017586 | 0.9816837 | 0.00176 | ** | NA |
| PTPRG | vemurafenib | 0.0017601 | 0.4141788 | 0.00176 | ** | NA |
| ATAD5 | gefitinib | 0.0017649 | 0.9513640 | 0.00176 | ** | NA |
| EXT2 | lapatinib | 0.0017712 | 0.8488319 | 0.00177 | ** | NA |
| ANKH | cabozantinib | 0.0017714 | 0.1771797 | 0.00177 | ** | NA |
| CIT | regorafenib | 0.0017718 | 0.6627240 | 0.00177 | ** | NA |
| ETV1 | erlotinib | 0.0017720 | 0.7436781 | 0.00177 | ** | NA |
| FDXR | cabozantinib | 0.0017745 | 0.1771797 | 0.00177 | ** | NA |
| MYO15A | erlotinib | 0.0017761 | 0.7436781 | 0.00178 | ** | NA |
| VSX1 | gefitinib | 0.0017776 | 0.9513640 | 0.00178 | ** | NA |
| P4HTM | crizotinib | 0.0017781 | 0.9965659 | 0.00178 | ** | NA |
| ZNF600 | cabozantinib | 0.0017826 | 0.1771797 | 0.00178 | ** | NA |
| HAGHL | cabozantinib | 0.0017835 | 0.1771797 | 0.00178 | ** | NA |
| PAK6 | sunitinib | 0.0017919 | 0.6695527 | 0.00179 | ** | NA |
| ZFP36L2 | temozolomide | 0.0017933 | 0.8741265 | 0.00179 | ** | NA |
| SNTG2 | nilotinib | 0.0017952 | 0.7820181 | 0.00180 | ** | NA |
| ZNRF1 | cabozantinib | 0.0017964 | 0.1771956 | 0.00180 | ** | NA |
| SEMA7A | afatinib | 0.0017981 | 0.8943727 | 0.00180 | ** | NA |
| OR8B12 | olaparib | 0.0018015 | 0.9821538 | 0.00180 | ** | NA |
| ZFHX3 | nilotinib | 0.0018030 | 0.7820181 | 0.00180 | ** | NA |
| SSX2IP | sunitinib | 0.0018068 | 0.6695527 | 0.00181 | ** | NA |
| CBX2 | ibrutinib | 0.0018070 | 0.9136837 | 0.00181 | ** | NA |
| PNLIPRP3 | pazopanib | 0.0018078 | 0.9778540 | 0.00181 | ** | NA |
| IQSEC1 | sunitinib | 0.0018126 | 0.6695527 | 0.00181 | ** | NA |
| PYGO1 | gefitinib | 0.0018184 | 0.9513640 | 0.00182 | ** | NA |
| NFE2L2 | cabozantinib | 0.0018187 | 0.1771956 | 0.00182 | ** | NA |
| APLP2 | cabozantinib | 0.0018192 | 0.1771956 | 0.00182 | ** | NA |
| CRISPLD1 | regorafenib | 0.0018245 | 0.6627240 | 0.00182 | ** | NA |
| TLE2 | lapatinib | 0.0018257 | 0.8488319 | 0.00183 | ** | NA |
| RTFDC1 | gefitinib | 0.0018267 | 0.9513640 | 0.00183 | ** | NA |
| TTC30A | vemurafenib | 0.0018294 | 0.4141788 | 0.00183 | ** | NA |
| C9orf172 | cabozantinib | 0.0018347 | 0.1771956 | 0.00183 | ** | NA |
| ADCY9 | imatinib | 0.0018365 | 0.8762527 | 0.00184 | ** | NA |
| NOC2L | afatinib | 0.0018455 | 0.8943727 | 0.00185 | ** | NA |
| GPLD1 | cabozantinib | 0.0018483 | 0.1771956 | 0.00185 | ** | NA |
| STRC | cabozantinib | 0.0018517 | 0.1771956 | 0.00185 | ** | NA |
| NOA1 | erlotinib | 0.0018527 | 0.7436781 | 0.00185 | ** | NA |
| CSH1 | regorafenib | 0.0018561 | 0.6627240 | 0.00186 | ** | NA |
| PNN | imatinib | 0.0018586 | 0.8762527 | 0.00186 | ** | NA |
| TTF1 | olaparib | 0.0018671 | 0.9821538 | 0.00187 | ** | NA |
| CSN3 | regorafenib | 0.0018707 | 0.6627240 | 0.00187 | ** | NA |
| COPG1 | cabozantinib | 0.0018733 | 0.1771956 | 0.00187 | ** | NA |
| FES | cabozantinib | 0.0018754 | 0.1771956 | 0.00188 | ** | NA |
| RPUSD2 | lapatinib | 0.0018766 | 0.8488319 | 0.00188 | ** | NA |
| DLEC1 | cabozantinib | 0.0018775 | 0.1771956 | 0.00188 | ** | NA |
| ZNF441 | neratinib | 0.0018812 | 0.9827379 | 0.00188 | ** | NA |
| RBBP9 | crizotinib | 0.0018846 | 0.9965659 | 0.00188 | ** | NA |
| DDX21 | erlotinib | 0.0018930 | 0.7436781 | 0.00189 | ** | NA |
| ZNF629 | imatinib | 0.0018965 | 0.8762527 | 0.00190 | ** | NA |
| GJA8 | pazopanib | 0.0018996 | 0.9778540 | 0.00190 | ** | NA |
| ZNF570 | cabozantinib | 0.0019020 | 0.1776521 | 0.00190 | ** | NA |
| MRGPRX1 | gefitinib | 0.0019024 | 0.9513640 | 0.00190 | ** | NA |
| HSPA12A | cabozantinib | 0.0019033 | 0.1776521 | 0.00190 | ** | NA |
| TROAP | sunitinib | 0.0019042 | 0.6695527 | 0.00190 | ** | NA |
| CECR1 | nilotinib | 0.0019060 | 0.7820181 | 0.00191 | ** | NA |
| PTEN | trametinib | 0.0019075 | 0.9757752 | 0.0019 | ** | NA |
| MAP10 | lapatinib | 0.0019095 | 0.8488319 | 0.00191 | ** | NA |
| FAM19A4 | pazopanib | 0.0019105 | 0.9778540 | 0.00191 | ** | NA |
| ST3GAL3 | regorafenib | 0.0019135 | 0.6627240 | 0.00191 | ** | NA |
| DHTKD1 | dasatinib | 0.0019153 | 0.9816837 | 0.00192 | ** | NA |
| ARIH2 | cabozantinib | 0.0019265 | 0.1788415 | 0.00193 | ** | NA |
| GABBR2 | ibrutinib | 0.0019279 | 0.9136837 | 0.00193 | ** | NA |
| GPR98 | temozolomide | 0.0019318 | 0.8741265 | 0.00193 | ** | NA |
| GNAT3 | vemurafenib | 0.0019354 | 0.4141788 | 0.00194 | ** | NA |
| GPT | olaparib | 0.0019394 | 0.9821538 | 0.00194 | ** | NA |
| UPK3B | olaparib | 0.0019435 | 0.9821538 | 0.00194 | ** | NA |
| EYA1 | lapatinib | 0.0019444 | 0.8488319 | 0.00194 | ** | NA |
| SLC17A7 | cabozantinib | 0.0019453 | 0.1795979 | 0.00195 | ** | NA |
| GOLPH3L | vemurafenib | 0.0019460 | 0.4141788 | 0.00195 | ** | NA |
| STAP2 | crizotinib | 0.0019465 | 0.9965659 | 0.00195 | ** | NA |
| PPFIA2 | vemurafenib | 0.0019607 | 0.4141788 | 0.00196 | ** | NA |
| CTNND2 | sunitinib | 0.0019626 | 0.6695527 | 0.00196 | ** | NA |
| PIP4K2A | vemurafenib | 0.0019630 | 0.4141788 | 0.00196 | ** | NA |
| EP300 | cabozantinib | 0.0019685 | 0.1796467 | 0.00197 | ** | NA |
| ANKRD29 | cabozantinib | 0.0019708 | 0.1796467 | 0.00197 | ** | NA |
| FAM21A | dasatinib | 0.0019722 | 0.9816837 | 0.00197 | ** | NA |
| NLRP8 | cabozantinib | 0.0019775 | 0.1796467 | 0.00198 | ** | NA |
| GPRIN1 | sunitinib | 0.0019798 | 0.6695527 | 0.00198 | ** | NA |
| KLC2 | imatinib | 0.0019800 | 0.8762527 | 0.00198 | ** | NA |
| BCKDHA | vemurafenib | 0.0019820 | 0.4141788 | 0.00198 | ** | NA |
| OMP | sunitinib | 0.0019826 | 0.6695527 | 0.00198 | ** | NA |
| PRR23B | nilotinib | 0.0019847 | 0.7820181 | 0.00198 | ** | NA |
| PROSER1 | neratinib | 0.0019858 | 0.9827379 | 0.00199 | ** | NA |
| ARID3B | vandetanib | 0.0019899 | 0.8963224 | 0.00199 | ** | NA |
| SNX13 | nilotinib | 0.0019971 | 0.7820181 | 0.00200 | ** | NA |
| ZNF217 | afatinib | 0.0020075 | 0.8943727 | 0.00201 | ** | NA |
| VMO1 | cabozantinib | 0.0020084 | 0.1797062 | 0.00201 | ** | NA |
| FGF11 | afatinib | 0.0020143 | 0.8943727 | 0.00201 | ** | NA |
| KIAA1211 | vemurafenib | 0.0020156 | 0.4141788 | 0.00202 | ** | NA |
| ALMS1 | olaparib | 0.0020173 | 0.9821538 | 0.00202 | ** | NA |
| B3GALNT1 | cabozantinib | 0.0020202 | 0.1797062 | 0.00202 | ** | NA |
| ZNF683 | temozolomide | 0.0020232 | 0.8741265 | 0.00202 | ** | NA |
| DHTKD1 | gefitinib | 0.0020244 | 0.9513640 | 0.00202 | ** | NA |
| USP7 | trametinib | 0.0020279 | 0.9757752 | 0.0020 | ** | NA |
| CSNK1G3 | nilotinib | 0.0020289 | 0.7820181 | 0.00203 | ** | NA |
| CALCOCO1 | cabozantinib | 0.0020306 | 0.1797062 | 0.00203 | ** | NA |
| APC2 | cabozantinib | 0.0020307 | 0.1797062 | 0.00203 | ** | NA |
| MARCH10 | cabozantinib | 0.0020311 | 0.1797062 | 0.00203 | ** | NA |
| STK4 | lapatinib | 0.0020313 | 0.8488319 | 0.00203 | ** | NA |
| COL11A2 | temozolomide | 0.0020338 | 0.8741265 | 0.00203 | ** | NA |
| GMDS | crizotinib | 0.0020406 | 0.9965659 | 0.00204 | ** | NA |
| FAM212B | lapatinib | 0.0020421 | 0.8488319 | 0.00204 | ** | NA |
| PCDHGB7 | imatinib | 0.0020437 | 0.8762527 | 0.00204 | ** | NA |
| GTF3C6 | lapatinib | 0.0020445 | 0.8488319 | 0.00204 | ** | NA |
| RNF208 | fulvestrant | 0.0020451 | 0.9869407 | 0.00205 | ** | NA |
| DERL2 | gefitinib | 0.0020484 | 0.9513640 | 0.00205 | ** | NA |
| BRD2 | dasatinib | 0.0020569 | 0.9816837 | 0.00206 | ** | NA |
| INPPL1 | cabozantinib | 0.0020575 | 0.1807986 | 0.00206 | ** | NA |
| FGF11 | ibrutinib | 0.0020585 | 0.9136837 | 0.00206 | ** | NA |
| GRSF1 | afatinib | 0.0020590 | 0.8943727 | 0.00206 | ** | NA |
| TRIM69 | gefitinib | 0.0020618 | 0.9513640 | 0.00206 | ** | NA |
| PCLO | pazopanib | 0.0020734 | 0.9778540 | 0.00207 | ** | NA |
| GPRIN1 | cabozantinib | 0.0020767 | 0.1807986 | 0.00208 | ** | NA |
| TOMM70A | vemurafenib | 0.0020767 | 0.4141788 | 0.00208 | ** | NA |
| KRAS | cabozantinib | 0.0020791 | 0.1807986 | 0.00208 | ** | NA |
| CDC16 | erlotinib | 0.0020807 | 0.7436781 | 0.00208 | ** | NA |
| DTX3L | gefitinib | 0.0020815 | 0.9513640 | 0.00208 | ** | NA |
| KIF19 | temozolomide | 0.0020837 | 0.8741265 | 0.00208 | ** | NA |
| PI4KA | vemurafenib | 0.0020869 | 0.4141788 | 0.00209 | ** | NA |
| GLP2R | cabozantinib | 0.0020881 | 0.1807986 | 0.00209 | ** | NA |
| KRT3 | fluorouracil | 0.0020891 | 1.0000000 | 0.00209 | ** | NA |
| CROT | sunitinib | 0.0021046 | 0.6695527 | 0.00210 | ** | NA |
| LAD1 | cabozantinib | 0.0021069 | 0.1807986 | 0.00211 | ** | NA |
| ULK4 | regorafenib | 0.0021099 | 0.6627240 | 0.00211 | ** | NA |
| PYROXD2 | cabozantinib | 0.0021154 | 0.1807986 | 0.00212 | ** | NA |
| ZNF793 | temozolomide | 0.0021177 | 0.8741265 | 0.00212 | ** | NA |
| TENC1 | cabozantinib | 0.0021179 | 0.1807986 | 0.00212 | ** | NA |
| OCM | vandetanib | 0.0021279 | 0.8963224 | 0.00213 | ** | NA |
| PFDN1 | vandetanib | 0.0021279 | 0.8963224 | 0.00213 | ** | NA |
| OR6C75 | nilotinib | 0.0021282 | 0.7820181 | 0.00213 | ** | NA |
| SLC25A35 | fluorouracil | 0.0021296 | 1.0000000 | 0.00213 | ** | NA |
| RTKN2 | pazopanib | 0.0021300 | 0.9778540 | 0.00213 | ** | NA |
| FEZF1 | nilotinib | 0.0021379 | 0.7820181 | 0.00214 | ** | NA |
| TMEM260 | cabozantinib | 0.0021424 | 0.1815281 | 0.00214 | ** | NA |
| LRP1B | olaparib | 0.0021429 | 0.9821538 | 0.00214 | ** | NA |
| ARL16 | vemurafenib | 0.0021444 | 0.4141788 | 0.00214 | ** | NA |
| EXOC4 | neratinib | 0.0021494 | 0.9827379 | 0.00215 | ** | NA |
| WBP4 | vemurafenib | 0.0021505 | 0.4141788 | 0.00215 | ** | NA |
| GJA8 | cabozantinib | 0.0021511 | 0.1815281 | 0.00215 | ** | NA |
| COMP | afatinib | 0.0021546 | 0.8943727 | 0.00215 | ** | NA |
| TMEM252 | crizotinib | 0.0021547 | 0.9965659 | 0.00215 | ** | NA |
| ADD1 | cabozantinib | 0.0021585 | 0.1815281 | 0.00216 | ** | NA |
| ADCK1 | dasatinib | 0.0021625 | 0.9816837 | 0.00216 | ** | NA |
| NKD2 | afatinib | 0.0021625 | 0.8943727 | 0.00216 | ** | NA |
| GCKR | sunitinib | 0.0021651 | 0.6695527 | 0.00217 | ** | NA |
| TRIM41 | lapatinib | 0.0021660 | 0.8488319 | 0.00217 | ** | NA |
| HEATR6 | olaparib | 0.0021670 | 0.9821538 | 0.00217 | ** | NA |
| LRRC38 | sunitinib | 0.0021721 | 0.6695527 | 0.00217 | ** | NA |
| CPSF1 | cabozantinib | 0.0021771 | 0.1819554 | 0.00218 | ** | NA |
| MRPL37 | gefitinib | 0.0021799 | 0.9513640 | 0.00218 | ** | NA |
| TMEM102 | cabozantinib | 0.0021888 | 0.1819554 | 0.00219 | ** | NA |
| DMRT3 | vemurafenib | 0.0021910 | 0.4141788 | 0.00219 | ** | NA |
| IARS | vemurafenib | 0.0021957 | 0.4141788 | 0.00220 | ** | NA |
| EPHA7 | olaparib | 0.0021961 | 0.9821538 | 0.00220 | ** | NA |
| TPST2 | cabozantinib | 0.0021965 | 0.1819554 | 0.00220 | ** | NA |
| MDGA2 | erlotinib | 0.0021966 | 0.7436781 | 0.00220 | ** | NA |
| MGARP | regorafenib | 0.0022014 | 0.6627240 | 0.00220 | ** | NA |
| ZNF839 | crizotinib | 0.0022044 | 0.9965659 | 0.00220 | ** | NA |
| APOBEC3G | vemurafenib | 0.0022047 | 0.4141788 | 0.00220 | ** | NA |
| CTC1 | cabozantinib | 0.0022064 | 0.1819554 | 0.00221 | ** | NA |
| ROCK2 | vemurafenib | 0.0022127 | 0.4141788 | 0.00221 | ** | NA |
| SLC18A1 | imatinib | 0.0022150 | 0.8762527 | 0.00222 | ** | NA |
| FBXO30 | imatinib | 0.0022152 | 0.8762527 | 0.00222 | ** | NA |
| CCDC13 | ibrutinib | 0.0022180 | 0.9136837 | 0.00222 | ** | NA |
| SEMA3A | sunitinib | 0.0022200 | 0.6695527 | 0.00222 | ** | NA |
| ASXL3 | nilotinib | 0.0022231 | 0.7820181 | 0.00222 | ** | NA |
| GPR68 | vemurafenib | 0.0022246 | 0.4141788 | 0.00222 | ** | NA |
| RNF103 | pazopanib | 0.0022264 | 0.9778540 | 0.00223 | ** | NA |
| PRKAG2 | azd | 0.0022285 | 0.9984655 | 0.00223 | ** | NA |
| YTHDF2 | azd | 0.0022285 | 0.9984655 | 0.00223 | ** | NA |
| TRAPPC11 | vemurafenib | 0.0022307 | 0.4141788 | 0.00223 | ** | NA |
| OLFML2B | cabozantinib | 0.0022319 | 0.1829973 | 0.00223 | ** | NA |
| ZNF804B | imatinib | 0.0022366 | 0.8762527 | 0.00224 | ** | NA |
| SLC30A3 | selumetinib | 0.0022369 | 0.9983774 | 0.00224 | ** | NA |
| ZNF367 | afatinib | 0.0022401 | 0.8943727 | 0.00224 | ** | NA |
| GARS | erlotinib | 0.0022520 | 0.7436781 | 0.00225 | ** | NA |
| INTS10 | olaparib | 0.0022543 | 0.9821538 | 0.00225 | ** | NA |
| MSH5 | cabozantinib | 0.0022564 | 0.1829973 | 0.00226 | ** | NA |
| MED13 | cabozantinib | 0.0022577 | 0.1829973 | 0.00226 | ** | NA |
| TEX2 | crizotinib | 0.0022585 | 0.9965659 | 0.00226 | ** | NA |
| SLC43A1 | regorafenib | 0.0022588 | 0.6627240 | 0.00226 | ** | NA |
| OR51M1 | pazopanib | 0.0022598 | 0.9778540 | 0.00226 | ** | NA |
| FNDC8 | selumetinib | 0.0022628 | 0.9983774 | 0.00226 | ** | NA |
| SNTG2 | vemurafenib | 0.0022650 | 0.4141788 | 0.00227 | ** | NA |
| SEMA3G | cabozantinib | 0.0022656 | 0.1829973 | 0.00227 | ** | NA |
| CEP128 | regorafenib | 0.0022686 | 0.6627240 | 0.00227 | ** | NA |
| DERL2 | erlotinib | 0.0022686 | 0.7436781 | 0.00227 | ** | NA |
| SFMBT2 | dasatinib | 0.0022720 | 0.9816837 | 0.00227 | ** | NA |
| RASGRF2 | cabozantinib | 0.0022729 | 0.1829973 | 0.00227 | ** | NA |
| RAPGEF2 | vemurafenib | 0.0022743 | 0.4141788 | 0.00227 | ** | NA |
| FAM210A | regorafenib | 0.0022744 | 0.6627240 | 0.00227 | ** | NA |
| IDH3A | temozolomide | 0.0022761 | 0.8741265 | 0.00228 | ** | NA |
| TLE1 | sunitinib | 0.0022782 | 0.6695527 | 0.00228 | ** | NA |
| UNKL | sunitinib | 0.0022871 | 0.6695527 | 0.00229 | ** | NA |
| WDR24 | temozolomide | 0.0022957 | 0.8741265 | 0.00230 | ** | NA |
| NAALADL2 | vemurafenib | 0.0022958 | 0.4141788 | 0.00230 | ** | NA |
| ZNF45 | neratinib | 0.0022972 | 0.9827379 | 0.00230 | ** | NA |
| SLC6A6 | vemurafenib | 0.0023029 | 0.4141788 | 0.00230 | ** | NA |
| MMP14 | imatinib | 0.0023040 | 0.8762527 | 0.00230 | ** | NA |
| MYO18B | ibrutinib | 0.0023046 | 0.9136837 | 0.00230 | ** | NA |
| C7orf43 | vemurafenib | 0.0023058 | 0.4141788 | 0.00231 | ** | NA |
| TIMP4 | vemurafenib | 0.0023058 | 0.4141788 | 0.00231 | ** | NA |
| ALMS1 | crizotinib | 0.0023094 | 0.9965659 | 0.00231 | ** | NA |
| KCNN3 | cabozantinib | 0.0023228 | 0.1860116 | 0.00232 | ** | NA |
| TUBGCP4 | imatinib | 0.0023254 | 0.8762527 | 0.00233 | ** | NA |
| CXXC5 | gefitinib | 0.0023303 | 0.9513640 | 0.00233 | ** | NA |
| SERPINB2 | dabrafenib | 0.0023393 | 0.9104067 | 0.00234 | ** | NA |
| B3GAT1 | dabrafenib | 0.0023403 | 0.9104067 | 0.00234 | ** | NA |
| DNHD1 | olaparib | 0.0023421 | 0.9821538 | 0.00234 | ** | NA |
| CILP2 | cabozantinib | 0.0023427 | 0.1860116 | 0.00234 | ** | NA |
| WFDC8 | sunitinib | 0.0023480 | 0.6695527 | 0.00235 | ** | NA |
| DTX3L | erlotinib | 0.0023561 | 0.7436781 | 0.00236 | ** | NA |
| EXOC6B | cabozantinib | 0.0023595 | 0.1860116 | 0.00236 | ** | NA |
| TMEM117 | erlotinib | 0.0023630 | 0.7436781 | 0.00236 | ** | NA |
| FAM65C | nilotinib | 0.0023709 | 0.7820181 | 0.00237 | ** | NA |
| KIAA1045 | cabozantinib | 0.0023727 | 0.1860116 | 0.00237 | ** | NA |
| BDKRB2 | temozolomide | 0.0023771 | 0.8741265 | 0.00238 | ** | NA |
| ASUN | nilotinib | 0.0023774 | 0.7820181 | 0.00238 | ** | NA |
| RIMKLB | cabozantinib | 0.0023808 | 0.1860116 | 0.00238 | ** | NA |
| ARFGEF2 | cabozantinib | 0.0023810 | 0.1860116 | 0.00238 | ** | NA |
| ENPP6 | sunitinib | 0.0023824 | 0.6695527 | 0.00238 | ** | NA |
| CILP | temozolomide | 0.0023848 | 0.8741265 | 0.00238 | ** | NA |
| UGT1A10 | cabozantinib | 0.0023870 | 0.1860116 | 0.00239 | ** | NA |
| IGFLR1 | lapatinib | 0.0023995 | 0.8488319 | 0.00240 | ** | NA |
| ANK3 | olaparib | 0.0024019 | 0.9821538 | 0.00240 | ** | NA |
| OLFM4 | vemurafenib | 0.0024076 | 0.4207683 | 0.00241 | ** | NA |
| OLFML2B | lapatinib | 0.0024079 | 0.8488319 | 0.00241 | ** | NA |
| YTHDC1 | temozolomide | 0.0024118 | 0.8741265 | 0.00241 | ** | NA |
| IQCD | nilotinib | 0.0024140 | 0.7820181 | 0.00241 | ** | NA |
| GEN1 | erlotinib | 0.0024248 | 0.7436781 | 0.00242 | ** | NA |
| ARHGEF18 | pazopanib | 0.0024271 | 0.9778540 | 0.00243 | ** | NA |
| KCNA7 | regorafenib | 0.0024302 | 0.6627240 | 0.00243 | ** | NA |
| RIPK1 | cabozantinib | 0.0024317 | 0.1862158 | 0.00243 | ** | NA |
| SMG1 | dasatinib | 0.0024325 | 0.9816837 | 0.00243 | ** | NA |
| PLCE1 | temozolomide | 0.0024363 | 0.8741265 | 0.00244 | ** | NA |
| FGD4 | cabozantinib | 0.0024377 | 0.1862158 | 0.00244 | ** | NA |
| ANKRD55 | lapatinib | 0.0024385 | 0.8488319 | 0.00244 | ** | NA |
| GEMIN2 | cabozantinib | 0.0024400 | 0.1862158 | 0.00244 | ** | NA |
| TMEM106B | cabozantinib | 0.0024400 | 0.1862158 | 0.00244 | ** | NA |
| DRD5 | vemurafenib | 0.0024415 | 0.4207683 | 0.00244 | ** | NA |
| UBP1 | vemurafenib | 0.0024421 | 0.4207683 | 0.00244 | ** | NA |
| FOXG1 | vemurafenib | 0.0024587 | 0.4207683 | 0.00246 | ** | NA |
| PROSER1 | gefitinib | 0.0024607 | 0.9513640 | 0.00246 | ** | NA |
| KIAA1324 | cabozantinib | 0.0024649 | 0.1862158 | 0.00246 | ** | NA |
| MYH10 | vemurafenib | 0.0024658 | 0.4207683 | 0.00247 | ** | NA |
| ZNF320 | cabozantinib | 0.0024797 | 0.1862158 | 0.00248 | ** | NA |
| PAX6 | regorafenib | 0.0024809 | 0.6627240 | 0.00248 | ** | NA |
| ERAP2 | selumetinib | 0.0024816 | 0.9983774 | 0.00248 | ** | NA |
| ZNF596 | erlotinib | 0.0024851 | 0.7436781 | 0.00249 | ** | NA |
| NMRK1 | vandetanib | 0.0024864 | 0.8963224 | 0.00249 | ** | NA |
| EGFLAM | fulvestrant | 0.0024868 | 0.9869407 | 0.00249 | ** | NA |
| OSTF1 | gefitinib | 0.0024874 | 0.9513640 | 0.00249 | ** | NA |
| BRD1 | regorafenib | 0.0024881 | 0.6627240 | 0.00249 | ** | NA |
| CSN3 | sunitinib | 0.0024904 | 0.6695527 | 0.00249 | ** | NA |
| IL6ST | nilotinib | 0.0024911 | 0.7820181 | 0.00249 | ** | NA |
| CREBZF | ibrutinib | 0.0024957 | 0.9136837 | 0.00250 | ** | NA |
| THSD4 | fulvestrant | 0.0024981 | 0.9869407 | 0.00250 | ** | NA |
| MYRIP | lapatinib | 0.0025000 | 0.8488319 | 0.00250 | ** | NA |
| AGBL4 | erlotinib | 0.0025017 | 0.7436781 | 0.00250 | ** | NA |
| AQP9 | cabozantinib | 0.0025024 | 0.1862158 | 0.00250 | ** | NA |
| CDK11A | lapatinib | 0.0025100 | 0.8488319 | 0.00251 | ** | NA |
| USP50 | lapatinib | 0.0025106 | 0.8488319 | 0.00251 | ** | NA |
| SYCP1 | regorafenib | 0.0025109 | 0.6627240 | 0.00251 | ** | NA |
| COPA | cabozantinib | 0.0025218 | 0.1862158 | 0.00252 | ** | NA |
| ERMARD | imatinib | 0.0025219 | 0.8762527 | 0.00252 | ** | NA |
| MRPS30 | cabozantinib | 0.0025249 | 0.1862158 | 0.00252 | ** | NA |
| PFDN1 | neratinib | 0.0025267 | 0.9827379 | 0.00253 | ** | NA |
| RRP15 | sunitinib | 0.0025269 | 0.6695527 | 0.00253 | ** | NA |
| DSCR3 | neratinib | 0.0025290 | 0.9827379 | 0.00253 | ** | NA |
| ARHGAP24 | belinostat | 0.0025293 | 1.0000000 | 0.0025 | ** | NA |
| FREM1 | cabozantinib | 0.0025319 | 0.1862158 | 0.00253 | ** | NA |
| TAB1 | afatinib | 0.0025322 | 0.8943727 | 0.00253 | ** | NA |
| TMEM199 | cabozantinib | 0.0025357 | 0.1862158 | 0.00254 | ** | NA |
| PVRL3 | fluorouracil | 0.0025363 | 1.0000000 | 0.00254 | ** | NA |
| EHBP1L1 | cabozantinib | 0.0025428 | 0.1862158 | 0.00254 | ** | NA |
| NRAS | ibrutinib | 0.0025472 | 0.9136837 | 0.00255 | ** | NA |
| TSTD2 | fluorouracil | 0.0025476 | 1.0000000 | 0.00255 | ** | NA |
| GPR4 | sunitinib | 0.0025504 | 0.6695527 | 0.00255 | ** | NA |
| CA10 | cabozantinib | 0.0025505 | 0.1862158 | 0.00255 | ** | NA |
| POU6F2 | erlotinib | 0.0025505 | 0.7436781 | 0.00255 | ** | NA |
| KIF24 | sunitinib | 0.0025544 | 0.6695527 | 0.00255 | ** | NA |
| LINS | cabozantinib | 0.0025546 | 0.1862158 | 0.00255 | ** | NA |
| SYVN1 | cabozantinib | 0.0025615 | 0.1862158 | 0.00256 | ** | NA |
| C7 | gefitinib | 0.0025628 | 0.9513640 | 0.00256 | ** | NA |
| CTHRC1 | temozolomide | 0.0025750 | 0.8741265 | 0.00258 | ** | NA |
| GNAI2 | neratinib | 0.0025805 | 0.9827379 | 0.00258 | ** | NA |
| GFI1B | vemurafenib | 0.0025816 | 0.4245575 | 0.00258 | ** | NA |
| ADAMTS13 | gefitinib | 0.0025837 | 0.9513640 | 0.00258 | ** | NA |
| PRAMEF2 | cabozantinib | 0.0025863 | 0.1862158 | 0.00259 | ** | NA |
| RBBP8 | dabrafenib | 0.0025917 | 0.9104067 | 0.00259 | ** | NA |
| CLDN8 | lapatinib | 0.0025919 | 0.8488319 | 0.00259 | ** | NA |
| PFKFB3 | erlotinib | 0.0025944 | 0.7436781 | 0.00259 | ** | NA |
| FBXO25 | olaparib | 0.0025949 | 0.9821538 | 0.00259 | ** | NA |
| FAM3D | vemurafenib | 0.0025977 | 0.4245575 | 0.00260 | ** | NA |
| GMCL1 | regorafenib | 0.0025995 | 0.6627240 | 0.00260 | ** | NA |
| NCDN | temozolomide | 0.0026014 | 0.8741265 | 0.00260 | ** | NA |
| KRT14 | cabozantinib | 0.0026083 | 0.1862158 | 0.00261 | ** | NA |
| TBC1D10B | olaparib | 0.0026108 | 0.9821538 | 0.00261 | ** | NA |
| DRGX | vandetanib | 0.0026132 | 0.8963224 | 0.00261 | ** | NA |
| PPP2R1A | regorafenib | 0.0026137 | 0.6627240 | 0.00261 | ** | NA |
| CDK8 | vemurafenib | 0.0026171 | 0.4245575 | 0.00262 | ** | NA |
| GRIN3B | fluorouracil | 0.0026176 | 1.0000000 | 0.00262 | ** | NA |
| CXXC5 | fluorouracil | 0.0026180 | 1.0000000 | 0.00262 | ** | NA |
| CHKB | afatinib | 0.0026201 | 0.8943727 | 0.00262 | ** | NA |
| PPP2R4 | cabozantinib | 0.0026212 | 0.1862158 | 0.00262 | ** | NA |
| ALDH8A1 | cabozantinib | 0.0026230 | 0.1862158 | 0.00262 | ** | NA |
| CEP135 | ibrutinib | 0.0026234 | 0.9136837 | 0.00262 | ** | NA |
| CYLC2 | imatinib | 0.0026256 | 0.8762527 | 0.00263 | ** | NA |
| FAM171B | cabozantinib | 0.0026266 | 0.1862158 | 0.00263 | ** | NA |
| SRC | sunitinib | 0.0026281 | 0.6695527 | 0.00263 | ** | NA |
| CSGALNACT2 | cabozantinib | 0.0026321 | 0.1862158 | 0.00263 | ** | NA |
| PLEKHO1 | trametinib | 0.0026339 | 0.9757752 | 0.0026 | ** | NA |
| C17orf75 | afatinib | 0.0026346 | 0.8943727 | 0.00263 | ** | NA |
| NRBP1 | imatinib | 0.0026356 | 0.8762527 | 0.00264 | ** | NA |
| DPY19L3 | cabozantinib | 0.0026361 | 0.1862158 | 0.00264 | ** | NA |
| IZUMO2 | cabozantinib | 0.0026472 | 0.1862158 | 0.00265 | ** | NA |
| EGFL8 | temozolomide | 0.0026477 | 0.8741265 | 0.00265 | ** | NA |
| DUOXA2 | afatinib | 0.0026489 | 0.8943727 | 0.00265 | ** | NA |
| COL3A1 | olaparib | 0.0026507 | 0.9821538 | 0.00265 | ** | NA |
| SEMA4B | olaparib | 0.0026518 | 0.9821538 | 0.00265 | ** | NA |
| C14orf2 | lapatinib | 0.0026546 | 0.8488319 | 0.00265 | ** | NA |
| UVRAG | neratinib | 0.0026629 | 0.9827379 | 0.00266 | ** | NA |
| SLC38A6 | vemurafenib | 0.0026630 | 0.4245575 | 0.00266 | ** | NA |
| ARHGAP23 | imatinib | 0.0026635 | 0.8762527 | 0.00266 | ** | NA |
| F5 | cabozantinib | 0.0026636 | 0.1862158 | 0.00266 | ** | NA |
| FRY | cabozantinib | 0.0026637 | 0.1862158 | 0.00266 | ** | NA |
| TAS2R43 | olaparib | 0.0026686 | 0.9821538 | 0.00267 | ** | NA |
| IFT57 | nilotinib | 0.0026713 | 0.7820181 | 0.00267 | ** | NA |
| ZNF606 | nilotinib | 0.0026739 | 0.7820181 | 0.00267 | ** | NA |
| TAF4 | olaparib | 0.0026750 | 0.9821538 | 0.00267 | ** | NA |
| LRRIQ1 | temozolomide | 0.0026855 | 0.8741265 | 0.00269 | ** | NA |
| SERPINE1 | trametinib | 0.0026873 | 0.9757752 | 0.0027 | ** | NA |
| FAM181A | ibrutinib | 0.0026899 | 0.9136837 | 0.00269 | ** | NA |
| PDZD2 | cabozantinib | 0.0026910 | 0.1871701 | 0.00269 | ** | NA |
| P2RX5 | gefitinib | 0.0026913 | 0.9513640 | 0.00269 | ** | NA |
| ESPN | temozolomide | 0.0026994 | 0.8741265 | 0.00270 | ** | NA |
| PTEN | gefitinib | 0.0027031 | 0.9513640 | 0.00270 | ** | NA |
| ANKRD55 | vemurafenib | 0.0027078 | 0.4245575 | 0.00271 | ** | NA |
| NOLC1 | fluorouracil | 0.0027087 | 1.0000000 | 0.00271 | ** | NA |
| PLCE1 | nilotinib | 0.0027089 | 0.7820181 | 0.00271 | ** | NA |
| TRIM50 | ibrutinib | 0.0027094 | 0.9136837 | 0.00271 | ** | NA |
| TMEM117 | lapatinib | 0.0027102 | 0.8488319 | 0.00271 | ** | NA |
| CLN8 | sunitinib | 0.0027131 | 0.6695527 | 0.00271 | ** | NA |
| EVI5L | nilotinib | 0.0027179 | 0.7820181 | 0.00272 | ** | NA |
| FDFT1 | nilotinib | 0.0027203 | 0.7820181 | 0.00272 | ** | NA |
| NASP | cabozantinib | 0.0027220 | 0.1871701 | 0.00272 | ** | NA |
| OR1B1 | ibrutinib | 0.0027238 | 0.9136837 | 0.00272 | ** | NA |
| KIAA0825 | temozolomide | 0.0027299 | 0.8741265 | 0.00273 | ** | NA |
| TPTE | regorafenib | 0.0027309 | 0.6627240 | 0.00273 | ** | NA |
| SLC9A5 | sunitinib | 0.0027314 | 0.6695527 | 0.00273 | ** | NA |
| OR6T1 | cabozantinib | 0.0027327 | 0.1871701 | 0.00273 | ** | NA |
| MPP4 | gefitinib | 0.0027347 | 0.9513640 | 0.00273 | ** | NA |
| PLTP | gefitinib | 0.0027377 | 0.9513640 | 0.00274 | ** | NA |
| RAB40C | vandetanib | 0.0027387 | 0.8963224 | 0.00274 | ** | NA |
| ST6GAL2 | olaparib | 0.0027408 | 0.9821538 | 0.00274 | ** | NA |
| VPS13B | regorafenib | 0.0027418 | 0.6627240 | 0.00274 | ** | NA |
| SLC17A7 | vemurafenib | 0.0027425 | 0.4245575 | 0.00274 | ** | NA |
| PTCHD4 | afatinib | 0.0027480 | 0.8943727 | 0.00275 | ** | NA |
| GPR110 | nilotinib | 0.0027491 | 0.7820181 | 0.00275 | ** | NA |
| TAF4B | lapatinib | 0.0027497 | 0.8488319 | 0.00275 | ** | NA |
| RBFOX2 | cabozantinib | 0.0027501 | 0.1871701 | 0.00275 | ** | NA |
| KPNA3 | imatinib | 0.0027539 | 0.8762527 | 0.00275 | ** | NA |
| MBTPS1 | dasatinib | 0.0027583 | 0.9816837 | 0.00276 | ** | NA |
| STAP2 | cabozantinib | 0.0027583 | 0.1871701 | 0.00276 | ** | NA |
| LMX1B | gefitinib | 0.0027586 | 0.9513640 | 0.00276 | ** | NA |
| TP53BP2 | vemurafenib | 0.0027653 | 0.4245575 | 0.00277 | ** | NA |
| DNAJC6 | cabozantinib | 0.0027653 | 0.1871701 | 0.00277 | ** | NA |
| MAPK8 | vemurafenib | 0.0027765 | 0.4245575 | 0.00278 | ** | NA |
| LRIT2 | cabozantinib | 0.0027779 | 0.1871701 | 0.00278 | ** | NA |
| RAP1GAP | imatinib | 0.0027826 | 0.8762527 | 0.00278 | ** | NA |
| STAP2 | sunitinib | 0.0027832 | 0.6695527 | 0.00278 | ** | NA |
| ZNF217 | temozolomide | 0.0027869 | 0.8741265 | 0.00279 | ** | NA |
| C10orf120 | vemurafenib | 0.0027901 | 0.4245575 | 0.00279 | ** | NA |
| DMRT3 | regorafenib | 0.0027904 | 0.6627240 | 0.00279 | ** | NA |
| DNAJB9 | cabozantinib | 0.0027916 | 0.1871701 | 0.00279 | ** | NA |
| HID1 | afatinib | 0.0027956 | 0.8943727 | 0.00280 | ** | NA |
| ZFP69 | gefitinib | 0.0027964 | 0.9513640 | 0.00280 | ** | NA |
| OR6B2 | regorafenib | 0.0028042 | 0.6627240 | 0.00280 | ** | NA |
| PRDM11 | trametinib | 0.0028066 | 0.9757752 | 0.0028 | ** | NA |
| PTH1R | erlotinib | 0.0028070 | 0.7436781 | 0.00281 | ** | NA |
| AOC2 | nilotinib | 0.0028084 | 0.7820181 | 0.00281 | ** | NA |
| PLCH2 | cabozantinib | 0.0028130 | 0.1871701 | 0.00281 | ** | NA |
| RHD | vemurafenib | 0.0028157 | 0.4245575 | 0.00282 | ** | NA |
| KIF3C | vemurafenib | 0.0028158 | 0.4245575 | 0.00282 | ** | NA |
| MTBP | sunitinib | 0.0028197 | 0.6695527 | 0.00282 | ** | NA |
| SPIB | cabozantinib | 0.0028198 | 0.1871701 | 0.00282 | ** | NA |
| DLG4 | cabozantinib | 0.0028204 | 0.1871701 | 0.00282 | ** | NA |
| DPY19L1 | neratinib | 0.0028222 | 0.9827379 | 0.00282 | ** | NA |
| TFCP2L1 | afatinib | 0.0028254 | 0.8943727 | 0.00283 | ** | NA |
| LRRC7 | selumetinib | 0.0028301 | 0.9983774 | 0.00283 | ** | NA |
| TTLL2 | gefitinib | 0.0028314 | 0.9513640 | 0.00283 | ** | NA |
| RPE65 | cabozantinib | 0.0028419 | 0.1871701 | 0.00284 | ** | NA |
| UCP1 | cabozantinib | 0.0028457 | 0.1871701 | 0.00285 | ** | NA |
| DMXL1 | regorafenib | 0.0028461 | 0.6627240 | 0.00285 | ** | NA |
| DSCR3 | lapatinib | 0.0028493 | 0.8488319 | 0.00285 | ** | NA |
| HCFC2 | cabozantinib | 0.0028506 | 0.1871701 | 0.00285 | ** | NA |
| ITPKA | vemurafenib | 0.0028521 | 0.4245575 | 0.00285 | ** | NA |
| ARHGEF11 | cabozantinib | 0.0028532 | 0.1871701 | 0.00285 | ** | NA |
| ASPM | cabozantinib | 0.0028536 | 0.1871701 | 0.00285 | ** | NA |
| CCIN | regorafenib | 0.0028549 | 0.6627240 | 0.00285 | ** | NA |
| ATP8B1 | afatinib | 0.0028557 | 0.8943727 | 0.00286 | ** | NA |
| GLDC | nilotinib | 0.0028577 | 0.7820181 | 0.00286 | ** | NA |
| ATP10A | vemurafenib | 0.0028593 | 0.4245575 | 0.00286 | ** | NA |
| UBA2 | vemurafenib | 0.0028627 | 0.4245575 | 0.00286 | ** | NA |
| PDLIM4 | neratinib | 0.0028640 | 0.9827379 | 0.00286 | ** | NA |
| L3MBTL4 | olaparib | 0.0028679 | 0.9821538 | 0.00287 | ** | NA |
| TRPV4 | sunitinib | 0.0028708 | 0.6695527 | 0.00287 | ** | NA |
| ASAP1 | cabozantinib | 0.0028718 | 0.1873947 | 0.00287 | ** | NA |
| DHRS11 | regorafenib | 0.0028721 | 0.6627240 | 0.00287 | ** | NA |
| ZNF573 | sunitinib | 0.0028775 | 0.6695527 | 0.00288 | ** | NA |
| MORC2 | cabozantinib | 0.0028791 | 0.1873947 | 0.00288 | ** | NA |
| MGAM | temozolomide | 0.0028845 | 0.8741265 | 0.00288 | ** | NA |
| PMPCB | pazopanib | 0.0028882 | 0.9778540 | 0.00289 | ** | NA |
| TAF1L | pazopanib | 0.0028911 | 0.9778540 | 0.00289 | ** | NA |
| PHYKPL | vemurafenib | 0.0028913 | 0.4245575 | 0.00289 | ** | NA |
| ZBTB7C | crizotinib | 0.0028963 | 0.9965659 | 0.00290 | ** | NA |
| TPBGL | dasatinib | 0.0028968 | 0.9816837 | 0.00290 | ** | NA |
| PIK3R2 | olaparib | 0.0028987 | 0.9821538 | 0.00290 | ** | NA |
| DNMT3A | lapatinib | 0.0028992 | 0.8488319 | 0.00290 | ** | NA |
| MAP10 | neratinib | 0.0029011 | 0.9827379 | 0.00290 | ** | NA |
| ABCB6 | cabozantinib | 0.0029034 | 0.1882581 | 0.00290 | ** | NA |
| CNGB3 | imatinib | 0.0029078 | 0.8762527 | 0.00291 | ** | NA |
| AOX1 | olaparib | 0.0029089 | 0.9821538 | 0.00291 | ** | NA |
| A2ML1 | pazopanib | 0.0029116 | 0.9778540 | 0.00291 | ** | NA |
GDSC:
gdsc <- read.delim("./data_munging/data_drug_auc_gdsc_10_12_2018.csv", sep = "\t", header = TRUE, row.names = 1, check.names = FALSE)
gdsc <- merge(drug_meta, gdsc, by = "CID")
gdsc_melt <- melt(gdsc, id.vars = c("CID", "Drug"), measure.vars = colnames(gdsc)[3:ncol(gdsc)], variable.name = "accession_id", value.name = "AUC")
gdsc_grid <- expand.grid("accession_id" = unique(gdsc_melt$accession_id), "Hugo_Symbol" = as.character(unique(crispr_data$Hugo_Symbol)))
system.time({ gdsc_data_allgenes <- WilcoxonByDrugAllGenes(gdsc_melt, gdsc_grid, "GDSC") })
saveRDS(gdsc_data_allgenes, "./data_munging/rds/gdsc_data_18Q3_allgenes.rds", compress = "xz")
gdsc_data_allgenes <- readRDS("./data_munging/rds/gdsc_data_18Q3_allgenes.rds")
gdsc_data_allgenes <- gdsc_data_allgenes[order(gdsc_data_allgenes$p),]
knitr::kable(gdsc_data_allgenes[1:1000, c("Hugo_Symbol", "Drug", "p", "p.adj", "p.format", "p.signif", "p.signif.adj")], caption = "GDSC: by-drug Wilcoxon test results for point mutations in genes targeted in CRISPR screen (* p <= 0.05, ** p <= 0.01, *** p <= 0.001, **** p <= 0.0001)") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | Drug | p | p.adj | p.format | p.signif | p.signif.adj |
|---|---|---|---|---|---|---|
| KRAS | trametinib | 0.0000000 | 0.0001434 | 8.5e-09 | **** | *** |
| KRT3 | gefitinib | 0.0000006 | 0.0092957 | 5.6e-07 | **** | ** |
| KRT3 | afatinib | 0.0000033 | 0.0544399 | 3.3e-06 | **** | NA |
| KRT3 | docetaxel | 0.0000230 | 0.3833031 | 2.3e-05 | **** | NA |
| LRRC16B | tretinoin | 0.0000319 | 0.3065581 | 3.2e-05 | **** | NA |
| GLI3 | tretinoin | 0.0000368 | 0.3065581 | 3.7e-05 | **** | NA |
| CCDC11 | trametinib | 0.0000772 | 0.6129716 | 7.7e-05 | **** | NA |
| ANKRD11 | midostaurin | 0.0000949 | 0.8485531 | 9.5e-05 | **** | NA |
| NF1 | midostaurin | 0.0001013 | 0.8485531 | 0.00010 | *** | NA |
| GRM7 | gefitinib | 0.0001055 | 0.8784133 | 0.00011 | *** | NA |
| BRAF | dabrafenib | 0.0001234 | 0.9305571 | 0.00012 | *** | NA |
| STK36 | temozolomide | 0.0001286 | 0.6902774 | 0.00013 | *** | NA |
| ZNF502 | pazopanib | 0.0001430 | 0.9978452 | 0.00014 | *** | NA |
| BRAF | trametinib | 0.0001576 | 0.6129716 | 0.00016 | *** | NA |
| CALD1 | tretinoin | 0.0001594 | 0.5222109 | 0.00016 | *** | NA |
| RETSAT | gefitinib | 0.0001619 | 0.8957015 | 0.00016 | *** | NA |
| APOB | trametinib | 0.0001645 | 0.6129716 | 0.00016 | *** | NA |
| SLC6A17 | tretinoin | 0.0001648 | 0.5222109 | 0.00016 | *** | NA |
| DPCR1 | cabozantinib | 0.0001688 | 0.8298252 | 0.00017 | *** | NA |
| ING1 | alectinib | 0.0001695 | 0.9168760 | 0.00017 | *** | NA |
| HCFC2 | temozolomide | 0.0001863 | 0.6902774 | 0.00019 | *** | NA |
| IVL | ruxolitinib | 0.0001893 | 0.9787856 | 0.00019 | *** | NA |
| DCHS1 | cabozantinib | 0.0001897 | 0.8298252 | 0.00019 | *** | NA |
| TTN | trametinib | 0.0002005 | 0.6129716 | 0.00020 | *** | NA |
| KAT6A | tretinoin | 0.0002041 | 0.5222109 | 0.00020 | *** | NA |
| PTEN | belinostat | 0.0002105 | 0.9983823 | 0.00021 | *** | NA |
| TNRC18 | trametinib | 0.0002193 | 0.6129716 | 0.00022 | *** | NA |
| ZNF304 | tretinoin | 0.0002225 | 0.5222109 | 0.00022 | *** | NA |
| MBNL1 | cabozantinib | 0.0002280 | 0.8298252 | 0.00023 | *** | NA |
| AZGP1 | tretinoin | 0.0002550 | 0.5222109 | 0.00026 | *** | NA |
| BICD1 | tretinoin | 0.0002627 | 0.5222109 | 0.00026 | *** | NA |
| PLEKHA5 | temozolomide | 0.0002708 | 0.6902774 | 0.00027 | *** | NA |
| SLC2A5 | dabrafenib | 0.0002882 | 0.9305571 | 0.00029 | *** | NA |
| SEC31B | dabrafenib | 0.0002925 | 0.9305571 | 0.00029 | *** | NA |
| TNC | trametinib | 0.0002990 | 0.7165039 | 0.00030 | *** | NA |
| TTLL11 | alectinib | 0.0003022 | 0.9168760 | 0.00030 | *** | NA |
| PRR14 | gefitinib | 0.0003066 | 0.8957015 | 0.00031 | *** | NA |
| SLC28A3 | alectinib | 0.0003397 | 0.9168760 | 0.00034 | *** | NA |
| CASP8 | ruxolitinib | 0.0003630 | 0.9787856 | 0.00036 | *** | NA |
| XIRP2 | lapatinib | 0.0003744 | 0.8107014 | 0.00037 | *** | NA |
| TNRC18 | dabrafenib | 0.0003745 | 0.9305571 | 0.00037 | *** | NA |
| GART | alectinib | 0.0003784 | 0.9168760 | 0.00038 | *** | NA |
| SZT2 | pazopanib | 0.0003837 | 0.9978452 | 0.00038 | *** | NA |
| PCDHB1 | nilotinib | 0.0003863 | 0.8055751 | 0.00039 | *** | NA |
| CDKN2A | trametinib | 0.0003927 | 0.7896655 | 0.00039 | *** | NA |
| ABCC12 | tretinoin | 0.0003991 | 0.5222109 | 0.00040 | *** | NA |
| DBF4 | palbociclib | 0.0004053 | 0.9551671 | 0.00041 | *** | NA |
| OTOG | temozolomide | 0.0004084 | 0.6902774 | 0.00041 | *** | NA |
| ANGPTL2 | dabrafenib | 0.0004196 | 0.9305571 | 0.00042 | *** | NA |
| UGT2A1 | afatinib | 0.0004220 | 0.9267832 | 0.00042 | *** | NA |
| KIAA0319 | trametinib | 0.0004237 | 0.7896655 | 0.00042 | *** | NA |
| GJA10 | tretinoin | 0.0004279 | 0.5222109 | 0.00043 | *** | NA |
| PCDHGB4 | midostaurin | 0.0004291 | 0.8795120 | 0.00043 | *** | NA |
| MYH8 | tretinoin | 0.0004310 | 0.5222109 | 0.00043 | *** | NA |
| UBR4 | gefitinib | 0.0004353 | 0.8957015 | 0.00044 | *** | NA |
| SEZ6L | alectinib | 0.0004383 | 0.9168760 | 0.00044 | *** | NA |
| SLC7A9 | tretinoin | 0.0004383 | 0.5222109 | 0.00044 | *** | NA |
| PCDHGB4 | ponatinib | 0.0004386 | 1.0000000 | 0.00044 | *** | NA |
| HECTD1 | cabozantinib | 0.0004417 | 0.8298252 | 0.00044 | *** | NA |
| MTF2 | midostaurin | 0.0004560 | 0.8795120 | 0.00046 | *** | NA |
| TP53 | docetaxel | 0.0004703 | 0.9106700 | 0.00047 | *** | NA |
| TWF2 | midostaurin | 0.0005002 | 0.8795120 | 0.00050 | *** | NA |
| PDGFRB | cabozantinib | 0.0005036 | 0.8298252 | 0.00050 | *** | NA |
| GSPT1 | docetaxel | 0.0005113 | 0.9106700 | 0.00051 | *** | NA |
| ZNF85 | tretinoin | 0.0005235 | 0.5222109 | 0.00052 | *** | NA |
| DOCK6 | ruxolitinib | 0.0005280 | 0.9787856 | 0.00053 | *** | NA |
| FOXA1 | vismodegib | 0.0005480 | 0.9623352 | 0.00055 | *** | NA |
| CAMK4 | tretinoin | 0.0005565 | 0.5222109 | 0.00056 | *** | NA |
| FGD6 | tretinoin | 0.0005638 | 0.5222109 | 0.00056 | *** | NA |
| SMEK2 | tretinoin | 0.0005725 | 0.5222109 | 0.00057 | *** | NA |
| PTH1R | afatinib | 0.0005796 | 0.9267832 | 0.00058 | *** | NA |
| DSEL | tretinoin | 0.0005844 | 0.5222109 | 0.00058 | *** | NA |
| GLG1 | cabozantinib | 0.0005860 | 0.8298252 | 0.00059 | *** | NA |
| ATG16L1 | rucaparib | 0.0005872 | 0.9990814 | 0.00059 | *** | NA |
| ESRP2 | cabozantinib | 0.0005887 | 0.8298252 | 0.00059 | *** | NA |
| LRP5 | temozolomide | 0.0006198 | 0.6902774 | 0.00062 | *** | NA |
| PABPC4 | temozolomide | 0.0006343 | 0.6902774 | 0.00063 | *** | NA |
| MDH1B | dabrafenib | 0.0006353 | 0.9305571 | 0.00064 | *** | NA |
| MUC16 | docetaxel | 0.0006486 | 0.9106700 | 0.00065 | *** | NA |
| ROBO2 | erlotinib | 0.0006603 | 0.7991878 | 0.00066 | *** | NA |
| SARS2 | dabrafenib | 0.0006646 | 0.9305571 | 0.00066 | *** | NA |
| CDKN2A | docetaxel | 0.0006721 | 0.9106700 | 0.00067 | *** | NA |
| LPAR5 | docetaxel | 0.0006722 | 0.9106700 | 0.00067 | *** | NA |
| NAPB | temozolomide | 0.0006842 | 0.6902774 | 0.00068 | *** | NA |
| TRMT44 | afatinib | 0.0007182 | 0.9267832 | 0.00072 | *** | NA |
| GABRA5 | nilotinib | 0.0007210 | 0.8055751 | 0.00072 | *** | NA |
| KBTBD12 | docetaxel | 0.0007266 | 0.9106700 | 0.00073 | *** | NA |
| RABL6 | temozolomide | 0.0007371 | 0.6902774 | 0.00074 | *** | NA |
| PRKCB | bosutinib monohydrate | 0.0007390 | 1.0000000 | 0.00074 | *** | NA |
| OR12D2 | alectinib | 0.0007538 | 0.9168760 | 0.00075 | *** | NA |
| CPAMD8 | midostaurin | 0.0007559 | 0.8795120 | 0.00076 | *** | NA |
| STAM | temozolomide | 0.0007729 | 0.6902774 | 0.00077 | *** | NA |
| NOTO | ruxolitinib | 0.0007812 | 0.9787856 | 0.00078 | *** | NA |
| PRDM15 | cabozantinib | 0.0007818 | 0.8298252 | 0.00078 | *** | NA |
| SNAP91 | nilotinib | 0.0007848 | 0.8055751 | 0.00078 | *** | NA |
| A2M | cabozantinib | 0.0008079 | 0.8298252 | 0.00081 | *** | NA |
| CYP2A6 | docetaxel | 0.0008086 | 0.9106700 | 0.00081 | *** | NA |
| MUC5B | tretinoin | 0.0008235 | 0.5222109 | 0.00082 | *** | NA |
| DOCK6 | cabozantinib | 0.0008245 | 0.8298252 | 0.00082 | *** | NA |
| KCNC4 | nilotinib | 0.0008246 | 0.8055751 | 0.00082 | *** | NA |
| GPA33 | trametinib | 0.0008408 | 0.9852344 | 0.00084 | *** | NA |
| ACAD11 | tretinoin | 0.0008461 | 0.5222109 | 0.00085 | *** | NA |
| ALPL | gefitinib | 0.0008712 | 0.8957015 | 0.00087 | *** | NA |
| HCFC2 | vismodegib | 0.0008896 | 0.9623352 | 0.00089 | *** | NA |
| GOLPH3L | nilotinib | 0.0008929 | 0.8055751 | 0.00089 | *** | NA |
| SNX14 | nilotinib | 0.0009023 | 0.8055751 | 0.00090 | *** | NA |
| CCDC17 | temozolomide | 0.0009029 | 0.6902774 | 0.00090 | *** | NA |
| XIRP2 | rucaparib | 0.0009195 | 0.9990814 | 0.00092 | *** | NA |
| OR6C70 | cabozantinib | 0.0009205 | 0.8298252 | 0.00092 | *** | NA |
| TCEA2 | cabozantinib | 0.0009677 | 0.8298252 | 0.00097 | *** | NA |
| FSTL4 | tretinoin | 0.0009720 | 0.5222109 | 0.00097 | *** | NA |
| ZNF846 | pazopanib | 0.0009734 | 0.9978452 | 0.00097 | *** | NA |
| MTMR7 | tretinoin | 0.0009774 | 0.5222109 | 0.00098 | *** | NA |
| OR2M5 | vismodegib | 0.0009854 | 0.9623352 | 0.00099 | *** | NA |
| GRID1 | afatinib | 0.0009931 | 0.9267832 | 0.00099 | *** | NA |
| OSR2 | trametinib | 0.0009981 | 0.9852344 | 0.00100 | *** | NA |
| KLHDC7A | trametinib | 0.0010019 | 0.9852344 | 0.00100 | ** | NA |
| ZKSCAN5 | ponatinib | 0.0010078 | 1.0000000 | 0.00101 | ** | NA |
| SLCO6A1 | cabozantinib | 0.0010088 | 0.8298252 | 0.00101 | ** | NA |
| GSPT1 | nilotinib | 0.0010113 | 0.8055751 | 0.00101 | ** | NA |
| KCNG2 | tretinoin | 0.0010395 | 0.5222109 | 0.00104 | ** | NA |
| SGCE | midostaurin | 0.0010401 | 0.8795120 | 0.00104 | ** | NA |
| GSC | nilotinib | 0.0010428 | 0.8055751 | 0.00104 | ** | NA |
| GNAI1 | alectinib | 0.0010441 | 0.9168760 | 0.00104 | ** | NA |
| TIAM2 | trametinib | 0.0010478 | 0.9852344 | 0.00105 | ** | NA |
| SLC25A39 | tretinoin | 0.0010508 | 0.5222109 | 0.00105 | ** | NA |
| VCPIP1 | ponatinib | 0.0010548 | 1.0000000 | 0.00105 | ** | NA |
| LILRB2 | crizotinib | 0.0010550 | 0.7869686 | 0.0011 | ** | NA |
| SEMA4A | belinostat | 0.0010554 | 0.9983823 | 0.00106 | ** | NA |
| PDHA2 | palbociclib | 0.0010572 | 0.9551671 | 0.00106 | ** | NA |
| ZNF202 | dabrafenib | 0.0010622 | 0.9305571 | 0.00106 | ** | NA |
| OR56A4 | midostaurin | 0.0010691 | 0.8795120 | 0.00107 | ** | NA |
| PCSK2 | belinostat | 0.0010719 | 0.9983823 | 0.00107 | ** | NA |
| XYLT1 | tretinoin | 0.0010746 | 0.5222109 | 0.00107 | ** | NA |
| MLLT4 | tretinoin | 0.0010936 | 0.5222109 | 0.00109 | ** | NA |
| IGSF9 | docetaxel | 0.0011031 | 0.9106700 | 0.00110 | ** | NA |
| KALRN | dabrafenib | 0.0011216 | 0.9305571 | 0.00112 | ** | NA |
| BFSP1 | afatinib | 0.0011233 | 0.9267832 | 0.00112 | ** | NA |
| TMEM82 | cabozantinib | 0.0011246 | 0.8298252 | 0.00112 | ** | NA |
| FAM198A | dabrafenib | 0.0011259 | 0.9305571 | 0.00113 | ** | NA |
| HCFC2 | nilotinib | 0.0011346 | 0.8055751 | 0.00113 | ** | NA |
| GZMH | tretinoin | 0.0011441 | 0.5222109 | 0.00114 | ** | NA |
| DNAH9 | docetaxel | 0.0011562 | 0.9106700 | 0.00116 | ** | NA |
| KDM4B | temozolomide | 0.0011595 | 0.6902774 | 0.00116 | ** | NA |
| MAP3K12 | rucaparib | 0.0011725 | 0.9990814 | 0.00117 | ** | NA |
| SUPT16H | temozolomide | 0.0011771 | 0.6902774 | 0.00118 | ** | NA |
| ACAD11 | nilotinib | 0.0011832 | 0.8055751 | 0.00118 | ** | NA |
| RPS6KA1 | tretinoin | 0.0011844 | 0.5222109 | 0.00118 | ** | NA |
| IL10RB | gefitinib | 0.0011848 | 0.8957015 | 0.00118 | ** | NA |
| EZH2 | bosutinib monohydrate | 0.0011913 | 1.0000000 | 0.00119 | ** | NA |
| PHLDB3 | sunitinib | 0.0012033 | 0.7819868 | 0.0012 | ** | NA |
| TRMT13 | cabozantinib | 0.0012095 | 0.8298252 | 0.00121 | ** | NA |
| POLR2A | palbociclib | 0.0012142 | 0.9551671 | 0.00121 | ** | NA |
| SEMA5A | afatinib | 0.0012154 | 0.9267832 | 0.00122 | ** | NA |
| OR5T2 | trametinib | 0.0012326 | 0.9852344 | 0.00123 | ** | NA |
| PYGO1 | afatinib | 0.0012345 | 0.9267832 | 0.00123 | ** | NA |
| GSPT1 | temozolomide | 0.0012353 | 0.6902774 | 0.00124 | ** | NA |
| RFPL4AL1 | alectinib | 0.0012390 | 0.9168760 | 0.00124 | ** | NA |
| WDR6 | gefitinib | 0.0012433 | 0.8957015 | 0.00124 | ** | NA |
| PIGN | cabozantinib | 0.0012484 | 0.8298252 | 0.00125 | ** | NA |
| PCSK7 | afatinib | 0.0012497 | 0.9267832 | 0.00125 | ** | NA |
| BMPER | belinostat | 0.0012548 | 0.9983823 | 0.00125 | ** | NA |
| OTOG | nilotinib | 0.0012594 | 0.8055751 | 0.00126 | ** | NA |
| DMBT1 | cabozantinib | 0.0012632 | 0.8298252 | 0.00126 | ** | NA |
| GJA10 | vismodegib | 0.0012708 | 0.9623352 | 0.00127 | ** | NA |
| ACIN1 | trametinib | 0.0012721 | 0.9852344 | 0.00127 | ** | NA |
| USP5 | ruxolitinib | 0.0012753 | 0.9787856 | 0.00128 | ** | NA |
| ZNF644 | tretinoin | 0.0012913 | 0.5222109 | 0.00129 | ** | NA |
| ACKR3 | temozolomide | 0.0012959 | 0.6902774 | 0.00130 | ** | NA |
| TRPM5 | ponatinib | 0.0012976 | 1.0000000 | 0.00130 | ** | NA |
| KRT9 | temozolomide | 0.0013003 | 0.6902774 | 0.00130 | ** | NA |
| NEGR1 | gefitinib | 0.0013015 | 0.8957015 | 0.00130 | ** | NA |
| FBXW10 | palbociclib | 0.0013029 | 0.9551671 | 0.00130 | ** | NA |
| EXOSC9 | cabozantinib | 0.0013032 | 0.8298252 | 0.00130 | ** | NA |
| CACNA1C | docetaxel | 0.0013040 | 0.9106700 | 0.00130 | ** | NA |
| SDAD1 | nilotinib | 0.0013062 | 0.8055751 | 0.00131 | ** | NA |
| ZNF528 | temozolomide | 0.0013101 | 0.6902774 | 0.00131 | ** | NA |
| IGSF9B | nilotinib | 0.0013195 | 0.8055751 | 0.00132 | ** | NA |
| PIK3C2B | dabrafenib | 0.0013202 | 0.9305571 | 0.00132 | ** | NA |
| TRPM5 | cabozantinib | 0.0013202 | 0.8298252 | 0.00132 | ** | NA |
| STK36 | cabozantinib | 0.0013279 | 0.8298252 | 0.00133 | ** | NA |
| MAP2 | tretinoin | 0.0013346 | 0.5222109 | 0.00133 | ** | NA |
| FBN3 | gefitinib | 0.0013395 | 0.8957015 | 0.00134 | ** | NA |
| SEC63 | tretinoin | 0.0013611 | 0.5222109 | 0.00136 | ** | NA |
| LRFN5 | gefitinib | 0.0013738 | 0.8957015 | 0.00137 | ** | NA |
| SERPIND1 | alectinib | 0.0013792 | 0.9168760 | 0.00138 | ** | NA |
| SPEG | trametinib | 0.0013912 | 0.9852344 | 0.00139 | ** | NA |
| GDF11 | cabozantinib | 0.0013978 | 0.8298252 | 0.00140 | ** | NA |
| SEL1L2 | ruxolitinib | 0.0013991 | 0.9787856 | 0.00140 | ** | NA |
| ERVV-1 | afatinib | 0.0014031 | 0.9267832 | 0.00140 | ** | NA |
| CDHR5 | lapatinib | 0.0014107 | 0.8107014 | 0.00141 | ** | NA |
| SLC2A10 | cabozantinib | 0.0014259 | 0.8298252 | 0.00143 | ** | NA |
| TTN | cabozantinib | 0.0014280 | 0.8298252 | 0.00143 | ** | NA |
| MUC16 | cabozantinib | 0.0014396 | 0.8298252 | 0.00144 | ** | NA |
| KIAA1244 | tretinoin | 0.0014413 | 0.5222109 | 0.00144 | ** | NA |
| HCFC2 | docetaxel | 0.0014446 | 0.9106700 | 0.00144 | ** | NA |
| FCHSD1 | sunitinib | 0.0014492 | 0.7819868 | 0.0014 | ** | NA |
| CNNM2 | gefitinib | 0.0014516 | 0.8957015 | 0.00145 | ** | NA |
| KCNT1 | tretinoin | 0.0014564 | 0.5222109 | 0.00146 | ** | NA |
| CNTNAP2 | tretinoin | 0.0014589 | 0.5222109 | 0.00146 | ** | NA |
| TRMT44 | gefitinib | 0.0014720 | 0.8957015 | 0.00147 | ** | NA |
| C5 | tretinoin | 0.0014839 | 0.5222109 | 0.00148 | ** | NA |
| ZNF785 | tretinoin | 0.0014923 | 0.5222109 | 0.00149 | ** | NA |
| CDH18 | afatinib | 0.0014976 | 0.9267832 | 0.00150 | ** | NA |
| RRAGD | tretinoin | 0.0014983 | 0.5222109 | 0.00150 | ** | NA |
| LAMA2 | tretinoin | 0.0015069 | 0.5222109 | 0.00151 | ** | NA |
| KCNAB1 | tretinoin | 0.0015148 | 0.5222109 | 0.00151 | ** | NA |
| A2ML1 | tretinoin | 0.0015364 | 0.5222109 | 0.00154 | ** | NA |
| ZNF93 | trametinib | 0.0015428 | 0.9852344 | 0.00154 | ** | NA |
| C19orf18 | trametinib | 0.0015539 | 0.9852344 | 0.00155 | ** | NA |
| C16orf71 | trametinib | 0.0015550 | 0.9852344 | 0.00155 | ** | NA |
| LAMC3 | gefitinib | 0.0015574 | 0.8957015 | 0.00156 | ** | NA |
| WWP2 | bosutinib monohydrate | 0.0015609 | 1.0000000 | 0.00156 | ** | NA |
| PAXBP1 | cabozantinib | 0.0015702 | 0.8298252 | 0.00157 | ** | NA |
| PHTF2 | vismodegib | 0.0015704 | 0.9623352 | 0.00157 | ** | NA |
| PTPRB | midostaurin | 0.0015720 | 0.8795120 | 0.00157 | ** | NA |
| CLEC4F | cabozantinib | 0.0015766 | 0.8298252 | 0.00158 | ** | NA |
| HCFC2 | tretinoin | 0.0015812 | 0.5222109 | 0.00158 | ** | NA |
| BICD1 | nilotinib | 0.0015833 | 0.8055751 | 0.00158 | ** | NA |
| PSIP1 | ponatinib | 0.0015943 | 1.0000000 | 0.00159 | ** | NA |
| SIGLEC5 | alectinib | 0.0016045 | 0.9168760 | 0.00160 | ** | NA |
| CCIN | nilotinib | 0.0016092 | 0.8055751 | 0.00161 | ** | NA |
| LPIN3 | midostaurin | 0.0016122 | 0.8795120 | 0.00161 | ** | NA |
| TAAR8 | dabrafenib | 0.0016175 | 0.9305571 | 0.00162 | ** | NA |
| POGK | ruxolitinib | 0.0016239 | 0.9787856 | 0.00162 | ** | NA |
| SCN8A | temozolomide | 0.0016278 | 0.6902774 | 0.00163 | ** | NA |
| RINL | docetaxel | 0.0016283 | 0.9106700 | 0.00163 | ** | NA |
| FAM207A | nilotinib | 0.0016338 | 0.8055751 | 0.00163 | ** | NA |
| FIGNL1 | afatinib | 0.0016356 | 0.9267832 | 0.00164 | ** | NA |
| TNC | dabrafenib | 0.0016383 | 0.9305571 | 0.00164 | ** | NA |
| NDUFS3 | pazopanib | 0.0016405 | 0.9978452 | 0.00164 | ** | NA |
| KIAA1683 | ruxolitinib | 0.0016411 | 0.9787856 | 0.00164 | ** | NA |
| CIITA | tretinoin | 0.0016484 | 0.5222109 | 0.00165 | ** | NA |
| DCLK2 | nilotinib | 0.0016547 | 0.8055751 | 0.00165 | ** | NA |
| ZNF391 | dabrafenib | 0.0016585 | 0.9305571 | 0.00166 | ** | NA |
| PCDHGC4 | palbociclib | 0.0016592 | 0.9551671 | 0.00166 | ** | NA |
| GLP2R | nilotinib | 0.0016642 | 0.8055751 | 0.00166 | ** | NA |
| ABLIM3 | ponatinib | 0.0016682 | 1.0000000 | 0.00167 | ** | NA |
| DAZAP1 | tretinoin | 0.0016683 | 0.5222109 | 0.00167 | ** | NA |
| RSPH10B2 | tretinoin | 0.0016799 | 0.5222109 | 0.00168 | ** | NA |
| UPF3A | temozolomide | 0.0016804 | 0.6902774 | 0.00168 | ** | NA |
| ZDHHC23 | tretinoin | 0.0016847 | 0.5222109 | 0.00168 | ** | NA |
| NUCB1 | temozolomide | 0.0016859 | 0.6902774 | 0.00169 | ** | NA |
| PTGIR | alectinib | 0.0016935 | 0.9168760 | 0.00169 | ** | NA |
| ELF5 | tretinoin | 0.0016961 | 0.5222109 | 0.00170 | ** | NA |
| COL4A3 | tretinoin | 0.0017038 | 0.5222109 | 0.00170 | ** | NA |
| ALS2CL | temozolomide | 0.0017044 | 0.6902774 | 0.00170 | ** | NA |
| PTPRU | ponatinib | 0.0017063 | 1.0000000 | 0.00171 | ** | NA |
| KRAS | palbociclib | 0.0017081 | 0.9551671 | 0.00171 | ** | NA |
| GABRP | afatinib | 0.0017226 | 0.9267832 | 0.00172 | ** | NA |
| FYCO1 | gefitinib | 0.0017341 | 0.8957015 | 0.00173 | ** | NA |
| NPAS3 | afatinib | 0.0017352 | 0.9267832 | 0.00174 | ** | NA |
| ITGB2 | temozolomide | 0.0017490 | 0.6902774 | 0.00175 | ** | NA |
| ZNF737 | vismodegib | 0.0017519 | 0.9623352 | 0.00175 | ** | NA |
| HKR1 | midostaurin | 0.0017579 | 0.8795120 | 0.00176 | ** | NA |
| MAP3K9 | nilotinib | 0.0017661 | 0.8055751 | 0.00177 | ** | NA |
| UPP2 | temozolomide | 0.0017737 | 0.6902774 | 0.00177 | ** | NA |
| FBN3 | trametinib | 0.0017748 | 0.9852344 | 0.00177 | ** | NA |
| TRMT10B | alectinib | 0.0017834 | 0.9168760 | 0.00178 | ** | NA |
| PDCD11 | crizotinib | 0.0017889 | 0.7869686 | 0.0018 | ** | NA |
| CCDC175 | tretinoin | 0.0017920 | 0.5222109 | 0.00179 | ** | NA |
| DSEL | vismodegib | 0.0018062 | 0.9623352 | 0.00181 | ** | NA |
| PRICKLE2 | temozolomide | 0.0018082 | 0.6902774 | 0.00181 | ** | NA |
| CSPG4 | tretinoin | 0.0018088 | 0.5222109 | 0.00181 | ** | NA |
| ABCG5 | vismodegib | 0.0018143 | 0.9623352 | 0.00181 | ** | NA |
| DPYSL2 | gefitinib | 0.0018158 | 0.8957015 | 0.00182 | ** | NA |
| CACNA1I | gefitinib | 0.0018318 | 0.8957015 | 0.00183 | ** | NA |
| HCFC2 | ruxolitinib | 0.0018327 | 0.9787856 | 0.00183 | ** | NA |
| CTAGE9 | bosutinib monohydrate | 0.0018332 | 1.0000000 | 0.00183 | ** | NA |
| ERVV-1 | gefitinib | 0.0018430 | 0.8957015 | 0.00184 | ** | NA |
| DSG2 | palbociclib | 0.0018458 | 0.9551671 | 0.00185 | ** | NA |
| SCRIB | nilotinib | 0.0018508 | 0.8055751 | 0.00185 | ** | NA |
| USP24 | tretinoin | 0.0018509 | 0.5222109 | 0.00185 | ** | NA |
| RASGRF2 | nilotinib | 0.0018627 | 0.8055751 | 0.00186 | ** | NA |
| SCIN | pazopanib | 0.0018732 | 0.9978452 | 0.00187 | ** | NA |
| ZNF320 | tretinoin | 0.0018740 | 0.5222109 | 0.00187 | ** | NA |
| APOBEC3B | alectinib | 0.0018822 | 0.9168760 | 0.00188 | ** | NA |
| RFPL4AL1 | ruxolitinib | 0.0018832 | 0.9787856 | 0.00188 | ** | NA |
| DNAH9 | belinostat | 0.0018840 | 0.9983823 | 0.00188 | ** | NA |
| UNC13D | crizotinib | 0.0018881 | 0.7869686 | 0.0019 | ** | NA |
| CDYL2 | vismodegib | 0.0018928 | 0.9623352 | 0.00189 | ** | NA |
| ZBTB10 | docetaxel | 0.0018952 | 0.9106700 | 0.00190 | ** | NA |
| PLA2R1 | trametinib | 0.0019052 | 0.9852344 | 0.00191 | ** | NA |
| STARD9 | cabozantinib | 0.0019131 | 0.8298252 | 0.00191 | ** | NA |
| ALPL | afatinib | 0.0019315 | 0.9267832 | 0.00193 | ** | NA |
| MYO5A | afatinib | 0.0019417 | 0.9267832 | 0.00194 | ** | NA |
| FBXO4 | midostaurin | 0.0019517 | 0.8795120 | 0.00195 | ** | NA |
| ZNF613 | bosutinib monohydrate | 0.0019531 | 1.0000000 | 0.00195 | ** | NA |
| MCF2L | temozolomide | 0.0019561 | 0.6902774 | 0.00196 | ** | NA |
| SH3PXD2B | tretinoin | 0.0019596 | 0.5222109 | 0.00196 | ** | NA |
| EMR3 | nilotinib | 0.0019609 | 0.8055751 | 0.00196 | ** | NA |
| EXOC6B | vismodegib | 0.0019609 | 0.9623352 | 0.00196 | ** | NA |
| CLSTN3 | temozolomide | 0.0019815 | 0.6902774 | 0.00198 | ** | NA |
| CHD8 | tretinoin | 0.0019977 | 0.5222109 | 0.00200 | ** | NA |
| ZNRF3 | temozolomide | 0.0020141 | 0.6902774 | 0.00201 | ** | NA |
| FER1L6 | afatinib | 0.0020174 | 0.9267832 | 0.00202 | ** | NA |
| ANKRD24 | cabozantinib | 0.0020209 | 0.8298252 | 0.00202 | ** | NA |
| RPH3AL | afatinib | 0.0020276 | 0.9267832 | 0.00203 | ** | NA |
| IQCH | tretinoin | 0.0020292 | 0.5222109 | 0.00203 | ** | NA |
| SPRY4 | afatinib | 0.0020307 | 0.9267832 | 0.00203 | ** | NA |
| FOCAD | nilotinib | 0.0020323 | 0.8055751 | 0.00203 | ** | NA |
| WIF1 | tretinoin | 0.0020387 | 0.5222109 | 0.00204 | ** | NA |
| VHL | gefitinib | 0.0020451 | 0.8957015 | 0.00205 | ** | NA |
| PCDHGA10 | tretinoin | 0.0020471 | 0.5222109 | 0.00205 | ** | NA |
| OLFM1 | palbociclib | 0.0020585 | 0.9551671 | 0.00206 | ** | NA |
| OR52J3 | tretinoin | 0.0020620 | 0.5222109 | 0.00206 | ** | NA |
| PC | ruxolitinib | 0.0020630 | 0.9787856 | 0.00206 | ** | NA |
| KIAA1045 | alectinib | 0.0020665 | 0.9168760 | 0.00207 | ** | NA |
| SNX3 | palbociclib | 0.0020699 | 0.9551671 | 0.00207 | ** | NA |
| SKIDA1 | docetaxel | 0.0020855 | 0.9106700 | 0.00209 | ** | NA |
| PIK3C3 | rucaparib | 0.0020895 | 0.9990814 | 0.00209 | ** | NA |
| GNPTG | tretinoin | 0.0020907 | 0.5222109 | 0.00209 | ** | NA |
| FOXA1 | nilotinib | 0.0021074 | 0.8055751 | 0.00211 | ** | NA |
| PHOX2B | rucaparib | 0.0021102 | 0.9990814 | 0.00211 | ** | NA |
| SORCS1 | tretinoin | 0.0021108 | 0.5222109 | 0.00211 | ** | NA |
| PRG4 | afatinib | 0.0021197 | 0.9267832 | 0.00212 | ** | NA |
| TECPR2 | gefitinib | 0.0021260 | 0.8957015 | 0.00213 | ** | NA |
| PRKRIR | ruxolitinib | 0.0021277 | 0.9787856 | 0.00213 | ** | NA |
| HKR1 | sunitinib | 0.0021396 | 0.7819868 | 0.0021 | ** | NA |
| GABRA5 | vismodegib | 0.0021417 | 0.9623352 | 0.00214 | ** | NA |
| HPS4 | tretinoin | 0.0021449 | 0.5222109 | 0.00214 | ** | NA |
| NOTCH3 | palbociclib | 0.0021467 | 0.9551671 | 0.00215 | ** | NA |
| SCN5A | tretinoin | 0.0021559 | 0.5222109 | 0.00216 | ** | NA |
| OR6P1 | palbociclib | 0.0021606 | 0.9551671 | 0.00216 | ** | NA |
| XIRP2 | trametinib | 0.0021617 | 0.9852344 | 0.00216 | ** | NA |
| PXDN | trametinib | 0.0021638 | 0.9852344 | 0.00216 | ** | NA |
| SLC25A18 | docetaxel | 0.0021651 | 0.9106700 | 0.00217 | ** | NA |
| AK8 | vismodegib | 0.0021681 | 0.9623352 | 0.00217 | ** | NA |
| MYO1B | ruxolitinib | 0.0021777 | 0.9787856 | 0.00218 | ** | NA |
| NSFL1C | trametinib | 0.0021790 | 0.9852344 | 0.00218 | ** | NA |
| ZBTB12 | dabrafenib | 0.0021808 | 0.9305571 | 0.00218 | ** | NA |
| HMGCR | temozolomide | 0.0021878 | 0.6902774 | 0.00219 | ** | NA |
| APLF | tretinoin | 0.0022027 | 0.5222109 | 0.00220 | ** | NA |
| ZBTB38 | dabrafenib | 0.0022028 | 0.9305571 | 0.00220 | ** | NA |
| TRA2B | vismodegib | 0.0022098 | 0.9623352 | 0.00221 | ** | NA |
| POM121 | tretinoin | 0.0022150 | 0.5222109 | 0.00222 | ** | NA |
| KRT75 | afatinib | 0.0022198 | 0.9267832 | 0.00222 | ** | NA |
| SCN4A | nilotinib | 0.0022199 | 0.8055751 | 0.00222 | ** | NA |
| AMHR2 | tretinoin | 0.0022367 | 0.5222109 | 0.00224 | ** | NA |
| MMP13 | tretinoin | 0.0022402 | 0.5222109 | 0.00224 | ** | NA |
| TIAM1 | cabozantinib | 0.0022451 | 0.8298252 | 0.00225 | ** | NA |
| C18orf63 | temozolomide | 0.0022496 | 0.6902774 | 0.00225 | ** | NA |
| KIAA0556 | pazopanib | 0.0022510 | 0.9978452 | 0.00225 | ** | NA |
| HAUS6 | vismodegib | 0.0022531 | 0.9623352 | 0.00225 | ** | NA |
| CCDC43 | ruxolitinib | 0.0022599 | 0.9787856 | 0.00226 | ** | NA |
| TMEM232 | midostaurin | 0.0022624 | 0.8795120 | 0.00226 | ** | NA |
| HAL | palbociclib | 0.0022696 | 0.9551671 | 0.00227 | ** | NA |
| PRRC2C | tretinoin | 0.0022705 | 0.5222109 | 0.00227 | ** | NA |
| MARK1 | nilotinib | 0.0022734 | 0.8055751 | 0.00227 | ** | NA |
| C1S | trametinib | 0.0022828 | 0.9852344 | 0.00228 | ** | NA |
| LPHN1 | docetaxel | 0.0022869 | 0.9106700 | 0.00229 | ** | NA |
| DNAAF1 | tretinoin | 0.0022911 | 0.5222109 | 0.00229 | ** | NA |
| KIAA1551 | temozolomide | 0.0022914 | 0.6902774 | 0.00229 | ** | NA |
| NLRP13 | trametinib | 0.0022947 | 0.9852344 | 0.00229 | ** | NA |
| CCR4 | cabozantinib | 0.0022978 | 0.8298252 | 0.00230 | ** | NA |
| TRIO | tretinoin | 0.0022997 | 0.5222109 | 0.00230 | ** | NA |
| CPT1B | vismodegib | 0.0023004 | 0.9623352 | 0.00230 | ** | NA |
| GTPBP10 | temozolomide | 0.0023042 | 0.6902774 | 0.00230 | ** | NA |
| FAM198A | alectinib | 0.0023090 | 0.9168760 | 0.00231 | ** | NA |
| TMEM194A | alectinib | 0.0023125 | 0.9168760 | 0.00231 | ** | NA |
| SMURF2 | tretinoin | 0.0023160 | 0.5222109 | 0.00232 | ** | NA |
| SFXN4 | alectinib | 0.0023208 | 0.9168760 | 0.00232 | ** | NA |
| CNNM1 | temozolomide | 0.0023212 | 0.6902774 | 0.00232 | ** | NA |
| CAMK4 | cabozantinib | 0.0023222 | 0.8298252 | 0.00232 | ** | NA |
| SAMD4B | alectinib | 0.0023392 | 0.9168760 | 0.00234 | ** | NA |
| ST8SIA2 | afatinib | 0.0023419 | 0.9267832 | 0.00234 | ** | NA |
| RTDR1 | gefitinib | 0.0023423 | 0.8957015 | 0.00234 | ** | NA |
| NID1 | tretinoin | 0.0023533 | 0.5222109 | 0.00235 | ** | NA |
| ZSCAN5B | docetaxel | 0.0023538 | 0.9106700 | 0.00235 | ** | NA |
| DOK1 | docetaxel | 0.0023570 | 0.9106700 | 0.00236 | ** | NA |
| PARK2 | imatinib | 0.0023597 | 0.7706799 | 0.0024 | ** | NA |
| PIK3CA | docetaxel | 0.0023604 | 0.9106700 | 0.00236 | ** | NA |
| ZNF441 | temozolomide | 0.0023649 | 0.6902774 | 0.00236 | ** | NA |
| PTH1R | gefitinib | 0.0023747 | 0.8957015 | 0.00237 | ** | NA |
| TNXB | trametinib | 0.0023752 | 0.9852344 | 0.00238 | ** | NA |
| HCFC2 | dabrafenib | 0.0023758 | 0.9305571 | 0.00238 | ** | NA |
| CYP51A1 | bosutinib monohydrate | 0.0023771 | 1.0000000 | 0.00238 | ** | NA |
| BMP2K | afatinib | 0.0023826 | 0.9267832 | 0.00238 | ** | NA |
| SH2D7 | temozolomide | 0.0023844 | 0.6902774 | 0.00238 | ** | NA |
| TFEB | cabozantinib | 0.0023871 | 0.8298252 | 0.00239 | ** | NA |
| BEGAIN | tretinoin | 0.0023880 | 0.5222109 | 0.00239 | ** | NA |
| PLEKHH2 | nilotinib | 0.0023899 | 0.8055751 | 0.00239 | ** | NA |
| PAXIP1 | pazopanib | 0.0023983 | 0.9978452 | 0.00240 | ** | NA |
| PTGDR2 | alectinib | 0.0023984 | 0.9168760 | 0.00240 | ** | NA |
| CD200R1L | ponatinib | 0.0024075 | 1.0000000 | 0.00241 | ** | NA |
| ZFP69B | tretinoin | 0.0024081 | 0.5222109 | 0.00241 | ** | NA |
| AASDH | tretinoin | 0.0024209 | 0.5222109 | 0.00242 | ** | NA |
| NLGN2 | midostaurin | 0.0024225 | 0.8795120 | 0.00242 | ** | NA |
| DLC1 | gefitinib | 0.0024260 | 0.8957015 | 0.00243 | ** | NA |
| GRID1 | gefitinib | 0.0024436 | 0.8957015 | 0.00244 | ** | NA |
| FAM171B | gefitinib | 0.0024570 | 0.8957015 | 0.00246 | ** | NA |
| ACVR1 | cabozantinib | 0.0024585 | 0.8298252 | 0.00246 | ** | NA |
| KIF2B | gefitinib | 0.0024656 | 0.8957015 | 0.00247 | ** | NA |
| PLCZ1 | tretinoin | 0.0024661 | 0.5222109 | 0.00247 | ** | NA |
| SSH2 | nilotinib | 0.0024686 | 0.8055751 | 0.00247 | ** | NA |
| SHC4 | cabozantinib | 0.0024767 | 0.8298252 | 0.00248 | ** | NA |
| DERL1 | gefitinib | 0.0024801 | 0.8957015 | 0.00248 | ** | NA |
| WIBG | temozolomide | 0.0024821 | 0.6902774 | 0.00248 | ** | NA |
| OSBPL1A | ruxolitinib | 0.0024889 | 0.9787856 | 0.00249 | ** | NA |
| ABCA12 | gefitinib | 0.0024950 | 0.8957015 | 0.00249 | ** | NA |
| MAP1B | vismodegib | 0.0024952 | 0.9623352 | 0.00250 | ** | NA |
| ATP9B | trametinib | 0.0024959 | 0.9852344 | 0.00250 | ** | NA |
| BCLAF1 | docetaxel | 0.0024960 | 0.9106700 | 0.00250 | ** | NA |
| RSL1D1 | midostaurin | 0.0024963 | 0.8795120 | 0.00250 | ** | NA |
| JAG1 | tretinoin | 0.0025001 | 0.5222109 | 0.00250 | ** | NA |
| GTPBP2 | tretinoin | 0.0025038 | 0.5222109 | 0.00250 | ** | NA |
| AQR | midostaurin | 0.0025065 | 0.8795120 | 0.00251 | ** | NA |
| ZNF556 | bosutinib monohydrate | 0.0025146 | 1.0000000 | 0.00251 | ** | NA |
| ACTR3B | alectinib | 0.0025215 | 0.9168760 | 0.00252 | ** | NA |
| ADAMDEC1 | cabozantinib | 0.0025226 | 0.8298252 | 0.00252 | ** | NA |
| TMEM8A | tretinoin | 0.0025233 | 0.5222109 | 0.00252 | ** | NA |
| GTSE1 | palbociclib | 0.0025280 | 0.9551671 | 0.00253 | ** | NA |
| TUBA3E | trametinib | 0.0025319 | 0.9852344 | 0.00253 | ** | NA |
| ANXA9 | temozolomide | 0.0025388 | 0.6902774 | 0.00254 | ** | NA |
| MDC1 | cabozantinib | 0.0025417 | 0.8298252 | 0.00254 | ** | NA |
| WDR53 | nilotinib | 0.0025683 | 0.8055751 | 0.00257 | ** | NA |
| CTNNA3 | temozolomide | 0.0025739 | 0.6902774 | 0.00257 | ** | NA |
| KDM2A | tretinoin | 0.0025772 | 0.5222109 | 0.00258 | ** | NA |
| POU4F2 | temozolomide | 0.0025813 | 0.6902774 | 0.00258 | ** | NA |
| METTL16 | belinostat | 0.0025825 | 0.9983823 | 0.00258 | ** | NA |
| PDGFD | ponatinib | 0.0025850 | 1.0000000 | 0.00258 | ** | NA |
| GSC | dabrafenib | 0.0025874 | 0.9305571 | 0.00259 | ** | NA |
| MYH2 | midostaurin | 0.0025880 | 0.8795120 | 0.00259 | ** | NA |
| NCKAP1L | trametinib | 0.0025885 | 0.9852344 | 0.00259 | ** | NA |
| FIGNL1 | gefitinib | 0.0025961 | 0.8957015 | 0.00260 | ** | NA |
| MAB21L2 | vismodegib | 0.0026191 | 0.9623352 | 0.00262 | ** | NA |
| ZNF280D | rucaparib | 0.0026326 | 0.9990814 | 0.00263 | ** | NA |
| TMEM174 | ponatinib | 0.0026364 | 1.0000000 | 0.00264 | ** | NA |
| STK36 | ruxolitinib | 0.0026417 | 0.9787856 | 0.00264 | ** | NA |
| PRR16 | dabrafenib | 0.0026430 | 0.9305571 | 0.00264 | ** | NA |
| DDX47 | midostaurin | 0.0026506 | 0.8795120 | 0.00265 | ** | NA |
| IL10RB | afatinib | 0.0026534 | 0.9267832 | 0.00265 | ** | NA |
| PLEKHH2 | tretinoin | 0.0026560 | 0.5222109 | 0.00266 | ** | NA |
| OR13F1 | temozolomide | 0.0026615 | 0.6902774 | 0.00266 | ** | NA |
| SNTG2 | tretinoin | 0.0026625 | 0.5222109 | 0.00266 | ** | NA |
| OSTF1 | vismodegib | 0.0026628 | 0.9623352 | 0.00266 | ** | NA |
| SLC12A6 | tretinoin | 0.0026644 | 0.5222109 | 0.00266 | ** | NA |
| UPF3A | afatinib | 0.0026671 | 0.9267832 | 0.00267 | ** | NA |
| SNAI2 | gefitinib | 0.0026711 | 0.8957015 | 0.00267 | ** | NA |
| PEX1 | temozolomide | 0.0026728 | 0.6902774 | 0.00267 | ** | NA |
| CCDC11 | dabrafenib | 0.0026752 | 0.9305571 | 0.00268 | ** | NA |
| NOP14 | tretinoin | 0.0026895 | 0.5222109 | 0.00269 | ** | NA |
| ANKRD55 | ruxolitinib | 0.0026905 | 0.9787856 | 0.00269 | ** | NA |
| FNDC9 | gefitinib | 0.0026953 | 0.8957015 | 0.00270 | ** | NA |
| ZNF555 | temozolomide | 0.0026957 | 0.6902774 | 0.00270 | ** | NA |
| STAC | belinostat | 0.0027013 | 0.9983823 | 0.00270 | ** | NA |
| KRT26 | vismodegib | 0.0027018 | 0.9623352 | 0.00270 | ** | NA |
| TECTA | midostaurin | 0.0027031 | 0.8795120 | 0.00270 | ** | NA |
| ZNF500 | trametinib | 0.0027055 | 0.9852344 | 0.00271 | ** | NA |
| CBLL1 | vismodegib | 0.0027060 | 0.9623352 | 0.00271 | ** | NA |
| QTRTD1 | tretinoin | 0.0027144 | 0.5222109 | 0.00271 | ** | NA |
| IVL | temozolomide | 0.0027149 | 0.6902774 | 0.00271 | ** | NA |
| DNAH10 | midostaurin | 0.0027294 | 0.8795120 | 0.00273 | ** | NA |
| ZNF345 | nilotinib | 0.0027464 | 0.8055751 | 0.00275 | ** | NA |
| LRIG2 | sunitinib | 0.0027470 | 0.7819868 | 0.0027 | ** | NA |
| GFRA2 | midostaurin | 0.0027471 | 0.8795120 | 0.00275 | ** | NA |
| ROCK2 | cabozantinib | 0.0027474 | 0.8298252 | 0.00275 | ** | NA |
| F11R | gefitinib | 0.0027558 | 0.8957015 | 0.00276 | ** | NA |
| FPR1 | docetaxel | 0.0027627 | 0.9106700 | 0.00276 | ** | NA |
| ZNF48 | dabrafenib | 0.0027673 | 0.9305571 | 0.00277 | ** | NA |
| NEB | trametinib | 0.0027840 | 0.9852344 | 0.00278 | ** | NA |
| ACACB | cabozantinib | 0.0028157 | 0.8298252 | 0.00282 | ** | NA |
| GFM2 | tretinoin | 0.0028289 | 0.5222109 | 0.00283 | ** | NA |
| RFWD2 | tretinoin | 0.0028289 | 0.5222109 | 0.00283 | ** | NA |
| TATDN2 | gefitinib | 0.0028397 | 0.8957015 | 0.00284 | ** | NA |
| PHKG1 | sunitinib | 0.0028448 | 0.7819868 | 0.0028 | ** | NA |
| TRAM1L1 | erlotinib | 0.0028483 | 0.7991878 | 0.00285 | ** | NA |
| CACNA1C | palbociclib | 0.0028535 | 0.9551671 | 0.00285 | ** | NA |
| MED23 | palbociclib | 0.0028551 | 0.9551671 | 0.00286 | ** | NA |
| PWWP2A | pazopanib | 0.0028564 | 0.9978452 | 0.00286 | ** | NA |
| SERPIND1 | ruxolitinib | 0.0028592 | 0.9787856 | 0.00286 | ** | NA |
| ZNF341 | temozolomide | 0.0028607 | 0.6902774 | 0.00286 | ** | NA |
| RSPO1 | cabozantinib | 0.0028623 | 0.8298252 | 0.00286 | ** | NA |
| TGFB1I1 | cabozantinib | 0.0028663 | 0.8298252 | 0.00287 | ** | NA |
| ZDHHC16 | temozolomide | 0.0028669 | 0.6902774 | 0.00287 | ** | NA |
| RIPK4 | docetaxel | 0.0028737 | 0.9106700 | 0.00287 | ** | NA |
| TMPPE | docetaxel | 0.0028753 | 0.9106700 | 0.00288 | ** | NA |
| IGDCC4 | midostaurin | 0.0028765 | 0.8795120 | 0.00288 | ** | NA |
| HKDC1 | gefitinib | 0.0028791 | 0.8957015 | 0.00288 | ** | NA |
| PHTF2 | tretinoin | 0.0028898 | 0.5222109 | 0.00289 | ** | NA |
| TLE2 | trametinib | 0.0028928 | 0.9852344 | 0.00289 | ** | NA |
| ANKRD11 | ponatinib | 0.0028964 | 1.0000000 | 0.00290 | ** | NA |
| ATP13A1 | midostaurin | 0.0028999 | 0.8795120 | 0.00290 | ** | NA |
| CAD | tretinoin | 0.0029012 | 0.5222109 | 0.00290 | ** | NA |
| GLUL | rucaparib | 0.0029129 | 0.9990814 | 0.00291 | ** | NA |
| H1FNT | gefitinib | 0.0029235 | 0.8957015 | 0.00292 | ** | NA |
| MEGF6 | tretinoin | 0.0029287 | 0.5222109 | 0.00293 | ** | NA |
| GSPT1 | vismodegib | 0.0029328 | 0.9623352 | 0.00293 | ** | NA |
| WSCD2 | lapatinib | 0.0029371 | 0.8107014 | 0.00294 | ** | NA |
| FAT2 | tretinoin | 0.0029698 | 0.5222109 | 0.00297 | ** | NA |
| CSRNP1 | alectinib | 0.0029742 | 0.9168760 | 0.00297 | ** | NA |
| FBN3 | cabozantinib | 0.0029871 | 0.8298252 | 0.00299 | ** | NA |
| TM9SF1 | cabozantinib | 0.0029940 | 0.8298252 | 0.00299 | ** | NA |
| MBLAC2 | dabrafenib | 0.0029963 | 0.9305571 | 0.00300 | ** | NA |
| APOBEC3F | ruxolitinib | 0.0030038 | 0.9787856 | 0.00300 | ** | NA |
| LARP1 | afatinib | 0.0030100 | 0.9267832 | 0.00301 | ** | NA |
| OSTF1 | temozolomide | 0.0030143 | 0.6902774 | 0.00301 | ** | NA |
| MFF | ponatinib | 0.0030414 | 1.0000000 | 0.00304 | ** | NA |
| FAM135B | lapatinib | 0.0030442 | 0.8107014 | 0.00304 | ** | NA |
| PRKD3 | nilotinib | 0.0030513 | 0.8055751 | 0.00305 | ** | NA |
| LRFN5 | midostaurin | 0.0030626 | 0.8795120 | 0.00306 | ** | NA |
| CDK14 | rucaparib | 0.0030667 | 0.9990814 | 0.00307 | ** | NA |
| SALL2 | imatinib | 0.0030780 | 0.7706799 | 0.0031 | ** | NA |
| GLDC | afatinib | 0.0030952 | 0.9267832 | 0.00310 | ** | NA |
| SLAMF9 | midostaurin | 0.0030968 | 0.8795120 | 0.00310 | ** | NA |
| GJA10 | nilotinib | 0.0031090 | 0.8055751 | 0.00311 | ** | NA |
| SFRP1 | palbociclib | 0.0031124 | 0.9551671 | 0.00311 | ** | NA |
| RTDR1 | afatinib | 0.0031141 | 0.9267832 | 0.00311 | ** | NA |
| HERC6 | tretinoin | 0.0031151 | 0.5222109 | 0.00312 | ** | NA |
| RHBDD3 | palbociclib | 0.0031156 | 0.9551671 | 0.00312 | ** | NA |
| ZSWIM6 | midostaurin | 0.0031161 | 0.8795120 | 0.00312 | ** | NA |
| RFX6 | bosutinib monohydrate | 0.0031182 | 1.0000000 | 0.00312 | ** | NA |
| STK31 | pazopanib | 0.0031215 | 0.9978452 | 0.00312 | ** | NA |
| CCT6A | temozolomide | 0.0031292 | 0.6902774 | 0.00313 | ** | NA |
| PLCB4 | rucaparib | 0.0031302 | 0.9990814 | 0.00313 | ** | NA |
| SCARF2 | temozolomide | 0.0031312 | 0.6902774 | 0.00313 | ** | NA |
| TAS2R60 | nilotinib | 0.0031337 | 0.8055751 | 0.00313 | ** | NA |
| KIF27 | sunitinib | 0.0031384 | 0.7819868 | 0.0031 | ** | NA |
| WIF1 | cabozantinib | 0.0031441 | 0.8298252 | 0.00314 | ** | NA |
| ZNF225 | trametinib | 0.0031448 | 0.9852344 | 0.00314 | ** | NA |
| SENP6 | tretinoin | 0.0031453 | 0.5222109 | 0.00315 | ** | NA |
| RETSAT | afatinib | 0.0031521 | 0.9267832 | 0.00315 | ** | NA |
| E2F2 | dabrafenib | 0.0031522 | 0.9305571 | 0.00315 | ** | NA |
| PLA1A | tretinoin | 0.0031562 | 0.5222109 | 0.00316 | ** | NA |
| C1orf168 | tretinoin | 0.0031568 | 0.5222109 | 0.00316 | ** | NA |
| CYP2C19 | trametinib | 0.0031592 | 0.9852344 | 0.00316 | ** | NA |
| DIP2C | ruxolitinib | 0.0031624 | 0.9787856 | 0.00316 | ** | NA |
| TOPORS | afatinib | 0.0031639 | 0.9267832 | 0.00316 | ** | NA |
| NPTX2 | vismodegib | 0.0031662 | 0.9623352 | 0.00317 | ** | NA |
| NFE2L3 | cabozantinib | 0.0031676 | 0.8298252 | 0.00317 | ** | NA |
| KIAA0319 | docetaxel | 0.0031700 | 0.9106700 | 0.00317 | ** | NA |
| KLHL42 | dabrafenib | 0.0031727 | 0.9305571 | 0.00317 | ** | NA |
| TMOD2 | bosutinib monohydrate | 0.0031763 | 1.0000000 | 0.00318 | ** | NA |
| RIMBP2 | dasatinib | 0.0031769 | 0.8707378 | 0.0032 | ** | NA |
| PAMR1 | midostaurin | 0.0031777 | 0.8795120 | 0.00318 | ** | NA |
| DNAI1 | cabozantinib | 0.0031781 | 0.8298252 | 0.00318 | ** | NA |
| CALCOCO1 | tretinoin | 0.0031845 | 0.5222109 | 0.00318 | ** | NA |
| SALL2 | gefitinib | 0.0031880 | 0.8957015 | 0.00319 | ** | NA |
| GPR98 | palbociclib | 0.0032017 | 0.9551671 | 0.00320 | ** | NA |
| PDGFRB | tretinoin | 0.0032063 | 0.5222109 | 0.00321 | ** | NA |
| CUL3 | tretinoin | 0.0032137 | 0.5222109 | 0.00321 | ** | NA |
| MS4A1 | ruxolitinib | 0.0032143 | 0.9787856 | 0.00321 | ** | NA |
| ANKRD30A | lapatinib | 0.0032293 | 0.8107014 | 0.00323 | ** | NA |
| RERE | tretinoin | 0.0032334 | 0.5222109 | 0.00323 | ** | NA |
| ARHGEF40 | palbociclib | 0.0032348 | 0.9551671 | 0.00323 | ** | NA |
| AGTPBP1 | crizotinib | 0.0032505 | 0.7869686 | 0.0033 | ** | NA |
| CEP55 | tretinoin | 0.0032556 | 0.5222109 | 0.00326 | ** | NA |
| DAO | bosutinib monohydrate | 0.0032606 | 1.0000000 | 0.00326 | ** | NA |
| KIAA1551 | ruxolitinib | 0.0032740 | 0.9787856 | 0.00327 | ** | NA |
| TNFSF18 | tretinoin | 0.0032850 | 0.5222109 | 0.00329 | ** | NA |
| SSH2 | vismodegib | 0.0032852 | 0.9623352 | 0.00329 | ** | NA |
| ENTPD7 | cabozantinib | 0.0032884 | 0.8298252 | 0.00329 | ** | NA |
| MAB21L1 | docetaxel | 0.0032911 | 0.9106700 | 0.00329 | ** | NA |
| ZC3HC1 | ponatinib | 0.0032913 | 1.0000000 | 0.00329 | ** | NA |
| ZNF345 | vismodegib | 0.0032958 | 0.9623352 | 0.00330 | ** | NA |
| TTC30A | tretinoin | 0.0032964 | 0.5222109 | 0.00330 | ** | NA |
| ZNF469 | midostaurin | 0.0033005 | 0.8795120 | 0.00330 | ** | NA |
| GZMH | gefitinib | 0.0033013 | 0.8957015 | 0.00330 | ** | NA |
| RCL1 | temozolomide | 0.0033031 | 0.6902774 | 0.00330 | ** | NA |
| MICAL2 | tretinoin | 0.0033065 | 0.5222109 | 0.00331 | ** | NA |
| CREM | gefitinib | 0.0033076 | 0.8957015 | 0.00331 | ** | NA |
| OAS2 | alectinib | 0.0033091 | 0.9168760 | 0.00331 | ** | NA |
| KNOP1 | temozolomide | 0.0033168 | 0.6902774 | 0.00332 | ** | NA |
| EPHA1 | vismodegib | 0.0033182 | 0.9623352 | 0.00332 | ** | NA |
| CPSF6 | pazopanib | 0.0033192 | 0.9978452 | 0.00332 | ** | NA |
| SRC | alectinib | 0.0033265 | 0.9168760 | 0.00333 | ** | NA |
| XPO1 | tretinoin | 0.0033296 | 0.5222109 | 0.00333 | ** | NA |
| CYP3A43 | alectinib | 0.0033312 | 0.9168760 | 0.00333 | ** | NA |
| ASB4 | docetaxel | 0.0033389 | 0.9106700 | 0.00334 | ** | NA |
| HTR4 | tretinoin | 0.0033443 | 0.5222109 | 0.00334 | ** | NA |
| LRIT2 | tretinoin | 0.0033443 | 0.5222109 | 0.00334 | ** | NA |
| STK11 | cabozantinib | 0.0033445 | 0.8298252 | 0.00334 | ** | NA |
| FERMT2 | sunitinib | 0.0033446 | 0.7819868 | 0.0033 | ** | NA |
| FBXL20 | nilotinib | 0.0033491 | 0.8055751 | 0.00335 | ** | NA |
| SLC29A3 | cabozantinib | 0.0033578 | 0.8298252 | 0.00336 | ** | NA |
| PCDHA11 | tretinoin | 0.0033650 | 0.5222109 | 0.00336 | ** | NA |
| ZNF583 | temozolomide | 0.0033751 | 0.6902774 | 0.00338 | ** | NA |
| TMEM174 | midostaurin | 0.0033796 | 0.8795120 | 0.00338 | ** | NA |
| CCIN | bosutinib monohydrate | 0.0033815 | 1.0000000 | 0.00338 | ** | NA |
| SYNCRIP | nilotinib | 0.0033909 | 0.8055751 | 0.00339 | ** | NA |
| OR52E6 | vismodegib | 0.0033939 | 0.9623352 | 0.00339 | ** | NA |
| SNAP91 | tretinoin | 0.0033941 | 0.5222109 | 0.00339 | ** | NA |
| SLC2A13 | trametinib | 0.0033949 | 0.9852344 | 0.00339 | ** | NA |
| ERCC4 | gefitinib | 0.0033983 | 0.8957015 | 0.00340 | ** | NA |
| SMARCC1 | palbociclib | 0.0034009 | 0.9551671 | 0.00340 | ** | NA |
| PREX1 | belinostat | 0.0034014 | 0.9983823 | 0.00340 | ** | NA |
| ALX3 | pazopanib | 0.0034042 | 0.9978452 | 0.00340 | ** | NA |
| DYRK2 | midostaurin | 0.0034044 | 0.8795120 | 0.00340 | ** | NA |
| TCFL5 | cabozantinib | 0.0034075 | 0.8298252 | 0.00341 | ** | NA |
| OR10A3 | belinostat | 0.0034122 | 0.9983823 | 0.00341 | ** | NA |
| PDIA3 | temozolomide | 0.0034192 | 0.6902774 | 0.00342 | ** | NA |
| PARP8 | bosutinib monohydrate | 0.0034240 | 1.0000000 | 0.00342 | ** | NA |
| MFSD6L | palbociclib | 0.0034259 | 0.9551671 | 0.00343 | ** | NA |
| RC3H1 | tretinoin | 0.0034274 | 0.5222109 | 0.00343 | ** | NA |
| FAM91A1 | cabozantinib | 0.0034309 | 0.8298252 | 0.00343 | ** | NA |
| TSR1 | docetaxel | 0.0034369 | 0.9106700 | 0.00344 | ** | NA |
| ST18 | tretinoin | 0.0034529 | 0.5222109 | 0.00345 | ** | NA |
| ADAM20 | docetaxel | 0.0034631 | 0.9106700 | 0.00346 | ** | NA |
| SFI1 | nilotinib | 0.0034720 | 0.8055751 | 0.00347 | ** | NA |
| TMEM185B | docetaxel | 0.0034753 | 0.9106700 | 0.00348 | ** | NA |
| PSMD11 | docetaxel | 0.0034760 | 0.9106700 | 0.00348 | ** | NA |
| SYTL2 | cabozantinib | 0.0034811 | 0.8298252 | 0.00348 | ** | NA |
| NEK9 | temozolomide | 0.0034824 | 0.6902774 | 0.00348 | ** | NA |
| GALNT10 | ruxolitinib | 0.0034830 | 0.9787856 | 0.00348 | ** | NA |
| TMCO3 | cabozantinib | 0.0034859 | 0.8298252 | 0.00349 | ** | NA |
| SLC17A3 | alectinib | 0.0034902 | 0.9168760 | 0.00349 | ** | NA |
| PRKRIR | alectinib | 0.0035037 | 0.9168760 | 0.00350 | ** | NA |
| MAMSTR | temozolomide | 0.0035106 | 0.6902774 | 0.00351 | ** | NA |
| NMUR1 | gefitinib | 0.0035119 | 0.8957015 | 0.00351 | ** | NA |
| NRG1 | tretinoin | 0.0035285 | 0.5222109 | 0.00353 | ** | NA |
| GNB1 | ruxolitinib | 0.0035419 | 0.9787856 | 0.00354 | ** | NA |
| MTMR12 | dasatinib | 0.0035438 | 0.8707378 | 0.0035 | ** | NA |
| GLG1 | belinostat | 0.0035444 | 0.9983823 | 0.00354 | ** | NA |
| LNPEP | dabrafenib | 0.0035456 | 0.9305571 | 0.00355 | ** | NA |
| KCNC4 | vismodegib | 0.0035459 | 0.9623352 | 0.00355 | ** | NA |
| ZNF530 | docetaxel | 0.0035471 | 0.9106700 | 0.00355 | ** | NA |
| VPS8 | docetaxel | 0.0035558 | 0.9106700 | 0.00356 | ** | NA |
| SDPR | tretinoin | 0.0035611 | 0.5222109 | 0.00356 | ** | NA |
| GZMH | imatinib | 0.0035651 | 0.7706799 | 0.0036 | ** | NA |
| ASNSD1 | gefitinib | 0.0035719 | 0.8957015 | 0.00357 | ** | NA |
| EPS8L2 | temozolomide | 0.0035724 | 0.6902774 | 0.00357 | ** | NA |
| DMPK | nilotinib | 0.0035782 | 0.8055751 | 0.00358 | ** | NA |
| ODF3L2 | temozolomide | 0.0035825 | 0.6902774 | 0.00358 | ** | NA |
| CAT | tretinoin | 0.0035862 | 0.5222109 | 0.00359 | ** | NA |
| DLGAP1 | bosutinib monohydrate | 0.0035863 | 1.0000000 | 0.00359 | ** | NA |
| CBLL1 | tretinoin | 0.0035927 | 0.5222109 | 0.00359 | ** | NA |
| OR10J3 | cabozantinib | 0.0036043 | 0.8298252 | 0.00360 | ** | NA |
| SLC22A12 | cabozantinib | 0.0036127 | 0.8298252 | 0.00361 | ** | NA |
| SMEK2 | vismodegib | 0.0036209 | 0.9623352 | 0.00362 | ** | NA |
| CNTNAP5 | palbociclib | 0.0036271 | 0.9551671 | 0.00363 | ** | NA |
| ZNF347 | midostaurin | 0.0036303 | 0.8795120 | 0.00363 | ** | NA |
| STXBP5 | dabrafenib | 0.0036311 | 0.9305571 | 0.00363 | ** | NA |
| SLC29A2 | tretinoin | 0.0036455 | 0.5222109 | 0.00365 | ** | NA |
| TF | docetaxel | 0.0036495 | 0.9106700 | 0.00365 | ** | NA |
| ZFHX3 | tretinoin | 0.0036551 | 0.5222109 | 0.00366 | ** | NA |
| ARHGAP19 | nilotinib | 0.0036563 | 0.8055751 | 0.00366 | ** | NA |
| GPR179 | palbociclib | 0.0036565 | 0.9551671 | 0.00366 | ** | NA |
| CTHRC1 | cabozantinib | 0.0036590 | 0.8298252 | 0.00366 | ** | NA |
| CELF2 | ponatinib | 0.0036630 | 1.0000000 | 0.00366 | ** | NA |
| DNAH9 | trametinib | 0.0036631 | 0.9852344 | 0.00366 | ** | NA |
| UBN1 | gefitinib | 0.0036686 | 0.8957015 | 0.00367 | ** | NA |
| ANKLE1 | alectinib | 0.0036707 | 0.9168760 | 0.00367 | ** | NA |
| RNF214 | bosutinib monohydrate | 0.0036712 | 1.0000000 | 0.00367 | ** | NA |
| MYH2 | tretinoin | 0.0036752 | 0.5222109 | 0.00368 | ** | NA |
| GGT5 | tretinoin | 0.0036979 | 0.5222109 | 0.00370 | ** | NA |
| TOP1 | tretinoin | 0.0036979 | 0.5222109 | 0.00370 | ** | NA |
| SH3D21 | tretinoin | 0.0037019 | 0.5222109 | 0.00370 | ** | NA |
| KLHL1 | vismodegib | 0.0037029 | 0.9623352 | 0.00370 | ** | NA |
| ROS1 | cabozantinib | 0.0037056 | 0.8298252 | 0.00371 | ** | NA |
| TIAL1 | docetaxel | 0.0037113 | 0.9106700 | 0.00371 | ** | NA |
| ACTC1 | gefitinib | 0.0037425 | 0.8957015 | 0.00374 | ** | NA |
| PLEKHH3 | trametinib | 0.0037429 | 0.9852344 | 0.00374 | ** | NA |
| ZNF304 | temozolomide | 0.0037465 | 0.6902774 | 0.00375 | ** | NA |
| TBK1 | temozolomide | 0.0037563 | 0.6902774 | 0.00376 | ** | NA |
| GPRC6A | trametinib | 0.0037567 | 0.9852344 | 0.00376 | ** | NA |
| EBF4 | alectinib | 0.0037585 | 0.9168760 | 0.00376 | ** | NA |
| TM6SF2 | ponatinib | 0.0037616 | 1.0000000 | 0.00376 | ** | NA |
| FANCD2 | pazopanib | 0.0037632 | 0.9978452 | 0.00376 | ** | NA |
| RAD54L | dabrafenib | 0.0037813 | 0.9305571 | 0.00378 | ** | NA |
| DOK3 | gefitinib | 0.0037934 | 0.8957015 | 0.00379 | ** | NA |
| PLEKHM1 | temozolomide | 0.0037978 | 0.6902774 | 0.00380 | ** | NA |
| SCN4A | dabrafenib | 0.0038145 | 0.9305571 | 0.00381 | ** | NA |
| TIMM44 | dabrafenib | 0.0038163 | 0.9305571 | 0.00382 | ** | NA |
| KIAA1467 | midostaurin | 0.0038174 | 0.8795120 | 0.00382 | ** | NA |
| METTL17 | tretinoin | 0.0038267 | 0.5222109 | 0.00383 | ** | NA |
| ZNF85 | nilotinib | 0.0038429 | 0.8055751 | 0.00384 | ** | NA |
| FMNL3 | gefitinib | 0.0038442 | 0.8957015 | 0.00384 | ** | NA |
| EXOC6B | tretinoin | 0.0038551 | 0.5222109 | 0.00386 | ** | NA |
| ENTHD1 | tretinoin | 0.0038569 | 0.5222109 | 0.00386 | ** | NA |
| GLP2R | tretinoin | 0.0038581 | 0.5222109 | 0.00386 | ** | NA |
| FERMT2 | crizotinib | 0.0038589 | 0.7869686 | 0.0039 | ** | NA |
| MPO | belinostat | 0.0038632 | 0.9983823 | 0.00386 | ** | NA |
| APOBEC3B | nilotinib | 0.0038803 | 0.8055751 | 0.00388 | ** | NA |
| FAM160A2 | pazopanib | 0.0038834 | 0.9978452 | 0.00388 | ** | NA |
| TBK1 | tretinoin | 0.0038873 | 0.5222109 | 0.00389 | ** | NA |
| MLKL | alectinib | 0.0038915 | 0.9168760 | 0.00389 | ** | NA |
| MAPK15 | midostaurin | 0.0038951 | 0.8795120 | 0.00390 | ** | NA |
| XIRP2 | erlotinib | 0.0038961 | 0.7991878 | 0.00390 | ** | NA |
| RUNDC1 | ruxolitinib | 0.0038966 | 0.9787856 | 0.00390 | ** | NA |
| GLDC | temozolomide | 0.0038975 | 0.6902774 | 0.00390 | ** | NA |
| ANGEL1 | bosutinib monohydrate | 0.0038991 | 1.0000000 | 0.00390 | ** | NA |
| NFE2L2 | alectinib | 0.0039010 | 0.9168760 | 0.00390 | ** | NA |
| PER3 | pazopanib | 0.0039077 | 0.9978452 | 0.00391 | ** | NA |
| XIRP2 | gefitinib | 0.0039079 | 0.8957015 | 0.00391 | ** | NA |
| FOXC2 | tretinoin | 0.0039092 | 0.5222109 | 0.00391 | ** | NA |
| RBM5 | tretinoin | 0.0039123 | 0.5222109 | 0.00391 | ** | NA |
| KLK14 | docetaxel | 0.0039190 | 0.9106700 | 0.00392 | ** | NA |
| GTDC1 | ponatinib | 0.0039200 | 1.0000000 | 0.00392 | ** | NA |
| TAF9 | temozolomide | 0.0039233 | 0.6902774 | 0.00392 | ** | NA |
| ATP1A1 | dabrafenib | 0.0039274 | 0.9305571 | 0.00393 | ** | NA |
| PPIL2 | nilotinib | 0.0039300 | 0.8055751 | 0.00393 | ** | NA |
| TANGO2 | docetaxel | 0.0039375 | 0.9106700 | 0.00394 | ** | NA |
| PRR14 | afatinib | 0.0039418 | 0.9267832 | 0.00394 | ** | NA |
| MX1 | afatinib | 0.0039427 | 0.9267832 | 0.00394 | ** | NA |
| SHPRH | temozolomide | 0.0039499 | 0.6902774 | 0.00395 | ** | NA |
| SKAP1 | gefitinib | 0.0039598 | 0.8957015 | 0.00396 | ** | NA |
| CCDC101 | alectinib | 0.0039649 | 0.9168760 | 0.00396 | ** | NA |
| EXTL3 | alectinib | 0.0039653 | 0.9168760 | 0.00397 | ** | NA |
| PDE6A | bosutinib monohydrate | 0.0039683 | 1.0000000 | 0.00397 | ** | NA |
| FNTB | rucaparib | 0.0039781 | 0.9990814 | 0.00398 | ** | NA |
| CYP1A1 | ponatinib | 0.0039820 | 1.0000000 | 0.00398 | ** | NA |
| LTBP1 | alectinib | 0.0039844 | 0.9168760 | 0.00398 | ** | NA |
| GALNT12 | pazopanib | 0.0039859 | 0.9978452 | 0.00399 | ** | NA |
| SLC26A2 | tretinoin | 0.0039861 | 0.5222109 | 0.00399 | ** | NA |
| PCDHAC1 | ruxolitinib | 0.0039908 | 0.9787856 | 0.00399 | ** | NA |
| TLN2 | tretinoin | 0.0040015 | 0.5222109 | 0.00400 | ** | NA |
| PCDHAC2 | alectinib | 0.0040065 | 0.9168760 | 0.00401 | ** | NA |
| ZFAT | docetaxel | 0.0040074 | 0.9106700 | 0.00401 | ** | NA |
| B3GNT4 | cabozantinib | 0.0040168 | 0.8298252 | 0.00402 | ** | NA |
| FZD10 | temozolomide | 0.0040175 | 0.6902774 | 0.00402 | ** | NA |
| EHMT1 | temozolomide | 0.0040248 | 0.6902774 | 0.00402 | ** | NA |
| NRAS | imatinib | 0.0040262 | 0.7706799 | 0.0040 | ** | NA |
| TMEM185B | afatinib | 0.0040348 | 0.9267832 | 0.00403 | ** | NA |
| OR5M11 | alectinib | 0.0040398 | 0.9168760 | 0.00404 | ** | NA |
| PAPD4 | crizotinib | 0.0040403 | 0.7869686 | 0.0040 | ** | NA |
| SGK3 | cabozantinib | 0.0040435 | 0.8298252 | 0.00404 | ** | NA |
| UGGT1 | pazopanib | 0.0040568 | 0.9978452 | 0.00406 | ** | NA |
| NGFR | alectinib | 0.0040600 | 0.9168760 | 0.00406 | ** | NA |
| ZBTB7A | temozolomide | 0.0040620 | 0.6902774 | 0.00406 | ** | NA |
| ZSWIM6 | temozolomide | 0.0040658 | 0.6902774 | 0.00407 | ** | NA |
| NR2C2 | crizotinib | 0.0040666 | 0.7869686 | 0.0041 | ** | NA |
| TBX10 | temozolomide | 0.0040676 | 0.6902774 | 0.00407 | ** | NA |
| ACVR1 | tretinoin | 0.0040744 | 0.5222109 | 0.00407 | ** | NA |
| KDM8 | afatinib | 0.0040752 | 0.9267832 | 0.00408 | ** | NA |
| CACNB1 | tretinoin | 0.0040781 | 0.5222109 | 0.00408 | ** | NA |
| CEP70 | tretinoin | 0.0040781 | 0.5222109 | 0.00408 | ** | NA |
| RBM26 | dabrafenib | 0.0040816 | 0.9305571 | 0.00408 | ** | NA |
| PIK3C2G | tretinoin | 0.0040835 | 0.5222109 | 0.00408 | ** | NA |
| TEKT3 | nilotinib | 0.0040859 | 0.8055751 | 0.00409 | ** | NA |
| ARHGAP19 | docetaxel | 0.0040892 | 0.9106700 | 0.00409 | ** | NA |
| HERPUD1 | temozolomide | 0.0040901 | 0.6902774 | 0.00409 | ** | NA |
| TFAP2A | palbociclib | 0.0040902 | 0.9551671 | 0.00409 | ** | NA |
| ATAD5 | gefitinib | 0.0040938 | 0.8957015 | 0.00409 | ** | NA |
| TRAF3 | alectinib | 0.0041005 | 0.9168760 | 0.00410 | ** | NA |
| HOXB1 | tretinoin | 0.0041060 | 0.5222109 | 0.00411 | ** | NA |
| KRT3 | bosutinib monohydrate | 0.0041080 | 1.0000000 | 0.00411 | ** | NA |
| PGLYRP4 | nilotinib | 0.0041112 | 0.8055751 | 0.00411 | ** | NA |
| TMEM129 | cabozantinib | 0.0041127 | 0.8298252 | 0.00411 | ** | NA |
| C2CD3 | cabozantinib | 0.0041201 | 0.8298252 | 0.00412 | ** | NA |
| HSP90AB1 | ponatinib | 0.0041202 | 1.0000000 | 0.00412 | ** | NA |
| WDR6 | afatinib | 0.0041203 | 0.9267832 | 0.00412 | ** | NA |
| GALNT14 | rucaparib | 0.0041209 | 0.9990814 | 0.00412 | ** | NA |
| CSMD1 | palbociclib | 0.0041270 | 0.9551671 | 0.00413 | ** | NA |
| GLB1L | pazopanib | 0.0041303 | 0.9978452 | 0.00413 | ** | NA |
| ASCL1 | nilotinib | 0.0041462 | 0.8055751 | 0.00415 | ** | NA |
| PGBD3 | tretinoin | 0.0041531 | 0.5241182 | 0.00415 | ** | NA |
| SPATA31A3 | trametinib | 0.0041610 | 0.9852344 | 0.00416 | ** | NA |
| FES | nilotinib | 0.0041648 | 0.8055751 | 0.00416 | ** | NA |
| RUVBL1 | docetaxel | 0.0041653 | 0.9106700 | 0.00417 | ** | NA |
| GGT5 | nilotinib | 0.0041751 | 0.8055751 | 0.00418 | ** | NA |
| C1orf185 | cabozantinib | 0.0041843 | 0.8298252 | 0.00418 | ** | NA |
| LETMD1 | alectinib | 0.0041904 | 0.9168760 | 0.00419 | ** | NA |
| MS4A6A | crizotinib | 0.0041960 | 0.7869686 | 0.0042 | ** | NA |
| PITRM1 | nilotinib | 0.0041977 | 0.8055751 | 0.00420 | ** | NA |
| CDK8 | nilotinib | 0.0042116 | 0.8055751 | 0.00421 | ** | NA |
| HKR1 | ponatinib | 0.0042168 | 1.0000000 | 0.00422 | ** | NA |
| FCHSD1 | midostaurin | 0.0042184 | 0.8795120 | 0.00422 | ** | NA |
| PCLO | cabozantinib | 0.0042190 | 0.8298252 | 0.00422 | ** | NA |
| OR6C70 | afatinib | 0.0042238 | 0.9267832 | 0.00422 | ** | NA |
| PCDHB8 | nilotinib | 0.0042246 | 0.8055751 | 0.00422 | ** | NA |
| ALPP | palbociclib | 0.0042301 | 0.9551671 | 0.00423 | ** | NA |
| PTRF | ponatinib | 0.0042344 | 1.0000000 | 0.00423 | ** | NA |
| HMGCR | tretinoin | 0.0042468 | 0.5241182 | 0.00425 | ** | NA |
| GLRB | sunitinib | 0.0042484 | 0.7819868 | 0.0042 | ** | NA |
| LRFN5 | afatinib | 0.0042568 | 0.9267832 | 0.00426 | ** | NA |
| GNB1 | alectinib | 0.0042631 | 0.9168760 | 0.00426 | ** | NA |
| SYCE2 | midostaurin | 0.0042640 | 0.8795120 | 0.00426 | ** | NA |
| TEX15 | midostaurin | 0.0042660 | 0.8795120 | 0.00427 | ** | NA |
| SNAI2 | afatinib | 0.0042691 | 0.9267832 | 0.00427 | ** | NA |
| SLC25A39 | vismodegib | 0.0042845 | 0.9623352 | 0.00428 | ** | NA |
| LRRK1 | cabozantinib | 0.0042924 | 0.8298252 | 0.00429 | ** | NA |
| ZNF786 | sunitinib | 0.0042925 | 0.7819868 | 0.0043 | ** | NA |
| ANPEP | dabrafenib | 0.0043005 | 0.9305571 | 0.00430 | ** | NA |
| CLUH | temozolomide | 0.0043014 | 0.6902774 | 0.00430 | ** | NA |
| SNX14 | dabrafenib | 0.0043102 | 0.9305571 | 0.00431 | ** | NA |
| GOLGA8B | dasatinib | 0.0043267 | 0.8707378 | 0.0043 | ** | NA |
| DFFB | tretinoin | 0.0043345 | 0.5241182 | 0.00433 | ** | NA |
| CAT | nilotinib | 0.0043388 | 0.8055751 | 0.00434 | ** | NA |
| APC | trametinib | 0.0043403 | 0.9852344 | 0.00434 | ** | NA |
| LCOR | temozolomide | 0.0043447 | 0.6902774 | 0.00434 | ** | NA |
| GGT7 | tretinoin | 0.0043524 | 0.5241182 | 0.00435 | ** | NA |
| FAM160A2 | midostaurin | 0.0043546 | 0.8795120 | 0.00435 | ** | NA |
| GJA10 | temozolomide | 0.0043584 | 0.6902774 | 0.00436 | ** | NA |
| ZNF470 | tretinoin | 0.0043619 | 0.5241182 | 0.00436 | ** | NA |
| SSFA2 | ruxolitinib | 0.0043628 | 0.9787856 | 0.00436 | ** | NA |
| FSIP2 | ruxolitinib | 0.0043677 | 0.9787856 | 0.00437 | ** | NA |
| ZNF112 | gefitinib | 0.0043740 | 0.8957015 | 0.00437 | ** | NA |
| FBLN7 | alectinib | 0.0043865 | 0.9168760 | 0.00439 | ** | NA |
| KRAS | pazopanib | 0.0043870 | 0.9978452 | 0.00439 | ** | NA |
| RBP4 | alectinib | 0.0043896 | 0.9168760 | 0.00439 | ** | NA |
| DCLK2 | tretinoin | 0.0043910 | 0.5241182 | 0.00439 | ** | NA |
| GLT1D1 | tretinoin | 0.0043989 | 0.5241182 | 0.00440 | ** | NA |
| FLT1 | cabozantinib | 0.0044037 | 0.8298252 | 0.00440 | ** | NA |
| MOCS2 | tretinoin | 0.0044042 | 0.5241182 | 0.00440 | ** | NA |
| ZNF844 | midostaurin | 0.0044044 | 0.8795120 | 0.00440 | ** | NA |
| TTN | rucaparib | 0.0044075 | 0.9990814 | 0.00441 | ** | NA |
| MACF1 | tretinoin | 0.0044088 | 0.5241182 | 0.00441 | ** | NA |
| FSIP2 | docetaxel | 0.0044132 | 0.9106700 | 0.00441 | ** | NA |
| RARA | alectinib | 0.0044172 | 0.9168760 | 0.00442 | ** | NA |
| PCDHB1 | temozolomide | 0.0044207 | 0.6902774 | 0.00442 | ** | NA |
| GINS3 | trametinib | 0.0044247 | 0.9852344 | 0.00442 | ** | NA |
| HAL | trametinib | 0.0044325 | 0.9852344 | 0.00443 | ** | NA |
| ZNF671 | tretinoin | 0.0044355 | 0.5241182 | 0.00444 | ** | NA |
| APOBEC3B | rucaparib | 0.0044389 | 0.9990814 | 0.00444 | ** | NA |
| CPD | ruxolitinib | 0.0044406 | 0.9787856 | 0.00444 | ** | NA |
| THEG | nilotinib | 0.0044599 | 0.8055751 | 0.00446 | ** | NA |
| SRP54 | afatinib | 0.0044687 | 0.9267832 | 0.00447 | ** | NA |
| LENG8 | trametinib | 0.0044770 | 0.9852344 | 0.00448 | ** | NA |
| TAF4 | docetaxel | 0.0044851 | 0.9106700 | 0.00449 | ** | NA |
| RYR3 | gefitinib | 0.0045044 | 0.8957015 | 0.00450 | ** | NA |
| FAM171A1 | dasatinib | 0.0045091 | 0.8707378 | 0.0045 | ** | NA |
| EPS8L2 | alectinib | 0.0045107 | 0.9168760 | 0.00451 | ** | NA |
| GGA3 | palbociclib | 0.0045148 | 0.9551671 | 0.00451 | ** | NA |
| ATPAF1 | vismodegib | 0.0045201 | 0.9623352 | 0.00452 | ** | NA |
| SLC44A3 | belinostat | 0.0045235 | 0.9983823 | 0.00452 | ** | NA |
| LINS | rucaparib | 0.0045241 | 0.9990814 | 0.00452 | ** | NA |
| NETO1 | vismodegib | 0.0045380 | 0.9623352 | 0.00454 | ** | NA |
| ATP5A1 | palbociclib | 0.0045397 | 0.9551671 | 0.00454 | ** | NA |
| ZNF131 | cabozantinib | 0.0045415 | 0.8298252 | 0.00454 | ** | NA |
| TMED7 | alectinib | 0.0045513 | 0.9168760 | 0.00455 | ** | NA |
| ABCA12 | trametinib | 0.0045515 | 0.9852344 | 0.00455 | ** | NA |
| SOX30 | tretinoin | 0.0045520 | 0.5318267 | 0.00455 | ** | NA |
| SDR16C5 | bosutinib monohydrate | 0.0045545 | 1.0000000 | 0.00455 | ** | NA |
| ZMYM5 | trametinib | 0.0045590 | 0.9852344 | 0.00456 | ** | NA |
| GRHL3 | docetaxel | 0.0045590 | 0.9106700 | 0.00456 | ** | NA |
| MTX1 | temozolomide | 0.0045648 | 0.6902774 | 0.00456 | ** | NA |
| OR4K1 | ponatinib | 0.0045701 | 1.0000000 | 0.00457 | ** | NA |
| WDR3 | trametinib | 0.0045726 | 0.9852344 | 0.00457 | ** | NA |
| SKIDA1 | alectinib | 0.0045811 | 0.9168760 | 0.00458 | ** | NA |
| SEMA4A | afatinib | 0.0045872 | 0.9267832 | 0.00459 | ** | NA |
| FBN1 | cabozantinib | 0.0045918 | 0.8298252 | 0.00459 | ** | NA |
| PM20D1 | temozolomide | 0.0045924 | 0.6902774 | 0.00459 | ** | NA |
| MEF2C | palbociclib | 0.0045937 | 0.9551671 | 0.00459 | ** | NA |
| CHN2 | afatinib | 0.0046015 | 0.9267832 | 0.00460 | ** | NA |
| CCDC142 | alectinib | 0.0046040 | 0.9168760 | 0.00460 | ** | NA |
| FEZF1 | tretinoin | 0.0046051 | 0.5318267 | 0.00461 | ** | NA |
| DST | midostaurin | 0.0046100 | 0.8795120 | 0.00461 | ** | NA |
| IGFN1 | afatinib | 0.0046119 | 0.9267832 | 0.00461 | ** | NA |
| NEUROD1 | cabozantinib | 0.0046142 | 0.8298252 | 0.00461 | ** | NA |
| TMEM151A | cabozantinib | 0.0046258 | 0.8298252 | 0.00463 | ** | NA |
| OPCML | afatinib | 0.0046279 | 0.9267832 | 0.00463 | ** | NA |
| WDR93 | cabozantinib | 0.0046329 | 0.8298252 | 0.00463 | ** | NA |
| ADAMTS9 | alectinib | 0.0046333 | 0.9168760 | 0.00463 | ** | NA |
| HDAC9 | cabozantinib | 0.0046438 | 0.8298252 | 0.00464 | ** | NA |
| ITPKC | docetaxel | 0.0046452 | 0.9106700 | 0.00465 | ** | NA |
| BLZF1 | pazopanib | 0.0046539 | 0.9978452 | 0.00465 | ** | NA |
| PCDHB2 | lapatinib | 0.0046634 | 0.8107014 | 0.00466 | ** | NA |
| RHOBTB3 | cabozantinib | 0.0046689 | 0.8298252 | 0.00467 | ** | NA |
| KLHL7 | vismodegib | 0.0046771 | 0.9623352 | 0.00468 | ** | NA |
| IGFN1 | gefitinib | 0.0046773 | 0.8957015 | 0.00468 | ** | NA |
| LGR6 | temozolomide | 0.0046792 | 0.6902774 | 0.00468 | ** | NA |
| GLYATL1 | nilotinib | 0.0046803 | 0.8055751 | 0.00468 | ** | NA |
| NCOA2 | crizotinib | 0.0046821 | 0.7869686 | 0.0047 | ** | NA |
| CUEDC1 | ponatinib | 0.0046975 | 1.0000000 | 0.00470 | ** | NA |
| MYO1F | nilotinib | 0.0047037 | 0.8055751 | 0.00470 | ** | NA |
| PQLC3 | ponatinib | 0.0047224 | 1.0000000 | 0.00472 | ** | NA |
| NUGGC | dabrafenib | 0.0047318 | 0.9305571 | 0.00473 | ** | NA |
| MYH10 | sunitinib | 0.0047341 | 0.7819868 | 0.0047 | ** | NA |
| DCST2 | nilotinib | 0.0047347 | 0.8055751 | 0.00473 | ** | NA |
| ATP13A5 | temozolomide | 0.0047421 | 0.6902774 | 0.00474 | ** | NA |
| AKAP12 | temozolomide | 0.0047464 | 0.6902774 | 0.00475 | ** | NA |
| KLHDC3 | palbociclib | 0.0047493 | 0.9551671 | 0.00475 | ** | NA |
| MLF1 | tretinoin | 0.0047538 | 0.5318267 | 0.00475 | ** | NA |
| YTHDC2 | midostaurin | 0.0047543 | 0.8795120 | 0.00475 | ** | NA |
| AGTPBP1 | ponatinib | 0.0047624 | 1.0000000 | 0.00476 | ** | NA |
| PLCZ1 | sunitinib | 0.0047635 | 0.7819868 | 0.0048 | ** | NA |
| MYT1L | temozolomide | 0.0047717 | 0.6902774 | 0.00477 | ** | NA |
| NPBWR1 | midostaurin | 0.0047740 | 0.8795120 | 0.00477 | ** | NA |
| JAG1 | temozolomide | 0.0047745 | 0.6902774 | 0.00477 | ** | NA |
| CSMD1 | vismodegib | 0.0047927 | 0.9623352 | 0.00479 | ** | NA |
| CDHR5 | dasatinib | 0.0048229 | 0.8707378 | 0.0048 | ** | NA |
| RABEP1 | cabozantinib | 0.0048293 | 0.8298252 | 0.00483 | ** | NA |
| ZNF500 | dabrafenib | 0.0048328 | 0.9305571 | 0.00483 | ** | NA |
| ZNF865 | palbociclib | 0.0048368 | 0.9551671 | 0.00484 | ** | NA |
| MTMR6 | cabozantinib | 0.0048455 | 0.8298252 | 0.00485 | ** | NA |
| OR2M7 | bosutinib monohydrate | 0.0048597 | 1.0000000 | 0.00486 | ** | NA |
| CPD | gefitinib | 0.0048657 | 0.8957015 | 0.00487 | ** | NA |
| THBS2 | alectinib | 0.0048736 | 0.9168760 | 0.00487 | ** | NA |
| ANKLE1 | ruxolitinib | 0.0048743 | 0.9787856 | 0.00487 | ** | NA |
| LRP5 | sunitinib | 0.0048761 | 0.7819868 | 0.0049 | ** | NA |
| TRPM7 | tretinoin | 0.0048796 | 0.5318267 | 0.00488 | ** | NA |
| ABCA3 | tretinoin | 0.0048850 | 0.5318267 | 0.00488 | ** | NA |
| ZC3H6 | dasatinib | 0.0048860 | 0.8707378 | 0.0049 | ** | NA |
| PFKFB3 | afatinib | 0.0048861 | 0.9267832 | 0.00489 | ** | NA |
| ANKS1B | nilotinib | 0.0048863 | 0.8055751 | 0.00489 | ** | NA |
| ANXA10 | alectinib | 0.0048901 | 0.9168760 | 0.00489 | ** | NA |
| PUS7L | gefitinib | 0.0049001 | 0.8957015 | 0.00490 | ** | NA |
| NUP35 | alectinib | 0.0049004 | 0.9168760 | 0.00490 | ** | NA |
| PTPRK | tretinoin | 0.0049046 | 0.5318267 | 0.00490 | ** | NA |
| MNS1 | palbociclib | 0.0049132 | 0.9551671 | 0.00491 | ** | NA |
| WSCD1 | rucaparib | 0.0049138 | 0.9990814 | 0.00491 | ** | NA |
| ANKRD65 | cabozantinib | 0.0049197 | 0.8298252 | 0.00492 | ** | NA |
| LPL | vismodegib | 0.0049280 | 0.9623352 | 0.00493 | ** | NA |
| FSD2 | trametinib | 0.0049306 | 0.9852344 | 0.00493 | ** | NA |
| RPL3 | temozolomide | 0.0049333 | 0.6902774 | 0.00493 | ** | NA |
| SUMF1 | rucaparib | 0.0049437 | 0.9990814 | 0.00494 | ** | NA |
| RNF38 | trametinib | 0.0049443 | 0.9852344 | 0.00494 | ** | NA |
| NLGN2 | palbociclib | 0.0049507 | 0.9551671 | 0.00495 | ** | NA |
| KRT31 | sunitinib | 0.0049648 | 0.7819868 | 0.0050 | ** | NA |
| SUPT3H | temozolomide | 0.0049775 | 0.6902774 | 0.00498 | ** | NA |
| RGR | trametinib | 0.0049804 | 0.9852344 | 0.00498 | ** | NA |
| RPL13A | ponatinib | 0.0049804 | 1.0000000 | 0.00498 | ** | NA |
| FADS6 | midostaurin | 0.0049816 | 0.8795120 | 0.00498 | ** | NA |
| PGLYRP1 | tretinoin | 0.0049953 | 0.5318267 | 0.00500 | ** | NA |
| NYAP1 | palbociclib | 0.0050106 | 0.9551671 | 0.00501 | ** | NA |
| TBC1D10B | pazopanib | 0.0050180 | 0.9978452 | 0.00502 | ** | NA |
| MFSD1 | tretinoin | 0.0050182 | 0.5318267 | 0.00502 | ** | NA |
| FCHSD1 | ponatinib | 0.0050184 | 1.0000000 | 0.00502 | ** | NA |
| CDH23 | pazopanib | 0.0050184 | 0.9978452 | 0.00502 | ** | NA |
| NSRP1 | rucaparib | 0.0050213 | 0.9990814 | 0.00502 | ** | NA |
| C2orf48 | alectinib | 0.0050241 | 0.9168760 | 0.00502 | ** | NA |
| GLYATL2 | gefitinib | 0.0050341 | 0.8957015 | 0.00503 | ** | NA |
| SLC45A4 | cabozantinib | 0.0050435 | 0.8298252 | 0.00504 | ** | NA |
| SLC15A1 | gefitinib | 0.0050458 | 0.8957015 | 0.00505 | ** | NA |
| ANKRD55 | docetaxel | 0.0050477 | 0.9106700 | 0.00505 | ** | NA |
| MORN1 | gefitinib | 0.0050496 | 0.8957015 | 0.00505 | ** | NA |
| MYLK4 | tretinoin | 0.0050508 | 0.5318267 | 0.00505 | ** | NA |
| DUS3L | nilotinib | 0.0050508 | 0.8055751 | 0.00505 | ** | NA |
| TEX14 | nilotinib | 0.0050508 | 0.8055751 | 0.00505 | ** | NA |
| AXIN2 | cabozantinib | 0.0050512 | 0.8298252 | 0.00505 | ** | NA |
| PALLD | temozolomide | 0.0050522 | 0.6902774 | 0.00505 | ** | NA |
| LIPM | dabrafenib | 0.0050527 | 0.9305571 | 0.00505 | ** | NA |
| SLC7A11 | belinostat | 0.0050530 | 0.9983823 | 0.00505 | ** | NA |
| SPRED1 | rucaparib | 0.0050537 | 0.9990814 | 0.00505 | ** | NA |
| NRXN3 | rucaparib | 0.0050580 | 0.9990814 | 0.00506 | ** | NA |
| ITPRIPL1 | ponatinib | 0.0050595 | 1.0000000 | 0.00506 | ** | NA |
| USP6NL | midostaurin | 0.0050614 | 0.8795120 | 0.00506 | ** | NA |
| CD40 | bosutinib monohydrate | 0.0050669 | 1.0000000 | 0.00507 | ** | NA |
| GOLGA2 | lapatinib | 0.0050730 | 0.8107014 | 0.00507 | ** | NA |
| PCDHGC4 | cabozantinib | 0.0050757 | 0.8298252 | 0.00508 | ** | NA |
| ZC3H15 | tretinoin | 0.0050788 | 0.5318267 | 0.00508 | ** | NA |
| TMEM126B | vismodegib | 0.0050928 | 0.9623352 | 0.00509 | ** | NA |
| LCE1A | nilotinib | 0.0050962 | 0.8055751 | 0.00510 | ** | NA |
| KIAA0825 | cabozantinib | 0.0051012 | 0.8298252 | 0.00510 | ** | NA |
| TDRKH | bosutinib monohydrate | 0.0051031 | 1.0000000 | 0.00510 | ** | NA |
| UVRAG | afatinib | 0.0051066 | 0.9267832 | 0.00511 | ** | NA |
| DUSP18 | nilotinib | 0.0051248 | 0.8055751 | 0.00512 | ** | NA |
| NAP1L1 | sunitinib | 0.0051289 | 0.7819868 | 0.0051 | ** | NA |
| FOXO1 | pazopanib | 0.0051311 | 0.9978452 | 0.00513 | ** | NA |
| GRSF1 | afatinib | 0.0051350 | 0.9267832 | 0.00513 | ** | NA |
| PIP4K2B | temozolomide | 0.0051431 | 0.6902774 | 0.00514 | ** | NA |
| FAM170A | docetaxel | 0.0051467 | 0.9106700 | 0.00515 | ** | NA |
| TRERF1 | temozolomide | 0.0051481 | 0.6902774 | 0.00515 | ** | NA |
| PCDHB1 | tretinoin | 0.0051580 | 0.5318267 | 0.00516 | ** | NA |
| TBC1D30 | alectinib | 0.0051609 | 0.9168760 | 0.00516 | ** | NA |
| YDJC | nilotinib | 0.0051622 | 0.8055751 | 0.00516 | ** | NA |
| MIER3 | rucaparib | 0.0051632 | 0.9990814 | 0.00516 | ** | NA |
| FANCI | tretinoin | 0.0051667 | 0.5318267 | 0.00517 | ** | NA |
| SLC22A16 | sunitinib | 0.0051720 | 0.7819868 | 0.0052 | ** | NA |
| FIBP | temozolomide | 0.0051771 | 0.6902774 | 0.00518 | ** | NA |
| MPRIP | temozolomide | 0.0051802 | 0.6902774 | 0.00518 | ** | NA |
| DDX60 | tretinoin | 0.0051829 | 0.5318267 | 0.00518 | ** | NA |
| RRBP1 | tretinoin | 0.0051871 | 0.5318267 | 0.00519 | ** | NA |
| TPCN2 | crizotinib | 0.0052050 | 0.7869686 | 0.0052 | ** | NA |
| CCDC114 | cabozantinib | 0.0052095 | 0.8298252 | 0.00521 | ** | NA |
| TAF9 | vismodegib | 0.0052159 | 0.9623352 | 0.00522 | ** | NA |
| FER1L6 | gefitinib | 0.0052195 | 0.8957015 | 0.00522 | ** | NA |
| FAAH | dabrafenib | 0.0052243 | 0.9305571 | 0.00522 | ** | NA |
| BSG | cabozantinib | 0.0052318 | 0.8298252 | 0.00523 | ** | NA |
| PNPLA1 | pazopanib | 0.0052343 | 0.9978452 | 0.00523 | ** | NA |
| PCDHGB4 | sunitinib | 0.0052393 | 0.7819868 | 0.0052 | ** | NA |
| OLFML1 | temozolomide | 0.0052458 | 0.6902774 | 0.00525 | ** | NA |
| FBXO15 | tretinoin | 0.0052478 | 0.5318267 | 0.00525 | ** | NA |
| COL17A1 | cabozantinib | 0.0052547 | 0.8298252 | 0.00525 | ** | NA |
| SLC17A4 | nilotinib | 0.0052581 | 0.8055751 | 0.00526 | ** | NA |
| KIF20A | temozolomide | 0.0052674 | 0.6902774 | 0.00527 | ** | NA |
| CYP2C9 | rucaparib | 0.0052723 | 0.9990814 | 0.00527 | ** | NA |
| PMPCB | docetaxel | 0.0052732 | 0.9106700 | 0.00527 | ** | NA |
| CR1 | belinostat | 0.0052768 | 0.9983823 | 0.00528 | ** | NA |
| LSM1 | gefitinib | 0.0052852 | 0.8957015 | 0.00529 | ** | NA |
| FNDC9 | afatinib | 0.0052854 | 0.9267832 | 0.00529 | ** | NA |
| RYR2 | docetaxel | 0.0052972 | 0.9106700 | 0.00530 | ** | NA |
| DNAJB7 | temozolomide | 0.0053054 | 0.6902774 | 0.00531 | ** | NA |
| LRIF1 | bosutinib monohydrate | 0.0053124 | 1.0000000 | 0.00531 | ** | NA |
| OR52D1 | nilotinib | 0.0053179 | 0.8055751 | 0.00532 | ** | NA |
| RABL3 | tretinoin | 0.0053246 | 0.5318267 | 0.00532 | ** | NA |
| CHST10 | docetaxel | 0.0053301 | 0.9106700 | 0.00533 | ** | NA |
| RASIP1 | temozolomide | 0.0053330 | 0.6902774 | 0.00533 | ** | NA |
| GPA33 | docetaxel | 0.0053355 | 0.9106700 | 0.00534 | ** | NA |
| EPS8L2 | ruxolitinib | 0.0053438 | 0.9787856 | 0.00534 | ** | NA |
| IRX4 | erlotinib | 0.0053489 | 0.7991878 | 0.00535 | ** | NA |
| AKR1B15 | lapatinib | 0.0053602 | 0.8107014 | 0.00536 | ** | NA |
| PEX1 | docetaxel | 0.0053660 | 0.9106700 | 0.00537 | ** | NA |
| DTHD1 | gefitinib | 0.0053703 | 0.8957015 | 0.00537 | ** | NA |
| PCDHB7 | midostaurin | 0.0053737 | 0.8795120 | 0.00537 | ** | NA |
| FBXO38 | temozolomide | 0.0053764 | 0.6902774 | 0.00538 | ** | NA |
| LYST | crizotinib | 0.0053766 | 0.7869686 | 0.0054 | ** | NA |
| REV3L | midostaurin | 0.0053955 | 0.8795120 | 0.00540 | ** | NA |
| COL7A1 | tretinoin | 0.0054001 | 0.5318267 | 0.00540 | ** | NA |
| SRGAP3 | midostaurin | 0.0054027 | 0.8795120 | 0.00540 | ** | NA |
| PQLC3 | tretinoin | 0.0054048 | 0.5318267 | 0.00540 | ** | NA |
| COL25A1 | belinostat | 0.0054054 | 0.9983823 | 0.00541 | ** | NA |
| SPTY2D1 | tretinoin | 0.0054103 | 0.5318267 | 0.00541 | ** | NA |
| TMEM26 | midostaurin | 0.0054202 | 0.8795120 | 0.00542 | ** | NA |
| PGLYRP1 | vismodegib | 0.0054230 | 0.9623352 | 0.00542 | ** | NA |
| TBXA2R | ruxolitinib | 0.0054246 | 0.9787856 | 0.00542 | ** | NA |
| MYZAP | temozolomide | 0.0054252 | 0.6902774 | 0.00543 | ** | NA |
| RUVBL1 | pazopanib | 0.0054301 | 0.9978452 | 0.00543 | ** | NA |
| TGFB1I1 | belinostat | 0.0054317 | 0.9983823 | 0.00543 | ** | NA |
| ZSWIM3 | gefitinib | 0.0054360 | 0.8957015 | 0.00544 | ** | NA |
crispr_data_g2p_summ <- unique(crispr_data_g2p[, c("Hugo_Symbol", "N_Nonsilent_Mutant", "N_Nonsilent_Other")])
crispr_data_g2p_summ$Percent_Mutant <- crispr_data_g2p_summ$N_Nonsilent_Mutant / (crispr_data_g2p_summ$N_Nonsilent_Mutant + crispr_data_g2p_summ$N_Nonsilent_Other) * 100
rownames(crispr_data_g2p_summ) <- NULL
# write.table(crispr_data_g2p_summ, file = "~/Desktop/crispr_data_g2p_summ_20181003.tsv", quote = FALSE, sep = "\t")
knitr::kable(crispr_data_g2p_summ, caption = "CRISPR: Level A G2P genes mutation status summary") %>% kable_styling(bootstrap_options = c("striped", "hover", "condensed", "responsive")) %>% scroll_box(width = "900px", height = "450px")
| Hugo_Symbol | N_Nonsilent_Mutant | N_Nonsilent_Other | Percent_Mutant |
|---|---|---|---|
| ABL1 | 32 | 457 | 6.5439673 |
| AKT1 | 11 | 476 | 2.2587269 |
| ALK | 38 | 451 | 7.7709611 |
| BRAF | 75 | 419 | 15.1821862 |
| BRCA1 | 33 | 453 | 6.7901235 |
| BRCA2 | 51 | 440 | 10.3869654 |
| CYP19A1 | 8 | 477 | 1.6494845 |
| DNMT3A | 29 | 457 | 5.9670782 |
| DPYD | 29 | 458 | 5.9548255 |
| EGFR | 43 | 449 | 8.7398374 |
| ERBB2 | 21 | 467 | 4.3032787 |
| ERBB3 | 29 | 457 | 5.9670782 |
| ESR1 | 14 | 471 | 2.8865979 |
| FLT3 | 27 | 459 | 5.5555556 |
| IDH2 | 6 | 479 | 1.2371134 |
| JAK2 | 14 | 472 | 2.8806584 |
| KIT | 21 | 466 | 4.3121150 |
| KRAS | 94 | 395 | 19.2229039 |
| MET | 29 | 459 | 5.9426230 |
| MGMT | 7 | 478 | 1.4432990 |
| MYD88 | 10 | 475 | 2.0618557 |
| NPM1 | 6 | 479 | 1.2371134 |
| PDGFB | 6 | 479 | 1.2371134 |
| PDGFRA | 30 | 457 | 6.1601643 |
| PDGFRB | 28 | 459 | 5.7494867 |
| PML | 22 | 465 | 4.5174538 |
| PTCH1 | 28 | 462 | 5.7142857 |
| RET | 20 | 465 | 4.1237113 |
| ROS1 | 47 | 440 | 9.6509240 |
| TPMT | 4 | 481 | 0.8247423 |
| TSC1 | 14 | 472 | 2.8806584 |
| TSC2 | 37 | 451 | 7.5819672 |
| UGT1A1 | 19 | 472 | 3.8696538 |
g2p_druggene_p_tally <- g2p %>% group_by(Drug_Gene) %>% tally()
g2p_druggene_p_summ <- merge(g2p_druggene_p_tally, ccle_signif_g2p[, c("Drug_Gene", "p")], by = "Drug_Gene", all.x = TRUE)
g2p_druggene_p_summ <- merge(g2p_druggene_p_summ, ctrp_signif_g2p[, c("Drug_Gene", "p")], by = "Drug_Gene", all.x = TRUE, suffixes = c("_CCLE", "_CTRP"))
g2p_druggene_p_summ <- merge(g2p_druggene_p_summ, gdsc_signif_g2p[, c("Drug_Gene", "p")], by = "Drug_Gene", all.x = TRUE)
colnames(g2p_druggene_p_summ)[colnames(g2p_druggene_p_summ) == "p_CCLE"] <- "CCLE"
colnames(g2p_druggene_p_summ)[colnames(g2p_druggene_p_summ) == "p_CTRP"] <- "CTRP"
colnames(g2p_druggene_p_summ)[colnames(g2p_druggene_p_summ) == "p"] <- "GDSC"
g2p_druggene_p_summ_melt <- melt(g2p_druggene_p_summ, id.vars = c("Drug_Gene", "n"), measure.vars = c("CCLE", "CTRP", "GDSC"), variable.name = "Dataset", value.name = "p")
g2p_druggene_p_summ_plot <- ggplot(data = g2p_druggene_p_summ_melt, aes(x = p, y = n, shape = Dataset, color = Dataset)) +
geom_point(size = 2) +
scale_color_manual(values = c("green3", "darkslategray4", "darkturquoise")) +
labs(x = "Gene-drug association p-value by mutation status", y = "Number of level A G2P associations")
g2p_druggene_p_summ_plot
# ggsave("./plots_18Q3/manuscript/g2p_druggene_p_summ_plot.png", g2p_druggene_p_summ_plot, device = "png", dpi = 450, width = 8, height = 4, units = "in")
ccle_druggene_mad_summ <- ccle_data_ptmuts %>% group_by(Drug_Gene, Mutation_Status_Nonsilent) %>% summarize(Mean_AUC = mean(AUC))
ccle_druggene_mad_summ <- dcast(ccle_druggene_mad_summ, Drug_Gene ~ Mutation_Status_Nonsilent)
ccle_druggene_mad_summ$MAD <- abs(ccle_druggene_mad_summ$Mutant - ccle_druggene_mad_summ$Other)
ccle_druggene_p_summ <- ccle_signif_g2p_ByDrug_all
ccle_druggene_p_summ$Drug_Gene <- paste0(ccle_druggene_p_summ$Drug, "_", ccle_druggene_p_summ$Hugo_Symbol)
ccle_druggene_summ <- merge(merge(g2p_druggene_p_tally, ccle_druggene_p_summ[, c("Drug_Gene", "p")], by = "Drug_Gene", all.y = TRUE), ccle_druggene_mad_summ, by = "Drug_Gene", all = TRUE)
ccle_druggene_summ$n <- ifelse(is.na(ccle_druggene_summ$n), 0, ccle_druggene_summ$n)
ccle_druggene_summ$InG2P <- ifelse(ccle_druggene_summ$n != 0, "Yes", "No")
ccle_druggene_summ$Dataset <- "CCLE"
ccle_p_ttest <- t.test(ccle_druggene_summ$p ~ ccle_druggene_summ$InG2P)
ccle_p_ttest_res <- paste0("t = ", round(ccle_p_ttest$statistic, 3), ", df = ", round(ccle_p_ttest$parameter, 3), ", p = ", round(ccle_p_ttest$p.value, 3))
ccle_mad_ttest <- t.test(ccle_druggene_summ$MAD ~ ccle_druggene_summ$InG2P)
ccle_mad_ttest_res <- paste0("t = ", round(ccle_mad_ttest$statistic, 3), ", df = ", round(ccle_mad_ttest$parameter, 3), ", p = ", round(ccle_mad_ttest$p.value, 3))
ctrp_druggene_mad_summ <- ctrp_data_ptmuts %>% group_by(Drug_Gene, Mutation_Status_Nonsilent) %>% summarize(Mean_AUC = mean(AUC))
ctrp_druggene_mad_summ <- dcast(ctrp_druggene_mad_summ, Drug_Gene ~ Mutation_Status_Nonsilent)
ctrp_druggene_mad_summ$MAD <- abs(ctrp_druggene_mad_summ$Mutant - ctrp_druggene_mad_summ$Other)
ctrp_druggene_p_summ <- ctrp_signif_g2p_ByDrug_all
ctrp_druggene_p_summ$Drug_Gene <- paste0(ctrp_druggene_p_summ$Drug, "_", ctrp_druggene_p_summ$Hugo_Symbol)
ctrp_druggene_summ <- merge(merge(g2p_druggene_p_tally, ctrp_druggene_p_summ[, c("Drug_Gene", "p")], by = "Drug_Gene", all.y = TRUE), ctrp_druggene_mad_summ, by = "Drug_Gene", all = TRUE)
ctrp_druggene_summ$n <- ifelse(is.na(ctrp_druggene_summ$n), 0, ctrp_druggene_summ$n)
ctrp_druggene_summ$InG2P <- ifelse(ctrp_druggene_summ$n != 0, "Yes", "No")
ctrp_druggene_summ$Dataset <- "CTRP"
ctrp_p_ttest <- t.test(ctrp_druggene_summ$p ~ ctrp_druggene_summ$InG2P)
ctrp_p_ttest_res <- paste0("t = ", round(ctrp_p_ttest$statistic, 3), ", df = ", round(ctrp_p_ttest$parameter, 3), ", p = ", round(ctrp_p_ttest$p.value, 3))
ctrp_mad_ttest <- t.test(ctrp_druggene_summ$MAD ~ ctrp_druggene_summ$InG2P)
ctrp_mad_ttest_res <- paste0("t = ", round(ctrp_mad_ttest$statistic, 3), ", df = ", round(ctrp_mad_ttest$parameter, 3), ", p = ", round(ctrp_mad_ttest$p.value, 3))
gdsc_druggene_mad_summ <- gdsc_data_ptmuts %>% group_by(Drug_Gene, Mutation_Status_Nonsilent) %>% summarize(Mean_AUC = mean(AUC))
gdsc_druggene_mad_summ <- dcast(gdsc_druggene_mad_summ, Drug_Gene ~ Mutation_Status_Nonsilent)
gdsc_druggene_mad_summ$MAD <- abs(gdsc_druggene_mad_summ$Mutant - gdsc_druggene_mad_summ$Other)
gdsc_druggene_p_summ <- gdsc_signif_g2p_ByDrug_all
gdsc_druggene_p_summ$Drug_Gene <- paste0(gdsc_druggene_p_summ$Drug, "_", gdsc_druggene_p_summ$Hugo_Symbol)
gdsc_druggene_summ <- merge(merge(g2p_druggene_p_tally, gdsc_druggene_p_summ[, c("Drug_Gene", "p")], by = "Drug_Gene", all.y = TRUE), gdsc_druggene_mad_summ, by = "Drug_Gene", all = TRUE)
gdsc_druggene_summ$n <- ifelse(is.na(gdsc_druggene_summ$n), 0, gdsc_druggene_summ$n)
gdsc_druggene_summ$InG2P <- ifelse(gdsc_druggene_summ$n != 0, "Yes", "No")
gdsc_druggene_summ$Dataset <- "GDSC"
gdsc_p_ttest <- t.test(gdsc_druggene_summ$p ~ gdsc_druggene_summ$InG2P)
gdsc_p_ttest_res <- paste0("t = ", round(gdsc_p_ttest$statistic, 3), ", df = ", round(gdsc_p_ttest$parameter, 3), ", p = ", round(gdsc_p_ttest$p.value, 3))
gdsc_mad_ttest <- t.test(gdsc_druggene_summ$MAD ~ gdsc_druggene_summ$InG2P)
gdsc_mad_ttest_res <- paste0("t = ", round(gdsc_mad_ttest$statistic, 3), ", df = ", round(gdsc_mad_ttest$parameter, 3), ", p = ", round(gdsc_mad_ttest$p.value, 3))
g2p_druggene_all_summ <- rbind(ccle_druggene_summ, ctrp_druggene_summ, gdsc_druggene_summ)
g2p_druggene_all_summ_text <- data.frame(Dataset = c("CCLE", "CTRP", "GDSC"),
Test_Results_p = c(ccle_p_ttest_res, ctrp_p_ttest_res, gdsc_p_ttest_res),
Test_Results_MAD = c(ccle_mad_ttest_res, ctrp_mad_ttest_res, gdsc_mad_ttest_res))
## MAD
plot_mad_point <- ggplot(data = g2p_druggene_all_summ) +
facet_wrap(~ Dataset, scales = "free_x") +
geom_point(mapping = aes(color = InG2P, x = MAD, y = n), alpha = 0.5) +
scale_y_continuous(breaks = seq(0, 110, by = 10), labels = seq(0, 110, by = 10)) +
geom_text(data = g2p_druggene_all_summ_text, mapping = aes(x = c(0.75, 4, 0.19), y = 110, label = Test_Results_MAD)) +
labs(x = "Gene-drug association difference in mean AUC between mutation groups", y = "Number of level A G2P associations", color = "Does the gene-drug combination have level A G2P indication?") +
theme(legend.position = "none", plot.margin = unit(c(0.05, 0.5, 0.5, 0.5), "cm"), strip.background = element_blank(), strip.text.x = element_blank())
plot_mad_box <- ggplot(data = g2p_druggene_all_summ) +
facet_wrap(~ Dataset, scales = "free_x") +
geom_boxplot(mapping = aes(color = InG2P, y = MAD, x = InG2P), alpha = 0.5) +
coord_flip() +
labs(x = "Level A G2P\nassociation") +
theme(legend.position = "none", axis.title.x = element_blank(), axis.text.x = element_blank(), axis.ticks.x = element_blank(), plot.margin = unit(c(0.5, 0.5, 0.05, 0.5), "cm"))
plot_mad_point <- ggplot_gtable(ggplot_build(plot_mad_point))
plot_mad_box <- ggplot_gtable(ggplot_build(plot_mad_box))
mad_maxWidth <- grid::unit.pmax(plot_mad_point$widths, plot_mad_box$widths)
plot_mad_point$widths <- as.list(mad_maxWidth)
plot_mad_box$widths <- as.list(mad_maxWidth)
g2p_druggene_all_mad_summ_plot <- cowplot::plot_grid(plot_mad_box,
plot_mad_point,
nrow = 2,
rel_heights = c(1, 4))
g2p_druggene_all_mad_summ_plot
# ggsave("./plots_18Q3/manuscript/g2p_druggene_all_mad_summ_plot.png", g2p_druggene_all_mad_summ_plot, device = "png", dpi = 450, width = 12, height = 7, units = "in")
## P-value
plot_p_point <- ggplot(data = g2p_druggene_all_summ) +
facet_wrap(~ Dataset, scales = "free_x") +
geom_point(mapping = aes(color = InG2P, x = p, y = n), alpha = 0.5) +
scale_y_continuous(breaks = seq(0, 110, by = 10), labels = seq(0, 110, by = 10)) +
geom_text(data = g2p_druggene_all_summ_text, mapping = aes(x = 0.5, y = 110, label = Test_Results_p)) +
labs(x = "Gene-drug association p-value between mutation groups", y = "Number of level A G2P associations", color = "Does the gene-drug combination have level A G2P indication?") +
theme(legend.position = "none", plot.margin = unit(c(0.05, 0.5, 0.5, 0.5), "cm"), strip.background = element_blank(), strip.text.x = element_blank())
plot_p_box <- ggplot(data = g2p_druggene_all_summ) +
facet_wrap(~ Dataset, scales = "free_x") +
geom_boxplot(mapping = aes(color = InG2P, y = p, x = InG2P), alpha = 0.5) +
coord_flip() +
labs(x = "Level A G2P\nassociation") +
theme(legend.position = "none", axis.title.x = element_blank(), axis.text.x = element_blank(), axis.ticks.x = element_blank(), plot.margin = unit(c(0.5, 0.5, 0.05, 0.5), "cm"))
plot_p_point <- ggplot_gtable(ggplot_build(plot_p_point))
plot_p_box <- ggplot_gtable(ggplot_build(plot_p_box))
p_maxWidth <- grid::unit.pmax(plot_p_point$widths, plot_p_box$widths)
plot_p_point$widths <- as.list(p_maxWidth)
plot_p_box$widths <- as.list(p_maxWidth)
g2p_druggene_all_p_summ_plot <- cowplot::plot_grid(plot_p_box,
plot_p_point,
nrow = 2,
rel_heights = c(1, 4))
g2p_druggene_all_p_summ_plot
# ggsave("./plots_18Q3/manuscript/g2p_druggene_all_p_summ_plot.png", g2p_druggene_all_p_summ_plot, device = "png", dpi = 450, width = 12, height = 7, units = "in")
Mutation status boxplots for genes identified in G2P.
Boxplots ordered by gene based on frequency of G2P associations.
crispr_data_g2p$Hugo_Symbol <- factor(crispr_data_g2p$Hugo_Symbol, levels = g2p_genes)
crispr_data_g2p_color <- as.character(crispr_data_g2p$Color_Nonsilent)
names(crispr_data_g2p_color) <- crispr_data_g2p$Mutation_Status_Nonsilent
crispr_label_text <- data.frame(p.signif.adj = crispr_signif_g2p_gene$p.signif.adj, p.signif = crispr_signif_g2p_gene$p.signif, Hugo_Symbol = crispr_signif_g2p_gene$Hugo_Symbol)
crispr_label_text <- filter(crispr_label_text, Hugo_Symbol %in% g2p_genes)
crispr_label_text$Hugo_Symbol <- factor(crispr_label_text$Hugo_Symbol, levels = g2p_genes)
crispr_data_g2p_plot <- ggplot(data = crispr_data_g2p, aes(x = Mutation_Status_Nonsilent, y = Score)) +
facet_wrap(~ Hugo_Symbol, drop = FALSE, nrow = 1) +
geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
geom_boxplot(mapping = aes(fill = Mutation_Status_Nonsilent), position = position_dodge(0.85)) +
scale_fill_manual(values = crispr_data_g2p_color) +
guides(color = FALSE) +
geom_text(data = crispr_label_text, mapping = aes(x = 1.5, y = 2, label = p.signif), nudge_y = 0.1) +
theme(strip.text.x = element_text(size = 10, angle = 45), legend.position = "top", axis.ticks.x = element_blank(), axis.text.x = element_blank(), axis.title.x = element_blank()) +
labs(title = "CRISPR", fill = "Mutation Status", y = "CERES Score", x = "Mutation Status")
crispr_data_g2p_plot
# ggsave("./plots_18Q3/manuscript/crispr_data_g2p_plot.png", crispr_data_g2p_plot, device = "png", dpi = 450, width = 20, height = 5, units = "in")
Plot code:
ccle_drugs <- as.character(unique(ccle_data_g2p_genesfilt$Drug))
ccle_g2p_drugboxplots <- lapply(ccle_drugs, makeDrugBoxplots, dataset = "CCLE")
ccle_g2p_drugboxplots_paths <- paste0(ccle_drugs, "_ccle_drugboxplots.png")
pwalk(list(ccle_g2p_drugboxplots_paths, ccle_g2p_drugboxplots), ggsave, path = "./plots_18Q3/manuscript/ccle_g2p_drugboxplots", dpi = 450, width = 20, height = 5, units = "in")
Data management:
ccle_g2p_drugboxplots <- paste0(list.files("./plots_18Q3/manuscript/ccle_g2p_drugboxplots", full.names = TRUE))
names(ccle_g2p_drugboxplots) <- str_replace_all(ccle_g2p_drugboxplots, c("_ccle_drugboxplots.png" = "", "./plots_18Q3/manuscript/ccle_g2p_drugboxplots/" = ""))
bsselect(ccle_g2p_drugboxplots, type = "img", live_search = TRUE, show_tick = TRUE, height = 100)
Plot code:
ctrp_drugs <- as.character(unique(ctrp_data_g2p_genesfilt$Drug))
ctrp_g2p_drugboxplots <- lapply(ctrp_drugs, makeDrugBoxplots, dataset = "ctrp")
ctrp_g2p_drugboxplots_paths <- paste0(ctrp_drugs, "_ctrp_drugboxplots.png")
pwalk(list(ctrp_g2p_drugboxplots_paths, ctrp_g2p_drugboxplots), ggsave, path = "./plots_18Q3/manuscript/ctrp_g2p_drugboxplots", dpi = 450, width = 20, height = 5, units = "in")
Data management:
ctrp_g2p_drugboxplots <- paste0(list.files("./plots_18Q3/manuscript/ctrp_g2p_drugboxplots", full.names = TRUE))
names(ctrp_g2p_drugboxplots) <- str_replace_all(ctrp_g2p_drugboxplots, c("_ctrp_drugboxplots.png" = "", "./plots_18Q3/manuscript/ctrp_g2p_drugboxplots/" = ""))
bsselect(ctrp_g2p_drugboxplots, type = "img", live_search = TRUE, show_tick = TRUE, height = 100)
Plot code:
gdsc_drugs <- as.character(unique(gdsc_data_g2p_genesfilt$Drug))
gdsc_g2p_drugboxplots <- lapply(gdsc_drugs, makeDrugBoxplots, dataset = "gdsc")
gdsc_g2p_drugboxplots_paths <- paste0(gdsc_drugs, "_gdsc_drugboxplots.png")
pwalk(list(gdsc_g2p_drugboxplots_paths, gdsc_g2p_drugboxplots), ggsave, path = "./plots_18Q3/manuscript/gdsc_g2p_drugboxplots", dpi = 450, width = 20, height = 5, units = "in")
Data management:
gdsc_g2p_drugboxplots <- paste0(list.files("./plots_18Q3/manuscript/gdsc_g2p_drugboxplots", full.names = TRUE))
names(gdsc_g2p_drugboxplots) <- str_replace_all(gdsc_g2p_drugboxplots, c("_gdsc_drugboxplots.png" = "", "./plots_18Q3/manuscript/gdsc_g2p_drugboxplots/" = ""))
bsselect(gdsc_g2p_drugboxplots, type = "img", live_search = TRUE, show_tick = TRUE, height = 100)
ccle_g2p_order <- as.character(ccle_signif_g2p$Drug_Gene)
ccle_data_g2p$Drug_Gene_Ordered <- factor(ccle_data_g2p$Drug_Gene, levels = ccle_g2p_order, labels = sapply(strsplit(x = ccle_g2p_order, split = "_"), function(x) paste0(x[1], "\n", x[2])))
ccle_signif_g2p$Drug_Gene_Ordered <- factor(ccle_signif_g2p$Drug_Gene, levels = ccle_g2p_order, labels = sapply(strsplit(x = ccle_g2p_order, split = "_"), function(x) paste0(x[1], "\n", x[2])))
ccle_data_g2p_color <- as.character(ccle_data_g2p$Color_Nonsilent)
names(ccle_data_g2p_color) <- ccle_data_g2p$Mutation_Status_Nonsilent
ccle_label_text <- data.frame(p.signif.adj = ccle_signif_g2p$p.signif.adj, p.signif = ccle_signif_g2p$p.signif, Drug_Gene_Ordered = ccle_signif_g2p$Drug_Gene_Ordered)
ccle_data_g2p_plot <- ggplot(data = ccle_data_g2p, aes(x = Mutation_Status_Nonsilent, y = AUC)) +
facet_wrap(~ Drug_Gene_Ordered, drop = FALSE, nrow = 1) +
geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
geom_boxplot(mapping = aes(fill = Mutation_Status_Nonsilent), position = position_dodge(0.85), outlier.shape = 3, outlier.size = 0.5) +
scale_fill_manual(values = ccle_data_g2p_color) +
guides(color = FALSE) +
geom_text(data = ccle_label_text, mapping = aes(x = 1.5, y = 7, label = p.signif), nudge_y = 0.1) +
theme(legend.position = "top", axis.ticks.x = element_blank(), axis.text.x = element_blank(), axis.title.x = element_blank()) +
labs(title = "CCLE", fill = "Mutation Status", y = "AUC", x = "Mutation Status")
ccle_data_g2p_plot
# ggsave("./plots_18Q3/manuscript/ccle_data_g2p_plot.png", ccle_data_g2p_plot, device = "png", dpi = 450, width = 12, height = 4, units = "in")
ctrp_g2p_order <- as.character(ctrp_signif_g2p$Drug_Gene)
ctrp_data_g2p$Drug_Gene_Ordered <- factor(ctrp_data_g2p$Drug_Gene, levels = ctrp_g2p_order, labels = sapply(strsplit(x = ctrp_g2p_order, split = "_"), function(x) paste0(x[1], "\n", x[2])))
ctrp_signif_g2p$Drug_Gene_Ordered <- factor(ctrp_signif_g2p$Drug_Gene, levels = ctrp_g2p_order, labels = sapply(strsplit(x = ctrp_g2p_order, split = "_"), function(x) paste0(x[1], "\n", x[2])))
ctrp_data_g2p_color <- as.character(ctrp_data_g2p$Color_Nonsilent)
names(ctrp_data_g2p_color) <- ctrp_data_g2p$Mutation_Status_Nonsilent
ctrp_label_text <- data.frame(p.signif.adj = ctrp_signif_g2p$p.signif.adj, p.signif = ctrp_signif_g2p$p.signif, Drug_Gene_Ordered = ctrp_signif_g2p$Drug_Gene_Ordered)
ctrp_data_g2p_plot <- ggplot(data = ctrp_data_g2p, aes(x = Mutation_Status_Nonsilent, y = AUC)) +
facet_wrap(~ Drug_Gene_Ordered, drop = FALSE, nrow = 3) +
geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
geom_boxplot(mapping = aes(fill = Mutation_Status_Nonsilent), position = position_dodge(0.85), outlier.shape = 3, outlier.size = 0.5) +
scale_fill_manual(values = ctrp_data_g2p_color) +
guides(color = FALSE) +
geom_text(data = ctrp_label_text, mapping = aes(x = 1.5, y = 22.5, label = p.signif), nudge_y = 0.1) +
theme(legend.position = "top", axis.ticks.x = element_blank(), axis.text.x = element_blank(), axis.title.x = element_blank()) +
labs(title = "CTRP", fill = "Mutation Status", y = "AUC", x = "Mutation Status")
ctrp_data_g2p_plot
# ggsave("./plots_18Q3/manuscript/ctrp_data_g2p_plot.png", ctrp_data_g2p_plot, device = "png", dpi = 450, width = 12, height = 7, units = "in")
gdsc_g2p_order <- as.character(gdsc_signif_g2p$Drug_Gene)
gdsc_data_g2p$Drug_Gene_Ordered <- factor(gdsc_data_g2p$Drug_Gene, levels = gdsc_g2p_order, labels = sapply(strsplit(x = gdsc_g2p_order, split = "_"), function(x) paste0(x[1], "\n", x[2])))
gdsc_signif_g2p$Drug_Gene_Ordered <- factor(gdsc_signif_g2p$Drug_Gene, levels = gdsc_g2p_order, labels = sapply(strsplit(x = gdsc_g2p_order, split = "_"), function(x) paste0(x[1], "\n", x[2])))
gdsc_data_g2p_color <- as.character(gdsc_data_g2p$Color_Nonsilent)
names(gdsc_data_g2p_color) <- gdsc_data_g2p$Mutation_Status_Nonsilent
gdsc_label_text <- data.frame(p.signif.adj = gdsc_signif_g2p$p.signif.adj, p.signif = gdsc_signif_g2p$p.signif, Drug_Gene_Ordered = gdsc_signif_g2p$Drug_Gene_Ordered)
gdsc_data_g2p_plot <- ggplot(data = gdsc_data_g2p, aes(x = Mutation_Status_Nonsilent, y = AUC)) +
facet_wrap(~ Drug_Gene_Ordered, drop = FALSE, nrow = 3) +
geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
geom_boxplot(mapping = aes(fill = Mutation_Status_Nonsilent), position = position_dodge(0.85), outlier.shape = 3, outlier.size = 0.5) +
scale_fill_manual(values = gdsc_data_g2p_color) +
guides(color = FALSE) +
geom_text(data = gdsc_label_text, mapping = aes(x = 1.5, y = 1, label = p.signif), nudge_y = 0.1) +
theme(legend.position = "top", axis.ticks.x = element_blank(), axis.text.x = element_blank(), axis.title.x = element_blank()) +
labs(title = "GDSC", fill = "Mutation Status", y = "AUC", x = "Mutation Status")
gdsc_data_g2p_plot
# ggsave("./plots_18Q3/manuscript/gdsc_data_g2p_plot.png", gdsc_data_g2p_plot, device = "png", dpi = 450, width = 12, height = 7, units = "in")
Match specific point mutations.
g2p_indications <- filter(read.delim("./data_munging/data_mutation_associations_appended.csv", sep = "\t", header = TRUE), Evidence.Level == "A")
maf_g2p_indications <- filter(maf_raw, Genome_Change %in% g2p_indications$MutationName)
crispr_g2p_indications <- merge(crispr_data_ptmuts, maf_g2p_indications, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
crispr_g2p_indications$Mutation_Status_Nonsilent <- ifelse(is.na(crispr_g2p_indications$Mutation_Status_Nonsilent), "Other", crispr_g2p_indications$Mutation_Status_Nonsilent)
dup_g2p_indications <- filter(crispr_g2p_indications[, c("Hugo_Symbol", "CCLE_Name", "Broad_ID")] %>% group_by(Hugo_Symbol, CCLE_Name, Broad_ID) %>% tally(), n > 1)
crispr_g2p_indications <- merge(crispr_g2p_indications, dup_g2p_indications, by = c("Hugo_Symbol", "CCLE_Name", "Broad_ID"), all.x = TRUE)
crispr_g2p_indications$Genome_Change <- factor(crispr_g2p_indications$Genome_Change, levels = unique(crispr_g2p_indications$Genome_Change))
crispr_g2p_indications_nonNA <- filter(crispr_g2p_indications, is.na(n))
crispr_g2p_indications_plot <- ggplot(crispr_g2p_indications, aes(x = Hugo_Symbol, y = Score)) +
geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
geom_boxplot(alpha = 0.5, color = "lightgray", outlier.shape = NA) +
geom_jitter(width = 0.3, mapping = aes(color = Mutation_Status_Nonsilent), size = 1) +
theme_light() +
theme(legend.title = element_blank()) +
labs(x = "Gene", y = "CERES Score")
crispr_g2p_indications_plot
crispr_g2p_indications_muts_plot <- ggplot(crispr_g2p_indications, aes(x = Protein_Change, y = Score)) +
facet_grid(~ Hugo_Symbol, scales = "free_x", space = "free") +
geom_hline(yintercept = 0, lty = 2, color = "darkgray") +
geom_boxplot(alpha = 0.5, color = "lightgray", outlier.shape = NA) +
geom_jitter(width = 0.1, mapping = aes(color = Mutation_Status_Nonsilent), size = 1) +
theme_light() +
theme(legend.title = element_blank(), axis.text.x = element_text(angle = 90, hjust = 1)) +
labs(x = "Gene", y = "CERES Score")
crispr_g2p_indications_muts_plot
# ggsave("./plots_18Q3/manuscript/crispr_g2p_indications_plot_test.png", crispr_g2p_indications_plot, width = 12, height = 5, units = "in")
# ggsave("./plots_18Q3/manuscript/crispr_g2p_indications_muts_plot_test.png", crispr_g2p_indications_muts_plot, width = 20, height = 5, units = "in")
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print(sessionInfo())
## R version 3.5.0 (2018-04-23)
## Platform: x86_64-apple-darwin15.6.0 (64-bit)
## Running under: macOS 10.14
##
## Matrix products: default
## BLAS: /Library/Frameworks/R.framework/Versions/3.5/Resources/lib/libRblas.0.dylib
## LAPACK: /Library/Frameworks/R.framework/Versions/3.5/Resources/lib/libRlapack.dylib
##
## locale:
## [1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8
##
## attached base packages:
## [1] stats graphics grDevices utils datasets methods base
##
## other attached packages:
## [1] bindrcpp_0.2.2 forcats_0.3.0 stringr_1.3.1
## [4] dplyr_0.7.6 purrr_0.2.5 readr_1.1.1
## [7] tidyr_0.8.1 tibble_1.4.2 tidyverse_1.2.1
## [10] reshape2_1.4.3 kableExtra_0.9.0 ggsignif_0.4.0
## [13] ggpubr_0.1.7.999 magrittr_1.5 ggplot2_3.0.0
## [16] data.table_1.11.4 bsselectR_0.1.0
##
## loaded via a namespace (and not attached):
## [1] tidyselect_0.2.4 haven_1.1.2 lattice_0.20-35
## [4] colorspace_1.3-2 htmltools_0.3.6 viridisLite_0.3.0
## [7] yaml_2.1.19 rlang_0.2.1 pillar_1.3.0
## [10] glue_1.3.0 withr_2.1.2 readxl_1.1.0
## [13] modelr_0.1.2 bindr_0.1.1 plyr_1.8.4
## [16] cellranger_1.1.0 munsell_0.5.0 gtable_0.2.0
## [19] rvest_0.3.2 htmlwidgets_1.2 evaluate_0.11
## [22] labeling_0.3 knitr_1.20 parallel_3.5.0
## [25] highr_0.7 broom_0.5.0 Rcpp_0.12.18
## [28] scales_1.0.0 backports_1.1.2 jsonlite_1.5.9000
## [31] hms_0.4.2 digest_0.6.15 stringi_1.2.4
## [34] cowplot_0.9.3 grid_3.5.0 rprojroot_1.3-2
## [37] cli_1.0.0 tools_3.5.0 lazyeval_0.2.1
## [40] crayon_1.3.4 pkgconfig_2.0.1 xml2_1.2.0
## [43] lubridate_1.7.4 assertthat_0.2.0 rmarkdown_1.10
## [46] httr_1.3.1 rstudioapi_0.7 R6_2.2.2
## [49] nlme_3.1-137 compiler_3.5.0